심장 점액종에 의한 중심망막동맥폐쇄 1예

김준오(Jun o Kim),최인호(In Ho Choi),최경식(Kyung Seek Choi) 대한안과학회 2017 대한안과학회지 Vol.58 No.4

목적: 중심망막동맥폐쇄 진단 후에 심장점액종이 발견되어 흉부외과에서 수술적 제거 후 경과관찰 중인 1예를 보고하고자 한다. 증례요약: 47세 여자 환자가 갑작스럽게 발생한 좌안의 시력저하를 주소로 안과에 내원하였다. 내원 당시 좌안 시력 안전수동, 안압 15.4 mmHg 측정되었으며, 좌안에 상대적 구심동공운동 장애가 관찰되었다. 안저검사에서 앵두반점 및 창백안저가 관찰되었으며, 빛간섭단층촬영검사상 황반부의 부종이 관찰되었다. 형광안저혈관조영에서 초기 및 후기에 맥락막 및 망막 혈관의 혈류 충만 장애 소견이 관찰되었고, 이를 바탕으로 좌안의 중심망막동맥폐쇄로 진단하였다. 신경외과에서 시행한 뇌혈관조영술에서 안동맥은 정상적으로 조영되었고, 혈관폐쇄는 관찰되지 않았다. 동맥폐쇄의 원인을 찾기 위해 심장내과와 신경과에 의뢰하였고, 심장초음파검사에서 좌심방에 4.46 × 2.09 cm의 심장점액종이 발견되었으며, 뇌 자기공명영상검사 후 급성 뇌경색을 진단하였다. 보존적 치료를 시행하며, 급성기 뇌경색 치료로 전신적 혈전 용해제를 사용하였고 흉부외과에서 좌심방점액종 절제술을 시행하였다. 심장점액종 절제술 시행 후 1개월째 시행한 형광안저혈관조영술상 망막의 혈액순환이 호전되었으나 시력은 개선되지 않았고, 3개월째 시행한 빛간섭단층촬영에서 황반부 부종은 감소했으나 망막층의 위축과 망막전막이 관찰되었다. 결론: 중심망막동맥폐쇄는 눈뿐만 아니라 전신적 질환을 함께 고려해야 하는 질병이다. 고혈압이나 심장질환, 당뇨 및 경동맥협착 등의 다양한 기저질환이 중심망막동맥폐쇄의 원인으로 알려져 있으며, 저자들은 심장점액종에 의해 망막중심동맥이 폐쇄된 증례를 경험하였기에 이를 보고하고자 한다. Purpose: We report the case of a patient diagnosed with central retinal artery occlusion caused by cardiac myxoma who underwent surgery to remove the myxoma. Case summary: A 47-year-old woman came to our clinic presenting with a sudden decrease of visual acuity in the left eye. At the first visit, left eye visual acuity was hand motion, and intraocular pressure was 15.4 mmHg. A relative afferent pupillary defect was observed in the left eye. On fundus examination, a pale retina and cherry-red spot were observed at the posterior pole. On optical coherence tomography, macular edema was found. On fluorescein angiography and indocyanine green angiography, delayed blood circulation of the retina and choroid was found at early and late stages. Cerebral angiography was performed in the neurosurgery department and showed no occlusion of the ophthalmic artery. Cardiac ultrasonography and brain magnetic resonance imaging were performed. On cardiac ultrasonography, 4.46 × 2.09 cm cardiac myxoma was found. Resection of the cardiac myxoma was conducted in the thoracic and cardiovascular surgery department. Multiple cerebral infarcts were detected by brain imaging, and antithrombotic treatment was administered. After one month, blood circulation in the retina and choroid was observed in fluorescence angiography, but there was no improvement of visual acuity. At the 3-month follow-up visit, macular edema was decreased, but retinal atrophy and epiretinal membrane were observed on optical coherence tomography. Conclusions: Central retinal artery occlusion is a disease related to one’s general condition. We experienced this case of central retinal artery occlusion caused by cardiac myxoma.

Evaluation and Selection of Optimal Promoters for the Hyper-Enhanced Baculovirus Expression System

Kyu Seek Kim,Jun Su Bae,Cheol June Choi,Jin Yong Lee,Ho Young Ji,Soo Dong Woo 한국응용곤충학회 2021 한국응용곤충학회 학술대회논문집 Vol.2021 No.04

A 28-DAYS REPEATED SODE TOXICITY STUDY OF PERFLUOROHEXANESULFONATE (PFHS) IN SPRAGUE-DAWLEY RATS

Seung Jun Kwack,Beom Seok Han,Gyu Seek Rhee,Jee-Eun Kim,Ji Myoung Kim,Mi Na Choi,Ji Seon Yang,Hyo Jung An,Soon Young Han,Sue Nie Park 한국환경독성학회 2009 한국독성학회 심포지움 및 학술발표회 Vol.2009 No.11

