New conceptual approaches toward dentinregeneration using the drug repositioningstrategy with Wnt signaling pathways

Eui-Seon Lee,Tae-Young Kim,Yam Prasad Aryal,Kihyun Kim,Seongsoo Byun,Dongju Song,Yejin Shin,Dany Lee,Jooheon Lee,Gilyoung Jung,Seunghoon Chi,Yoolim Choi,Youngkyun Lee,Chang-Hyeon An,Jae-Young Kim 대한구강생물학회 2021 International Journal of Oral Biology Vol.46 No.2

This study summarizes the recent cutting-edge approaches for dentin regeneration that still do not offer adequate solutions. Tertiary dentin is formed when odontoblasts are directly affected by various stimuli. Recent preclinical studies have reported that stimulation of the Wnt/β-catenin signaling pathway could facilitate the formation of reparative dentin and thereby aid in the structural and functional development of the tertiary dentin. A range of signaling pathways, including the Wnt/β-catenin pathway, is activated when dental tissues are damaged and the pulp is exposed. The application of small molecules for dentin regeneration has been suggested as a drug repositioning approach. This study reviews the role of Wnt signaling in tooth formation, particularly dentin formation and dentin regeneration. In addition, the application of the drug repositioning strategy to facilitate the development of new drugs for dentin regeneration has been discussed in this study.

헐거운 마스크 착용이 눈물막파괴시간에 미치는 영향에 대한 고찰

이주헌(Jooheon Lee),안민원(Minwon Ahn),최재원(Jaewon Choi),박민지(Minji Park) 대한안과학회 2023 대한안과학회지 Vol.64 No.5

목적: 마스크의 헐거운 착용이 안구의 눈물막파괴시간에 어떠한 영향을 주는지에 대하여 단면 연구 및 실험 방법을 통하여 확인하고자 하였다. 대상과 방법: 안구건조증이 있거나 있지 않은 60인의 60안을 대상으로 연속적으로 마스크 미착용, 마스크 헐겁게 착용, 마스크 밀착착용 등 3가지 조건에서 10분간 각각의 상태 유지 후 비침습적 눈물막파괴시간(non-invasive tear-film break-up time)을 비교 분석하였다. 비침습적 눈물막파괴시간의 측정은 각막지형도(Keratograph)를 이용하였다. 결과: 단면 연구 분석에서 눈물막파괴시간은 마스크 미착용 시를 기준으로 마스크를 헐겁게 착용 시, 마스크 밀착 착용 시 각각 7.53 ± 0.83초, 6.19 ± 0.78초, 7.36 ± 0.68초로 확인되었으며 미착용 시와 밀착 착용 시 비교에서는 유의미한 차이를 보이지 않았으나(p-value=0.517) 마스크를 헐겁게 착용하였을 때 다른 2가지 조건과 비교하여 통계적으로 유의하게 눈물막파괴시간이 감소하였다(p-value=0.013). 결론: 헐거운 마스크 착용은 건성안의 유무와 관계없이 눈물막파괴시간을 감소시키며 건성안 증상을 유발하거나 악화시키는 요인으로 작용할 수 있다. Purpose: We investigated the the effect of wearing a loose mask on tear-film break-up time using cross-sectional and experimental methods. Methods: This was a comparative analysis of non-invasive tear-film break-up time (NIBUT) after wearing no mask, loose mask, and tight mask for 10 minutes each in 60 eyes with or without dry eye syndrome. NIBUT measurements were performed using a keratograph. Results: The NIBUT values were 7.53 ± 0.83 seconds, 6.19 ± 0.78 seconds, and 7.36 ± 0.68 seconds for the no mask, loose mask, and tight mask groups, respectively. There was no significant difference between the no mask and tight mask groups (ρ -value = 0.517), but the loose mask group had a significantly reduced NIBUT compared with the other groups (ρ-value = 0.013 and 0.022, respectively). Conclusions: Wearing a loose mask reduced the tear-film break-up time regardless of the presence or absence of dry eyes and may cause or worsen dry eye symptoms.

