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Jiyoung Yun,Hyung Hwa Jeong,Jonghan Cho,김은기,엄진섭,한현호 대한성형외과학회 2018 Archives of Plastic Surgery Vol.45 No.3
Background Slim patients or those with large breasts may be ineligible for breast reconstruction with an abdominal flap, as the volume of the flap may be insufficient. This study aimed to establish that abdominal tissue–based breast reconstruction can be well suited for Korean patients, despite their thin body habitus. Methods A total of 252 patients who underwent postmastectomy breast reconstruction with an abdominal flap from October 2006 to May 2013 were retrospectively reviewed. The patients’ age and body mass index were analyzed, and a correlation analysis was performed between the weight of the mastectomy specimen and that of the initial abdominal flap. Results The average weights of the mastectomy specimen and initial abdominal flap were 451.03 g and 644.95 g, respectively. The ratio of the weight of the mastectomy specimen to that of the initial flap was 0.71±0.23. There was a strong positive linear relationship between the weight of the mastectomy specimen and that of the initial flap (Pearson correlation coefficient, 0.728). Thirty nulliparous patients had a final-to-initial flap weight ratio of 0.66±0.11. The 25 patients who underwent a contralateral procedure had a ratio of 0.96±0.30. The adjusted ratio of the final flap weight to the initial flap weight was 0.66±0.12. Conclusions Breast weight had a strong positive relationship with abdominal flap weight in Koreans. Abdominal flaps provided sufficient soft tissue for breast reconstruction in most Korean patients, including nulliparous patients. However, when the mastectomy weight is estimated to be >700 g, a contralateral reduction procedure may be considered.
Augmentation by Hypercholesterolemia of Amyloid β Peptide-Induced Learning and Memory Deficit
Yun-Bae Kim,Dongsun Park,Jiyoung Oh,Tae Kyun Kim,Young Jin Cho,Sun Hee Lee,Dae-Kwon Bae,Yun-Hui Yang,Goeun Yang,Seock-Yeon Hwang 충북대학교 동물의학연구소 2009 Journal of Biomedical and Translational Research Vol.10 No.2
The present study was carried out to establish an animal model, displaying long-term learning and memory dysfunction, since single intracerebroventricular (icv) injection of amyloid β peptide (Aβ) causes a short-term memory impairment. Male ICR mice were fed a high-cholesterol diet (HCD) containing 3% cholesterol, 1% corn oil and 0.5% cholic acid, and 1 week later, icv injected with Aβ<sub>1-42</sub> (5 μg/head). Learning/ memory function was assessed via passive avoidance performances 1 day and 2, 4, and 6 weeks after Aβ<sub>1-42</sub> injection, in addition to blood biochemical analyses for lipid profiles and hepatic function. Total cholesterol, lowdensity lipoproteins and hepatic dysfunction parameters markedly increased, while high-density lipoproteins were reduced following HCD feeding. Whereas single injection of Aβ induced temporary memory loss 1 day after administration, exhibiting full recovery after 2 weeks, Aβ treatment in combination with HCD feeding lasted the learning/memory impairment up to 6 weeks. Therefore, it is suggested that hypercholesterolemia augments Aβ-induced memory loss, and that Aβ injection plus HCD feeding could be a long-term memorydeficit model suitable for long-term treatment with drugs or stem cells.
Yun, Jiyoung,Jeong, Hyung Hwa,Cho, Jonghan,Kim, Eun Key,Eom, Jin Sup,Han, Hyun Ho Korean Society of Plastic and Reconstructive Surge 2018 Archives of Plastic Surgery Vol.45 No.3
Background Slim patients or those with large breasts may be ineligible for breast reconstruction with an abdominal flap, as the volume of the flap may be insufficient. This study aimed to establish that abdominal tissue-based breast reconstruction can be well suited for Korean patients, despite their thin body habitus. Methods A total of 252 patients who underwent postmastectomy breast reconstruction with an abdominal flap from October 2006 to May 2013 were retrospectively reviewed. The patients' age and body mass index were analyzed, and a correlation analysis was performed between the weight of the mastectomy specimen and that of the initial abdominal flap. Results The average weights of the mastectomy specimen and initial abdominal flap were 451.03 g and 644.95 g, respectively. The ratio of the weight of the mastectomy specimen to that of the initial flap was $0.71{\pm}0.23$. There was a strong positive linear relationship between the weight of the mastectomy specimen and that of the initial flap (Pearson correlation coefficient, 0.728). Thirty nulliparous patients had a final-to-initial flap weight ratio of $0.66{\pm}0.11$. The 25 patients who underwent a contralateral procedure had a ratio of $0.96{\pm}0.30$. The adjusted ratio of the final flap weight to the initial flap weight was $0.66{\pm}0.12$. Conclusions Breast weight had a strong positive relationship with abdominal flap weight in Koreans. Abdominal flaps provided sufficient soft tissue for breast reconstruction in most Korean patients, including nulliparous patients. However, when the mastectomy weight is estimated to be >700 g, a contralateral reduction procedure may be considered.
