Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

PASS (polyamic acid alkylamine salts) LB막의 유전 특성

강도열,김태완,박준수 弘益大學校 科學技術硏究所 1994 科學技術硏究論文集 Vol.4 No.-

Dielectric properties of PAAS LB films were studies in a frequency range of 10 Hz to 13 MHz. Y-type films were made under a surface pressure of 30mN/m using Kuhn type apparatus. It was found that there is a dielectric dispersion of electric polarization near 105 Hz. The effect of electric polarization was also confirmed by charging and discharging current under an application of dc voltage.

복막유착의 원인 규명과 예방을 위한 실험적 연구

강대영,송규상,노승무,조준식,이태용 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

Postoperative peritoneal adhesion is the most common cause of intestinal obstruction, and intestinal obstruction is one of the most difficult problems in abdominal surgery. In this experimental study for developing peritoneal adhesion model and its prevention, we divided rats into 5 groups; the talc powder treated group, the cotton-fluff treated group, the talc+fluff treated group, the ischemia group and the control group. There were 16 rats in each group. We made incisions on the midabdomen of the rats and administered talc powder, cotton fluff and talc powder+fluff into the peritoneal cavity respectively. In the ischemia group, we clamped the root of superior mesenteric artery for two minutes to induce ischemia on the small bowel of the rat. We counted the number of the peritoneal adhesive sites in peritoneal cavity on the 7th, 14th , 21st and 42nd postoperative day after peritoneal adhesion induced operation, and observed the characters of the adhesion state. The average number of the peritoneal adhesions were 1.25 per one rat in the talc powder group, 1.44 in the fluff group, 1.31 in the talc+fluff group and 1.31 in the ischemia group compared with 0.94 per one rat in the control group performed sham operation. 91.6% of the all adhesions were observed on the peritoneum of the previous incision sites and only 8.4% of the adhesions were adhered to the peritoneal surface of non-incision sites. The data of this study suggest that peritoneal injury and inflammatory reaction is the major cause of peritoneal adhesion. Also this study indicates that foreign bodies can develop peritoneal adhesion, but the effect is much lower than that of peritoneal injury with inflammatoty reaction.

Optical sensor를 이용한 M/T길이 자동 측정기

강준길 光云大學校 1988 論文集 Vol.17 No.-

본 연구는, Optical sensor를 이용하여 Magnetic Tape의 길이를 측정하여 Leader의 수 및 품질규격을 판정하는 프로세서 제어기에 관한 연구이다. CPU, ROM, RAM, I/O Port가 내장된 One-Chip Microprocessor 8031AH를 사용하여 30,000cm/min의 길이를 측정할 수 있게 하여 기존의 3,000(10cm/min)를 사용한 반기계식 자동 측정기보다 정확 및 정밀성이 향상되었으며 작업 상황을 Printer로 기록할 수 있어 공장 자동화의 역할을 할 수 있다.

RGB 칼라공간의 2차원 투영면을 이용한 효율적인 피부영역검출

강호진,최종무,이준호 成均館大學校 科學技術硏究所 2001 論文集 Vol.52 No.2

본 논문에서는 조명변화가 있는 영상에서 높은 피부영역의 검출 성능을 얻기 위해, RGB 칼라영상을 HSI 혹은 YIQ 칼라공간으로의 변환 없이 직접 RGB공간에서 피부영역을 검출하는 방법을 제안하고 실험하였다. RGB 칼라공간에서 피부영역이 선형적으로 분포하는 것을 이용하여 RGB 칼라영상에 주성분 분석(Principal Component Analysis)을 수행한다. 분산이 가장 큰 첫 번째 성분을 제외하고 분산이 적은 두 번째와 세 번째 축으로 이루어진 2차원 평면의 인덱싱 테이블을 만들어 피부영역 검출에 이용하였다. 조명 변화가 있는 영상에서 기존의 방법인 HSI 혹은 YIQ 칼라공간을 사용한 피부영역의 검출 성능보다 더 강인한 검출성능을 보였다. 제안한 방법의 검출성능을 평가하기 위해 Hue/Saturation 공간에서의 피부영역 검출성능을 비교 평가하였다.