국세징수권의 소멸시효 중단사유로서 재판상 청구의 인정 여부 - 대법원 2020. 3. 2. 선고 2017두41771 판결을 중심으로 -

이주헌(Lee Jooheon) 한국세법학회 2021 조세법연구 Vol.27 No.1

민법 제168조, 제170조 내지 제177조는 일반적인 채권의 소멸시효 중단 사유에 관하여 규정하고 있다. 그리고 국세기본법은 제27조 제 1 항에서 국세징수권의 소멸시효 기간을 정한 뒤 그 제 2 항에서 “제 1 항의 소멸시효에 관하여는 이 법 또는 세법에 특별한 규정이 있는 것을 제외하고는 민법에 따른다”라고 규정하면서, 제28조 제 1 항에서 소멸시효 중단 사유로 납부고지, 독촉, 교부청구, 압류의 네 가지만을 규정하고 있다. 이처럼 일반적인 채권의 소멸시효 중단 사유에 관한 위 민법 규정과 조세징수권의 소멸시효 중단 사유를 규정한 국세기본법 제28조 제 1 항은 일치하지 않는데, 그렇다면 위 국세기본법 조문에 규정되어 있지 않은 소멸시효의 중단 사유도 위 국세기본법 제27조 제 2 항에 따라 당연히 국세징수권에 준용되는지 여부가 문제될 수 있다. 이와 관련하여 최근 민법 제168조 제 1 호 및 제170조에 규정된 재판상 청구가 국세징수권의 소멸시효 중단 사유가 되는가에 관하여, 대법원은 예외적으로 납세자가 무자력이거나 소재불명으로 압류의 집행에도 착수할 수 없는 경우로서 시효중단조치를 충실히 취하였음에도 시효완성이 근접한 경우에는 재판상의 청구도 조세채권의 소멸시효 중단사유가 된다고 판단하였다. 그러나 관련 법령의 문언과 취지, 관련 규정의 전체적인 체계, 조세정책적인 타당성, 그리고 무자력 상태라 어쩔 수 없이 세금을 체납하고 있는 납세자들에게도 상당한 영향력을 미치게 되고, 행정실무에도 많은 어려움을 가져올 수 있다는 점 등을 감안하여 보면, 조세채권에 대해서는 민법 제168조 제 1 항 제 1 호의 ‘청구’ 중 ‘재판상 청구’가 소멸 시효 중단 사유가 되지 않고, 이러한 결론은 대법원이 인정하는 예외적인 경우라 하더라도 마찬가지라고 봄이 타당하다. Article 170 to 177 of the Civil Act prescribe causes of interrupting extinctive prescription for general civil claims. Article 27, paragraph 1 of The Basic Act for National Taxes provides extinctive prescription periods and paragraph 2 stipulates, “Except as provided otherwise by this Act or other tax-related Acts, the provisions of the Civil Act shall be applied to the extinctive prescription as referred to in paragraph 1 above.” Furthermore, Article 28, paragraph 1 of the Act provides only four causes of interrupting extinctive prescription : notification on tax payment, urging, request for delivery, and attachment. Likewise, the causes of interrupting extinctive prescription specified in the Civil Act and the Basic Act for National Taxes are not similar. Therefore, issue whether or not the causes of interruption which were stipulated in the Civil Act but not in the Basic Act for National Taxes can be applied to tax claims according to the Article 27, paragraph 2 of The Basic Act for National Taxes. The Supreme Court recently ruled that filing of judicial proceedings which is prescribed in the Article 168, item 1 and Article 170 of the Civil Act can be a cause of interrupting extinctive prescription for tax claims, if the claims are sure to be uncollectible and nearing the expiration because the taxpayer is insolvent or nowhere to be found. However, the embarkment of judicial proceedings shall not be regarded as a cause of interruption even in the exceptional situation the ruling mentioned considering the terms and overall structures of the relevant provisions, burden on their administration, etc.

