동하중 측정 신호처리의 개발에 관한 연구

신영균,이영준,박찬원,신형재,안광희 江原大學校 産業技術硏究所 1998 産業技術硏究 Vol.18 No.-

A high speed and stable A/D conversion data process is required to weigh a mass on moving conveyer weighing platter. The paper presents a new method to obtain stable and fast automatic weighing A/D conversion data process. Dynamic weighting system which is constructed with dual load cell is realized by the stable A/D conversion data preocess algorithm using DSP. The proposed memthod is applied to the real design, and that experimental results showed good performances of the weighing stability.

좌새골하정맥을 통하여 중심정맥도관 삽입 3 일 후에 발생한 상대정맥천공과 우흉수 : 증례 보고 A case report

조형찬,손주태,최준영,신일우,이헌근,정영균 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.4

A 67-year-old male patient had coronary artery bypass graft. Before the induction of general anesthesia, 16 gauge central venous catheter was inserted via left subclavian vein. Initial chest anteroposterior (AP) radiograph showed adequate position, and the central venous pressure measurement through it was satisfactory. This patient's progress was satisfactory, and he was extubated on the second postoperative day. Daily chest AP radiograph had been unremarkable until the third postoperative day, when a right-sided pleural effusion was seen. A day later, the patient complained severe chest pain and dyspnea. We suspected perforation of superior vena cava wall by tip of central venous catheter on the chest computerized tomograph (CT). The injection of radiopaque dye through the central venous catheter confirmed spillage into the mediastinum on the chest CT. Right chest tube was inserted. The patient's condition dramatically improved after chest tube insertion. (Korean J Anesthesiol 2002; 43: 525~530)

중추성 요붕증이 동반된 랑게르한스 세포 조직구증 1예

김진호,문준성,문선중,이지은,최재원,은미정,천경아,조인호,윤지성,원규장,이경희 신덕섭,이형우 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2

Central diabetes insipidus (DI) is a syndrome characterized by thirst, polydipsia and polyuria. Langerhans cell histiocytosis is one of the etiologies of DI. Recently we experienced a central DI associated with Langerhans cell histiocytosis. The 44 years old female patient complained right hip pain polydipsia and polyuria. We carried out water deprivation test. After vasopressin injection, urine osmotic pressure was increased form 109mOsmol/Kg to 327mOsmol/Kg (300%). Brain MRI showed a thickened pituitary stalk and at hot bone CT.CT guided biopsy revealed abnormal histiocytes proliferation and abundant lymphocytes, The final diagnosis was central DI associated with systemic Langerhans cell histiocytosis invading hip bone, L-spine and pituitary stalk. Desmopressin and etoposide chemotherapy were performed to the patient.

연강우량 자료를 이용한 수문시계열의 특성 분석

유재성,강인식,박준일,신형우 慶尙大學校生産技術硏究所 1999 生産技術硏究所論文集 Vol.15 No.-

As the water resources planning is work out, it should have stationarity and randomness to be used hydrological time series data for frequency analysis or modeling which are kinds of probability analysis. But, in the case of domestic, we assume that the hydrological time series data is stationarity but, is not randomness, so it is usual to work out the hydrological analysis. Therefore, as a result, we can not be eliminate the possibility that the hydrological analysis brings about distorted results. Accordingly, in this research, to analysis the properties of hydrological time series data, the trend test, stationary and randomness test were used. The summary of results is as below. Result of the properties of hydrological time series data, in most of the points, the tendency is not indicated, the time series was revealed as randomness which does not have hydrological persistence as definitely stationary. But, from data of yearly rainfall, points for Taegwallyong, Ullungdo, both nonstationarity and persistence were indicated.

Changes of depression and job stress in workers after merger without downsizing

Jun Ick Jung,Jun Seok Son,Young Ouk Kim,Chang Ho Chae,Chan Woo Kim,Hyoung Ouk Park,Jun Ho Lee,Young Hoo Shin,Jea Chul Ha 대한직업환경의학회 2018 대한직업환경의학회지 Vol.30 No.-

