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( He Yun Choi ),( Ji Hye Park ),( Woong Bi Jang ),( Seung Taek Ji ),( Seok Yun Jung ),( Da Yeon Kim ),( Songhwa Kang ),( Yeon Ju Kim ),( Jisoo Yun ),( Jae Ho Kim ),( Sang Hong Baek ),( Sang Mo Kwon ) 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.4
Cardiovascular disease is the most common cause of death in diabetic patients. Hyperglycemia is the primary characteristic of diabetes and is associated with many complications. The role of hyperglycemia in the dysfunction of human cardiac progenitor cells that can regenerate damaged cardiac tissue has been investigated, but the exact mechanism underlying this association is not clear. Thus, we examined whether hyperglycemia could regulate mitochondrial dynamics and lead to cardiac progenitor cell dysfunction, and whether blocking glucose uptake could rescue this dysfunction. High glucose in cardiac progenitor cells results in reduced cell viability and decreased expression of cell cycle-related molecules, including CDK2 and cyclin E. A tube formation assay revealed that hyperglycemia led to a significant decrease in the tube-forming ability of cardiac progenitor cells. Fluorescent labeling of cardiac progenitor cell mitochondria revealed that hyperglycemia alters mitochondrial dynamics and increases expression of fission-related proteins, including Fis1 and Drp1. Moreover, we showed that specific blockage of GLUT1 improved cell viability, tube formation, and regulation of mitochondrial dynamics in cardiac progenitor cells. To our knowledge, this study is the first to demonstrate that high glucose leads to cardiac progenitor cell dysfunction through an increase in mitochondrial fission, and that a GLUT1 blocker can rescue cardiac progenitor cell dysfunction and downregulation of mitochondrial fission. Combined therapy with cardiac progenitor cells and a GLUT1 blocker may provide a novel strategy for cardiac progenitor cell therapy in cardiovascular disease patients with diabetes.
Choi, He Yun,Park, Ji Hye,Jang, Woong Bi,Ji, Seung Taek,Jung, Seok Yun,Kim, Da Yeon,Kang, Songhwa,Kim, Yeon Ju,Yun, Jisoo,Kim, Jae Ho,Baek, Sang Hong,Kwon, Sang-Mo The Korean Society of Applied Pharmacology 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.4
Cardiovascular disease is the most common cause of death in diabetic patients. Hyperglycemia is the primary characteristic of diabetes and is associated with many complications. The role of hyperglycemia in the dysfunction of human cardiac progenitor cells that can regenerate damaged cardiac tissue has been investigated, but the exact mechanism underlying this association is not clear. Thus, we examined whether hyperglycemia could regulate mitochondrial dynamics and lead to cardiac progenitor cell dysfunction, and whether blocking glucose uptake could rescue this dysfunction. High glucose in cardiac progenitor cells results in reduced cell viability and decreased expression of cell cycle-related molecules, including CDK2 and cyclin E. A tube formation assay revealed that hyperglycemia led to a significant decrease in the tube-forming ability of cardiac progenitor cells. Fluorescent labeling of cardiac progenitor cell mitochondria revealed that hyperglycemia alters mitochondrial dynamics and increases expression of fission-related proteins, including Fis1 and Drp1. Moreover, we showed that specific blockage of GLUT1 improved cell viability, tube formation, and regulation of mitochondrial dynamics in cardiac progenitor cells. To our knowledge, this study is the first to demonstrate that high glucose leads to cardiac progenitor cell dysfunction through an increase in mitochondrial fission, and that a GLUT1 blocker can rescue cardiac progenitor cell dysfunction and downregulation of mitochondrial fission. Combined therapy with cardiac progenitor cells and a GLUT1 blocker may provide a novel strategy for cardiac progenitor cell therapy in cardiovascular disease patients with diabetes.
Engineered Chondroitin Sulfate Hydrogel for Cartilage Tissue Engineering
Jisoo SHIN,Eun-Hye KANG,Soojeong CHOI,Donyoung KANG,Hyungsuk LEE,In Sik YUN,Seung-Woo CHO 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Biomaterials mimicking the extracellular matrix (ECM) for cartilage tissue engineering have been broadly studied. Among those ECM-like biomaterials, chondroitin sulfate (CS), which is the main component of the cartilage ECM, has been paid attention. However, current CS-based hydrogel systems with unsuitable degradation kinetics, insufficient mechanical property, and lack of integration remain challenging. In this study, we utilized mussel-inspired catechol (CA) chemistry to overcome such limitations. Engineered CA functionalized CS hydrogel (CS-CA) showed tunable physical and mechanical properties, and excellent tissue adhesion. Furthermore, the chondrogenic differentiation of human adipose-derived mesenchymal stem cells was promoted by incorporating decellularized cartilage tissue dice. Finally, the transplantation of autologous cartilage dice using tissue-adhesive CS-CA hydrogels enhanced cartilage integration with host tissue and neo-cartilage formation. Our study showed a great potential of the CS-CA hydrogel system for cartilage tissue engineering.