낮은 각막내피세포 밀도를 보인 환자에서 시행한 공막고정술

이용준(Yong Jun Lee),최경식(Kyung Seek Choi),이성진(Sung Jin Lee),이미리(Mi Ri Rhee) 대한검안학회 2012 Annals of optometry and contact lens Vol.11 No.1

목적: 1,000 cells/mm² 미만의 낮은 각막내피세포 밀도를 보인 환자에서 공막고정술을 시행한 후 각막내피세포의 손상 정도를 평가해 보았다. 대상과 방법: 공막고정술을 시행한 환자들 중 술 전 1,000 cells/mm² 미만의 낮은 각막내피세포 밀도를 보였던 7안을 대상으로 의무 기록을 후향적으로 조사하였다. 후방 인공수정체 탈구는 외부 공막고정술을, 무수정체안은 작은 공막 절개창과 접형 인공 수정체를 이용한 공막고정술을 시행하였다. 술 전후 경면 현미경을 통한 각막내피세포의 손상 정도와 임상 결과 및 합병증에 대해 알아보았다. 결과: 술 전 평균 교정시력(LogMAR)은 0.44±0.24였고, 술 후 최종 평균 교정시력(LogMAR)은 0.25±0.19였다. 수술 전후 각막내피세포 밀도는 평균 56.0±86.1 cells/mm² 감소하였다. 술 후 각막내피세포 감소율은 7.5±9.7%였으며, 연령에 따른 자연적인 감소분을 고려하면 수술로 인한 각막 내피세포감소율은 6.6±10.0%였다. 술 중 1안에서 전방출혈이 있었으며 술 후 2안에서 부분적인 수포 각막병증이 관찰되었다. 결론: 각막내피세포의 손상을 줄일 수 있는 방법들을 잘 적용하면 낮은 각막내피세포 밀도를 가진 눈에서 비교적 큰 손상 없이 공막고정술을 시행할 수 있을 것이다. Purpose: To investigate the endothelial cell loss after scleral fixation of posterior chamber intraocular lens (PCIOL) in low endothelial cell density (ECD) under 1,000 cells/mm². Methods: Retrospective review of 7 eyes were subjected to scleral fixation of PCIOL in low ECD. PCIOL subluxated eyes were operated with ab externo scleral fixation and aphakic eyes were operated with scleral fixation using foldable PCIOL. Endothelial cell loss, complications and postoperative outcomes were analyzed. Results: Mean LogMAR best corrected visual acuity improved from 0.44±0.24 to 0.25±0.19. Mean observed endothelial cell loss was 7.5±9.7% (56.0±86.1 cells/mm², 6.6±10.0% corrected for a natural endothelial cell loss of 0.6% a year). One eye had a intraoperative hyphema during the operation and 2 eyes had a postoperative localized bullous keratopathy. Conclusions: The scleral fixation with careful endothelial cell protection appeared to reduced endothelial cell loss and resulted visual improvement in low ECD.

Thimerosal의 발생독성에 관한 연구

곽승준(Seung Jun Kwack),이규식(Gyu Seek Rhee),김순선(Soon Sun Kim),손경희(Kyung Hee Sohn),김소희(So Hee Kim),채수영(Soo Young Chae),최요우(Yo Woo Choi),원용혁(Yong Hyuck Won),박귀례(Kui Lea Park) 한국독성학회 2003 Toxicological Research Vol.19 No.4

The purpose of our study was to evaluate the toxicity of the thimerosal in embryos and neonates. Thimerosal (also known as mercurothiolate) is a mercury-containing compound used in<br/> trace amounts to prevent bacteria and other organisms from contaminating vaccines, especially in opened multi-dose vials. The toxicity of mercury is well known and those most at risk occurrs in<br/> unborn babies and newborn babies. Test methods included in vitro whole embryo culture (WEC) system and in vivo test of neonatal toxicity in Wistar rats. Ethylmercury and methylmercury were used as positive controls for the evaluating of toxic effects of mercury. In WEC assay, treated concentrations of thimerosal, ethylmercury and methylmercury were up to 0.01, 0.025, 0.05, 0.1, 0.25, 0.5, 1, 2.5 and 5 mg/ml, respectively. All compounds didn’t show any morphological abnormalities, but showed retardation<br/> of growth and development in dose dependent manner (>0.5㎍/ml). These data indicated that thimerosal showed developmental toxicity in vitro. In vivo neonatal toxicity, Wistar rats were administered<br/> subcutaneously with thimerosal, ethylmercury, or methylmercury (5, 25, 50, 250, and 500 mg/kg) during from postnatal day (PND) 4 to 25. Significant effects of these compounds on relative organ<br/> weights and organ morphology were not observed in this experiment. However, accumulation of mercury was detected in the kidney and testis when treated with thimerosal, ethylmercury, or methylmercury. These results suggest that thimerosal may be a harmful compound to embryo and neonate, but used concentration of thimerosal in these experiments is much higher than that of clinical application. Further investigation is needed on the safety of vaccine components, i.e. a thimerosal using in vitro and in vivo tests in the future.