Background: Since the 1980s, restructuring, which includes downsizing, closures, mergers, and privatization, has expanded worldwide, and various studies have investigated its effect on health. However, previous studies have mainly focused on restructuring accompanied by massive lay-offs, and the effect of a merger on workers’ health is still controversial. This study aims to investigate changes in worker depression and job stress after a merger without downsizing, which is unusual in Korea. Methods: Repeated surveys were done in April 2014, April 2015, and April 2016 involving the participation of 209 subjects. Participants were divided into two groups, which were comprised of blue-collar workers (104) and whitecollar workers (105). Sociodemographic characteristics, including age, education level, job tenure, gender, marital status, smoking status, and alcohol consumption, were measured via a survey. To determine the level of depression, the Korean version of the Center for Epidemiologic Studies Depression Scale (CES-D) was employed, and to investigate job stress, the Korean Occupational Stress Scale-Short Form (KOSS-SF) was used. For statistical analyses, Pearson’s chi-square test, the Student’s t-test, and repeated measure analysis of variance (ANOVA) were performed. Results: The results showed that depression (CES-D, F[2, 400] = 0.466, p = 0.628) was changed but without significance and job stress (KOSS-SF, F[1.899, 379.831] = 3.192, p = 0.045) were significantly different. The betweengroup difference in the CES-D score between the blue- and white-collar workers by survey administration time was not statistically significant (F = 0.316, p = 0.574). The interaction between the survey time and occupational group was also not statistically significant (F = 0.967, p = 0.381). The between-group difference in the KOSS-SF total score was not statistically significant (F = 1.132, p = 0.289), and the interaction between the survey administration time and occupational group was also not significant (F = 0.817, p = 0.437). In the job stress subgroup analyses Job insecurity and Lack of reward showed a significant difference by survey administration time. Conclusion: This study showed that a merger without massive downsizing can cause negative health effects such as an changes in depression and increase in job stress. To improve the health of workers, both the immediate negative effects on health, and the long-term effects or their resolution over time should be considered prior to the merger.

National Academy of Medicine of Korea (NAMOK) Key Statements on COVID-19

Shin Hyoung-Shik,Park Hyesook,Kwon Jun Soo,Namgoong Hyun,Kim Seong-Jun,Kim June Myung,Peck Kyong Ran,Lee Kyungwon,Lee Jong-koo,Lee JinHan,Han Hee Chul,Hong SungJin,Park Byung-Joo,Lim Tae Hwan,Hwang Eu 대한의학회 2021 Journal of Korean medical science Vol.36 No.41

Clusterin protects H9c2 cardiomyocytes from oxidative stress-induced apoptosis $via$ Akt/GSK-$3{\beta}$ signaling pathway

Jun, Hyoung-Oh,Kim, Dong-Hun,Lee, Sae-Won,Lee, Hye-Shin,Seo, Ji-Hae,Kim, Jeong-Hun,Kim, Jin-Hyoung,Yu, Young-Suk,Min, Bon-Hong,Kim, Kyu-Won Korean Society for Biochemistry and Molecular Bion 2011 Experimental and molecular medicine Vol.43 No.1

Clusterin is a secretory glycoprotein, which is highly up-regulated in a variety of normal and injury tissues undergoing apoptosis including infarct region of the myocardium. Here, we report that clusterin protects H9c2 cardiomyocytes from $H_2O_2$-induced apoptosis by triggering the activation of Akt and GSK-$3{\beta}$. Treatment with $H_2O_2$ induces apoptosis of H9c2 cells by promoting caspase cleavage and cytochrome c release from mitochondria. However, co-treatment with clusterin reverses the induction of apoptotic signaling by $H_2O_2$, thereby recovers cell viability. The protective effect of clusterin on $H_2O_2$-induced apoptosis is impaired by PI3K inhibitor LY294002, which effectively suppresses clusterin-induced activation of Akt and GSK-$3{\beta}$. In addition, the protective effect of clusterin is independednt on its receptor megalin, because inhibition of megalin has no effect on clusturin-mediated Akt/GSK-$3{\beta}$ phosphoylation and H9c2 cell viability. Collectively, these results suggest that clusterin has a role protecting cardiomyocytes from oxidative stress and the Akt/GSK-$3{\beta}$ signaling mediates anti-apoptotic effect of clusterin.

Effect of Pulsed Electric Field Processing on the Metabolite Profiles in Broccoli (Brassica oleracea)

Jun Hyoung Shin,Gyoung-Deuck Kim,Dong-Un Lee,Joong-Hyuck Auh 한국산업식품공학회 2016 학술대회 및 심포지엄 Vol.2016 No.10

