Kim's Femoral Stem의 임상적 고찰

김영민(Young Min Kim),김희중(Hee Joong Kim),진종수(Jong Soo Jin),문영완(Young Wan Moon) 대한정형외과학회 1991 대한정형외과학회지 Vol.26 No.5

관상동맥 질환에서 CD14 유전자형에 따른 세균 및 Heat Shock Protein에 대한 반응의 차이

한주용,최수연,조현주,김화평,강현재,구본권,김남중,김효수,손대원,오병희,박영배,최윤식 대한감염학회 2007 감염과 화학요법 Vol.39 No.1

Background : CD14 is the receptor for lipopolysaccharides and heat shock protein (HSP), which has been suggested being associated with increased risk of coronary artery disease (CAD). We investigated whether the response to infectious agents or HSP is different according to CD14 polymorphism in Koreans. Materials and Methods : Antibody titers to Helicobacter pylori, Chlamydia pneumoniae, and human HSP60 (hHSP60) were measured in 48 patients with stable CAD and in 41 healthy controls by ELISA. CD14 genotype was determined by PCR and high-sensitivity C-reactive protein (hs-CRP) was measured. Results : Seropositivity to C. pneumoniae and H. pylori, and antibody titer to hHSP60 were not significantly associated with the presence of CAD. CD14 genotype distribution was 31 TT (35%), 43 CT (48%), and 15 CC (17%). To compare the response to the infectious organism and hHSP60, we divided study population into 3 groups; CAD patients with non-TT genotype (group I, n=30), CAD patients with TT genotype (group II, n=18), and normal controls (group III, n=41). Seropositivity to C. pneumoniae and H. pylori, and antibody titer to hHSP60 were not significantly different among 3 groups. Though hs-CRP level was significantly different among 3 groups, post-Hoc analysis showed that hs-CRP level was not significantly different between group I and group II (group I: 1.6[1.1-3.5] mg/L and group II: 0.35[0.1-2.0] mg/L). Conclusions : This study suggests that the inflammatory responses to infectious organisms and HSP do not differ according to the CD14 genotype in Koreans. 목적 : 만성적인 세균 감염이나 자가 면역 반응이 동맥경화와 연관되어 있다는 주장이 제기되어 왔다. CD14은 lipopolysaccharides (LPS)와 heat shock protein(HSP)의 수용체로 C(-260)→T 다형성이 관상동맥 질환의 위험과 관련되어 있다고 제안되어 왔다. 본 연구에서는 한국인에서 CD14 다형성에 따른 LPS와 HSP에 대한 반응성을 염증표지자를 측정하여 살펴보고자 하였다. 재료 및 방법 : 안정형 관상동맥 환자 48명과 정상 대조군 41명을 대상으로 Chlamydia pneumoniae, Helicobacter pylori 항체 및 인체 HSP60 (hHSP60) 항체 역가를 enzyme-linked immunosorbent assay (ELISA) 방법으로 측정하였다. CD14 유전자형은 중합효소연쇄반응을 이용하여 결정하였고 hs-CRP를 측정하였다. 결과 : C. pneumonias 및 H. pylori 항체 양성 여부 및 항체 역가, 그리고 hHSP60에 대한 항체 역가는 안정형 관상동맥 질환의 유무와 유의한 상관관계는 없었다. CD14 유전자형의 분포는 TT 30명(39%), CT 31명(40%), 그리고 CC 16명(21%)이었다. 관상동맥 질환 군에서 TT 유전자형은 38%, 대조군에서는 32%로 TT 유전자형과 관상동맥 질환의 유무와는 유의한 상관관계가 발견되지 않았다(P>0.05). CD14 유전자형에 따라 C. pneumonias와 H.pylori 감염 및 hHSP60에 따른 반응에 차이가 있는지 여 부를 알아보기 위해, 관상동맥 질환 군을 다시 TT 유전자형 군과 non-TT 유전자형 군으로 나누어, 전체적으로 세군에서 항체 양성률과 역가를 비교하였다(I군: CD14 TT 유전자형을 가진 안정형 관상동맥 환자, II군: CD14 TT 유전자형을 가진 안정형 관상동맥 환자, III군: 정상 대조군). 세 군에서 C. pneumonias와 H. pylori 항체 양성률 및 hHSP60 항체 역가에는 유의한 차이가 없었다. 세 군사이에 hs-CRP 값에 유의한 차이가 있었지만, post-Hoc분석에서 II군의 hs-CRP 값이 I군에 비해 유의하게 높지는 않았다(0.35 [0.1-2.0] mg/L in group II vs. 1.6 [1.1-3.5]mg/L in group I, P>0.05). 결론 : 본 연구는 한국인에서 CD14 유전자형에 따라 LPS나 HSP에 대한 반응이 유의하게 다르지 않음을 시사한다.

