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Kim, Ji Yeong,Jeon, Woo Joo,Kim, Dong Hwee,Rhyu, Im Joo,Kim, Young Hwan,Youn, Inchan,Park, Jong Woong Medknow PublicationsMedia Pvt Ltd 2014 Neural regeneration research Vol.9 No.14
<P>Platelet-rich plasma containing various growth factors can promote nerve regeneration. An inside-out vein graft can substitute nerve autograft to repair short nerve defects. It is hypothesized that an inside-out vein graft filled with platelet-rich plasma shows better effects in the repair of short sciatic nerve defects. In this study, an inside-out vein autograft filled with platelet-rich plasma was used to bridge a 10 mm-long sciatic nerve defect in rats. The sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better improved than that of rats with a simple inside-out vein autograft. At 6 and 8 weeks, the sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better than that of rats undergoing nerve autografting. Compared with the sciatic nerve repaired with a simple inside-out vein autograft, the number of myelinated axons was higher, axon diameter and myelin sheath were greater in the sciatic nerve repaired with an inside-out vein autograft filled with platelet-rich plasma and they were similar to those in the sciatic nerve repaired with nerve autograft. These findings suggest that an inside-out vein graft filled with platelet-rich plasma can substitute nerve autograft to repair short sciatic nerve defects.</P>
Branching Patterns and Anatomical Course of the Common Fibular Nerve
Goo Young Kim,Chae Hyeon Ryou,Ki Hoon Kim,Dasom Kim,Im Joo Rhyu,Dong Hwee Kim 대한재활의학회 2019 Annals of Rehabilitation Medicine Vol.43 No.6
Objective To present the branching patterns and anatomical course of the common fibular nerve (CFN) and its relationship with fibular head (FH). Methods A total of 21 limbs from 12 fresh cadavers were dissected. The FH width (FH_width), distance between the FH and CFN (FH_CFN), and thickness of the nerve were measured. The ratio of the FH_CFN to FH_width was calculated as follows: <1, cross type and ≥1, posterior type. Angle between the CFN and vertical line of the lower limb 5 cm proximal to the tip of the FH was measured. Branching patterns of the lateral cutaneous nerve of the calf (LCNC) were classified into four types according to its origin and direction as follows: type 1a, lateral margin of the CFN; type 1b, medial margin of the CFN; type 2, lateral sural cutaneous nerve (LSCN); and type 3, CFN and LSCN. Results In the cross type (15 cases, 71.4%), the ratio of FH_CFN/FH_width was 0.83 and the angle was 13.0°. In the posterior type (6 cases, 28.6%), the ratio was 1.04 and the angle was 11.0°. In the branching patterns of LCNC, type 2 was the most common (10 cases), followed by types 1a and 1b (both, 5 cases). Conclusion Location of the CFN around the FH might be related to the development of its neuropathy, especially in the cross type of CFN. The LCNC showed various branching patterns and direction, which could be associated with difficulties of electrophysiologic testing.
ADP에 의해서 활성화된 인혈관세포의 Prothrombin과 골타액단백 부착에 관여하는 Integrin avβ3, avβ5, a5β1의 특성
주승재,최휘,김성만,차태준,이재우 고신대학교 의학부 2003 高神大學校 醫學部 論文集 Vol.18 No.1
Background : One of the most important features of integrins is that they exist in active and inactive states. Adenosine diphosphate (ADP), which is usually secreted from activated platelets, may activate integrins on vascular on vascular cells. Each integrin has its own activation-dependent ligands that have much higher affinity to active form than inactive one. Integrins that might mediate adhesion of human vascular cells to prothrombin(PT) and bone sialoprotein (BSP) after ADP stimulation were investigated. Methods : PT and BSP were used as activation-dependent ligands in adhesion assay. Adhesions of human umbilical vein endothelial cells (HUVEC) and human aortic smooth muscle cells (HASMC) were measured after stimulating with 100 μM of ADP, using ligand-coated 24-well plate and Fluorescence Multi-Well Plate Reader. Results : ADP activated HUVEC and HASMC to increase adhesions to PT and BSP in a dose-dependent manner. Adhesions of ADP-stimulated HUVEC to PT and BSP were almost completely inhibited by c7E3, a blocking monoclonal Ab to integrin β₃(96% and 92% inhibition, respectively), but not by P5H9, a blocking monoclonal Ab to integrin α_vβ_5. Adhesion of ADP-stimulated HASMC to PT was completely blocked by P5H9 (92% inhibition), but was not affected by c7E3. Adhesion of ADP-stimulated HASMC to BSP was partially inhibited either by P5H9 (46% inhibition) or by JBS5, a blocking monoclonal Ab to integrin inhibition), but was not affected by c7E3. However, it was completely blocked by cRGD (93% inhibition). Conclusion : These results indicate that the adhesion of ADP-stimulated HUVEC to PT or BSP was mediated by integrin α_vβ₃ and several integrins appeared to be involved in the adhesion of ADP-stimulated HASMC. While the adhesion of HASMC to PT was mediated by integrin α_vβ_5, the adhesion to BSP was associated with integrins α_vβ_5 and α_5β₁.
