관동맥질환에서 저밀도 지단백 입자 크기의 분포

임효영,김인숙,승기배,강동헌,전두수,장기육,박준철,이수영,홍순조,최규보 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

김치에서 분리한 Lactobacillus sp. JC-7과 Lactobacillus acidophilus 88간의 Electrofusion 최적조건 설정

조영배,최현정,백형석,전홍기 부산대학교 유전공학연구소 1997 분자생물학 연구보 Vol.13 No.-

김치 발효 숙성기간을 연장하고 신선도를 오랫동안 유지 할 수 있는 김치발효 starter의 개발을 목적으로 최적숙성기에 있는 김치로부터 bacteriocin생성능이 없는 유산균을 분리하여 동정하였으며, bacteriocin생성능이 우수한 L.acidophilus 88을 융합시키기 위해 electrofusion에 대한 최적 조건을 검토하였다. 분리균주는 Lactobacillus속으로 동정되어 Lactobacillus sp. JC-7이라 명명하였다. Electrofusion에 의해 생성된 융합주를 식별하기 위해 streptomycin(2.5㎎/ml)에 내성을 나타내는 Lactobacillus sp. JC-7변이주와 kanamycin(600㎍/ml)에 내성을 나타내는 L.acidophilus 88변이주를 분리하였다. Electrofusion을 100V/㎝, 120msec(72ohms,1670 capacitance) 에서 수행했을 때 융합효율이 가장 양호하였으며 전기장의 세기와 시간이 중가할수록 융합 효율이 현저히 감소하였다. 2가 양이온은 농도가 중가할수록 대체적으로 융합효율을 감소시키는 경향을 나타내었으나 1mM MGCl_2에서는 대조군에 비해 융합효율이 약간 증가하였다. PEG매개에 의한 융합법의 융합효율을 비교한 결과, 융합효율은 chemical fusion<electrofusion<electrofusion+20% PEG순을 나타내었다. Evaluation of Optimum Conditions for the Electrofusion between Lactobacillus sp. JC-7 Isolated from Kimchi and Lactobacillus acidophilus 88. Young-Bae Jo, Hyun-Jung Choi, Hyung-Suk Baik and Hong-Ki Jun*. Department of Microbiology, Pusan National University, Pusan 609-735,Korea-A lactic acid bacterium was isolated from kimchi. The isolated strain was identified as the genus Lactobacillus thrugh its morphological characteristics and named as Lactobacillus sp. JC-7. The optimum conditions for the electrofusion between streptomycin(2.5㎎/ml)resistant mutant of Lactobacillus acidophilus 88 and kanamycin(600㎍/ml) resistant mutant Lactobacillus sp. JC-7 were evaluated. The highest number of fusants were obtained at a capacitance value of 120msec(1670㎌), a field strength of 100V/㎝,and a pulse controller setting of 72Ω. The potimum pH of elecroporation buffer was 7.5 and the concentration of divalent cation was 1mM MG^2+. Electrofusants were efficiently obtained by addition 20% polyethylene glycol to electroporation buffer. The yield of fusion was better than that of using polyethylene glycol mediated chemical induction.

연령대별 요추 추간판탈출증 환자의 요근과 척추주위근 단면적에 대한 분석

공덕현 ( Deok Hyun Kong ),배광호 ( Kwang Ho Bae ),고호연 ( Ho Yeon Go ),강명진 ( Myung Jin Kang ),김준수 ( Jun Su Kim ),양기영 ( Kee Young Yang ),이재훈 ( Jae Hoon Lee ),은영준 ( Young Jun Eun ) 한방재활의학과학회 2010 한방재활의학과학회지 Vol.20 No.4

