급성 췌장염의 합병이 추정되는 한국형 출혈열 1예

박영수,김창오,김영근,홍성관,장경희,허애정,염준섭,송영구,김준명 대한감염학회 2001 감염 Vol.33 No.5

The Korean hemorrhagic fever (KHF) is an acute febrile disease with characteristic of fever, bleeding tendency, and renal failure. There are many complications of Korean hemorrhagic fever such as infection, anemia, internal bleeding, hypopituitarism, respiratory, and neurologic complication. A few cases were reported on acute pancreatitis with hemorrhagic fever abroad, but there was no case about Korean hemorrhagic fever with acute pancreatitis in this country. We experienced a case of Korean hemorrhagic fever associated with suspected acute pancreatits. With review of articles, we report a case of 51 year-old woman with KHF, where acute pancreatitis developed during management, (Korean J Infect Dis 33:376∼379, 2001)

전북지역 블루베리에 발생하는 해충종류와 블루베리혹파리 발생양상

임주락,김은주,문형철,조종현,한수곤,김희준,송영주,Lim, Ju-Rak,Kim, Eun-Ju,Moon, Hyung-Cheol,Cho, Chong-Hyeon,Han, Soo-Gon,Kim, Hee-June,Song, Young-Ju 한국응용곤충학회 2016 한국응용곤충학회지 Vol.55 No.1

2013~2014년 동안 전북지역 블루베리에서 총 37종의 해충이 조사되었다. 주요해충은 블루베리혹파리, 목화진딧물, 갈색날개매미충, 볼록총채벌레, 미국흰불나방, 장수쐐기나방 6종이었다. 목화진딧물 피해는 5월 중순 익산과 진안에서 심하게 발생하였다. 총채벌레 피해는 모든 지역에서 개화기인 6월초에 심하였고, 어린묘에서 심하였다. 갈색날개매미충은 중산간지역인 순창과 진안지역에서 대발생하여 전 지역으로 확산되고 있었다. 미국흰불나방은 6월 익산에서 특이적으로 집중 발생하는 경향이었다. 쐐기나방은 5종이 발생하였는데 그 중 장수쐐기나방이 모든 지역에서 발생밀도가 가장 높았다. 블루베리혹파리 피해는 중산간지대인 순창과 진안지역보다 평야지대인 익산지역에서 심하였고, 3년생 이하 어린 묘에서 피해율 60~78%로 5년생 이상 피해율 30~50%에 비하여 높았다. 또한, 하우스에서 피해율은 50~80%로 노지 피해율 30~40% 보다 높게 나타났다. Thirty-seven species of insect pests were surveyed on different area blueberry farms in Jeonbuk province during 2013~2014. Six principal insect pests were found, including Dasineura oxycoccana Johnson, Aphis gossypii Glover, Scirtothrips dorsalis Hood, Ricania sp., Hyphantria cunea Drury, and Latoia consocia Walker. A. gossypii infestation was severe at Iksan and Jinan in middle May. S. dorsalis infestation was severe at all surveyed area in early June, which is the flowering season, and the degree of damage caused was higher in young plants. Ricania sp. was abundant in Jinan and Sunchang, and then appeared to spread across all areas in Jeonbuk. H. cunea had a tendency to concentrate in Iksan during June. Five species of Limacodidae was found, including L. consocia, which was dominant in all areas surveyed, with densities higher then those of the others four species. The degree of damage due to D. oxycoccana was higher in the plain areas (Iksan) than in the middle-mountain areas (Jinan, Sunchang). The rate of damage was 60~78% higher in young plant stages (i.e., those under 3 years of tree age) than in those over 5 years old (30~50%). Moreover, the rate of damage observed in greenhouses was 50~80% higher than that observed in the field (30~40%).

