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- 저자 : JinTae Lee (검색결과 243 건)
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Lee, Jin‐,Hyung,Cho, Moo Hwan,Lee, Jintae Blackwell Publishing Ltd 2011 ENVIRONMENTAL MICROBIOLOGY Vol.13 No.1
<P><B>Summary</B></P><P>Intercellular signal indole and its derivative hydroxyindoles inhibit <I>Escherichia coli</I> biofilm and diminish <I>Pseudomonas aeruginosa</I> virulence. However, indole and bacterial indole derivatives are unstable in the microbial community because they are quickly degraded by diverse bacterial oxygenases. Hence, this work sought to identify novel, non‐toxic, stable and potent indole derivatives from plant sources for inhibiting the biofilm formation of <I>E. coli</I> O157:H7 and <I>P. aeruginosa</I>. Here, plant auxin 3‐indolylacetonitrile (IAN) was found to inhibit the biofilm formation of both <I>E. coli</I> O157:H7 and <I>P. aeruginosa</I> without affecting its growth. IAN more effectively inhibited biofilms than indole for the two pathogenic bacteria. Additionally, IAN decreased the production of virulence factors including 2‐heptyl‐3‐hydroxy‐4(1<I>H</I>)‐quinolone (PQS), pyocyanin and pyoverdine in <I>P. aeruginosa</I>. DNA microarray analysis indicated that IAN repressed genes involved in curli formation and glycerol metabolism, whereas IAN induced indole‐related genes and prophage genes in <I>E. coli</I> O157:H7. It appeared that IAN inhibited the biofilm formation of <I>E. coli</I> by reducing curli formation and inducing indole production. Also, corroborating phenotypic results of <I>P. aeruginosa</I>, whole‐transcriptomic data showed that IAN repressed virulence‐related genes and motility‐related genes, while IAN induced several small molecule transport genes. Furthermore, unlike bacterial indole derivatives, plant‐originated IAN was stable in the presence of either <I>E. coli</I> or <I>P. aeruginosa</I>. Additionally, indole‐3‐carboxyaldehyde was another natural biofilm inhibitor for both <I>E. coli</I> and <I>P. aeruginosa</I>.</P>
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Lee, Jin-Hyung,Kim, Yong-Guy,Park, Jae Gyu,Lee, Jintae Elsevier 2017 Food control Vol.80 No.-
<P>Biofilm formation by Staphylococcus aureus plays a critical role in the persistence of chronic infections because of the ability of the bacterium in biofilms to tolerate antibiotics and host defenses. S. aureus produces hemolysin, which has been implicated in the pathogenesis of sepsis and pneumonia. Hence, the inhibitions of biofilm formation and/or toxin production by S. aureus are viewed as alternative means of addressing infections. In the present study, the antibiofilm activities of Moringa oleifera extracts were examined. Of the various solvent extraction methods examined, the supercritical carbon dioxide extracts of the leaves and seeds of M. oleifera were found to efficiently inhibit biofilm formation by S. aureus. Analyses of the extracts by GC-MS revealed the presences of palmitoleic acid, oleic acid, linoleic acid, linolenic acid, cis-11-eicosenoic acid, and cis-11,14-eicosadienoic acid at concentrations of 0.01% significantly inhibited S. aureus biofilm formation. In addition, supercritical fluid extract of the leaves of M. oleifera and its major component cis-11-eicosenoic acid significantly decreased the hemolysis of human red blood cells by S. aureus. These findings suggest supercritical carbon dioxide fluid extract of M. oleifera and its unsaturated fatty acids are potentially useful for controlling biofilm formation by and the virulence of S. aureus. (C) 2017 Elsevier Ltd. All rights reserved.</P>
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Lee, Jin-Hyung,Kim, Yong-Guy,Lee, Kayeon,Kim, Chang-Jin,Park, Dong-Jin,Ju, Yoonjung,Lee, Jae-Chan,Wood, Thomas K.,Lee, Jintae Informa UK (TaylorFrancis) 2016 BIOFOULING -CHUR- Vol.32 No.1
<P>Staphylococcus aureus is a versatile human pathogen that produces diverse virulence factors, and its biofilm cells are difficult to eradicate due to their inherent ability to tolerate antibiotics. The anti-biofilm activities of the spent media of 252 diverse endophytic microorganisms were investigated using three S. aureus strains. An attempt was made to identify anti-biofilm compounds in active spent media and to assess their anti-hemolytic activities and hydrophobicities in order to investigate action mechanisms. Unlike other antibiotics, actinomycin D (0.5 mu g ml(-1)) from Streptomyces parvulus significantly inhibited biofilm formation by all three S. aureus strains. Actinomycin D inhibited slime production in S. aureus and it inhibited hemolysis by S. aureus and caused S. aureus cells to become less hydrophobic, thus supporting its anti-biofilm effect. In addition, surface coatings containing actinomycin D prevented S. aureus biofilm formation on glass surfaces. Given these results, FDA-approved actinomycin D warrants further attention as a potential antivirulence agent against S. aureus infections.</P>
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Roles of Indole as an Interspecies and Interkingdom Signaling Molecule
Lee, Jin-Hyung,Wood, Thomas K.,Lee, Jintae Elsevier 2015 Trends in microbiology Vol.23 No.11
<P>A number of bacteria, and some plants, produce large quantities of indole, which is widespread in animal intestinal tracts and in the rhizosphere. Indole, as an interspecies and interkingdom signaling molecule, plays important roles in bacterial pathogenesis and eukaryotic immunity. Furthermore, indole and its derivatives are viewed as potential antivirulence compounds against antibiotic-resistant pathogens because of their ability to inhibit quorum sensing and virulence factor production. Indole modulates oxidative stress, intestinal inflammation, and hormone secretion in animals, and it controls plant defense systems and growth. Insects and nematodes can recognize indole, which controls some of their behavior. This review presents current knowledge regarding indole and its derivatives, their biotechnological applications and their role in prokaryotic and eukaryotic systems.</P> <P><B>Trends</B></P> <P>A variety of bacteria, and some plants, produce large quantities of indole, and thus, indole and its derivatives are widespread in prokaryotic and eukaryotic communities. Recently, indole was shown to be an intercellular, interspecies, and interkingdom signaling molecule.</P> <P>Indole and its derivatives can suppress the bacterial pathogenesis of several antibiotic-resistant pathogens by inhibiting quorum sensing and virulence factor production.</P> <P>Insects sense indole, which controls their behavior. Furthermore, indole controls plant defense systems and growth, and modulates oxidative stress, intestinal inflammation, and hormone secretion in animals. Emerging data suggest that indoles may influence human diseases, such as inflammatory, neurological, and metabolic diseases.</P>
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Lee, Jin-Hyung,Kim, Yong-Guy,Shim, Sang Hee,Lee, Jintae Elsevier 2017 Phytomedicine Vol.36 No.-
<P>Conclusion: These findings strongly suggest that harmaline and norharmane could have potential use in antibiofilm strategy against persistent bacterial infections.</P>
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