Objectives :This study was designed to evaluate the correlation of the cross-sectional areas(CSA) of paraspinalis(iliocostalis lumborum, multifidus, longissimus thoracis parts lumborum) and psoas muscle and sex, age, change of the VAS(visual analogue scale) and past history of chronic low back pain in patients suffering from HIVD(herniation of intervertebral disc). Methods :Medical records of 140 subjects with HIVD were retrospectively reviewed. The MRI(magnetic resonance imaging) findings on the patients were scanned and analyzed by PiView program to find the paraspinal and psoas muscle CSA and were evaluated by the correlation of sex, age, change of the VAS, and past history of chronic low back pain. Results :There was significant difference between groups in male and female, young-adults age and middle age, middle age and old age, young-adults age and old age. But the correlation of the paraspinal and psoas muscle CSA and past history of chronic low back pain were partially significant. On the other hand, the correlation of the paraspinal and psoas muscle CSA and change of the VAS were not significant. Conclusions :These results suggest that the cross-sectional areas(CSA) of paraspinalis and psoas muscle have relevance to sex and age.

Direct effectiveness of pneumococcal polysaccharide vaccine against invasive pneumococcal disease and non-bacteremic pneumococcal pneumonia in elderly population in the era of pneumococcal conjugate vaccine: A case-control study

Kim, Jong Hun,Chun, Byung Chul,Song, Joon Young,Kim, Hyo Youl,Bae, In-Gyu,Kim, Dong-Min,Choi, Young Hwa,Jun, Yoon Hee,Choi, Won Suk,Kang, Seong Hee,Kwon, Hyun Hee,Jeong, Hye Won,Kee, Sae Yoon,Hur, Jia Elsevier Ltd. 2019 Vaccine Vol. No.

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>While herd effects and serotype replacement by childhood pneumococcal protein conjugated vaccines (PCVs) continues to accumulate worldwide, direct effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPV23) against pneumococcal diseases in the elderly has been challenged. We estimated the direct effectiveness of PPV23 in the elderly population.</P> <P><B>Methods</B></P> <P>For a hospital-based case-control study, cases of invasive pneumococcal disease (IPD) and non-bacteremic pneumococcal pneumonia (NBPP) (adults ≥ 65 years) were identified in 14 hospitals participated in the pneumococcal surveillance program from March 2013 to October 2015, following implementation of PPV23 national immunization program (NIP) for the elderly in the Republic of Korea. Controls matched by age, sex, and hospital were selected at ratios of 1:2 (IPD) or 1:1 (NBPP). Clinical data and vaccination records were collected. Vaccine effectiveness was calculated as (1-adjusted odds ratio) × 100.</P> <P><B>Results</B></P> <P>We enrolled 148 IPD and 557 NBPP cases, and 295 IPD and 557 NBPP controls for analyses. Overall effectiveness of PPV23 against IPD was 28.5% [95% confidence interval (CI) −5.8%–51.6%] and against NBPP was 10.2% (-15.1-30.6) in all patients ≥ 65 years. However, in subgroup analysis of patients aged 65–74 years, PPV23 was protective against IPD [effectiveness 57.4% (19.4–77.5)] and against NBPP [effectiveness 35.0% (2.3–56.7)]. Furthermore, serotype-specific effectiveness of PPV23 against IPD was 90.6% (27.6–98.8) for PPV23-unique serotypes and 81.3% (38.6–94.3) for PPV23 serotypes excluding serotype 3.</P> <P><B>Conclusions</B></P> <P>This study indicates that PPV23 with broad serotype coverage might be beneficial in preventing IPD and NBPP due to non-PCV13 serotypes in the young-elderly, with potentially increasing effectiveness in the setting of childhood PCV NIP.</P> <P><B>Highlights</B></P> <P> <UL> <LI> National immunization program for PPV23 for the elderly was implemented in Korea. </LI> <LI> PPV23 was effective against IPD and NBPP for young elderly patients aged 65–74. </LI> <LI> Effectiveness of PPV23 against IPD was higher for PPV23 unique serotypes. </LI> <LI> PPV23 was non-protective against IPD caused by PCV13 serotypes. </LI> </UL> </P>