백서의 복강내에 투여한 Mitomycin-C-Polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

송규상,강대영,최정목,노승무,정경수,오정연,김진향,양준목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

To evaluate the in-vivo effects of mitomycin-C-polyglycolic acid composite(MMC-PGA) the disk: shaped composite were implanted into the peritoneal cavity of the Sprague-Dawley rats. The pathologic changes were examined at various time points up to 12 weeks. Initially the soft tissue around the inserted disks showed capillary congestion at 3 days. Inflammatory infiltrates with foreign body giant cells appeared from the 2nd week and reached peak response at 6-8 weeks. These reaction diminished prominently at 12 weeks. No specific pathologic change was found in the liver, the kidneys, and the heart. The above results suggest that the MMC-PGA composite can serve as a new device for intraperitoneal chemotherapy of various types of cancers.

生物濾過를 利用한 侵出水 處理에 관한 硏究

宋在峻,李榮好 木浦大學校 工業技術硏究所 1995 工業技術硏究誌 Vol.5 No.-

Leachates from solid waste landfill in Kwangju City was collected, and its characteristics were analyzed. The leachate treatment removal characteristics of bio-filter filled with Netring filter media were experimentally examined with constant temperature, pH value and variable BOD loading and recirculation ratio. The results obtained are as follows: pH, TCOD, TBOD5, TKN, T-P's average concentrations were 6.5, 24,320mg/ℓ, 14,914mg/ℓ, 722.4mg/ℓ, 2.94mg/ℓ respectively. The ratio of TBOD/TCOD was 0.61 most of the organics is biodegradable by microorganisms, thus judged to require biological treatment. As a result of treatment with submerged biofilter maintaining F/M ratio of leachate at 0.1~0.4kg BOD/ kg MLVSS. day, the efficiency of BOD5 removal was 69.9~96.1% in raw leachate treatment process, and anaerobic digestive leachate process obtained BOD5 removal efficiency 51.4~90.7%. The BOD5 removal efficiency increases with the recirculation ratio, but the effenciency of increase becomes smaller as the recirculation ratio increases over 50.

嫌氣-無酸素-好氣法을 利用한 營養鹽類 除去에 關한 硏究

宋在峻,李榮好 木浦大學校 沿岸環境硏究所 1998 沿岸環境硏究 Vol.15 No.1

The Anaerobic-anoxic-oxic process, which can be applied practically as a slight modification of the existing facilities for wastewater treatment by activated sludge, is the simultaneous removal method of organic matter, nitrogen and phosphorous. The characteristics of nutrient from synthetic wastewater in the Anaerobic-anoxic-oxic process was investigated. Tests were made to establish the effluent level of COD, ??, T-P and other effects on nutrient removal in Anaerobic-anoxic-oxic process by decreasing hydraulic retention time (HRT) from 10.6 hours to 2.19 hours. The influent was synthesized to levels similar to the average influent of municipal wastewater treatment plants in Korea. Anaerobic-anoxic-oxic process was composed to anaerobic, anoxic, aeobic reactors in series and SARAN media with a porosity of 96.3% was packed. The COD removal efficiency of 95.1%, the ?? removal efficiency 88.5% and the T-P removal efficiency of 46.25% were achieved effectively at HRT of 10.6 hours. And the COD removal efficiency of 75.5%, the ?? removal efficiency 62% and the T-P removal efficiency of 20% were achieved effectively at HRT of 2.19 hours.

