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Sang Jun Han,Jee In Kim,Joshua H. Lipschutz,Kwon Moo Park 대한생리학회-대한약리학회 2021 The Korean Journal of Physiology & Pharmacology Vol.25 No.6
Primary cilia on kidney tubular cells play crucial roles in maintaining structure and physiological function. Emerging evidence indicates that the absence of primary cilia, and their length, are associated with kidney diseases. The length of primary cilia in kidney tubular epithelial cells depends, at least in part, on oxidative stress and extracellular signal-regulated kinase 1/2 (ERK) activation. Hydrogen sulfide (H2S) is involved in antioxidant systems and the ERK signaling pathway. Therefore, in this study, we investigated the role of H2S in primary cilia elongation and the downstream pathway. In cultured Madin-Darby Canine Kidney cells, the length of primary cilia gradually increased up to 4 days after the cells were grown to confluent monolayers. In addition, the expression of H2S-producing enzyme increased concomitantly with primary cilia length. Treatment with NaHS, an exogenous H2S donor, accelerated the elongation of primary cilia whereas DL-propargylglycine (a cystathionine γ-lyase inhibitor) and hydroxylamine (a cystathionine-β-synthase inhibitor) delayed their elongation. NaHS treatment increased ERK activation and Sec10 and Arl13b protein expression, both of which are involved in cilia formation and elongation. Treatment with U0126, an ERK inhibitor, delayed elongation of primary cilia and blocked the effect of NaHS-mediated primary cilia elongation and Sec10 and Arl13b upregulation. Finally, we also found that H2S accelerated primary cilia elongation after ischemic kidney injury. These results indicate that H2S lengthens primary cilia through ERK activation and a consequent increase in Sec10 and Arl13b expression, suggesting that H2S and its downstream targets could be novel molecular targets for regulating primary cilia
Yun, S.J.,Jun, K.J.,Komori, K.,Lee, M.J.,Kwon, M.H.,Chwae, Y.J.,Kim, K.,Shin, H.J.,Park, S. Pergamon Press 2016 Molecular immunology Vol.75 No.-
<P>Tim-3 is an immunomodulatory protein that is expressed constitutively on monocytes but is induced in activated T cells. The mechanisms involved in the regulation of TIM-3 transcription are poorly understood. In the present study, we investigated whether methylation of the TIM-3 promoter is involved in regulating TIM-3 transcription in T cells, and identified a transcription factor that regulates TIM-3 transcription by associating with the TIM-3 minimal promoter region. Pyrosequencing of the TIM-3 promoter up to 1440 bp revealed 11 hypermethylated CpG sites and 4 hypomethylated CpG sites in human CD4(+) T cells as well as in CD11b(+) cells. Dimethylation of histone H3 lysine 4 (H3K4), a mark of transcriptional activation, was predominantly found in the proximal TIM-3 promoter 954 to 34 by region, whereas trimethylation of H3K9 and H3K27, which are markers of transcriptional suppression, were mostly observed in the distal promoter -1549 to -1048 bp region in human CD4+ T cells and CD11b(+) cells. However, no change in the methylation status of CpG sites and the histone H3 in the TIM-3 promoter was found during induction of TIM-3 transcription in T cells. Finally, AP-1 involvement in TIM-3 transcription was shown in relation with the TIM-3 minimal promoter 146 to +144 by region. The present study defines the minimal TIM-3 promoter region and demonstrates its interaction with c-Jun during TIM-3 transcription in CD4(+) T cells. (C) 2016 Elsevier Ltd. All rights reserved.</P>
Kim, Su Jae,Cha, Su Young,Kim, Ji Young,Shin, Jong Moon,Cho, Yong Chan,Lee, Seunghun,Kim, Won-Kyung,Jeong, Se-Young,Yang, Y. S.,Cho, Chae Ryong,Choi, H. W.,Jung, Myung-Hwa,Jun, Byeong-Eog,Kwon, Ki-Yon American Chemical Society 2012 The Journal of Physical Chemistry Part C Vol.116 No.22
<P>There have been many studies of ferromagnetism in ZnCoO, and the results have been controversial. Secondary phases, such as Co oxides and Co metal clusters, in ZnCoO are easily produced during treatment, but the formation conditions are not well understood. We fabricated samples under hydrogen-injection conditions at different heat-treatment temperatures and examined the conditions by using synchrotron X-ray analysis under which Co<SUB>3</SUB>O<SUB>4</SUB> appeared or was transformed into Co metal. We investigated the transforming process of the ferromagnetic origin from intrinsic to extrinsic nature via intermediate region competition by Co–H–Co and Co metal cluster and suggest conditions that induce ferromagnetic spin ordering in ZnCoO due to Co–H–Co complexes through hydrogen mediation.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2012/jpccck.2012.116.issue-22/jp300536w/production/images/medium/jp-2012-00536w_0010.gif'></P>
화학 용액 담금의 열분해 방법에 의한 CdS 반도체의 성장
김홍복,김선미,권영규,차덕준,윤창선,김병호,고정곤,전용기,김광윤 群山大學校基礎科學硏究所 1998 基礎科學硏究 Vol.13 No.-
화학용액 담금의 방법에 의하여 다결정 CdS박막을 성장시켰다. 성장과정에서 온도조건, 몰농도 조건에 따라 CdS 다결정의 특성에 영향을 주는 요인들을 전자현미경, 광흡수 및 광전류 특성과 온도 및 빛의 세기에 따른 저항의 변화를 통해 분석하였다. Polycristalline CdS thin films have been grown by the chemical bath pyrolysis(CBP) method. The CdS films characteristics were investigated with scanning electron microscope(SEM), optical absorption measurements, photoconductivity, and resistance dependences on temperature and light intensity.