현대 디지털건축에서의 Metamorphosis적 표현특성에 관한 연구

배준현,반영선 동양대학교 2008 동양대학교 논문집 Vol.13 No.1

This study focuses on analysing the trends of forming in contemporary architecture through the multi-meaning characteristics of metamorphosis. Metamorphosis means the turning from the real world to another dimensional world, with the characteristics of surrealism, symbolism and the aspect of play. In contemporary architecture, there are conformal expression by conscious and original operation: formal genesis by incidental and indeterminate dimension tectonic, mechanic and technic or formal genesis massive application against suurrealistic trends to make unconsciousness to real form by form and shape of traditional concept.

BCK-代數에 관한 고찰

田英培 慶尙大學校 1988 論文集 Vol.27 No.1

BCK-代數에서의 準同型寫像과 아이디얼에 관하여 硏究하고 旣約필터를 定義하여 몇가지 性質을 얻었다.

약물전달체로서의 고분자 미셀의 특징 및 고분자 미셀을 이용한 제품

김준배, 손진영, 이은주, 조정원 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-

The amphiphilic block copolymers forms the self -assembled micelles in aqueous solution. that is called as polymeric micelle. Polymeric micelles as drug delivery carriers can protect the drug against bio-logical environments (eg. low pH. enzymes). allow drug ellcapsulation in the hydrophobic inner center. in-crease the solubility of hydrophobic drugs). facilitate drug targeting. and reduce the side effects of chemotherapy. Another advantage is that polymeric micelles can prolong the circulation time of the drug us-ing the ligand for the specific target because the surface properties of the drug delivery system affect the circulation time in the blood and are related to the life span of the drug delivery system. Recent advances in the properties and application of polymeric micelles as drug delivery carriers for poorly soluble drug have been discussed in this review.

양방향 연상기억장치를 이용한 지능적 패턴 인식

전선배,임영도 동아대학교 공과대학 부설 한국자원개발연구소 1990 硏究報告 Vol.14 No.2

Enhancements of encoding and decoding strategy of a discrete bidirectional associative memory (BAM) proposed B. Kosko are presented. This paper describes multiple training, which allow to achieve recall of single trained pair under suitable initial conditions of data (We fixed Hamming distance). Computer simulations are shown to lead to an improvement in some instances over the original Kosko strategy for recall of multiple pairs.

안양천 등 관내하천의 수질오염분석 및 생태학적 분석에 관한 연구(II)

