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손주환,온두현 全北大學校 1969 論文集 Vol.11 No.-
By the use of acetophenone containing P-toluene sulfonic acid, myoinositol have been converted into 1,2-0-(1-phenyl ethylidene) myoinositol. This Compound is important intermediate for stereochemical work. The preparation of 1, 4, 5, 6-0-acetylmyoinositol in good yield and the structure is described.
孫周煥,任齊彬 한국응용생명화학회 1982 Applied Biological Chemistry (Appl Biol Chem) Vol.25 No.3
느릅나무 粘液의 液性은 처음에는 中性이나 酸性으로 變한 다음 中性에 가까워지는 經時的 變化가 일어나며 粘液의 粘度低下는 黃蜀葵根 粘液 매우 緩慢하다. 또 이것은 遊離 還元糖을 含有하고 含量은 經時的으로 變化하여 처음에는 增加한 다음 急激하게 減少하며 糖含量과 粘度와의 사이에서 分明한 比例關係를 찾아볼 수는 없다. 糖類를 經詩的으로 分析한 結果 黃蜀葵根 粘液과는 달리 glucose 및 galacturonic acid等 2種의 糖類가 검출되었다. 그러나 粘質物의 加水分解 生成物에서 檢出된 糖類는 rhamnose, mannose, galactose, arabinose 그리고 galacturonic acid 等이며 黃蜀葵根 粘質物에서 檢出되었던 xylose는 檢出되지 아니하고 mannoserk 檢出되었다. The changes of hydrogen ton concentration, viscosity and free sugars in the water-soluble mucilage of Ulmus Coreana, Nakai root upon storage at 10℃ were studied, Hydrogen ion concentration in the mucilage changed pH7→pH4→pH6 or 7. The viscosity of mucilage decreased very slowly. The mucilage contained glucose and galacturonic acid. The hydrolyzed products of mucilage consisted of rhamnose, mannose, galactose, arabinose, xylose, glucose and galacturonic acid.
두경부 종양세포주에 대한 Mithramycin A의 세포자멸사 유도성 및Cisplatin 항암작용 증가효과
이강대,손성환,박종욱,김영록,이봉주,김주연 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.1
Background and Objectives : Cisplatin (CP) is a major chemotherapeutic agent for head and neck cancer. However, cancer cells can get drug resistance through recovering the DNA damage by CP. Mithramycin A (MA) can inhibit gene expression of multidrug resistance gene 1, c-myc or h-ras. The goal of this study is to evaluate the therapeutic effect of MA alone and combination of MA and CP on head and neck cancer cell lines. Materials and Methods : Two head and neck cancer cell lines (AMC-HN4, AMC-HN7) were treated with MA. The cellular proliferation, apoptosis and protein expression were measured with XTT assay, FACS analysis, and western blotting, respectively after MA treatment in cell lines. In order to know the combination effect of MA with CP, the cancer cell lines were treated with MA, CP, and MA/CP combination, and cellular proliferation, apoptosis and expression of apoptosis-associated proteins were measured. Results : MA inhibited the proliferation of head and neck cancer cells and induce dapoptosis. Increase of caspase activation, PLC-?1 fragmentation and percent apoptosis by MA treatment was blocked by z-VAD-fms, but not blocked by N-Acetyl Cystein. Combination of MA and CP significantly inhibited cancer cell growth and increased apoptosis compared to MA and CP alone, and it also suppressed the expression of anti-apoptotic proteins such as XIAP and Mcl-1. Conclusions : The present study suggests that MA alone andMA/CP combination chemotherapy could be a potential regiment for the control of the head and neck cancer.
2 - 아미노나프탈렌술폰산류의 자외선분광 광도법에 의한 분석
Sohn Joo Hwan(孫周煥),Kim Joo Youn(金宙元) 한국유화학회 1986 한국응용과학기술학회지 Vol.3 No.2
The sulfuric acid sulfonation mixtures of 2-aminonaphthalene, contained 2-aminonaphthalene, Dahl s acid, Broenner s acid, amino-F-acid and Baden acid, can be determined quantitatively by multicomponent spectrophotometric analysis. The analysis was performed in diluted sodium hydroxide aqueous solution and based on the ultraviolet absorption of the sodium salts of each isomers. The determination of quantity of each isomers was performed by subjection the absorbances of the unknown mixture and of its constituents, gathered at a large number of wavelengths, to a least square treatment by an electronic personer computer. This method provided a rapid analysis of such complex mixture, and the standard deviation was ±1.65 mole %.
