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문주연(Jooyeon Moon),임철희(Chul-Hee Lim),송철호(Cholho Song),이우균(Woo-Kyun Lee) 대한공간정보학회 2015 한국지형공간정보학회 학술대회 Vol.2015 No.5
도시의 녹지공간은 열섬현상 완화, 이산화탄소 흡수원의 기능 등과 같은 환경적 편익과 더불어 시민들에게 정신적, 육체적 공간 제공을 통한 기타 사회적 편익을 제공한다. 도시림이 제공하는 편익을 정량화하기 위한 연구는 많이 되어 있는 실정이나, 본 연구에서는 그 중에서도 도시림의 온도저감 기능에 집중하여 도시림이 국소지역의 미기후에 미치는 영향을 탐구하려한다. 이를 위해 서울시 25개 구 중 면적당 인구밀도가 가장 높고 공원조성 비율이 낮은 동대문구를 선정하여 도시림이 여름철 주변 지역 미기후에 영향을 미치는 정도를 실측기온자료를 통해 규명하고자 하였다.
Elucidating the Molecular Origin of Hydrolysis Energy of Pyrophosphate in Water
Hong, Jooyeon,Yoshida, Norio,Chong, Song-Ho,Lee, Chewook,Ham, Sihyun,Hirata, Fumio American Chemical Society 2012 Journal of chemical theory and computation Vol.8 No.7
<P>The molecular origin of the energy produced by the ATP hydrolysis has been one of the long-standing fundamental issues. A classical view is that the negative hydrolysis free energy of ATP originates from intramolecular effects connected with the backbone P–O bond, so called “high-energy bond”. On the other hand, it has also been recognized that solvation effects are essential in determining the hydrolysis free energy. Here, using the 3D-RISM-SCF (three-dimensional reference interaction site model self-consistent field) theory that integrates the <I>ab initio</I> quantum chemistry method and the statistical mechanical theory of liquids, we investigate the molecular origin of hydrolysis free energy of pyrophosphate, an ATP analogue, in water. We demonstrate that our theory quantitatively reproduces the experimental results without the use of empirical parameters. We clarify the crucial role of water in converting the hydrolysis free energy in the gas phase determined solely by intramolecular effects, which ranges from endothermic, thermoneutral, to highly exothermic depending on the charged state of pyrophosphate, into moderately exothermic in the aqueous phase irrespective of the charged state as observed in experimental data. We elucidate that this is brought about by different natures of solute–water interactions depending on the charged state of solute species: the hydration free energy of low-charged state is mainly subjected to short-range hydrogen-bonds, while that of high-charged state is dominated by long-range electrostatic interactions. We thus provide unambiguous evidence on the critical role of water in determining the ATP hydrolysis free energy.</P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ct300099e'>ACS Electronic Supporting Info</A></P>
Associations between Brain Perfusion and Sleep Disturbance in Patients with Alzheimer's Disease
Im, Jooyeon J.,Jeong, Hyeonseok S.,Park, Jong-Sik,Na, Seung-Hee,Chung, Yong-An,Yang, YoungSoon,Song, In-Uk Korean Dementia Association 2017 Dementia and Neurocognitive Disorders Vol.16 No.3
<P><B>Background and Purpose</B></P><P>Although sleep disturbances are common and considered a major burden for patients with Alzheimer's disease (AD), the fundamental mechanisms underlying the development and maintenance of sleep disturbance in AD patients have yet to be elucidated. The aim of this study was to examine the correlation between regional cerebral blood flow (rCBF) and sleep disturbance in AD patients using technetium-99m hexamethylpropylene amine oxime single-photon emission computed tomography (SPECT).</P><P><B>Methods</B></P><P>A total of 140 AD patients were included in this cross-sectional study. Seventy patients were assigned to the AD with sleep loss (SL) group and the rest were assigned to the AD without SL group. SL was measured using the sleep subscale of the Neuropsychiatric Inventory. A whole-brain voxel-wise analysis of brain SPECT data was conducted to compare the rCBF between the two groups.</P><P><B>Results</B></P><P>The two groups did not differ in demographic characteristics, severity of dementia, general cognitive function, and neuropsychiatric symptoms, with the exception of sleep disturbances. The SPECT imaging analysis displayed decreased perfusion in the bilateral inferior frontal gyrus, bilateral temporal pole, and right precentral gyrus in the AD patients with SL group compared with the AD patients without SL group. It also revealed increased perfusion in the right precuneus, right occipital pole, and left middle occipital gyrus in the AD with SL group compared with the AD without SL group.</P><P><B>Conclusions</B></P><P>The AD patients who experienced sleep disturbance had notably decreased perfusion in the frontal and temporal lobes and increased rCBF in the parietal and occipital regions. The findings of this study suggest that functional alterations in these brain areas may be the underlying neural correlates of sleep disturbance in AD patients.</P>
