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Precise Path Tracking with Hierarchy-Structured Dynamic Inversion Approach
Jun’ichiro Kawaguchi,Yoshikazu Miyazawa,Tetsujiro Ninomiya 한국항공우주학회 2008 한국항공우주학회 학술발표회 논문집 Vol.- No.-
This paper proposes an automatic flight control methodology for precise path tracking problems with hierarchy-structured dynamic inversion approach, which is based on multiple time-scale separation and multiple loop closure method. The dynamic equations for aircraft are grouped into four categories according to the time-scale of the variables and the commanded reference response for the faster variables is generated using dynamic inversion. The methodology features simple and systematic flight control design for path tracking problems since the guidance law and the attitude control law are synthesized using the complete 6DOF nonlinear aircraft dynamics. It also features that the aircraft model and the hierarchical control structure are independent from each other so that it realizes a universal design of automatic flight controllers which utilize the vehicle's 6DOF simulation data on board. This paper in the first place shows the outline of the control law development using hierarchy-structured dynamic inversion approach and its application to path tracking problems in flight control design, which is finally followed by a 6DOF nonlinear night simulation in order to ensure the validity of the methodology.
Discovery of New Fusion Inhibitor Peptides against SARS-CoV-2 by Targeting the Spike S2 Subunit
( Mahmoud Kandeel ),( Mizuki Yamamoto ),( Hideki Tani ),( Ayako Kobayashi ),( Jin Gohda ),( Yasushi Kawaguchi ),( Byoung Kwon Park ),( Hyung-joo Kwon ),( Jun-ichiro Inoue ),( Abdallah Alkattan ) 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.3
A novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), caused a worldwide pandemic. Our aim in this study is to produce new fusion inhibitors against SARS-CoV-2, which can be the basis for developing new antiviral drugs. The fusion core comprising the heptad repeat domains (HR1 and HR2) of SARS-CoV-2 spike (S) were used to design the peptides. A total of twelve peptides were generated, comprising a short or truncated 24-mer (peptide #1), a long 36-mer peptide (peptide #2), and ten peptide #2 analogs. In contrast to SARS-CoV, SARS-CoV-2 S-mediated cell-cell fusion cannot be inhibited with a minimal length, 24-mer peptide. Peptide #2 demonstrated potent inhibition of SARS-CoV-2 S-mediated cell-cell fusion at 1 μM concentration. Three peptide #2 analogs showed IC50 values in the low micromolar range (4.7-9.8 μM). Peptide #2 inhibited the SARSCoV- 2 pseudovirus assay at IC50=1.49 μM. Given their potent inhibition of viral activity and safety and lack of cytotoxicity, these peptides provide an attractive avenue for the development of new prophylactic and therapeutic agents against SARS-CoV-2.