포스터 전시회 : 가열된 표면 위에서 충돌하는 뉴턴과 비뉴턴 액적의 동적 거동

문주현 ( Joo Hyun Moon ),정찬호 ( Chan Ho Jeong ),이여해 ( Yeo Hae Lee ),이진운 ( Jin Woon Lee ),김주헌 ( Jooheon Kim ),유홍선 ( Hong Sun Ryou ),이성혁 ( Seong Hyuk Lee ) 한국액체미립화학회 2013 한국액체미립화학회 학술강연회 논문집 Vol.2013 No.-

This article illustrates the temperature dependent spreading and receding characteristics of a Newtonian and a non-Newtonian droplet impact on a heated solid surface at different Weber numbers with surface temperatures. To make non-Newtonian droplets, a xanthan gum solution was used with different concentrations. From a high-speed camera images, spreading and receding diameters were captured during the impact process. For impact velocity and solid surface temperature, distinct differences in spreading and receding motions were found between Newtonian and non-Newtonian droplets. If a solid surface temperature increases, the maximum spreading diameter slightly increased at DI-water droplet whereas the maximum spreading diameters of xanthan gum droplets were similar for all surface temperatures. This is due to viscosity change on thin liquid lamella contact with heated surface. The receding phenomena could be clearly distinguished on the heated surface. The retraction rate of a xanthan gum droplet increased by increase Weber number whereas DI-water droplets were constant. Because both shear thinning and heat affected liquid lamella influenced a droplet receding, shear viscosity of the xanthan gum droplets decreased faster than the DI-water.

Isolated Bilateral Superior Cerebellar Peduncular Lesion Presenting Square-Wave Jerks and Ataxia

Jooheon Kong,Sun-Uk Lee,Sungwook Yu,Ji-Soo Kim 대한신경과학회 2023 Journal of Clinical Neurology Vol.19 No.1

Thermal conductivity improvement of surface-enhanced polyetherimide (PEI) composites using polyimide-coated h-BN particles

Lee, Hoing Lae,Kwon, O Hwan,Ha, Sung Min,Kim, Byoung Gak,Kim, Yong Seok,Won, Jong Chan,Kim, Jooheon,Choi, Jong Han,Yoo, Youngjae The Royal Society of Chemistry 2014 Physical chemistry chemical physics Vol.16 No.37

<P>In this study, we investigated the thermal conductivities and mechanical properties of polyetherimide (PEI) composites using polyimide (PI)-coated h-BN (PI-BN) particles. We found that PI-coated h-BN effectively increased adhesion with the PEI matrix, imparting enhanced mechanical and thermal stability and thermal conductivity with increasing BN content. The thermal conductivity of the PEI composite containing 60 wt% PI-BN was 3.3 W m<SUP>−1</SUP> K<SUP>−1</SUP>, while the thermal conductivity of the PEI/BN composite without modification was 2.6 W m<SUP>−1</SUP> K<SUP>−1</SUP>. The PEI/PI–BN composites show higher impact strengths than the PEI/BN composites because of less BN particle agglomeration and good wettability between PEI and h-BN. The results indicate that the PI-coated BN incorporated into the PEI matrix effectively enhances the thermal conductivity and mechanical properties of the PEI composites.</P> <P>Graphic Abstract</P><P>Enhanced thermal conductivities of PEI/(PI–BN) composites and their thermographic images. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4cp02730b'> </P>

초음파(UT) 자동 탐상을 이용한 초고강도강 저항 점용접부의 기공 검출 알고리즘 개발

박주헌(Jooheon Park),김재성(Jaeseong Kim),정상혁(Sanghyeok Jeong),이경돈(Kyungdon Lee) 대한용접·접합학회 2019 대한용접학회 특별강연 및 학술발표대회 개요집 Vol.2019 No.5

이퀄라이징 서보건을 활용한 핫스템핑 강재의 저항점용접성 평가

박주헌(Jooheon Park),정상혁(Sanghyeok Jeong),김재성(Jaesung Kim),이승호(Seungho Lee) 대한용접·접합학회 2024 대한용접학회 특별강연 및 학술발표대회 개요집 Vol.2024 No.5