배준현,서정범,구본영 안양대학교 자연과학연구소 1997 自然科學硏究 Vol.4 No.-

안양천을 비롯한 10개 지천에 대한 환경오염 분석을 하였다. 전편(Ⅰ)에 이어 안양천의 관내지류인 산본천, 당정천, 오전천, 왕곡천, 통미천을 중심으로 하여 수질오염분석과 중금속오염도 조사 및 생태학적 분석에 대하여 연구하였다. 아울러 안양천 및 그 지류의 환경진단과 함께 하천을 살릴수 있는 몇가지 제안을 하였다. 안양천 및 지류의 수질오염분석결과 측정기간에 BOD 값이 평균 25.5 mg/l으로, 최저 17.0mg/l에서 최고 36.4mg/l으로 환경기준치를 초과하고 있다. COD는 평균 18.9mg/l으로 최저 12.7mg/l에서 최고 24.2mg/l로서 환경기준치인 5급수 수질을 초과하고 있으나 다른 수질의 지표에 비해 비교적 양호한 값을 나타내고 있다. SS는 평균 23.8mg/l으로 3급수 이내의 수질을 유지하고 있다. 총질소(T-N)는 평균치가 16.7mg/l으로 상류는 기준치 이하를 나타내고 있으나 중·하류는 5급수 이상의 높은 수치를 보이고 있어 제거대책이 강구되어야 할 것이다. 하천퇴적물에 대한 중금속 오염도 분석결과 5개항목 모두 기준치를 초과하여 높게 나타났으며 특히 아연(Zn)의 농도는 매우 심각한 것으오 분석되었다. 분석결과는 Zn>Cu>Pb>As>Cd순으로 나타났다. 생태학적 분석에 있어서는 안양천의 상류에서 하류에 이르기까지 어류는 서식하지 못하고 있으며 하류일부지역에서 오염에 강한 극소수 어류가 발견되었다. 식물도 하류로 갈수록 오염에 비교적 강한 식물이 군락을 이루고 있었다. Water pollution analysis about Anyangchun river and rivers within the province, investigation of a contamination level of heavy metal and ecological analysis were studies. The result of water pollution analysis Anyangchun river and its tributaries during the period of measure says BOD was average 25.5mg/l, ranging from minimum 17.0mg/l to maximum 36.4mg/l which exceeds and environmental standard level COD was average 18.9mg/l, ranging from minimum 12.7mg/l to maximum 24.2mg/lwhich exceeds fifth class of water quality, and environmental datum level, but represents relatively better value than the other base point of water quality. SS was average 23.8mg/l, which maintains water quality of below the third class. Total Nitrogen was average 16.7mg/l ; the upper water was seen below a base point, but the middle and lower showed exceeds fifth class of water quality. Therefore, a proper measure to remove nitrogen will have to be deviced. According to the analysis result of heavy metal contamination level about the river deposit, all of 5 items exceeded the environment base point. Specially, concentration of Zinc was considered very serious. The result of analysis was proven in the order to Zn>Cu>Pb>As>Cd. In ecological analysis, fish couldn't living from the upper water to the lower one in Anyang river with in province and a small minority of fish were discovered in part of the lower water. Hereby we suggested the alternative to decline water pollution in Anyang watercourse.

안양천 등 관내하천의 수질오염분석 및 생태학적 분석에 관한 연구(I)

배준현,이남훈,구본영 안양대학교 자연과학연구소 1996 自然科學硏究 Vol.3 No.-

안양천등 관내하천에 대한 수질오염분석과 중금속 오염도 조사 및 생태학적분석에 대하여 연구하였다. 아울러 안양천 및 그 지류의 환경진단과 함께 하천을 살릴 수 있는 몇가지 제안을 하였다. 안양천 및 지류의 수질오염분석결과는 측정기간에 BOD값이 평균 25.5mg/L으로, 최저 17.0mg/L에서 최고 36.4mg/L으로 환경기준치를 초과하고 있다. 하천퇴적물에 대한 중금속 오염도 분석결과 5개항목 모두 기준치를 초과하여 높게 나타났으며, 특히 아연(Zn)의 농도는 매우 심각한 것으로 분석되었다. 분석결과는 Zn>Cu> Pb> As> Cd 순을 나타났다. 생태학적 분석에 있어서는 안양천의 상류에서 하류에 이르기까지 어류는 서식하지 못하고 있으며 하류 일부지역에서 오염이 강한 극소수 어류가 발견되었다. The water pollution problem with which Anyangchun river is confronted has been investigated. Water pollution analysis about Anyangchun river and rivers within the province, investigation of a contamination level of heavy metal and ecological analysis were studies. Also, we suggested a few ways to make rivers survive with Anyang watercourse and its tributaries diagnosed environmentally. The result of water pollution analysis for Anyangchun river and its tributaries during the period of measured BOD was average 25.5mg/L, ranging from minimum 17.0mg/L to maximum 36.4mg/L, which exceeds an environment standard level. According to the analysis result of heavy metal contamination level about the river deposit, all of 5 items exceeded the environment base point. Especially, concentration of Zinc was considered very serious. The result of analysis was proven in the order of Zn, Cu, Pb, As, Cd. In ecological analysis, fish couldn't living from the upper water to the lower one in Anyang river and a small minority of fish were discovered in part of the lower water.