Jisoo Kim,Joo Yun Kim,Ji-Woong Jeong,Il dong Choi,Soo-Dong Park,Jung Lyoul Lee,Jae-Hun Sim 한국자원식물학회 2020 한국자원식물학회지 Vol.33 No.6
Lilium lancifolium (LL) is widely cultivated in East Asia and used to attenuate airway diseases. Our current study aimed to investigate the therapeutic effect of LL on pain level and inflammatory response in a rat model of monosodium iodoacetate (MIA)-induced osteoarthritis (OA). We first examined the effect of LL on inflammatory cytokines and inflammatory mediators in IL-1β-treated HTB-94 cells. The LL extract was found to significantly inhibit the levels of Interleukin-6 (IL-6), Interleukin-8 (IL-8), and prostaglandin-E2 (PGE-2) in Interleukin-1 β (IL-1β)-stimulated HTB-94 cells in a dose-dependent manner. Moreover, chronic oral administration of LL effectively restored the weight-bearing distribution in the rat model of MIA-induced OA. In addition, administration of LL inhibited inflammatory cytokines and inflammatory mediators, such as C-reactive protein (CRP), IL-6, leukotriene B4 (LTB-4), PGE-2, and matrix metalloproteinase-9 (MMP-9). Our findings collectively suggested LL as one of the potential therapeutic agents for OA, owing to its properties of reducing pain and inflammatory responses.
나노인덴테이션에 의한 재료의 탄성·소성변형 거동과 3차원 유한요소해석
김지수,양현윤,윤존도,조상봉 경남대학교 신소재연구소 2003 신소재연구 Vol.15 No.2
수 uN의 힘으로 수 nm 범위로 재료를 변위시켜 기계적 특성을 측정하는 나노압입 시험기인 나노인덴테이션을 이용하여, 재료의 탄성 ? 소겅 거동을 파악하였다. 순도 99.999% 알루미늄과 용융석영유리 시편을 사용하여 재료변화에 따른 거동을 관찰하였고, 베르코비치 압자와 원뿔 압자를 사용하여 압자의 형상변화에 따른 거동을 관찰하였다. 압자 아래부분에서 재료변형의 거동관찰 위해선 ANSYS 7.0 유한요소해석 소프트웨어를 이용해서 탄성, 탄소성, 소성 거동을 유한요소해석 시뮬레이션 하였다. Phenomena of elastic and plastic deformation was observed by using nanoindentation technique. Super purity aluminum(99.999%) and fused quartz glass were used for the specimen. Berkovich and the conical indenter were used. The ANSYS 7.0, finite element method software was used for the simulation of elastic, elastic-plastic or plastic phenomena under the indenter.
Joo Yun Kim,Soo-Dong Park,Woo Nam,Bora Nam,Chu Hyun Bae,Hyeon Ji Kim,Jisoo Kim,Jung-Lyoul Lee,Jae-Hun Sim 한국식품영양과학회 2020 Preventive Nutrition and Food Science Vol.25 No.2
Cudrania tricuspidata has been used as an East Asian folk remedy to treat various symptoms. Recently, scientific evidence of the efficacy of C. tricuspidata has emerged. The objective of this study was to elucidate protective role of C. tricuspidata in the gastric mucosa using pylorus-ligated Sprague-Dawley rats and primary parietal cells. C. tricuspidata ethanol extracts attenuated gastric mucosal damage, secretion, and juice acidity in pylorus-ligated rats; however, it did not affect expression of gastric acid-related genes [muscarinic acetylcholine receptor M3 receptor (M3R), histamine H2-receptors (H2R), and cholecystokinin-2/gastrin receptors (CCK2R)] or serum gastrin concentrations. Furthermore, extracts greatly reduced levels of gastric cyclic adenosine monophosphate (cAMP) and significantly increased mRNA levels of gastric-type mucins (MUC5AC and MUC6). To identify the mode of action of C. tricuspidata extract in regulating gastric acid secretion, intracellular cAMP and mRNA for H2R, M3R, and CCK2R were measured in primary parietal cells. mRNA levels of H2R, M3R, and CCK2R did not significantly differ following treatment with C. tricuspidata extract, whereas cAMP induced by the H2R-specific agonist was significantly decreased. C. tricuspidata may therefore reduce gastric acid secretion by inhibiting H2R activity rather than regulating mRNA expression. These finding suggest that ethanol extracts of C. tricuspidata inhibit H2R-related gastric acid secretion and increase gastric mucus to help prevent gastric mucosal damage. Therefore, C. tricuspidata extract has potential to be used in foods and medicines to prevent diseases related to gastric mucosal damage, such as gastritis and functional dyspepsia.
A Reel-Wound Carbon Nanotube Polarizer for Terahertz Frequencies
Kyoung, Jisoo,Jang, Eui Yun,Lima, Má,rcio D.,Park, Hyeong-Ryeol,Robles, Raquel Ovalle,Lepró,, Xavier,Kim, Yong Hyup,Baughman, Ray H.,Kim, Dai-Sik American Chemical Society 2011 NANO LETTERS Vol.11 No.10
<P>Utilizing highly oriented multiwalled carbon nanotube aerogel sheets, we fabricated micrometer-thick freestanding carbon nanotube (CNT) polarizers. Simple winding of nanotube sheets on a U-shaped polyethylene reel enabled rapid and reliable polarizer fabrication, bypassing lithography or chemical etching processes. With the remarkable extinction ratio reaching ∼37 dB in the broad spectral range from 0.1 to 2.0 THz, combined with the extraordinary gravimetric mechanical strength of CNTs, and the dispersionless character of freestanding sheets, the commercialization prospects for our CNT terahertz polarizers appear attractive.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2011/nalefd.2011.11.issue-10/nl202214y/production/images/medium/nl-2011-02214y_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl202214y'>ACS Electronic Supporting Info</A></P>