정휘정(Hwee Jeong Cheong),노주영(Joo Young Roh),오칠환(Chil Hwan Oh),김수남(Soo Nam Kim) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.3
A 21-year-old female is presented with semicircular lipoatrophy, which had developed since birth with annular depressed strophic lesion of the left thigh. Biopsy specimen from the depressed area of left thigh showed no abnormal pathologic findings. But X-ray and CT scan of the lower extremity revealed remarkably reduced fat layer of the left thigh, compared to the right side. (Kor J Dsrmatol 28(3): 358 361, 1990)
FoxO1 regulates leptin-induced mood behavior by targeting tyrosine hydroxylase
Son, Dong Hwee,Doan, Khanh V.,Yang, Dong Joo,Sun, Ji Su,Kim, Seul Ki,Kang, Namju,Kang, Jung Yun,Paik, Ji-Hye,DePinho, Ronald A.,Choi, Yun-Hee,Shin, Dong Min,Kim, Ki Woo Elsevier 2019 clinical and experimental Vol.91 No.-
<P><B>Abstract</B></P> <P><B>Purpose</B></P> <P>While leptin has been associated with various psycho-physiological functions, the molecular network in leptin-mediated mood regulation remains elusive.</P> <P><B>Methods</B></P> <P>Anxiolytic behaviors and tyrosine hydroxylase (TH) levels were examined after leptin administration. Functional roles of STAT3 and FoxO1 in regulation of TH expression were investigated using in vivo and in vitro systems. A series of animal behavioral tests using dopaminergic neuron-specific FoxO1 KO (FoxO1 KO<SUP>DAT</SUP>) were performed and investigated the roles of FoxO1 in regulation of mood behaviors.</P> <P><B>Results</B></P> <P>Here, we show that administration of leptin induces anxiolytic-like phenotype through the activation of signal transducer and activator of transcription 3 (STAT3) and the inhibition of forkhead box protein O1 (FoxO1) in dopaminergic (DA) neurons of the midbrain. Specifically, STAT3 and FoxO1 directly bind to and exert opposing effects on tyrosine hydroxylase (TH) expression, where STAT3 acts as an enhancer and FoxO1 acts as a prominent repressor. Accordingly, suppression of the prominent suppressor FoxO1 by leptin strongly increased TH expression. Furthermore, our previous results showed that specific deletion of FoxO1 in DA neurons (FoxO1 KO<SUP>DAT</SUP>) led to a profound elevation of TH activity and dopamine contents. Finally, FoxO1 KO<SUP>DAT</SUP> mice exhibited enhanced leptin sensitivity as well as displayed reduced anxiety- and depression-like behaviors.</P> <P><B>Conclusions</B></P> <P>This work establishes a novel molecular mechanism of mood behavior regulation by leptin and suggests FoxO1 suppression by leptin might be a key for leptin-induced behavioral manifestation in DA neurons.</P> <P><B>Highlights</B></P> <P> <UL> <LI> TH increment by leptin is via STAT3 activation and FoxO1 inhibition in midbrain. </LI> <LI> FoxO1 inhibition by leptin is a key in leptin-induced anxiolytic-like behavior. </LI> <LI> FoxO1 KO<SUP>DAT</SUP> mice showed enhanced leptin sensitivity and anxiolytic-like behavior. </LI> </UL> </P>