http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Jizi Jin (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
Jin, Jizi,Kang, Hye-Min,Park, Chan Taylor Francis 2010 Brain injury Vol.24 No.3
<P>Primary objective: This study explored the long-term effects of exercise on the proliferation, survival and migration of endogenous neural progenitor cells (NPCs) in the subventricular zone (SVZ) of the brain after intracerebral haemorrhage (ICH). Research design: ICH was induced by an injection of collagenase into the striatum. Animals in the voluntary running exercise group ran freely on a running wheel for 1, 3 and 6 weeks following the induction of ICH. Methods and procedure: Immunohistochemical labelling was performed to incorporate specific cell markers, such as Ki67 (proliferating cells), 5-bromodeoxyuridien (BrdU; surviving newborn cells) and doublecortin (DCX; neuroblasts or migrating cells). Main outcomes and results: Voluntary exercise for 3 and 6 weeks sustained more Ki67- or BrdU-immunostained cells in the SVZ after ICH than in the brains of sedentary mice. DCX-immunostained cells were more prominent in the striatum of the group that had exercised for 6 weeks compared to the time-matched sedentary group. Moreover, it was observed that proliferating green fluorescent protein (GFP)-positive cells that were infected with retrovirus were located more distally from the injection site in the exercise group than in the sedentary group. Conclusions: These data indicate that long-term exercise may enhance the proliferation and survival of NPCs and their migration toward injured areas, suggesting that exercise may contribute to neuronal injury recovery in cell-based therapies after ICH.</P>
-
Hye-Min Kang,Jizi Jin,Chan Park 대한스트레스학회 2009 스트레스硏究 Vol.17 No.3
스트레스에 의해 유도된 동인행동(motivational behavior) 변화에 대한 일산화질소(nitric oxide, NO)의 영향을 자발적인 쳇바퀴 운동(voluntary wheel running)을 이용하여 연구하였다. 생쥐에 매일 3시간씩 결박스트레스(restraint stress)를 가한 후 2주 동안 자발적인 운동량을 측정하였다. 그 결과, 결박스트레스에 의하여 초기 1일에서부터 7일째까지 자발적인 운동량이 유의하게 감소하였고, 8일 이후에는 스트레스 처치 이전(0일)의 수준으로 회복되었다. 이에 대한 일산화질소의 영향을 알아보기 위하여, 일산화질소의 전구물질인 L-arginine과 NO synthase의 억제제인 N-nitro-L- arginine methyl ester (L-NAME)을 결박 스트레스 후 복강 주사 하여 각각의 결과를 조사하였다. 그 결과, L-NAME 투여군에서 1일에서 3일째에 자발적인 운동의 감소가 유도되었다. 결박 스트레스 후 L-arginine을 투여한 군에서는 스트레스에 의한 초기 자발적 운동의 감소가 억제되었다. 반면, 결박 스트레스 후 L-NAME 투여군에서는 스트레스 후의 초기 자발적인 운동의 감소가 계속 유지되었다. 이상의 결과는 스트레스가 동인행동의 감소 현상를 초기에 유발 할 수 있고, 이러한 감소 현상은 스트레스에 의한 일산화질소 변화와 관련되어 있으며, 일산화질소의 전구체에 의하여 억제될 수 있음을 보여준다. The involvement of nitric oxide (NO) in stress-induced motivational behavior change in mice was evaluated using voluntary wheel running in the cage. The effects of daily restraint stress on voluntary running were followed for two weeks. Daily restraint stress for 3 hours reduced voluntary running from Day 1 to Day 7. The effects of the NO precursor, L-arginine, and the NO synthase inhibitor, N-nitro-L-arginine methyl ester (L-NAME), on voluntary running were also observed for two weeks. In the L-NAME-treated group, voluntary running decreased on Days 1 to 3 compared to the baseline level (Day 0; voluntary running levels before stress). Treatment with L-arginine following restraint stress markedly sustained the voluntary running activity to basal level, whereas treatment with L-NAME following restraint stress prolonged the decrease in voluntary running induced by stress. These results suggest that NO may protect against stress-induced motivational behavioral change. (Korean J Str Res 2009;17:277∼284)
-
A novel method for olfactory bulbectomy using photochemically induced lesion
Kang, Hye-Min,Jin, Jizi,Lee, Seungjoo,Ryu, Jonghoon,Park, Chan Lippincott Williams Wilkins, Inc. 2010 NEUROREPORT - Vol.21 No.3
We present the photochemically induced olfactory bulbectomy (P-bulbectomy) as a novel method to ablate the olfactory bulb thus inducing an animal model of depression. The photosensitizer Rose Bengal was injected through the tail vein and then the cool halogen light illuminated the skull region overlying of the olfactory bulb for 10 min. Two weeks after surgery, P-bulbectomy had completely removed olfactory bulb uniformly in all animals. P-bulbectomy induced typical depression-related behaviors such as hyperactivity in the open field test and an enhancement of immobility time and in the forced swimming test. Depression-related neurohistological phenomenon was also seen; reduction of choline-acetyltransferase-positive cell numbers in the medial septum and a decline in cell proliferation in the dentate gyrus of hippocampus. This study shows that P-bulbectomy may be a convenient and reproducible experimental method to produce an animal model of depression.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