SOHN, EUN JEONG,SHIN, MIN JEA,EUM, WON SIK,KIM, DAE WON,YONG, JI IN,RYU, EUN JI,PARK, JUNG HWAN,CHO, SU BIN,CHA, HYUN JU,KIM, SANG JIN,YEO, HYEON JI,YEO, EUN JI,CHOI, YEON JOO,IM, SEUNG KWON,KWEON, HA Spandidos Publications 2016 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.38 No.1
<P>Oxidative stress-induced apoptosis is associated with neuronal cell death and ischemia. The NOL3 [nucleolar protein 3 (apoptosis repressor with CARD domain)] protein protects against oxidative stress-induced cell death. However, the protective mechanism responsible for this effect as well as the effects of NOL3 against oxidative stress in ischemia remain unclear. Thus, we examined the protective effects of NOL3 protein on hydrogen peroxide (H2O2)-induced oxidative stress and the mechanism responsible for these effects in hippocampal neuronal HT22 cells and in an animal model of forebrain ischemia using Tat-fused NOL3 protein (Tat-NOL3). Purified Tat-NOL3 protein transduced into the H2O2-exposed HT22 cells and inhibited the production of reactive oxygen species (ROS), DNA fragmentation and reduced mitochondrial membrane potential (Delta(Psi m)). In addition, Tat-NOL3 prevented neuronal cell death through the regulation of apoptotic signaling pathways including Bax, Bcl-2, caspase-2, -3 and -8, PARP and p53. In addition, Tat-NOL3 protein transduced into the animal brains and significantly protected against neuronal cell death in the CA1 region of the hippocampus by regulating the activation of microglia and astrocytes. Taken together, these findings demonstrate that Tat-NOL3 protein protects against oxidative stress-induced neuronal cell death by regulating oxidative stress and by acting as an anti-apoptotic protein. Thus, we suggest that Tat-NOL3 represents a potential therapeutic agent for protection against ischemic brain injury.</P>
비이온성 계면활성제의 합성에 관한 연구(제2보) : Sucrose Monoester 류의 계면활성 Surface Activity of Sucrose Monoester
손주환,남기대,소희준 충북대학교 건설기술연구소 1982 建設技術論文集 Vol.1 No.1
Surface activities and physical properties that surface tension, foaming power, foam stability, dispersion effect, emulsifying power, wettability, penetrating effect, solubilization and critical micelle concentration of sucrose esters such as sucrose monolaurate, sucrose monomyristate, sucrose monopalmitate, sucrose monostearate and sucrose monooleate were determined and evaluated hydrophilic-lipophilic balance. The results show that all the sucrose monoesters are fairly good surface activities and exhibit specially the characteristics of oil in water type emulsifying agent, and values of their cmc are 24.5×10^(-5) 15.8×10^(-5), 10.3×10^(-5), 6.3×10^(-5) and 7.2×10^(-5) mole/ℓ at 25℃, respectively, and their HLB value are a range of 8∼12.
Sohn, Eunjin,Kim, Junghyun,Kim, Chan-Sik,Lee, Yun Mi,Jo, Kyuhyung,Shin, So Dam,Kim, Joo Hwan,Kim, Jin Sook Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>Increasing evidence indicates that advanced glycation end products (AGEs) contribute to the pathogenesis of diabetic nephropathy. The aim of this study was to investigate the protective effect of <I>L. japonica</I> extract (LJE) against renal damage in the db/db mouse. LJE (100 or 250 mg/kg per day) was given to diabetic mice for 12 weeks. Body weight, blood glucose levels, glycated hemoglobin (HbA1c) levels, and proteinuria were examined. In <I>in vitro</I> assay of the inhibition of AGE formation, immunohistochemical analysis of podocyte loss and AGE accumulations were performed. In 20-week-old db/db mice, severe hyperglycemia developed, and proteinuria was significantly increased. Diabetes induced markedly morphological alterations to the renal glomerular cells. AGE accumulations and podocyte loss were detected in renal glomeruli. LJE treatment significantly reduced proteinuria and AGE accumulations in diabetic mice. Moreover, the loss of nephrin, an important slit diaphragm component in the kidneys, was restored by LJE treatment. Our studies suggest that LJE might be beneficial for the treatment of diabetic nephropathy. The ability of LJE to attenuate proteinuria and podocyte dysfunction may be mediated by the inhibition of AGE accumulation in the context of diabetic nephropathy in db/db mice.</P>