S/N비를 개선하기 위한 LMS 적응 필터링에 관한 연구

강준길 光云大學校 1987 論文集 Vol.16 No.-

The perfomance of the adaptive filter, a digital filter composed of tapped delay line and adjustable weights, whose impulse response in controlled by an adaptive algorithm isis verified by the computer simulation. As a result, both the LMS adaptive filter using the error signal subtracting the estimated signal from the desired signal and the one using the error signal subtracting the estimated signal from the noisy input signal are showed about a 5dB improvement in signal-to-noise ratio(SNR).

디지탈 信號의 周波數 變移變調

康俊吉,洪義錫 光云大學校 1974 論文集 Vol.3 No.-

디지탈 통신 혹은 아날로그신호의 디지탈 메모리등을 위한 주파수 변조에 관한 시스템을 구성하였다. 본래는 양자화된 음성신호의 디지탈녹음을 위한 것으로서 디코딩을 행하였을때 본래의 아날로그 신호에 가까운 결과를 가져왔다. In the transmission or recording system for digital signals, some modulation techniques are used. High level and low level are shifted on frequencies of 50 KHz and 35 KHz respectively, and transmited to communication channel or to memory system. All system designed for these purposes showed in good results.

랜덤 액세스 통신망의 분석에 관한 연구

강준길 光云大學校 1995 論文集 Vol.24 No.-

본 논문에서는 Bernoulli 프로세스를 사용하여 슬롯으로 여러 사용자를 통신망에 랜덤 액세스하는 출력 프로세스를 분석한다. 이 출력 프로세스는 통신망내에서 패킷이 성공적으로 전송되는 것을 말한다. 이 프로세스를 근사화 하기 위한 변수는 특정한 랜덤 액세스 알고리즘에서 동작하는 임의의 통신망을 분석한다. 통신망 모델링은 성형(star topology)으로 구성된 서로 연결된 랜덤 액세스 통신망으로 가정한다. 성형구조의 중앙 노드에서 하나의 패킷이 소비하는 평균 시간은 상호 연결된 통신망에서 주어지는 출력 프로세스로부터 구한다. 그리고 통신망에서 트래픽이 많을때 효과적인 자원의 공유를 하기위해 우선순위를 부여하여 분석하였다. 이 결과 우선 순위의 레벨이 세분화되어감에 따라 슬롯당 패킷의 소요시간의 감소를 보였다. In this paper, Bernoulli process is used to the output process of a class of slotted multiuser random access communication networks. The output process is defined to be the process of the successfully transmitted packets within the network. The parameters of the processes are analytically calculated for a network operating under a specific random access algorithm. The applied methods are general and can be used to calculate these parameters in the case of the random access algorithm within a class. To evaluate performance, we consider a star topology of interconnected multiuser random- access communication networks. The mean time that a packet spends in the central node of the star topology is calculated under the output process of the interconnected networks. In the network traffic load, priority system performs better since it captures some of the strong dependencies, which are introduced by the priority level.

지속성 외래 복막투석환자에서 발생한 장간막경색증 1예

강동구,이준상,윤재호,장원철,조영일,송종호,전혜정 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.13 No.-

The mesenteric infarction, as a abdominal disease which show acute abdominal pain and almost need to emergency operation, has very high mortality. This mesenteric infarction has been reported very rarely. Also specific clinical manifestations are not clear, therefore initial diagnosis can be missed easily so that patients usually miss their opportunities for adequate treatment. Especially CAPD patients have high mortality because of their rareness and having similar symptoms like CAPD peritonitis. The authors report that the mesenteric infarction was miss-diagnosed to the CAF'D peritonitis with unspecific symptoms.

분자영상의학 개관

정준기,강주현 대한의사협회 2004 대한의사협회지 Vol.47 No.2