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Anti-Cancer Effects of Celecoxib in Head and Neck Carcinoma
Kim, Young-Youn,Lee, Eun-Jin,Kim, Yu-Kyoung,Kim, Soung-Min,Park, Ju-Yong,Myoung, Hoon,Kim, Myung-Jin Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.29 No.2
Although many studies highlighted cyclooxygenase2 (COX2) inhibition as a promising therapeutic strategy for cancer, more evidence is needed for clinical application. The purpose of this study was to investigate the feasibility of COX2 inhibition as a strategic treatment modality for head and neck carcinoma (HNC). We tested COX2 inhibitor, celecoxib in six types of HNC cells and analyzed the expression changes in proteins related to angiogenesis and apoptosis in vitro. We also evaluated proliferation, gelatinolysis and in vitro invasion. We used a hamster carcinogenesis model and a mouse tumorigenesis model for the in vivo evaluation of COX2 inhibition. We performed immunohistochemistry to assess changes in the expression of COX2, survivin and angiogenesis. Celecoxib administration caused decreases in the expressions of COX2, VEGF and survivin in vitro. Proliferation, in vitro invasion and gelatinolytic activity were reduced in HNC cell lines, but the effect was inconsistent across lines. COX2 inhibition retarded oral carcinogenesis from an early carcinogenic stage with increased apoptosis and decreased survivin expression. COX2 inhibition did not inhibit tumor growth, even with the COX2 downregulation and decrease in neovascularization. We conclude that COX2 inhibition has a chemopreventive effect, but its application as a treatment of HNC in a clinical setting still requires further research to overcome its limited anti-cancer effects.
현성희,성주연,최영길 ( Soung Hee Hyun,Ju Youn Soung,Yong Keel Choi ) 한국환경생물학회 1997 환경생물 : 환경생물학회지 Vol.15 No.2
Cyanobacteria (Anabaena cylindrica) lytic fungi were isolated from 4 reservoirs located in Kyonggi-Do, Korea. These isolates from Wangsong reservoir shown in eutrophication, were identified the genera Acremonium sp., and Penicillium sp. by morphological characters. The Penicillium sp. generally showed less algal lytic activity than the Acremonium sp. on the Anabaena cylindrica agar lawn, but the cultured supernatant of Penicillium sp. exhibited greater activity than the Acremonium sp. on Micrococcus luteus. In the mixed culture of Anabaena cylindrica and HCLF-34, the algae was segmented and lysed in 3 days. On the other hand, Anabaena cylindrica was aggregated, segmented, and lysed within 3 hours in the mixture of Anabaena cylindrica and the supernatant of HCLF-34. In addition, Anabaena cylindrica was segmented and the width sheath of Anabaena cylindrica was lysed on Scanning Electron Microscopy, in mixed culture of the algae and the fungi on agar plate.