국내 금속가공 중소기업의 스마트팩토리 활용 정도에 대한 실증적 연구

이종각 ( Jonggak Lee ),김주헌 ( Jooheon Kim ) 사단법인 아시아문화학술원 2020 인문사회 21 Vol.11 No.6

스마트팩토리는 국내 중소기업의 생산성 향상과 경쟁력 강화에 주요한 요소이며 국내기업에 스마트팩토리가 도입된지 5년이 지났다. 그렇지만 스마트팩토리를 활용하는 중소기업에 대한 분석이 부족한 실정이다. 이에 본 연구는 국내 금속가공 중소기업의 스마트팩토리 활용 정도를 실증적으로 분석하는데 그 목적이 있다. 국내 금속가공 중소기업에 대해서 내 외부 특성을 구분하여 스마트팩토리의 활용 정도를 설문조사를 통하여 심층적으로 분석하였다. 분석결과 국내 금속가공 중소기업의 경우 스마트팩토리 활용 정도에 통계적으로 유의하게 영향을 미치는 변수는 연구개발능력, 제품생산역량, 신뢰, 의존성, 협력, 영향력 등으로 파악되었다. 그리고 유의하지 않는 변수는 조직변화에 대한 태도, 위험감수성으로 분석되었다. 국내에 스마트팩토리는 지속적으로 도입되고 있으며 다양한 산업 분야에 적용되고 있다. 본 연구는 금속가공이라는 단일산업을 표본으로 하여 실증분석을 하였기에 그 결과를 일반화하는 데에는 한계가 존재한다. 스마트팩토리의 활용 정도와 구체적인 활용내용 그리고 성과 부분에 대해서 지속적인 후속연구가 있어야 하리라고 본다. Smart factory is a major factor in enhancing productivity and competitiveness of korea SMEs and Five years have passed since the introduction of smart factory to korea companies. Nevertheless, there is a lack of analysis on SMEs using smart factories. Therefore, the purpose of this study is to empirically analyze the degree of use of smart factories by Korea metal processing SMEs. The internal and external characteristics of domestic metal processing SMEs were classified and the degree of use of the smart factory was analyzed in-depth through a survey. As a result of the analysis, the variables that statistically significantly affect the degree of smart factory use in korea metal processing SMEs were identified as R&D capability, product production capability, trust, dependence, cooperation and influence. In addition, the variables that were not significant were analyzed as attitude toward organizational change and risk sensitivity. Smart factories are continuously being introduced in Korea and applied to various industrial fields. Since this study conducted an empirical analysis using a single industry called metal processing as a sample, there are limitations in generalizing the results. In the after, it is expected that there must be continuous follow-up research on the degree of use of the smart factory, the specific contents of use, and the performance.

국내 중소기업의 내·외부 요인이 스마트팩토리의 도입에 미치는 영향에 관한 탐색적 연구 : 금속가공업을 중심으로

이종각(Jonggak Lee),김주헌(Jooheon Kim) 한국IT서비스학회 2020 한국IT서비스학회지 Vol.19 No.6

Five years have passed since the introduction of the smart factory amid the new opportunities for growth and job creation in relation to domestic manufacturing companies. Nevertheless, there is a lack of analysis on SMEs introduction smart factories. This study empirically analyzed the effects on the introduction of smart factories of domestic metal processing SMEs by distinguishing the characteristics of enterprises In this study, 103 companies which introduced smart factories and another 106 companies which did not introduce them were sampled. The Introduction of the Smart Factory was analyzed by four categories such as the Company characteristics (R&D capability, product production capability, organizational change), entrepreneur characteristics (risk sensitivity), relational characteristics (trust, dependence, cooperation, Influence), and structural characteristics (competition). As a result of the research, we found out product production capacity, risk sensitivity, trust and cooperation, Influence, and competition are statistically significant in the introduction of smart factory. But competition was characterized by a negative (-) sign opposite to the hypothesis. This study is meaningful in that the scope of the analysis has been expanded by analyzing whether smart factory was introduced or not considering the characteristics of the company. And there should be continuous research on its utilization as well as the introduction of smart factory.