Jiyoung Kim,JooYeon Jhun,Jin Seok Woo,Seung Hoon Lee,Jeong-Hee Jeong,KyungAh Jung,Wonhee Hur,Seon-Yeong Lee,Jae Yoon Ryu,Young-Mee Moon,Yoon Ju Jung,Kyo Young Song,Kiyuk Chang,Seung Kew Yoon,Sung-Hwan 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Obesity, a condition characterized by excessive accumulation of body fat, is a metabolic disorder related to an increased risk of chronic inflammation. Obesity is mediated by signal transducer and activator of transcription (STAT) 3, which is regulated by genes associated with retinoid interferon-induced mortality (GRIM) 19, a protein ubiquitously expressed in various human tissues. In this study, we investigated the role of GRIM19 in diet-induced obese C57BL/6 mice via intra venous or intramuscular administration of a plasmid encoding GRIM19. Splenocytes from wild-type and GRIM19-overexpressing mice were compared using enzyme-linked immunoassay, real-time polymerase chain reaction, Western blotting, flow cytometry, and histological analyses. GRIM19 attenuated the progression of obesity by regulating STAT3 activity and enhancing brown adipose tissue (BAT) differentiation. GRIM19 regulated the differentiation of mouse-derived 3T3-L1 preadipocytes into adipocytes, while modulating gene expression in white adipose tissue (WAT) and BAT. GRIM19 overexpression reduced diet-induced obesity and enhanced glucose and lipid metabolism in the liver. Moreover, GRIM19 overexpression reduced WAT differentiation and induced BAT differentiation in obese mice. GRIM19-transgenic mice exhibited reduced mitochondrial superoxide levels and a reciprocal balance between Th17 and Treg cells. These results suggest that GRIM19 attenuates the progression of obesity by controlling adipocyte differentiation.
Progress and plans for the observational data assimilation module development at KIAPS
Hyo-Jong Song,Hyoung-Wook Chun,Su Jin Ha,Youngsoon Jo,Byoung-Joo Jung,Jeon-Ho Kang,Ji-Sun Kang,Hataek Kwon,Jihye Kwun,Sangil Kim,Ju-Hye Kim,Sihye Lee,Jooyeon Lim,Jong-Im Park,Young-Joon Kim 한국기상학회 2013 한국기상학회 학술대회 논문집 Vol.2013 No.4
New approach of using cortico-cortical evoked potential for functional brain evaluation
Hyunjin Jo,Dongyeop Kim,Jooyeon Song,Dae-Won Seo 대한임상신경생리학회 2021 Annals of Clinical Neurophysiology Vol.23 No.2
Cortico-cortical evoked potential (CCEP) mapping is a rapidly developing method for visualizing the brain network and estimating cortical excitability. The CCEP comprises the early N1 component the occurs at 10-30 ms poststimulation, indicating anatomic connectivity, and the late N2 component that appears at < 200 ms poststimulation, suggesting long-lasting effective connectivity. A later component at 200-1,000 ms poststimulation can also appear as a delayed response in some studied areas. Such delayed responses occur in areas with changed excitability, such as an epileptogenic zone. CCEP mapping has been used to examine the brain connections causally in functional systems such as the language, auditory, and visual systems as well as in anatomic regions including the frontoparietal neocortices and hippocampal limbic areas. Task-based CCEPs can be used to measure behavior. In addition to evaluations of the brain connectome, single-pulse electrical stimulation (SPES) can reflect cortical excitability, and so it could be used to predict a seizure onset zone. CCEP brain mapping and SPES investigations could be applied both extraoperatively and intraoperatively. These underused electrophysiologic tools in basic and clinical neuroscience might be powerful methods for providing insight into measures of brain connectivity and dynamics. Analyses of CCEPs might enable us to identify causal relationships between brain areas during cortical processing, and to develop a new paradigm of effective therapeutic neuromodulation in the future.