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- 저자 : Jorge Luis Lopes Zeredo (검색결과 1 건)
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Age Differences in Naloxone Reversibility of Electroacupuncture on the Jaw Opening Reflex in Rats
Hiromi Yamashita,Jorge Luis Lopes Zeredo,Kazuo Toda 사단법인약침학회 2021 Journal of Acupuncture & Meridian Studies Vol.14 No.4
Background: Electroacupuncture is one of the most popular physical treatments for clinical pain, but the potential influence of a patient’s age on the effectiveness of electro acupuncture treatment has not been clearly established. Objectives: The present study aimed to detect a potential difference in electroacu puncture-induced analgesia between juvenile and adult rats. Methods: In this study, we investigated the effects of electroacupuncture treatment on the nociceptive jaw-opening reflex evoked by tooth-pulp stimulation in juvenile and adult rats. Results: Our results showed there were age differences in electroacupuncture-induced analgesic effects in rats, especially with naloxone antagonization. The ratio of naloxonereversibility against electroacupuncture analgesia was greater in adult rats than in juvenile rats. Conclusion: These results suggest that electroacupuncture analgesia is produced mainly by the non-opioid system in juvenile rats and by the opioid system in adult rats.
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