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RISS 인기검색어
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- 저자 : Jingwei Zhang (검색결과 20 건)
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Jingwei Wang,Ruofang Zhang,Zhuoying Zhang,Chao Geng,Yanpeng Zhang 대한치과교정학회 2023 대한치과교정학회지 Vol.53 No.3
Objective: To investigate changes in the immature teeth of Sprague–Dawley rats during orthodontic treatment and to explore the changes in the peri-radicular alveolar bone through micro-computed tomography (CT). Methods: Twenty-five 26-day-old male Sprague–Dawley rats were included. The maxillary left first molar was moved mesially under a continuous force of 30 cN, and the right first molar served as the control. After orthodontic treatment for 7, 14, 21, 28, and 42 days, the root length, tooth volume, and alveolar bone mineral density (BMD) around the mesial root were measured through micro-CT. Results: The immature teeth continued to elongate after application of orthodontic force. The root length on the force side was significantly smaller than that on the control side, whereas the differences in the volume change between both sides were not statistically significant. Alveolar bone in the coronal part of the compression and tension sides showed no difference in BMD between the experimental and control groups. The BMD of the experimental group decreased from day 14 to day 42 in the apical part of the compression side and increased from day 7 to day 42 in the apical part of the tension side. The BMD of the experimental group decreased in the root apex part on day 7. Conclusions: The root length and volume of immature teeth showed continued development under orthodontic forces. Alveolar bone resorption was observed on the compression side, and bone formation was observed on the tension side.
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Jingwei Zhang,,Nabil Ebraheim,Ming Li,Xianfeng He,Jiayong Liu,Limei Zhu,Yihui Yu 대한정형외과학회 2015 Clinics in Orthopedic Surgery Vol.7 No.1
Background: The locking plates are often used for internal fixation of closed tibial fractures. The use of a locking plate as an externalfixator is still controversial, particularly for closed fractures. The purpose of this study is to evaluate the results of externalfixation using the femoral less invasive stabilization system (LISS) plate in proximal metaphyseal fractures of the tibia. Methods: We prospectively evaluated 35 patients (26 males and 9 females) with a mean age of 42 years (range, 21 to 62 years)who presented with fresh tibial proximal metaphyseal fractures. According to the AO Foundation and Orthopaedic Trauma Association(AO/OTA) classification, the fractures were identified as type 41-A2 in 18 cases and type 41-A3 in 17 cases, including 25closed fractures and 10 open fractures. The femoral LISS plate was used to fix these fractures, which was placed on the anteromedialaspect of the tibia as an external fixator. The mean follow-up period was 18 months (range, 13 to 22 months). Results: All fractures healed in a mean time of 14 weeks (range, 10 to 20 weeks). There was no case of nonunion, deep infection,and loosening of screws and plates. One month after the appearance of cortical bridging on biplanar radiographs, the locking platewas removed within 3 minutes in the clinic without any difficulty. According to the Hospital for Special Surgery (HSS) knee scoringsystem and American Orthopaedic Foot & Ankle Society (AOFAS) ankle scoring system, the mean HSS score was 91 (range, 85 to100) and 98 (range, 93 to 100), and the mean AOFAS score was 94 (range, 90 to 100) and 98 (range, 95 to 100) at 4 weeks postoperativelyand final follow-up, respectively. Conclusions: For proximal metaphyseal fracture of the tibia, external fixation using the femoral LISS plate is a safe and reliabletechnique with minimal complications and excellent outcomes. Its advantages include ease of performing the surgery, use of a lessinvasive technique, and convenience of plate removal after fracture healing.
