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The HadGEM2-ES implementation of CMIP5 centennial simulations
Jones, C. D.,Hughes, J. K.,Bellouin, N.,Hardiman, S. C.,Jones, G. S.,Knight, J.,Liddicoat, S.,O&,apos,Connor, F. M.,Andres, R. J.,Bell, C.,Boo, K.-O.,Bozzo, A.,Butchart, N.,Cadule, P.,Corbin, K. D. Copernicus GmbH 2011 Geoscientific model development Vol.4 No.3
<P><p><strong>Abstract.</strong> The scientific understanding of the Earth's climate system, including the central question of how the climate system is likely to respond to human-induced perturbations, is comprehensively captured in GCMs and Earth System Models (ESM). Diagnosing the simulated climate response, and comparing responses across different models, is crucially dependent on transparent assumptions of how the GCM/ESM has been driven - especially because the implementation can involve subjective decisions and may differ between modelling groups performing the same experiment. This paper outlines the climate forcings and setup of the Met Office Hadley Centre ESM, HadGEM2-ES for the CMIP5 set of centennial experiments. We document the prescribed greenhouse gas concentrations, aerosol precursors, stratospheric and tropospheric ozone assumptions, as well as implementation of land-use change and natural forcings for the HadGEM2-ES historical and future experiments following the Representative Concentration Pathways. In addition, we provide details of how HadGEM2-ES ensemble members were initialised from the control run and how the palaeoclimate and AMIP experiments, as well as the 'emission-driven' RCP experiments were performed.</p> </P>
Multi-target-directed phenol–triazole ligands as therapeutic agents for Alzheimer's disease
Jones, Michael R.,Mathieu, Emilie,Dyrager, Christine,Faissner, Simon,Vaillancourt, Zavier,Korshavn, Kyle J.,Lim, Mi Hee,Ramamoorthy, Ayyalusamy,Wee Yong, V.,Tsutsui, Shigeki,Stys, Peter K.,Storr, Tim Royal Society of Chemistry 2017 Chemical Science Vol.8 No.8
<▼1><P>A series of multi-target-directed ligands are described that bind Cu, act as antioxidants, modulate Aβ peptide aggregation, and abolish Aβ toxicity in primary neurons.</P></▼1><▼2><P>Alzheimer's disease (AD) is a multifactorial disease that is characterized by the formation of intracellular neurofibrillary tangles and extracellular amyloid-β (Aβ) plaque deposits. Increased oxidative stress, metal ion dysregulation, and the formation of toxic Aβ peptide oligomers are all considered to contribute to the etiology of AD. In this work we have developed a series of ligands that are multi-target-directed in order to address several disease properties. 2-(1-(3-Hydroxypropyl)-1<I>H</I>-1,2,3-triazol-4-yl)phenol (<B>POH</B>), 2-(1-(2-morpholinoethyl)-1<I>H</I>-1,2,3-triazol-4-yl)phenol (<B>PMorph</B>), and 2-(1-(2-thiomorpholinoethyl)-1<I>H</I>-1,2,3-triazol-4-yl)phenol (<B>PTMorph</B>) have been synthesized and screened for their antioxidant capacity, Cu-binding affinity, interaction with the Aβ peptide and modulation of Aβ peptide aggregation, and the ability to limit Aβ<SUB>1–42</SUB>-induced neurotoxicity in human neuronal culture. The synthetic protocol and structural variance incorporated <I>via</I> click chemistry, highlights the influence of R-group modification on ligand-Aβ interactions and neuroprotective effects. Overall, this study demonstrates that the phenol–triazole ligand scaffold can target multiple factors associated with AD, thus warranting further therapeutic development.</P></▼2>
Informed Consent for Scholarly Articles during the COVID-19 Pandemic
Jones Xaviar Michael,Zimba Olena,Gupta Latika 대한의학회 2021 Journal of Korean medical science Vol.36 No.3
The coronavirus disease 2019 pandemic has caused a breakdown in the healthcare system worldwide. The need to rapidly update guidelines in order to control the transmission in the population and for evidenced-based healthcare care has led to the need for timely, voluminous and valid research. Amid the quest for a vaccine and better therapies, researchers clamouring for information has led to a wide variety of ethical issues due to the unique situation. This paper aims to examine the positive and negative aspects of recent changes in the process of obtaining informed consent. The article outlines the various aspects, from history, previously described exemptions to consenting as well as those implemented during the pandemic and the current impact of virtual methods. Further, the authors make recommendations based on the outcome of suggested adjustments described in the literature. This article looks into increasing the awareness of physicians and researchers about ethical issues that need to be addressed to provide optimal care for patients while assuring their integrity and confidentiality.
Jones, Jana,Mirzaei, Mehdi,Ravishankar, Prathiba,Xavier, Dylan,Lim, Do Seon,Shin, Dong Hoon,Bianucci, Raffaella,Haynes, Paul A. Royal Society 2016 Philosophical transactions. Series A, Mathematical Vol.374 No.2079
<P>This article is part of the themed issue 'Quantitative mass spectrometry'.</P>
Jones, Roy The Korean Society of Animal Reproduction 1999 Reproductive & developmental biology Vol.23 No.4
Four important attributes for successful fertilization by a spermatozoon are (ⅰ) correct morphology, (ⅱ) correct presentation of egg recognition and fusion molecules, (ⅲ) progressive motility and (ⅳ), correct transfer of signalling molecules from sperm to egg for activation of development. In this presentation, these topics will be described and illustrated with emphasis on the endogenous control mechanisms that enable spermatozoa to respond to external signals. (omitted)
Fuzzy-PID Controller Applied to a Refrigeration System
JONES ERNI SCHMITZ,FLAVIO VASCONCELOS DA SILVA,ANA MARIA FRATTINI FILETI,LINCOLN CAMARGO NEVES FILHO,VIVALDO SILVEIRA JÚNIOR§ 대한설비공학회 2012 International Journal of Air-Conditioning and Refr Vol.20 No.2
A refrigeration system exhibits a dynamic behavior on which the variables are interdependent and subjected to oscillation, hence, implicating necessity of changes on operating conditions and undesirable energy expenses. These characteristics ratify the importance of adequate dimensioning and equipment selection to ¯nd pre-de¯ned operating conditions such as, the maximum cooling capacity and the evaporating and condensing temperatures. The application of fuzzy control in industrial processes is growing fast in the last decades, mainly in processes whose ¯rst principle models require complex methods to be simulated. In these cases, the fuzzy controllers'capacity of acting correctly based only on expert knowledge and on the capacity of inter-relating all the variables of the process are attractive features. This work presents the experimental development and evaluation of fuzzy-PID controllers for the maintenance of the evaporating temperature in a chiller. The system was submitted to load and set-point disturbances accomplishing an analysis based upon error parameters and transient response. The results showed that fuzzy controllers were adapted satisfactorily.