http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Lin, Yingjia,Li, Yang,Song, Zhi-Guang,Zhu, Hongyan,Jin, Ying-Hua The Korean Society of Ginseng 2017 Journal of Ginseng Research Vol.41 No.3
Background: Ginsenoside Rh2 (G-Rh2) is a ginseng saponin that is widely investigated because of its remarkable antitumor activity. However, the molecular mechanism by which (20S) G-Rh2 triggers its functions and how target animals avoid its cytotoxic action remains largely unknown. Methods: Phage display was used to screen the human targets of (20S) G-Rh2. Fluorescence spectroscopy and UV-visible absorption spectroscopy were used to confirm the interaction of candidate target proteins and (20S) G-Rh2. Molecular docking was utilized to calculate the estimated free energy of binding and to structurally visualize their interactions. MTT assay and immunoblotting were used to assess whether human serum albumin (HSA), bovine serum albumin (BSA), and bovine serum can reduce the cytotoxic activity of (20S) G-Rh2 in HepG2 cells. Results: In phage display, (20S) G-Rh2-beads and (20R) G-Rh2-beads were combined with numerous kinds of phages, and a total of 111 different human complementary DNAs (cDNA) were identified, including HSA which had the highest rate. The binding constant and number of binding site in the interaction between (20S)-Rh2 and HSA were $3.5{\times}10^5M^{-1}$ and 1, and those in the interaction between (20S) G-Rh2 and BSA were $1.4{\times}10^5M^{-1}$ and 1. The quenching mechanism is static quenching. HSA, BSA and bovine serum significantly reduced the proapoptotic effect of (20S) G-Rh2. Conclusion: HSA and BSA interact with (20S) G-Rh2. Serum inhibited the activity of (20S) G-Rh2 mainly due to the interaction between (20S) G-Rh2 and serum albumin (SA). This study proposes that HSA may enhance (20S) G-Rh2 water solubility, and thus might be used as nanoparticles in the (20S) G-Rh2 delivery process.
Layered silicate nanoparticles as a non-injectable drug delivery system for biomacromolecules
Song Jae Geun,Lee Sang Hoon,Bajracharya Rajiv,Ifekpolugo Nonye Linda,Kim Gyu-Lin,Park Seong Jin,정성훈,Lee Chang Hoon,한효경 한국약제학회 2024 Journal of Pharmaceutical Investigation Vol.54 No.5
Background Safe, efficient, and patient-friendly drug delivery systems are critical for enhancing therapeutic efficacy and the clinical application of drugs. Hence, various organic, inorganic, and hybrid materials have been extensively studied to develop effective drug delivery systems. When compared with a single material, nanocomposite materials based on the combination of different materials, possess more desirable and customized properties. Area covered Organically modified inorganic materials create synergy between organic and inorganic constituents, achieving properties that meet the specific design expectations for drug delivery carriers. Aminopropyl functionalized magnesium phyllosilicate (Aminoclay) exhibits unique properties derived from organic functional groups and three-dimensional inorganic silicates, and therefore, has broad biomedical and non-biomedical applications. Since aminoclay can interact with various drugs when dispersed in water as cationic nanosheets, and it is easily modifiable with functional ligands, it has great potential for use as a drug delivery carrier. It can improve the bioavailability of poorly soluble drugs, increase the thermal stability of drugs, and enhance cellular drug uptake. Furthermore, aminoclay-based drug delivery systems offer an avenue for non-invasive delivery of macromolecules, including proteins and antibodies. This review provides an overview of aminoclay, particular emphasis on their applications as a non-invasive drug delivery carrier for macromolecules. Expert Opinion Aminoclay mainly complexes with guest molecules via electrostatic interactions and its application can be extended to various biological molecules to design tailor-made drug delivery systems. However, despite its many advantages, aminoclay has challenges that should be resolved prior to its clinical applications. The long-term toxicity of aminoclay is not fully understood and should be clarified in relevant toxicology models. This will ultimately uncover a novel platform for the design of effective, versatile, and non-invasive delivery systems of biomacromolecules.