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Ruilian Xiu,Jie Jia,Qing Zhang,Fengjiao Liu,Yaxin Jia,Yuanyuan Zhang,Beibei Song,Xiaodan Liu,Jingwei Chen,Dongyang Huang,Fan Zhang,Juanjuan Ma,Honglin Li,Xuan Zhang,Yunyun Geng 대한약리학회 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.6
Transmembrane protein TMEM16A, which encodes calcium-activated chloride channel has been implicated in tumorigenesis. Overexpression of TMEM16A is associated with poor prognosis and low overall survival in multiple cancers including lung adenocarcinoma, making it a promising biomarker and therapeutic target. In this study, three structure-related sesquiterpene lactones (mecheliolide, costunolide and dehydrocostus lactone) were extracted from the traditional Chinese medicine Aucklandiae Radix and identified as novel TMEM16A inhibitors with comparable inhibitory effects. Their effects on the proliferation and migration of lung adenocarcinoma cells were examined. Whole-cell patch clamp experiments showed that these sesquiterpene lactones potently inhibited recombinant TMEM16A currents in a concentration- dependent manner. The half-maximal concentration (IC50) values for three tested sesquiterpene lactones were 29.9 ± 1.1 μM, 19.7 ± 0.4 μM, and 24.5 ± 2.1 μM, while the maximal effect (Emax) values were 100.0% ± 2.8%, 85.8% ± 0.9%, and 88.3% ± 4.6%, respectively. These sesquiterpene lactones also significantly inhibited the endogenous TMEM16A currents and proliferation, and migration of LA795 lung cancer cells. These results demonstrate that mecheliolide, costunolide and dehydrocostus lactone are novel TMEM16A inhibitors and potential candidates for lung adenocarcinoma therapy.
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Flow Behaviour and Constitutive Modelling of a Ferritic Stainless Steel at Elevated Temperatures
Jingwei Zhao,Zhengyi Jiang,Guoqing Zu,Wei Du,Xin Zhang,Laizhu Jiang 대한금속·재료학회 2016 METALS AND MATERIALS International Vol.22 No.3
The flow behaviour of a ferritic stainless steel (FSS) was investigated by a Gleeble 3500 thermal-mechanical test simulator over the temperature range of 900-1100 °C and strain rate range of 1-50 s -1 . Empirical and phenomenological constitutive models were established, and a comparative study was made on the predictability of them. The results indicate that the flow stress decreases with increasing the temperature and decreasing the strain rate. High strain rate may cause a drop in flow stress after a peak value due to the adiabatic heating. The Zener-Hollomon parameter depends linearly on the flow stress, and decreases with raising the temperature and reducing the strain rate. Significant deviations occur in the prediction of flow stress by the Johnson-Cook (JC) model, indicating that the JC model cannot accurately track the flow behaviour of the FSS during hot deformation. Both the multiple-linear and the Arrhenius-type models can track the flow behaviour very well under the whole hot working conditions, and have much higher accuracy in predicting the flow behaviour than that of the JC model. The multiple-linear model is recommended in the current work due to its simpler structure and less time needed for solving the equations relative to the Arrhenius-type model.
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Jingwei Pan,Mingyuan Yuan,Mengmeng Yu,Yajie Gao,Chengxing Shen,Yining Wang,Bin Lu,Jiayin Zhang 대한영상의학회 2019 Korean Journal of Radiology Vol.20 No.5
Objective: To investigate the association of myocardial blood flow (MBF) quantified by dynamic computed tomography (CT) myocardial perfusion imaging (MPI) with troponin level and left ventricle (LV) function in patients with ST-segment elevated myocardial infarction (STEMI). Materials and Methods: Thirty-five STEMI patients who successfully had undergone reperfusion treatment within 1 week of their infarction were consecutively enrolled. All patients were referred for dynamic CT-MPI. Serial high-sensitivity troponin T (hs-TnT) levels and left ventricular ejection fraction (LVEF) measured by echocardiography were recorded. Twenty-six patients with 427 segments were included for analysis. Various quantitative parameters derived from dynamic CT-MPI were analyzed to determine if there was a correlation between hs-TnT levels and LVEF on admission and again at the 6-month mark. Results: The mean radiation dose for dynamic CT-MPI was 3.2 ± 1.1 mSv. Infarcted territories had significantly lower MBF (30.5 ± 7.4 mL/min/100 mL versus 73.4 ± 8.1 mL/min/100 mL, p < 0.001) and myocardial blood volume (MBV) (2.8 ± 0.9 mL/100 mL versus 4.2 ± 1.1 mL/100 mL, p = 0.044) compared with those of reference territories. MBF showed the best correlation with the level of peak hs-TnT (r = -0.682, p < 0.001), and MBV showed a moderate correlation with the level of peak hs-TnT (r = -0.437, p = 0.026); however, the other parameters did not show any significant correlation with hs-TnT levels. As for the association with LV function, only MBF was significantly correlated with LVEF at the time of admission (r = 0.469, p = 0.016) and at 6 months (r = 0.585, p = 0.001). Conclusion: MBF quantified by dynamic CT-MPI is significantly inversely correlated with the level of peak hs-TnT. In addition, patients with lower MBF tended to have impaired LV function at the time of their admission and at 6 months.