Broccoli, one of Brassica vegetables, has been known to possess various health beneficial activities including anti-inflammation, anti-oxidation and anti-cancer etc. Various metabolites were indicated as active compounds in broccoli. Glucosinolates such as glucoraphanin, glucobrassicin, glucoerucin and isothiocyanates, i.e. sulforaphane, which is produced through the enzymatic action of myrosinase are getting focus as their bioactivities. In this study, we treated broccoli with pulsed electric field (PEF) processing and the metabolite profiles were investigated based on the metabolomics analysis. PEF process was applied to stem and floret of broccolis with three different levels; 500, 1000, 1500 pulses with 2 kV/cm, then metabolites were extracted with 70% methanol. Metabolomic analysis was carried out with mass spectrometry through multivariate statistical analysis based on the OPLS-DA model. Significant changes of metabolite profiles were observed by PEF treatment and specific metabolites were affected as dose dependent manner. Content of major glucosinolates compounds such as glucoerucin, glucoiberin, glucoraphanin, glucobrassicin, 4-hydroxy glucobrassicin, and 4-methoxy glucobrassicin were significantly reduced, while sulforaphane was distinctively increased in PEF treated broccolis. The results implied that myrosinase released from vacuole by PEF processing transformed glucosinolate into isothiocyanate, which would be useful findings for enhancing bioactivity of broccoli by simple PEF treatment.

웹 기반 교육 시스템에서 교수지원 컴포넌트의 구현

길준형(Jun-Hyoung Kil),신호준(Ho-Jun Shin),김성원(Soung-Won Kim),김행곤(Haeng-Kon Kim) 한국정보과학회 2001 한국정보과학회 학술발표논문집 Vol.28 No.1B

현재, 사회가 정보화 되어감에 따라 교육분야에서 컴퓨터의 가치는 더욱 높아지고 있으며, 기존의 교실위주의 수업보다 시간적 공간적 제약을 덜 받게 되는 WBI(Web Based Instruction)는 무한한 발전 가능성을 가지고 있다. 하지만 기존의 WBI에서는 교수의 강의가 끝나면 수업 평가 후 학생에게 수업의 결과를 알려주는 형식이었고, 또한 학습자에게는 일률적으로 평가가 적용되어 학생의 수준에 맞는 수업을 할 수가 없었으며, 교수의 입장에서도 학생들의 평가 결과가 수업의 질을 높이거나 내용을 변경시킬 근거가 될 수는 없었다. 따라서, 수준별 학습을 위한 단계별 예비 테스트와 학습 후 테스트의 평가내용을 다양한 방법으로 시각적으로 제시하고, 또한 교수가 평가의 준거를 입력하고 학습자의 평가결과와 교수자의 평가준거를 비교할 수 있는 교수지원 컴포넌트를 작성하고자 한다. 이는 체계적인 평가 방법론이 되고 학습의 패러다임을 바꾸거나 과목을 변경할 경우, 그 결과에 따라 교소 방법의 변화나 수업내용을 변경하고자할 때 용이하다. 또한 유사한 다른 패러다임의 WBI 시스템에서도 이미 개발된 컴포넌트를 사용함으로써, 사용의 용이성과 이식성, 재사용성을 높일 수 있게 한다.

Comparison of commonly used ICR stocks and the characterization of Korl:ICR

Hye-Jun Shin,Young Min Cho,Hee Jung Shin,Hae Deun Kim,Kyung Min Choi,Mi Gyeong Kim,Hyoung Doo Shin,Myeon-Woo Chung 한국실험동물학회 2017 Laboratory Animal Research Vol.33 No.1

Mouse is a commonly used animal in life science studies and is classified as outbred if genetically diverse and inbred if genetically homogeneous. Outbred mouse stocks, are used in toxicology, oncology, infection and pharmacology research. The National Institute of Food and Drug Safety Evaluation (NIFDS; former the Korea National Institute of Health) have bred ICR mice for more than 50 years. We investigated to provide users with information and promote accountability to the Korl:ICR. To secure the indigenous data, biological characteristics of Korl:ICR were identified by comparing with other ICR stocks. This domestic ICR stock was denominated as ‘Korl:ICR’. Phylogenetic analysis using SNPs indicated that the population stratification of the Korl:ICR was allocated different area with other ICR. In addition, we measured litter size, body weight, body length, various organ weight, hematology and clinical blood chemistry of the Korl:ICR compared to other ICR. Otherwise, there are no significant differences among the biological phenotypes of Korl:ICR and other ICR. These results suggest that as a genetically indigenous source colony, the Korl:ICR is seperated (or independent) stock with other ICR. Also, we confirmed that there is no difference among the Korl:ICR and other ICR on biological phenotypes. Therefore, the Korl:ICR source colony might be a new stock in distinction from other ICR, it is a good milestone in securing ownership of the national laboratory animal resource. The NIFDS expects that the Korl:ICR mice will be useful animal resource for our domestic researchers.