Jiyoung Yun,김경곤,MeeJoo Kang,Hyunsoo Kim,김선회,장진영,김영수 한국생물공학회 2013 Biotechnology and Bioprocess Engineering Vol.18 No.5
Pancreatic ductal adenocarcinoma (PDAC) is the fourth most frequent cause of cancer mortality in the United States. Because CA 19-9 increases not only in PDAC, but also in benign conditions, there is urgent need for an additional PDAC biomarker. Isotope tags for relative and absolute quantification (iTRAQ) were performed using 6 pairs of PDAC and normal tissues from the same patients, to obtain preliminary PDAC-specific proteins; and verification was performed by multiple reactions monitoring (MRM), using 30 PDAC and 20 normal serum, targeting high-abundant serum proteins without any pre-preparation. As a result, 17 candidate proteins from tissue iTRAQ were verified as potential markers (AUC values > 0.7). Multivariate analysis (MA) demonstrated that a 6-marker panel,consisting of alpha-1 antitrypsin, haptoglobin beta chain,hemopexin, transferrin, zinc alpha-2 glycoprotein, and apolipoprotein A4 from the MRM result, had comparable discriminatory power versus CA 19-9. Our study demonstrated that a combination of iTRAQ on PDAC tissue and verification MRM-MA on individual serum was an efficient method for the development of PDAC multimarkers.
두피에 생긴 광범위한 편평세포암의 수술적 치료로써 유리피판술의 증례
윤지영(Jiyoung Yun),김은기(Eun Key Kim) 대한두개저학회 2013 대한두개저학회지 Vol.8 No.1
Wide excision of extensive sq cc in scalp often requires free flap for adequate coverage. Various flaps can be considered depending on the size of the defect, donor site morbidity, or surgeon preferences etc. Here we report a case of extensive squamous cell carcinoma in scalp initially covered with free LD flap, which eventually required a free VRAM flap with wide skin paddle after severe atrophy of muscle portion probably due to adjuvant radiation. 51 year-old female was diagnosed SCC on three fourths of scalp. After wide excision, LD free flap was performed to cover the defect. After three months later, SCC was reccured on the skull, so artificial bone graft was performed with partial elevation of the previous LD flap. The patient underwent adjuvant radiation and developed a few events of infection afterwards. Infection finally subsided but artificial bone was exposed at thinned LD muscle portion. Finally a free VRAM flap covered the defect. There was no significant complication such as flap necrosis or fat necrosis. The VRAM flap was well maintained throughout the follow-up period. Postoperative radiotherapy could cause severe atrophy of a muscle flap and a thin muscle flap like LD might even develop full thickness defect. In such situation a MC flap with larger skin peddle and small muscle flap such as TRAM or VRAM would be a better option than a MC flap with small skin paddle and thin wide muscle such as LD.
2015 개정 교육과정의 ‘과학탐구실험’ 교과서 탐구활동에 나타난 과학과 교과 역량 분석
윤지영(Jiyoung Yun),최원호(Wonho Choi) 순천대학교 교육과학연구소 2023 현장수업연구 Vol.4 No.2
본 연구는 2015 개정 교육과정의 과학탐구실험 교과서의 ‘역사 속의 과학 탐구’ 단원 탐구 활동에 제시된 과학과 교과 역량을 분석하였다. 분석 결과, 탐구 활동에 제시된 과학과 교과 역량은 특정 역량으로 편중되어 있었으며, ‘과학적 문제 해결력’과 ‘과학적 참여와 평생 학습 능력’은 물리, 화학, 지구과학, 생명과학 영역 모두 거의 제시되지 않거나 전혀 제시되지 않았다. 그리고 교과서의 탐구 활동에 제시된 교과서 저자의 의도나 탐구 활동에 제시된 문장 표현은 학생들이 실제로 경험할 수 있는 교과 역량과 다른 경우가 있었다. 또한 탐구 활동의 주제에 따라 학생들이 경험할 수 있는 교과 역량에 차이가 있을 가능성을 확인하였다. 이러한 분석을 통해 교과서 집필 과정에서 고려할 몇 가지 제언을 하였다. This study analyzed science subject competencies in inquiry activities of ‘Science Inquiry in History’ unit of ‘Scientific Inquiry Experiment’ on the 2015 revised national curriculum. As a result of the analysis, science subject competencies presented in inquiry activities were biased on specific competencies and ‘Scientific problem solving’ and ‘Scientific participation & life-long learning’ were rarely or never presented in Physics, Chemistry, Earth science, and Life science. In addition, the textbook author’s intention or the sentence expression presented in the inquiry activities of the textbook were different from the subject competencies that students could actually experience. Also, we confirmed the possibility that there is a difference in the subject competency that students can experience according to the subject of the inquiry activity. Through this analysis, we made some suggestions to consider in the textbook writing process.