Corrosive Esophageal Injury due to a Commercial Vinegar Beverage in an Adolescent

Jiyeon Chang,Sang-eun Han,백승삼,Yong Joo Kim 대한소화기내시경학회 2020 Clinical Endoscopy Vol.53 No.3

Although gastroesophageal damage is commonly induced by accidental drinking of a strong acid or alkali, damage due to the consumption of a vinegar beverage is not well known. We report a case of corrosive esophageal ulcer found in an adolescent consuming vineagr drink daily. A 15-year-old male visited the emergency room presenting with hematemesis and severe epigastric pain. Multiple longitudinal ulcers, concurrent mucosal hemorrhage, and denuded mucosa were noted in the whole of the esophagus via and endoscopic examination. He had been drinking a vinegar beverage daily without sufficient dilution. The patient was treated with corticosteroid, antibiotic therapy, and mucosa protecting alginate medication and was asked to fast for a week. The follow-up endoscopy showed improvement of the esophageal injuries. Overall, continuous consumption of a vinegar beverage can result in acidic burns and desturction of the surface of the upper gastrointestinal tract. Therefore, vinegar beverages should be considered as corrosive agentes.

Adenosine-Prefabricated Adipose Tissue Improves Fat Graft Survival by Promoting VEGF-Dependent Angiogenesis

Chang Jiyeon,Song Woo Jin,Soedono Shindy,Sharlene Sharlene,Kim Yeong Jin,Choi Chang Yong,Cho Kae Won 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.5

BACKGROUND: Angiogenesis plays an important role in determining the fat graft survival. However, clinical preconditioning techniques that target angiogenesis during fat grafting have not been established so far. Adenosine has emerged as a regulator of angiogenesis under hypoxic conditions; therefore, the aim of this study was to investigate the effects and underlying mechanisms of adenosine prefabrication on fat graft survival. METHODS: In the first animal study, a total of 32 mice were transplanted with fat prefabricated with vehicle (Control, N = 16) or adenosine (Adenosine, N = 16). In the second animal study, 24 mice were divided into three groups based on the type of fat graft: Control (N = 8), Adenosine (N = 8), and Axitinib (cotreatment of adenosine with axitinib, N = 8). At 1- and 4-weeks post-transplantation, grafts were evaluated by histopathological and biochemical assessment. Adenosineinduced vascular endothelial growth factor (VEGF) production and angiogenesis were determined using cell cultures. RESULTS: The retention volumes of fat grafts in the adenosine group were significantly increased until 4 weeks. Fat grafts from the adenosine group exhibited greater structural integrity, reduced fibrosis, and increased blood vessels. The expression levels of angiogenesis-related genes, Vegfa, Vegfr1, Vegfr2, and Vwf, were elevated in the adenosine group. Furthermore, adenosine upregulated VEGF production in preadipocytes, thereby enhancing the migration of endothelial cells. Treatment with the axitinib, VEGF receptor inhibitor, abrogated the adenosine-induced angiogenesis in the fat grafts. CONCLUSION: Adenosine prefabrication in fat improved the graft survival by enhancing angiogenesis through the VEGF/VEGFR axis in the preadipocytes and endothelial cells. Therefore, this method may be used as a novel strategy to increase the retention rate in fat grafts.

고령자 집단의 뉴스 미디어 이용과 신뢰도 연구

박노일(Nohil Park),정지연(JiYeon Jeong),장정헌(Joengheon Chang) 서울대학교 언론정보연구소 2017 언론정보연구 Vol.54 No.1

고령화 사회에서 고령 사회로 진입하고 있는 한국은 고령자의 뉴스 미디어 이용패턴에 대한 이해가 부족한 상황이다. 본 연구는 고령자 집단(60대 이상)의 뉴스미디어 이용 패턴을 비(非) 고령자(20대∼30대, 40∼50대)와 비교 분석하고, 이들의 뉴스 미디어 이용 패턴의 변화를 통시적으로 진단해 보는 데 목적을 둔다. 이를 위해, 최근 3년간 수집된 언론 수용자 의식 조사 1만5205개의 답변 자료를 분석한 결과, 고령자 집단이 가장 의존하는 뉴스 미디어 채널은 지상파 방송과 신문이었다(집단 간 분석). 이는 2030세대가 포털뉴스에 의존적인 점과는 대조적인 결과이다. 반면, 2013년부터 최근 3년간 고령자들의 지상파 방송과 신문 뉴스 이용도는 감소하고 있었다. 그러나 흥미롭게도 고령자들의 지상파 방송과 신문 뉴스에 대한 신뢰도는 증가하고 있었다. 본 연구 결과는 고령 사회 진입이라는 국가적 이슈상황에서 고령자 집단의 뉴스 미디어 이용 패턴이 세대 간에 어떠한 차이를 나타내는지 뿐만 아니라, 고령자 집단의 뉴스 미디어 이용 행태 변화를 통시적으로 탐색하는 데 중요한 지침을 제공한다. Korea which is moving towards an aged society from aging society lacks understanding of the elderly’s media usage patterns. Therefore, the purpose of this study is to analyze the differences of the media usage patterns between the Korean elderly group (those over 60 years of age) and the non-elderly group those aged between 20 to 59 years of age, and understand the longitudinal changes in the media patterns that exist among them. Based on an analysis of 15,205 national surveys data collected for the recent three years, the elderly group were reported to use newspapers and public television news the most, which directly contrasts to the younger generation (those aged 20-39 years) who showed the highest usage in portal news. However, the results within-group analysis showed that the usage of public television news and newspapers of the elderly has been gradually decreasing for the last three years. One interesting to note is that while the usage of public television news and newspapers of the elderly has decreased, their credibility of the news media has steadily been on a rise. This research does not only verify the differences in news media usage patterns among generations in a national situation of entering into aged society, but also provide valuable guidelines for exploring the changes of news media usage of the elderly.