게임 시나리오 동기화 모델 GSSM의 설계 및 구현

김달중,성해경,하수철 대전대학교 산업기술연구소 1999 산업기술연구소 論文集 Vol.10 No.2

기존의 시공간 동기화에 대한 연구는 대부분 멀티미디어 객체의 시간 동기화와 공간 동기화에 관한 연구가 이루어져 왔다. 이러한 연구는 시공간 동기화 표현에 있어서 게임의 운영 상황과 흡족히 일치하지를 못하고 있는 형편이다. 본 논문에서는 시공간 동기화에 대한 연구를 새로 제안된 시간과 공간, 시공간 언명으로 게임 시나리오에 적용하여 표현하고자 한다. 또한 시간과 공간, 시공간 공식으로 제안된 언명을 정형화된 표현법으로 나타내었으며, 게임 시나리오 동기화 모델(Game scenario Spatio-Temporal Synchronization Model : GSSM)을 설계하고 구현하였다. Most previous studies on the spatio-temporal synchronization had focused on either temporal or spatial synchronization of multimedia objects. They are not fully accorded with the status of game operation. In this paper, we apply new proposed temporal, spatial and spatio-temporal assertions for the study of spatio-temporal synchronization to game scenarios and represent them. Proposed assertions are presented with formal representations. Also, we design and implement GSSM(Game scenario Spatio-Temporal Synchronization Model) about assertions.

複素零點과 極點을 갖는 補償回路

金秀重 경북대학교 공과대학 1971 工大硏究誌 Vol.1 No.-

A pair of complex poles near the imaginary axis is often encountered in transfer function of servo systems. Effective compensation would remove the open-loop dominant complex poles and replace them with poles located farther to the left. This means that the compensator should have a transfer function of the form, Gc(S) = (1+BS+AS^2) / (1+DS+CS^2) In this paper, it has been shown that a compensating circuit using an operational amplifier, without any inductance, can also has a transfer function of the desired form, and then its properties have been investigated.

Image digitzer의 設計 및 製作

金秀重,權宇鉉 慶北大學校 1983 論文集 Vol.35 No.-

A generalized image digitizer has been designed to accept a atandard NTSC video signal and to digitize an arbitrary selected window of a stationary image by the program. The digitizer has a maximum resolution 512×440 pixel, and each pixel has 256 gray level. The hardware is powerftl and is controlled by the software, so that it is connedted with any microcomputer or minicomputer. Tpe results are displayed on the CROMEMCO graphic terminal.