Foxp3 induces IL-4 gene silencing by affecting nuclear translocation of NFκB and chromatin structure
Kwon, H.K.,So, J.S.,Lee, C.G.,Sahoo, A.,Yi, H.J.,Park, J.N.,Lim, S.y.,Hwang, K.C.,Jun, C.D.,Chun, J.S.,Im, S.H. Pergamon Press 2008 Molecular immunology Vol.45 No.11
The forkhead family protein Foxp3 is a unique marker of regulatory T cells and plays a crucial role in the development and function of those cells. Ectopic expression of Foxp3 abolishes the expression of many cytokines in uncommitted cells but there is little information about whether it causes gene silencing in differentiated cells. In this study, we showed that ectopic expression of Foxp3 in primary T helper 2 cells abolished IL-4 gene expression. Foxp3 inhibited nuclear translocation of NFκB by increasing the stability of the NFκB inhibitor IκBα, which in turn reduced in vivo binding of NFκB to the IL-4 promoter region. Moreover, Foxp3 over-expression induced inactive chromatin structure by decreasing in vivo binding levels of acetylated histone 3 while increasing methylated histone 3 at lysine 9 in the IL-4 genomic locus. Our results suggest that Foxp3 could induce gene silencing by inhibiting NFκB activity and by causing its target loci to adopt an inactive chromatin configuration.
Age—Gender Difference in the Biomechanical Features of Sit-to-Stand Movement
Kwon, Y.,Heo, J.-H.,Jeon, H.-M.,Min, S. D.,Jun, J.-H.,Tack, G.-R.,Park, B. K.,Kim, J.-W.,Eom, G.-M. World Scientific 2016 Journal of mechanics in medicine and biology Vol.16 No.8
<P>The purpose of this study was to investigate the effects of age and gender on the biomechanical features of sit-to-stand (STS) movement. Twenty young subjects and 20 elderly subjects participated in this study. Nine events during STS movement were defined where joint angles and joint moments were extracted for further analyses. Two-way repeated measures ANOVA was performed for joint angles and joint moments with age and gender as independent factors. Major gender differences were shown in joint angles. Women used a sliding forward strategy more than men (more flexion of ankle and knee joint) during mid-phases of STS movement (p < 0.01) and men used an exaggerated trunk flexion strategy more than women (more hip flexion) in later phases of STS movement (p < 0.01). Age differences were shown in joint moments. Elderly subjects showed smaller knee extension moment (normalized by body weight) but greater ankle plantar flexion moment than young subjects in mid-to-late phases of STS movement (p < 0.001). More anterior positioning of center of mass (COM) in the elderly might be the reason for the strategy difference. That is, the shorter distance of COM from the knee joint would require less knee extension moment, and likewise, the more forward displacement of COM with respect to the ankle joint would need more plantar flexion moment. More anterior positioning of COM in the elderly, compared to the young was reflected on center of pressure (COP), and the forward displacement of COP was correlated well with the higher body mass index (BMI) and shorter thigh length (r = 0.359-0.66; p < 0.01).</P>
Effect of corrosion on the fatigue life of aged EMU under fatigue loading
Jun, H. K.,Seo, J. W.,Kwon, S. J.,Lee, D. H.,Park, S. H. Springer Science + Business Media 2016 International Journal of Precision Engineering and Vol.17 No.1
<P>It is very useful to know in advance the remaining life of long life span structure for the reasons of safety assurance or setting up cost effective overhaul strategy. A railroad car is designed to have a very long life span over 40 years, and therefore corrosion and fatigue damage on the major components of the structure are known to big problems. The fatigue damage is accelerated with the growth of corrosion due to the falling-off in strength. For this reason, the railroad industry performs diagnosis of the remaining life of aged railroad cars considering fatigue and corrosion effects on the structure. In this study, the remaining fatigue life of aged railroad cars was calculated by considering the effectivity of corrosion on the static and dynamic strength of the car-body For this purpose, a series of finite element analyses was performed to quantify) the effectivity of corrosion. And the results were implemented for the fatigue life prediction of aged car bodies. The fatigue life was reduced by about 20% at the corrosion thickness of 0.3 mm, the measured thickness on the 23 years aged car, and about 40% at the corrosion thickness of 0.72 mm, the predicted thickness on the 40 years aged car, compared to the base thickness of the car-body. Therefore it can be concluded that consideration of the corrosion effect is very important in prediction of the remaining fatigue life.</P>