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Zhang, Wentao,Xu, Yongxiang,Ren, Jingwei,Su, Jianyong,Zou, Jibin The Korean Institute of Power Electronics 2019 JOURNAL OF POWER ELECTRONICS Vol.19 No.6
Ear-piercing high-frequency noise from electromagnetic vibrations in motors has become unacceptable in sensitive environments, due to the application of pulse width modulation (PWM) and in consideration of switching losses. This paper proposed a synchronous periodic frequency modulation (SPFM) method based on the interleaving technique for paralleled three-phase voltage source inverters (VSIs) to eliminate PWM vibration noise. The proposed SPFM technique is able to effectively remove unpleasant high-frequency vibration noise as well as acoustic noise more effectively than the conventional periodic carrier frequency modulation (PCFM) and interleaving technique. It completely eliminates the vibration noise near odd-order carrier frequencies and reduces the PWM vibration noise near even-order carrier frequencies depending on the switching frequency variation range. Furthermore, the SPFM method is simple to implement and does not employ additional circuits in the drive system. Finally, the effectiveness of the proposed method has been confirmed by detailed experimental results.
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Lichen Zhang,Linlin Wang,Jingwei Cai,Ting Yang,Jianke Li,Guowei Shu 한국식품과학회 2024 Food Science and Biotechnology Vol.33 No.4
Consuming pomegranate juice (PJ) is beneficial for hypertensive regulation because of the phenolic compounds in PJ and their inhibitory activity on angiotensin-I-converting enzyme (ACE). To better utilize bioactive function of food, microorganism fermentation has been adopted to alter phenolic metabolism. This study confirms that even under in vitro digestion, fermented PJ (FPJ) maintains higher ACE inhibitory activity than that of PJ. The main phenolic compounds in PJ were compared either under fermentation or in vitro digestion. This study finds that fermentation promotes antioxidant capacity of PJ. The chemical properties of FPJ are evaluated and the corresponding relationship with bioactivities is analyzed. A sensory evaluation comparison is conducted between FPJ and PJ, furnishing interesting information for consumers. This study highlights the relationship between ACE inhibitory activity of PJ and phenolic composition under fermentation and in vitro digestion, providing novel insights for diet regulation of phenolic-rich FPJ in ACE inhibition therapy.
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Wentao Zhang,Yongxiang Xu,Jingwei Ren,Jianyong Su,Jibin Zou 전력전자학회 2019 JOURNAL OF POWER ELECTRONICS Vol.19 No.6
Ear-piercing high-frequency noise from electromagnetic vibrations in motors has become unacceptable in sensitive environments, due to the application of pulse width modulation (PWM) and in consideration of switching losses. This paper proposed a synchronous periodic frequency modulation (SPFM) method based on the interleaving technique for paralleled three-phase voltage source inverters (VSIs) to eliminate PWM vibration noise. The proposed SPFM technique is able to effectively remove unpleasant high-frequency vibration noise as well as acoustic noise more effectively than the conventional periodic carrier frequency modulation (PCFM) and interleaving technique. It completely eliminates the vibration noise near odd-order carrier frequencies and reduces the PWM vibration noise near even-order carrier frequencies depending on the switching frequency variation range. Furthermore, the SPFM method is simple to implement and does not employ additional circuits in the drive system. Finally, the effectiveness of the proposed method has been confirmed by detailed experimental results.
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