난소암조직 Acid Deoxyribonuclease의 분리와 성상에 관한 연구

김두상,김영신,고재경,한중수 한양대학교 의과대학 1992 한양의대 학술지 Vol.12 No.1

In order to find out a possible role of acid deoxyribonuclease (DNase) in carcinogenesis of the ovary, activity of the enzyme was measured and the nature of the enzyme was studied in serous cystadenocarcinoma and endodermal sinus tumor of the ovary following the purification of the acid DNase in the tumor tissue of the ovary. (1)The acid DNase activity was greatly increased in the tumor tissues of the ovary, serous cystadenocarcinoma and endodermal sinus tumor tissues, while neutral and alkaline DNase activities were unchanged in the tumor tissues. This may indicate that the acid DNase can be used as a biochemical marker for the ovary tumors. (2)Proteins in the tumor tissues of the ovary were separated by a DEAE-cellulose column chromatography into 7 peak, respectively, of which one peak protein each appeared to be specific for serous cystadenocarcinoma and endodermal sinus tumor. (3)Acid DNases in the tumor tissues of the ovary were isolated into a single peak, respectively. The size of peak in the tumor tissues was greater than that in the control tissue of the ovary, indicating that the acid DNases in the tumor tissues were activated, but not specific for the tumors. (4)Acid DNases in the tumor tissues of the ovary were partially purified by centrifugation and a DEAE-cellulose column chromatography. The purified enzyme was highly active against double stranded DNA (ds-DNA), even though some activity was found against single stranded DNA (ss DNA). Observations that acid DNase from serous cystadenocarcinoma tissue was highly active and specific to ds DNA compared with ss DNA suggested that the enzyme might play a role in transforming normal ovarian cells into cancer cells.

간과된 건성 추지의 수술적 치료

김융성,서중배,이석재,홍장수 충북대학교 의학연구소 2001 忠北醫大學術誌 Vol.11 No.2

연구목적 . 손상 후 3주 이상 경과된 건성 추지에 대하여 tuft를 만들어 주고 신전상태에서 K-강선으로 고정하는 수술적 치료 방법의 유용성을 분석하고자 하였다. 대상 및 방범: 1997년 8월부터 2001년 3월까지 본 교실에서 건성 추지로 치료받은 예 중 손상 후부터 3주 이상 경과된 환자 11예를 대상으로 하였다. 평균 추시 기간은 7개월(3개월-9개월)이었으며, 평균 연령은 19세(2년 3개월-48세)였다. 11예 중 4예는 15세 미만의 소아였다. 수상 후 수술까지 경과된 기간은 평균 12개월(3주-7년)이었다. 우측 수부가 7예였고, 좌측은 4예였다 수지 별로는 인지가 3예, 중지가 4예, 약지가 2예, 소지가 2예였다. 모든 예에서 신전건의 절단, K-강선에 의한 원위지 관절의 고정, tuft의 형성, Roll-stitch 등의 동일한 방법을 사용하였으며, 최종 추시일에 Crawford 평가방법을 사용하여 환자를 평가하였다. 결과: Crawford의 방법을 이용한 평가 결과, 11예 중 7예(64%)가 우수(Excellent)의 결과를 보였고, 3예(27%)는 우량(Good), 1예(9%)는 양호(Fair)로 판명되었다. 즉 11예 중 1예를 제외하고는 모두, 즉 91%에서 만족스런 결과를 얻었다 우량 또는 양호의 결과를 보였던 4예의 경우 수상 후 경과된 기간이 각각 4개월, 9개월, 3년, 7년으로 수상 후 경과된 기간이 길수록 결과가 나빴다. 15세 미만의 소아 4예는 모두 우수한(Excellent) 결과를 보였고, 반면에 양호로 판정된 환자는 연령이 48세로 대상 환자 중 가장 고령이었다. 손상된 수지가 좌측이거나 우측인지 여부와 몇 번째 수지인지 여부는 결과와 무관한 것으로 보인다. 성별과도 관련성을 알 수 없었다. 결론: 손상 후 상당기간이 경과한 후에도 비교적 간단한 수술 방법에 의한 치료가 가능하였으며, 결과도 만족스러웠으나, 지나치게 오래된(손상 후 수 개월 이상이 경과한) 건성 추지의 경우, 그리고 나이가 많은 경우 예후가 좋지 않다는 사실을 알게 되었다. Purpose : The authors have attempted to analyze the effectiveness of making tuft and fixing the distal interphalangeal joint in extension with a K-wire in patients whose injured finger were left over 3 weeks without treatment for the tendinous mallet finger. Materials and Methods : Eleven fingers of eleven patients were analyzed who were treated operatively from August 1997 to March 2001. The average follow-up period was 7 months(3-9 months). The average age of the patients was 19 years(2 years 3 months-48 years) Four out of the 11 cases were children under age of 15. The average duration between injury and operation was 12 months(3 weeks-7 years) . All cases were treated by only one surgeon(Seo, JB) and with same procedure, just cutting and reattaching the extensor tendon tightly(tuft) and fixing the joint in extension. Crawford method was used for evaluating the patients. Results : Ten out of eleven patients(91%) came out to be satisfactory according to Crawford method. Excellent in 7 cases, good in 3, fair in 1, respectively. Four patients whose duration between injury and surgery seemed to be too long(4 months, 9 months, 3 years, 7 years respectively), have not showed excellent results. Excellent results were reported in all children. On the contrary, the age of the patient who had the poorest result was 48 years(the oldest in our series) Which hands or which fingers were injured seemed to have not made any differences. So as the surgery was performed earlier and the patients were younger, the results were better. Conclusion : We advocate that it is possible to treat operatively and to get good results in Patients with neglected mallet finger deformities. But it should be emphasized that the earlier the operation is performed, and the younger the patients are, the better the results are.