Hypermethylation of PDX1, EN2, and MSX1 predicts the prognosis of colorectal cancer

Lee Yeongun,Dho So Hee,Lee Jiyeon,Hwang Ji-Hyun,Kim Minjung,Choi Won-Young,Lee Jin-Young,Lee Jongwon,Chang Woochul,Lee Min Young,Choi Jungmin,Kim Tae-You,Kim Lark Kyun 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

Despite numerous observations regarding the relationship between DNA methylation changes and cancer progression, only a few genes have been verified as diagnostic biomarkers of colorectal cancer (CRC). To more practically detect methylation changes, we performed targeted bisulfite sequencing. Through co-analysis of RNA-seq, we identified cohort-specific DNA methylation markers: CpG islands of the intragenic regions of PDX1, EN2, and MSX1. We validated that these genes have oncogenic features in CRC and that their expression levels are increased in correlation with the hypermethylation of intragenic regions. The reliable depth of the targeted bisulfite sequencing data enabled us to design highly optimized quantitative methylation-specific PCR primer sets that can successfully detect subtle changes in the methylation levels of candidate regions. Furthermore, these methylation levels can divide CRC patients into two groups denoting good and poor prognoses. In this study, we present a streamlined workflow for screening clinically significant differentially methylated regions. Our discovery of methylation markers in the PDX1, EN2, and MSX1 genes suggests their promising performance as prognostic markers and their clinical application in CRC patients.

Terminal Uridylyltransferases Execute Programmed Clearance of Maternal Transcriptome in Vertebrate Embryos

Chang, Hyeshik,Yeo, Jinah,Kim, Jeong-gyun,Kim, Hyunjoon,Lim, Jaechul,Lee, Mihye,Kim, Hyun Ho,Ohk, Jiyeon,Jeon, Hee-Yeon,Lee, Hyunsook,Jung, Hosung,Kim, Kyu-Won,Kim, V. Narry Elsevier 2018 Molecular cell Vol.70 No.1

<P><B>Summary</B></P> <P>During the maternal-to-zygotic transition (MZT), maternal RNAs are actively degraded and replaced by newly synthesized zygotic transcripts in a highly coordinated manner. However, it remains largely unknown how maternal mRNA decay is triggered in early vertebrate embryos. Here, through genome-wide profiling of RNA abundance and 3′ modification, we show that uridylation is induced at the onset of maternal mRNA clearance. The temporal control of uridylation is conserved in vertebrates. When the homologs of terminal uridylyltransferases TUT4 and TUT7 (TUT4/7) are depleted in zebrafish and <I>Xenopus</I>, maternal mRNA clearance is significantly delayed, leading to developmental defects during gastrulation. Short-tailed mRNAs are selectively uridylated by TUT4/7, with the highly uridylated transcripts degraded faster during the MZT than those with unmodified poly(A) tails. Our study demonstrates that uridylation plays a crucial role in timely mRNA degradation, thereby allowing the progression of early development.</P> <P><B>Highlights</B></P> <P> <UL> <LI> TUT4 and TUT7 are conserved writers of U tail in vertebrates </LI> <LI> mRNA uridylation is induced during early embryogenesis </LI> <LI> Uridylation facilitates the programmed elimination of maternal RNAs </LI> <LI> TUT4 and TUT7 are required for gastrulation in zebrafish and <I>Xenopus</I> </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>

Serum PCDDs/PCDFs levels for the residents living in the vicinity and workers of the municipal waste incinerators in Seoul, Korea