3-MCPD의 생식˙발생독성에 관한 연구

곽승준(Seung Jun Kwack),김순선(Soon Sun Kim),최요우(Yo Woo Choi),이규식(Gyu Seek Rhee),손경희(Kyung Hee Sohn),이이다(Rhee Da Lee),채수영(Soo Young Chae),정용현(Yong-Hyun Chung1),유일재(Il Je Yu1),박귀례(Kui Lea Park) 한국독성학회 2004 Toxicological Research Vol.20 No.2

3-Monochloro-1,2-propanediol(3-MCPD) is a toxic compound, often present in different foods containing acid hydrolyzed(AH) protein, like seasonings and savory food products. The purpose of the present study was to investigate the effects of 3-MCPD on male fertility, sperm and testosterone secretion. In vivo male fertility test was performed for observing the adverse effects of 3-MCPD on the function of male reproductive system and pregnancy outcome. 0.01, 0.05, 0.25, 1 and 5 mg/kg b.w. of 3-MCPD was given daily by gavage to groups of 15 adult male SD rats for 4 weeks. At the end of pre-treatment period, males were mated overnight with normal females. Following morning, males demonstrating successful induction of pregnancy were sacrificed on that day to assess sperm parameters and histopathology of reproductive organs. The resulting pregnant females were sacrificed on day 20 of gestation to evaluate pregnancy outcome. As a result, four-week paternal administration with 3-MCPD resulted in adverse effects on male fertility and pregnancy outcome without remarkable histopathological changes in testes and epididymides; sperm motility, copulation index and fertility index were markedly decreased in the treated group and numbers of live fetuses showed steep dose-response curves. Also, spermatogenesis was investigated in this experiment. However, no<br/> effect was observed on production of sperm in testes treated with 3-MCPD for 4 weeks. Hormone assay was performed for observing the effects of 3-MCPD on testosterone and luteinizing hormone (LH) in blood and testes of male SD rats and cultured primary Leydig cell. In result, significant changes of related hormones did not observed by treatment of 3-MCPD. These results indicated that paternal treatment with 3-MCPD induced spermatotoxic effect, which caused an antifertility on male.

3-MCPD의 생식ㆍ발생독성에 관한 연구

곽승준(Seung Jun Kwack),김순선(Soon Sun Kim),최요우(Yo Woo Choi),이규식(Gyu Seek Rhee),손경희(Kyung Hee Sohn),이이다(Rhee Da Lee),채수영(Soo Young Chae),정용현(Yong-Hyun Chung),유일재(Il Je Yu),박귀례(Kui Lea Park) 한국독성학회 2004 Toxicological Research Vol.20 No.1

3-Monochloro-1,2-propanediol(3-MCPD) is a toxic compound, often present in different foods containing acid hydrolyzed(AH) protein, like seasonings and savory food products. The purpose of the present study was to investigate the effects of 3-MCPD on male fertility, sperm and testosterone secretion. In vivo male fertility test was performed for observing the adverse effects of 3-MCPD on the function of male reproductive system and pregnancy outcome. 0.01, 0.05, 0.25, 1 and 5 mg/kg b.w. of 3-MCPD was given daily by gavage to groups of 15 adult male SD rats for 4 weeks. At the end of pre-treatment period, males were mated overnight with normal females. Following morning, males demonstrating successful induction of pregnancy were sacrificed on that day to assess<br/> sperm parameters and histopathology of reproductive organs. The resulting pregnant females were sacrificed on day 20 of gestation to evaluate pregnancy outcome. As a result, four-week paternal<br/> administration with 3-MCPD resulted in adverse effects on male fertility and pregnancy outcome without remarkable histopathological changes in testes and epididymides; sperm motility, copulation index and fertility index were markedly decreased in the treated group and numbers of live fetuses showed<br/> steep dose-response curves. Also, spermatogenesis was investigated in this experiment. However, no effect was observed on production of sperm in testes treated with 3-MCPD for 4 weeks. Hormone assay was performed for observing the effects of 3-MCPD on testosterone and luteinizing hormone (LH) in blood and testes of male SD rats and cultured primary Leydig cell. In result, significant changes of related hormones did not observed by treatment of 3-MCPD. These results indicated that paternal treatment with 3-MCPD induced spermatotoxic effect, which caused an antifertility on male.