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

혈액투석 환자에서 대퇴신경범증으로 발현된 장골근 및 요근 농양 1예

이준상,강동구,신상열,윤재호,조영일,고성은,유영범,전혜정,진춘조,송종오 대한신장학회 2004 대한신장학회잡지 Vol.23 No.1

피부종양에서 Single-strand Conformation Polymorphisms 법에 의한 p53 유전자 돌연변이 검색

류영욱,손보성,권호준,이규석,송준영 啓明大學校 醫科大學 1995 계명의대학술지 Vol.14 No.4

The tumor suppressor gene p53, located on the short arm of chromosome 17, encodes for nuclear protein which regulates cell proliferation by inhibiting cells entering S-phase. Mutation in p53 gene are the most frequent genetic alteration found in human cancers to date. This study was examined mutant p53 gene mutation using PCR-SSCP method and mutant p53 oncoprotein expression using avidin biotin peroxidase complex method immunohistochemically, in 2 seborrheic keratosis, 3 basal cell carcinoma, 3 squamous cell carcinoma and 1 metaststic squamous cell carcinoma cases. With PCR-SSCP methods in exon 5 and 7, no genetic mutation of p53 gene was observed in 2 seborrheic keratosis, 3 basal cell carcinoma, 3 squamous cell carcinoma, and 1 metaststic squamous cell carcinoma cases. With immunohistochemical staining with ABC method, a case of squamous cell carcinoma developed on lower lip was positive but another were all negative. This result means that p53 gene mutation on skin tumor may develope in squamous cell carcinoma developed on sun exposed area and this mutation on squamous cell carcinoma can develope other exonal site except exon 5 and 7.

복막유착의 원인 규명과 예방을 위한 실험적 연구

강대영,송규상,노승무,조준식,이태용 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

Postoperative peritoneal adhesion is the most common cause of intestinal obstruction, and intestinal obstruction is one of the most difficult problems in abdominal surgery. In this experimental study for developing peritoneal adhesion model and its prevention, we divided rats into 5 groups; the talc powder treated group, the cotton-fluff treated group, the talc+fluff treated group, the ischemia group and the control group. There were 16 rats in each group. We made incisions on the midabdomen of the rats and administered talc powder, cotton fluff and talc powder+fluff into the peritoneal cavity respectively. In the ischemia group, we clamped the root of superior mesenteric artery for two minutes to induce ischemia on the small bowel of the rat. We counted the number of the peritoneal adhesive sites in peritoneal cavity on the 7th, 14th , 21st and 42nd postoperative day after peritoneal adhesion induced operation, and observed the characters of the adhesion state. The average number of the peritoneal adhesions were 1.25 per one rat in the talc powder group, 1.44 in the fluff group, 1.31 in the talc+fluff group and 1.31 in the ischemia group compared with 0.94 per one rat in the control group performed sham operation. 91.6% of the all adhesions were observed on the peritoneum of the previous incision sites and only 8.4% of the adhesions were adhered to the peritoneal surface of non-incision sites. The data of this study suggest that peritoneal injury and inflammatory reaction is the major cause of peritoneal adhesion. Also this study indicates that foreign bodies can develop peritoneal adhesion, but the effect is much lower than that of peritoneal injury with inflammatoty reaction.

공초점 원리를 이용한 3차원 표면형상 측정에 관한 연구

강영준,송대호,유원재 한국비파괴검사학회 2001 한국비파괴검사학회지 Vol.21 No.2

근대 산업에서 기계 부품들의 정밀도와 표면 마무리 조건은 그 어느 때보다 더 절박하게 요구되고 있는 가운데, 표면 형상의 측정과 이해는 공학 기술자뿐만 아니라 물리학자나 화학자도 높은 관심을 갖게 되었다. 이런 상황에서 광학적 측정 방법은 opto-mechatronics의 이점을 가지고 진동 측정이나 균열, 결함의 검출 등의 분야에서 유용한 측정 방법으로 사용되고 있고, 표면 형상학의 분야에서 다시 한 번 중요한 역할을 할 것으로 기대를 받고 있다. 본 연구에서는 공초점 현미경의 원리에 대해 서술하였고, 기존의 스캔 방식 공초점 현미경보다 한 차원 개선된 3차원 표면형상 측정 시스템을 개발하였다. 그리고, 표면의 기하적인 형상에 대한 정보를 얻고 그 형상을 가시화하기 위해 컴퓨터 시스템과 통합하고 그에 필요한 소프트웨어를 개발하였다. In modern industry, the accuracy and the surface-finish requirements for machined parts have been becoming ever more stringent. In addition, the measurement and understanding of surface topography is rapidly attracting the attention of the physicist and chemist as well as the engineer. Optical measuring method is used in vibration measurement, crack and defect detection with the advent of opto-mechatronics, and it is expected to play an important role in surface topography. In this study, the principle of confocal microscope is described, and the advanced 3-D surface measuring system that has better performance than the traditional confocal microscope is developed. Suitable fixtures are developed and integrated with the computer system for generating 3-D surface and form data. Software for data acquistion and analysis of various parameters in surface geometrical features has been developed.