http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Jun‑Pil Jee,Won Young Lee,Md. Asadujjaman 한국약제학회 2019 Journal of Pharmaceutical Investigation Vol.49 No.4
Background Long-acting injectable formulations (LAIFs) have received substantial attention recently due to their advantages over conventional formulations, including easy administration, continuous and controlled release of drug over months, and the ability to maintain drug concentrations within the therapeutic range. The constant advances in biotechnology produce complex active pharmaceuticals that might be difficult to administer by conventional means. In particular, peptides, proteins, and antibodies are hard to administer orally given their physicochemical instability in the gastrointestinal tract and short half lives in blood. Therefore, LAIFs are a good candidate delivery system for such drugs. LAIFs reduce the frequency of application and improve patient compliance. For instance, LAIF-based antipsychotics can be more effective in patients with bipolar disorder and schizoaffective disorder. Area covered This review provides an overview of the various drug delivery technologies using LAIFs. Poly (lactic-coglycolic acid) microspheres, hydrogels, organogels, and liquid crystals were chosen as representative LAIFs, and their preparation methods, advantages, limitations, challenges, and prospects are discussed. Expert opinion LAIFs are an attractive delivery system for bio-macromolecules that might participate in the new drug paradigm in the future. While each LAIF-based delivery technology has its own unique advantages, there are still some limitations that need to be overcome, and studies are being performed to understand and address these limitations.
Seyeon Kim, Jun-Pil Jee, Joon Hee Hong 조선대학교 기초과학연구원 2015 조선자연과학논문집 Vol.8 No.2
Novel 2'(β)-fluoro-3'(α)-hydroxy-threose nucleosides (iso-FMAU) as antiviral agents were designed and racemically synthesized from Solketal. Condensation successfully proceeded from a glycosyl donor 9 under Vorbrüggen conditions yielded the nucleoside analogues. Ammonolysis and hydrolysis of isopropylidene protection group gave the desired nucleoside analogues 12, 15, 18, and 19. The antiviral activities of the synthesized compounds were evaluated against the HIV-1, HSV-1, HSV-2 and HCMV. Compound 12 displayed some anti-HCMV activity (EC50=24.7 μg/ml) without exhibiting any cytotoxicity up to 100 μM.
The Korea Cohort Consortium: The Future of Pooling Cohort Studies
Sang-Jun Lee,Kwang-Pil Ko,Jung Eun Lee,Inah Kim,Sun Ha Jee,Aesun Shin,Sun-Seog Kweon,Min-Ho Shin,Sangmin Park,Seungho Ryu,Sun Young Yang,Seung Ho Choi,Jeongseon Kim,Sang-Wook Yi,Daehee Kang,Keun-Young 대한예방의학회 2022 예방의학회지 Vol.55 No.5
Objectives: We introduced the cohort studies included in the Korean Cohort Consortium (KCC), focusing on large-scale cohort studies established in Korea with a prolonged follow-up period. Moreover, we also provided projections of the follow-up and estimates of the sample size that would be necessary for big-data analyses based on pooling established cohort studies, including population-based genomic studies. Methods: We mainly focused on the characteristics of individual cohort studies from the KCC. We developed “PROFAN”, a Shiny application for projecting the follow-up period to achieve a certain number of cases when pooling established cohort studies. As examples, we projected the follow-up periods for 5000 cases of gastric cancer, 2500 cases of prostate and breast cancer, and 500 cases of non-Hodgkin lymphoma. The sample sizes for sequencing-based analyses based on a 1:1 case-control study were also calculated. Results: The KCC consisted of 8 individual cohort studies, of which 3 were community-based and 5 were health screening-based cohorts. The population-based cohort studies were mainly organized by Korean government agencies and research institutes. The projected follow-up period was at least 10 years to achieve 5000 cases based on a cohort of 0.5 million participants. The mean of the minimum to maximum sample sizes for performing sequencing analyses was 5917-72 102. Conclusions: We propose an approach to establish a large-scale consortium based on the standardization and harmonization of existing cohort studies to obtain adequate statistical power with a sufficient sample size to analyze high-risk groups or rare cancer subtypes.
Lee, Suk Jun,Bae, Joonbeom,Kim, Sunhee,Jeong, Seonah,Choi, Chang-Yong,Choi, Sang-Pil,Kim, Hyun-Sook,Jung, Woon-Won,Imm, Jee-Young,Kim, Sae Hun,Chun, Taehoon Kluwer Academic Publishers 2013 Biotechnology letters. Vol.35 No.2
<P>Treatment of helper T (Th) cells with saponins from soy bean and mung bean prevented their activation by inhibiting cell proliferation and cytokine secretion. However, the saponins did not affect the expression of major histocompatibility complex class II (A(b)) and co-stimulatory molecule (CD86) on professional antigen-presenting cells. Instead, the saponins directly inhibited Th cell proliferation by blocking the G(1) to S phase cell cycle transition. Moreover, blocking of the cell cycle by the saponins was achieved by decreased expression of cyclin D1 and cyclin E, and constitutive expression of p27(KIP1). Saponins also increased stability of p27(KIP1) in Th cells after antigenic stimulation.</P>
김포공항 주변(서울시 강서구, 경기도 부천시)의 거미상
김주필(Joo Pil Kim),예용택(Yong Taek Ye),장지현(Jee Hyeon Jang),예성훈(Seong Hun Ye),성원준(Won Jun Seong),김태우(Tae Woo Kim),김대희(Dae Hee Kim) 한국거미연구소 2015 한국거미 Vol.31 No.1
한국거미연구회 회원들은 2014년 10월 9일부터 11일까지 주야로 김포 공항 주변 A지구 오쇠천 주변, B지구 공항유류저장소 주변, C지구 (구)경호훈련장 및 동부간선수로(대보뚝, 간선뚝) 주변 그리고 D지구는 육군 5602부대 독수리훈련장 건너편 지역을 채집 조사한 결과 16과 21속 27종을 보고 발표한다. The authors investigated the spiders around the Kimpo airport in 2014, In the present paper 27 species of 21 genera belong to 16 families were identified. These specimens are deposited at the Arachnological Institute of Korea, Namyangju-si, Gyeonggi-do.
김주필(Joo Pil Kim),예용택(Yong Taek Ye),예성훈(Seong Hun Ye),유혜성(Hye Seong Yeu),장지현(Jee Hyeon Jang),오종화(Jong Hwa Oh),채준호(Jun Ho Chae),김태우(Tae Woo Kim),김민섭(Min Seob Kim),변진관(Jin Gwan Byun),이형민(Hyung Min Lee),김 한국거미연구소 2015 한국거미 Vol.31 No.2
2014년 8월 5일부터 7일까지 경상남도 창녕군 일대에 위치한 대한민국 최대의 내륙 습지인 우포늪 일대를 한국거미연구회 회원(김주필, 예용택, 장지현, 오종화, 예성훈, 유혜성, 채준호, 김태우, 김민섭, 변진관, 성민규, 김지후, 김대희, 김녕, 이정준, 이형민 등 16명)들이 채집 조사한 결과 16과 48속 69종의 거미가 조사 연구되어 이에 보고하는 바이다. The authors investigated the spiders of the Upo wetland from 5th August to 7th August, 2014. In the present paper 69 species of 48 genera belong to 16 families were identified. These specimens are deposited at the Joo-Pil Spider Museum, Namyangju-Si, Kyunggi-Do.