Jiyeon Yang,Youngwook Lim,Moongee Ho,Hohyen Kim,Yoonseok Chang,Dongchun Shin 환경독성보건학회 2006 한국독성학회 심포지움 및 학술발표회 Vol.- No.-

A Case Study on Corporate Social Responsibility of Domestic Large Companies -CSR seen from the center of Large companies

Chang-Mu Lee,Hye-In Na,Jiyeon Lee,Jae-Soo Kim 한국콘텐츠학회 2020 한국콘텐츠학회 ICCC 논문집 Vol.2020 No.11

Treatment of Morsicatio Buccarum by Oral Appliance: Case Report

Chang, Min,Kim, Jiyeon,Park, YounJung,Kwon, Jeong-Seung,Kim, Seong-Taek,Choi, Jong-Hoon,Ahn, Hyung-Joon Korean Academy of Orofacial Pain and Oral Medicine 2021 Journal of Oral Medicine and Pain Vol.46 No.3

Morsicatio buccarum is a condition caused by chronic cheek biting. It means frictional hyperkeratosis by repetitive cheek biting, which may be associated with obsessive compulsion. Clinically it presents as rough, shaggy, whitish, often peeling surface. We report a 9-year-old female patient who complained oral ulceration on both buccal mucosa. The initial diagnosis was oral candidiasis because of whitish plaques which were peeled off. Topical antifungal agent was ineffective and the symptom did not disappear. By incisional biopsy, she was diagnosed with morsicatio buccarum. A soft oral appliance was placed in the patient's oral cavity. Although morsicatio buccarum improved significantly when the appliance was used, the oral lesion had a tendency to recur, when the patient stopped using the appliance. In case of recurrence, cognitive behavioral therapy for obsessive-compulsive disorder is needed for the fundamental treatment.

Serum PCDDs/PCDFs Levels for the Residents Living in the Vicinity and Workers of the Municipal Waste Incinerators in Seoul, Korea

Jiyeon Yang(양지연),Youngook Lim(임영욱),Yoonseok Chang(장윤석),Changsoo Kim(김창수),Dongchun Shin(신동천) 환경독성보건학회 2006 환경독성보건학회지 Vol.21 No.4

이 연구의 목적은 자원회수시설 근로자 및 인근 지역 거주 주민의 혈중 다이옥신류 농도를 평가하고, 혈중 다이옥신류 농도에 영향을 미치는 요인을 평가하는 것이다. 2002~2004년까지 대상 자원회수시설에 3년 이상 근무하 근로자 31명과 시설로부터 300 m 이내 지역에서 3년 이상 거주한 주민 68명을 선정하여 혈액을 채취하였다. 참고 자료로 대상 자원회수시설에 영향을 받지 않는 도시 지역에 거주하는 일반 주민 11명을 함게 평가하였다. 혈액 채취시 개인 특성에 대한 설문조사도 함께 실시하였다. 시설 근로자의 혈중 다이옥신류 농도는 평균 2.09~66.67 pg/g lipid, 인근 거주 주민은 1.00~29.33 pg/g lipid, 일반 도시 주민은 5.29~35.93 pg/g lipid로 측정되었다. 시설 인근 지역 거주 주민 및 일반 도시 주민 중 비흡연자의 인체 부하량은 각각 3.0 ng TEQ/g lipid와 4.5 ng TEQ/g lipid로 평가되었다. 대상군의 특성에 따른 혈중 다이옥신류 농도 차이는 관찰되지 않았으며, 연령과 유의한 양의 상관성이 있었다.

The Effect of Education and Training on Service Quality, Customer Satisfaction and Loyalty in Airline Industry

JiYeon Paek,Chang Won Lee KINFORMS 2018 Management Review Vol.13 No.1

This study examines on the education and training of an airlines’ ground staff. Also it studies on employees’perceived service quality that can make an influence on customer satisfaction and loyalty. After searching the education and training and service quality through the literature reviews related to the subject, established is a framework of an empirical study about the subject of study. In order to achieve the purpose of this study, the survey method is conducted to the airlines’ground staff members and the time frame and the target subjects are set. Collected data is used for frequency analysis, reliability analysis, factor analysis, regression analysis and with the SPSS 21.0 for a statistical package program. The study results are shown as follows: first, education and training have a positive influence on the five factors of the service quality. Second, employees’perceived service quality show positive impacts on customer satisfaction and loyalty. The majority of studies on airline employee training have focused on the cabin crew. As a result, the number of studies involving ground staff is lacking. This study therefore aims to empirically verify the relationship between training of ground staff, service quality, and customer satisfaction. Given the difficulties in accessing customers for their feedback, few studies have been conducted on the effects of employee training on customer satisfaction. This empirical study used questionnaires, which are administered to airline employees and customers via one-to-one interviews, to provide theoretical and practical implications of the findings.