Lin, Chao,Shinde, Sambhaji S.,Jiang, Zheng,Song, Xiaokai,Sun, Yu,Guo, Linli,Zhang, Hao,Jung, Jin-Young,Li, Xiaopeng,Lee, Jung-Ho The Royal Society of Chemistry 2017 Journal of materials chemistry. A, Materials for e Vol.5 No.27
<▼1><P>A “three birds one stone” strategy for preparing 1D N-doped porous carbon nanotubes embedded with Co@CoOx nanoparticles results in the unprecedentedly high-rate Zn–air batteries.</P></▼1><▼2><P>In this work, we demonstrate a “three birds one stone” strategy for preparing 1D N-doped porous carbon nanotubes embedded with core–shell Co@CoOx nanoparticles (Co@CoOx/NCNTs) from bimetallic ZnO@Zn/Co-ZIF nanowires. The ZnO nanowires played three roles: (i) ZnO acted as a template for 1D metal–organic framework (MOF) growth, (ii) <I>in situ</I> evaporation of Zn during pyrolysis prevented the aggregation of the carbon framework and benefited the formation of hierarchical pores, and (iii) the excess oxygen species released from ZnO <I>in situ</I> reacted with metallic cobalt nanoparticles during pyrolysis, leading to the configuration of a Co@CoOx core–shell structure. The as-prepared 1D Co@CoOx/NCNTs exhibited excellent oxygen reduction reaction performance, including a high kinetic current (4.6 times better compared to 20 wt% Pt/C at 0.7 V), a low Tafel slope of 80 mV dec<SUP>−1</SUP>, outstanding stability, and strong tolerance to CH3OH crossover. The assembled Zn–air batteries with Co@CoOx/NCNTs yielded high open-circuit voltage (1.52 V), superior stability (over 100 h of operation), and unprecedented rate performance that ranged from 1 to 500 mA cm<SUP>−2</SUP>, while existing batteries have never achieved a galvanostatic discharge current density larger than 300 mA cm<SUP>−2</SUP>. Such exceptional rate capability was ascribed to the formation of a uniform interconnected nanotube network, facilitated electron transport, and an enlarged electrochemically accessible surface area in the unique 1D porous tubular structure.</P></▼2>
Song, Qing-Kun,Li, Jing,Huang, Rong,Fan, Jin-Hu,Zheng, Rong-Shou,Zhang, Bao-Ning,Zhang, Bin,Tang, Zhong-Hua,Xie, Xiao-Ming,Yang, Hong-Jian,He, Jian-Jun,Li, Hui,Li, Jia-Yuan,Qiao, You-Lin,Chen, Wan-Qin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22
Background: The study aimed to describe the age distribution of breast cancer diagnosis among Chinese females for comparison with the United States and the European Union, and provide evidence for the screening target population in China. Materials and Methods: Median age was estimated from hospital databases from 7 tertiary hospitals in China. Population-based data in China, United States and European Union was extracted from the National Central Cancer Registry, SEER program and GLOBOCAN 2008, respectively. Age-standardized distribution of breast cancer at diagnosis in the 3 areas was estimated based on the World Standard Population 2000. Results: The median age of breast cancer at diagnosis was around 50 in China, nearly 10 years earlier than United States and European Union. The diagnosis age in China did not vary between subgroups of calendar year, region and pathological characteristics. With adjustment for population structure, median age of breast cancer at diagnosis was 50~54 in China, but 55~59 in United States and European Union. Conclusions: The median diagnosis age of female breast cancer is much earlier in China than in the United States and the European Union pointing to racial differences in genetics and lifestyle. Screening programs should start at an earlier age for Chinese women and age disparities between Chinese and Western women warrant further studies.
Jin, Jie,Cai, Lin,Liu, Zhi-Ming,Zhou, Xue-Song Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6
Deregulated miRNAs participate in osteosarcoma genesis. In this study, the expression of miRNA-218 in human osteosarcomas, adjacent normal tissues and Saos-2 human osteosarcoma cells was first assessed. Then the precise role of miRNA-218 in osteosarcoma cells was investigated. Upon transfection with a miR-218 expression vector, the proliferation of Saos-2 human osteosarcoma cells determined using the ATPlite assay was significantly suppressed, whilw migration of Saos-2 cells detected by wound healing and invasion determined using transwells were dramatically inhibited. Potential target genes of miR-218 were predicted and T-cell lymphoma invasion and metastasis 1 (TIAM1) and matrix metalloproteinase 2 (MMP2) and 9 (MMP9) were identified. This was confirmed by western blotting, which showed that miR-218 expression inhibited TIAM1, MMP2 and MMP9 protein expression. Collectively, these data suggest that miR-218 acts as a tumor suppressor in osteosarcomas by down-regulating TIAM1, MMP2 and MMP9 expression.
Song-Lin Hu,Jin-Liang Liu,Zhao-Ping Du 제어·로봇·시스템학회 2011 International Journal of Control, Automation, and Vol.9 No.6
This paper is concerned with the stabilization problem of discrete-time networked control systems with partly known transmission delay. Considering the random property of the networked-induced delay, the original system is transformed into a new delay model with stochastic parameter matrices by introducing a novel state augmentation technique. Based on the new model, a new delay-distribution-dependent criterion for the mean square stability of the closed-loop system is derived by using the Lyapunov-Krasovskii functional approach and linear matrix inequality technique. The solvability of the derived criterion depends on not only the size of the delay, but also the probability distribution of the delay taking value in a finite set. Finally, two numerical examples are given to demonstrate the effectiveness of the proposed method.
Xue-Song Sun,Yu-Jing Liang,Sai-Lan Liu,Qiu-Yan Chen,Shan-Shan Guo,Yue-Feng Wen,Li-Ting Liu,Hao-Jun Xie,Qing-Nan Tang,Xiao-Yun Li,Jin-Jie Yan,Lin-Quan Tang,Hai-Qiang Mai 대한암학회 2019 Cancer Research and Treatment Vol.51 No.4
Purpose The purpose of this study was to subdivide M1 stage nasopharyngeal carcinoma (NPC) patients with bone-only metastases for prognosis prediction while identifying the treatment effect of locoregional radiotherapy (LRRT) and metastasis radiotherapy (MRT) among patients with different risk. Materials and Methods From November 2006 to October 2016, a total of 226 patients with bone-only metastasic NPC were retrospectively enrolled. All patients developed distant lesions before receiving treatment. All potential prognostic factors were considered and the correlation of the M1 subdivisions with overall survival (OS) was determined by Cox regression hazards model. Kaplan-Meier curves were used to appraise survival condition and log-rank testing was used to compare the differences. Results The median follow-up time was 33.9 months (range, 3 to 126 months). According to multivariate Cox proportional hazard analysis, the number of metastatic lesions and Epstein-Barr virus (EBV) DNA status after palliative chemotherapy (PCT) were independent prognostic factors for OS. Thus, we subdivided patients into three risk groups according to these two factors. Systemic chemotherapy combined with LRRT may benefit patients in low- and intermediate-risk groups but not in the high-risk group. Further aggressive MRT based on systemic chemotherapy showed no survival benefit in any risk group. Conclusion The stratification of NPC patients with bone-only metastasis based on EBV DNA after PCT and the number of metastatic lesions provided promising prognostic value and could aid clinicians in person-specific treatment.