국내 야생 조류에서의 뉴캣슬병 바이러스 항체분포율 조사

최강석(Kang-Seuk Choi),전우진(Woo-Jin Jeon),계수정(Soo-Jeong Kye),윤순식(Soon-Seek Yoon),정우석(Wooseog Jeong),김지예(Ji-Ye Kim),권준헌(Jun-Hun Kwon) 韓國家禽學會 2012 韓國家禽學會誌 Vol.39 No.2

Newcastle disease virus (NDV) infects a variety of birds with a wide range of clinical signs from asymptomatic to severe. During a 10-month period in 2011, a total of 1,024 sera from wild birds including 42 species of birds in 8 orders were collected and the seroprevalence of NDV in wild birds was evaluated by hemagglutination inhibition (HI) test. Evidence of NDV infection was observed in 12.6% (129/1,024) of wild birds with a maximum prevalence reported in Mandarin duck (27.8%, 32/115) followed by Mallard duck (20.8%, 57/274), Spot-billed duck (11.9%, 36/303), Pintail (2.9%, 1/34), Blacktailed gull (2.9%, 1/34), White-fronted goose (1.8%, 1/56) and Common teal (1.4%, 1/69). None of the other 35 species of wild birds were antibody-positive for NDV. Mandarin duck, Mallard duck and Spot-billed duck showed high sero-prevalance of 12.2% to 42% during winter season (November to March). Our results indicate that Mandarin duck, Mallard duck and Spot-billed duck might be natural reservoirs for NDV in Korea and the prevalence of NDV infection in wild birds displayed a seasonal pattern with high prevalence of NDV in winter season (November to March).

고위험 증식당뇨망막병증에서 범망막광응고술과 유리체강내 베바시주맙 병합치료의 장기간 효과

최준호,이성진,최경식,Jun Ho Choi,Sung Jin Lee,Kyung Seek Choi 대한안과학회 2010 대한안과학회지 Vol.51 No.6

Purpose: To evaluate long-term effects and usefulness of combined intravitreal injection of bevacizumab and panretinal photocoagulation (PRP) in patients with high-risk proliferative diabetic retinopathy. Methods: The authors retrospectively reviewed the records of 40 patients (40 eyes) with high-risk proliferative diabetic retinopathy who had been treated with PRP alone (laser treatment group, n=20) or intravitreal bevacizumab before PRP (combined treatment group, n=20). Changes in best corrected visual acuity (BCVA), central macular thickness (CMT) and the total area of leakage from active new vessels (NVs) were compared between the groups at one, three, and six months and at one year post-treatment. Results: In the combined treatment group, CMT decreased significantly at one month (p=0.021), and the areas of active NVs decreased significantly at one month (p=0.001) and three months (p=0.014) compared to those of the laser treatment group. However, there were no differences between the two groups after three months. In the combined treatment group, elevated intraocular pressures were found in three cases after one month, and there were vitreous hemorrhages in two cases after three months. Conclusions: The combined treatment showed significant early improvements in BCVA, CMT, and NVs regression for up to three months. However, long-term follow-up and additional treatment was necessary in the patients with persistent or recurred NVs and macular edema after three months. J Korean Ophthalmol Soc 2010;51(6):842-848

당뇨황반부종의 치료: 비교 연구

이용준,최경식,이성진,Yong Jun Lee,MD,Kyung Seek Choi,MD,PhD,Sung Jin Lee,MD,PhD 대한안과학회 2010 대한안과학회지 Vol.51 No.6

Purpose: To compare the effect and complications of treatments for diabetic macular edema. Methods: Literature review using the Korean medical database and the Korean Ophthalmological Society database was performed. Studies used consisted of patients with diabetic macular edema, comparing intravitreal triamcinolone acetonide (IVTA) injection with posterior subtenon triamcinolone acetonide (STTA) injection or intravitreal bevacizumab (IVB) injection, according to visual acuity (VA) outcomes, central macular thickness (CMT), and intraocular pressure (IOP) at 1, 3, and 6 months. Results: In the three studies comparing IVTA injection with STTA injection, IVTA injection demonstrated greater improvement in VA at 1 month and CMT at 6 months. The patients who received IVTA injection had significantly higher IOP at 3 months. In the three studies comparing IVTA injection with IVB injection, IVTA injection demonstrated greater improvement in VA at 3 months and CMT at 6 months. Conclusions: The functional and anatomical improvements are achieved by IVTA injection, STTA injection, and IVB injection for diabetic macular edema, and the effect of IVTA injection is more prominent than other injection types with longer duration. J Korean Ophthalmol Soc 2010;51(6):849-859