ART의 부분 병렬 처리 알고리즘

김중수 안동대학교 기초과학연구소 1992 基礎科學 硏究論文集 Vol.3 No.1

It is shown that ART is partially parallel processed by systolic algorithm with matrix-vector multiplication in the learning phase. In the search phase, also MAXNET is adopted because of systolic algorithm. Without limitation of neuron number, this algorithm is designed. Since computation of weights sum is parallelly processed with full pipelinability, time complexity of O(n^(2)) is reduced to O(n).

중합효소연쇄반응법을 이용한 급성 치수 및 치근단 질환의 병원성 세균의 동정

김지훈,유소영,임선아,국중기,임상수,박슬희,황호길 大韓齒科保存學會 2003 Restorative Dentistry & Endodontics Vol.28 No.2

The purpose of this study was to investigate the frequency of 7 putative pathogens in endodontic infections. The specimens were collected from infected pulpal tissue of patients who were referred for root canal treatment to the department of conservative dentisty, Chosun University. Samples were collected aseptically using a barbed broach and a paper point. The cut barbed broaches and paper points were transferred to an eppendorf tube containing 500 ml of 1 X PBS. DNAs were extracted from the samples by direct DNA extraction method using lysis buffer (0.5% EDTA, 1% Triton X-100). Identification of 7 putative pathogens was performed by PCR based on 16S rDNA. The target species were as follows: Porphyromonas endodontalis, Porphyromonas gingivalis, Prevotella intermedia, Prevotella nigrescens, Bacteroides forsythus, Actinobacillus actinomycetemcomitans, and Treponema denticola. Our data revealed that the prevalence of P.endodontalis was found in 88.6% (39 / 54), P.gingivalis 52.3% (23 / 44), P.nigrescens 18.2%(8 / 44), P.intermedia 15.9% (7 / 44), B.forsythus 18.2% (8 / 44), A.actinomycetemcomitans 2.3% (1 / 44), T.denticola 25% (11 / 44) of the samples. The high prevalence of P. endodontalis and P.gingivalis suggests that they may play an important role in the etiology of endodontic infections.

수치모형실험을 통한 콘크리트 구조물의 결함탐지에 관한 연구

김용인,변중무,손권익,서백수 江原大學校 産業技術硏究所 2004 産業技術硏究 Vol.24 No.B

In this study, First, the results of travel-time inversion (first arrival inversion using the travel-time of the first arrival) were compared with those of full-wave inversion for numerical data. Numerical experiments to find key parameters other than initial velocity model showed that the frequency of source has a great effect on the result of full-wave inversion. Finally, this research presented the corrected full-wave inversion applying the correction term to the final result of full-wave inversion. The corrected full-wave inversion depicted cavities inside concretes even when the inversion started with 20% error in an initial velocity model for cavities. However, full-wave inversion did not reveal cavities.