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Regulation of Vacuolar H<SUP></SUP>-ATPase c Gene Expression by Oxidative Stress
Whan-Jong Kwak,Seong-Mook Kim,Min-Sung Kim,Jung-Hoon Kang,Dong-Jin Kim,Ho-Shik Kim,Oh-Joo Kown,In-Kyung Kim,Seong-Whan Jeong 대한생리학회-대한약리학회 2005 The Korean Journal of Physiology & Pharmacology Vol.9 No.5
By using differential display, we identified one of the genes encoding the multi-subunit complex protein V-ATPase, c subunit gene (ATP6L), and showed alterations of the gene expression by oxidative stresses. Expression of the ATP6L gene in Neuro-2A cells was increased by the treatment with H<SUB>2</SUB>O<SUB>2</SUB> and incubation in hypoxic chamber, implying that the expression of the ATP6L gene is regulated by oxidative stresses. To examine mechanisms involved in the regulation of the gene expression by oxidative stresses, the transcriptional activity of the rat ATP6L promoter was studied. Transcription initiation site was determined by primer extension analysis and DNA sequencing, and promoter of the rat ATP6L and its deletion clones were constructed in reporter assay vector. Significant changes of the promoter activities in Neuro-2A cells were observed in two regions within the proximal 1 kbp promoter, and one containing a suppressor was in 195 to 220, which contains GC box that is activated by binding of Sp1 protein. The suppression of promoter activity was lost in mutants of the GC box. We confirmed by electrophoretic mobility shift and supershift assays that Sp1 protein specifically binds to the GC box. The promoter activity was not changed by the H<SUB>2</SUB>O<SUB>2</SUB> treatment and incubation in hypoxic chamber, however, H<SUB>2</SUB>O<SUB>2</SUB> increased the stability of ATP6L mRNA. These data suggest that the expression of the ATP6L gene by oxidative stresses is regulated at posttranscriptional level, whereas the GC box is important in basal activities of the promoter.
Regulation of Vacuolar $H^+-ATPase$ c Gene Expression by Oxidative Stress
Kwak, Whan-Jong,Kim, Seong-Mook,Kim, Min-Sung,Kang, Jung-Hoon,Kim, Dong-Jin,Kim, Ho-Shik,Kown, Oh-Joo,Kim, In-Kyung,Jeong, Seong-Whan The Korean Society of Pharmacology 2005 The Korean Journal of Physiology & Pharmacology Vol.9 No.5
By using differential display, we identified one of the genes encoding the multi-subunit complex protein V-ATPase, c subunit gene (ATP6L), and showed alterations of the gene expression by oxidative stresses. Expression of the ATP6L gene in Neuro-2A cells was increased by the treatment with $H_2O_2$ and incubation in hypoxic chamber, implying that the expression of the ATP6L gene is regulated by oxidative stresses. To examine mechanisms involved in the regulation of the gene expression by oxidative stresses, the transcriptional activity of the rat ATP6L promoter was studied. Transcription initiation site was determined by primer extension analysis and DNA sequencing, and promoter of the rat ATP6L and its deletion clones were constructed in reporter assay vector. Significant changes of the promoter activities in Neuro-2A cells were observed in two regions within the proximal 1 kbp promoter, and one containing a suppressor was in -195 to -220, which contains GC box that is activated by binding of Sp1 protein. The suppression of promoter activity was lost in mutants of the GC box. We confirmed by electrophoretic mobility shift and supershift assays that Sp1 protein specifically binds to the GC box. The promoter activity was not changed by the $H_2O_2$ treatment and incubation in hypoxic chamber, however, $H_2O_2$ increased the stability of ATP6L mRNA. These data suggest that the expression of the ATP6L gene by oxidative stresses is regulated at posttranscriptional level, whereas the GC box is important in basal activities of the promoter.
Kwak, Jin Ku,Yun, Dong Yeol,Son, Dong Ick,Jung, Jae Hun,Lee, Dea Uk,Kim, Tae Whan American Scientific Publishers 2010 Journal of Nanoscience and Nanotechnology Vol.10 No.11
<P>Organic bistable devices fabircated utilizing SnO2 nanoparticles embedded in a poly(methyl methacrylate) (PMMA) polymer layer were formed by using a spin coating method. Transmission electon microscopy images and photoluminescence spectra showed that synethized SnO2 nanoparticles were randomly distributed in the dibutyl ehter solution. Current-voltage (I-V) measurements on the Al/SnO2 nanoparticles embedded in PMMA layer/ITO devices at 300 K showed current bistability due to the existence of SnO2 nanoparticles. Current-time (I-t) results showed the memory retention characteristic of the device. Carrier transport mechanisms of the device are described on the basis of the I-V experimental results and electronic structures.</P>
( Hyo Jin Lee ),( Jaeyoung Cho ),( Nakwon Kwak ),( Sun Mi Choi ),( Jinwoo Lee ),( Chang-hoon Lee ),( Young Sik Park ),( Sang-min Lee ),( Chul-gyu Yoo ),( Young Whan Kim ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: In general populations, short and long duration of sleep negatively affect health-related quality of life (HRQOL). However, the association of sleep duration with HRQOL in patients with chronic kidney disease (CKD) remains uncertain. Methods: In this cross-sectional study, data from 1,659 adult participants with CKD enrolled in the 2007- 2015 Korea National Health and Nutrition Examination Survey (KNHANES) were analyzed. CKD was defined by estimated glomerular filtration rate < 60 ml/min/1.73m2, using the CKD Epidemiology Collaboration creatinine equation. Participants were categorized into three groups according to self-reported sleep duration < 6 (short sleeper), 6-8, and > 8 hours (long sleeper). HRQOL was measured with the European Quality of Life-5 Dimensions (EQ-5D) index. Results: In multiple linear regression, short and long sleep duration were associated with lower EQ- 5D index (β= -0.030; 95% confidence interval [CI], -0.050 to -0.009 for short sleepers; β= -0.033 ; 95% CI, -0.061 to -0.005 for long sleepers). The adjusted EQ-5D index was 0.814 (95% CI, 0.796 to 0.831) for short sleepers, 0.849 (95% CI, 0.838 to 0.859) for 6 to 8-hour sleepers, 0.809 (95% CI, 0.783 to 0.835) for long sleepers (P < 0.001). In subgroup analysis, there was a statistically significant interaction between sleep duration and depression (P for interaction = 0.047). Short and long sleep duration were not associated lower HRQOL in patients with CKD and depression (P = 0.668 and P = 0.068, respectively) whereas its associations were significant in those without depression. Conclusions: In patients with CKD, both short and long sleep duration were associated with poor HRQOL. However, sleep duration was not associated with self-reported HRQOL in patients with CKD and depression.
이진우 ( Jin Woo Lee ),박영식 ( Young Sik Park ),임효정 ( Hyo Jeong Lim ),곽민선 ( Min Sun Kwak ),임우현 ( Woo Hyun Lim ),임재준 ( Jae Joon Yim ),양석철 ( Seok Chul Yang ),유철규 ( Chul Gyu Yoo ),김영환 ( Young Whan Kim ),한성구 ( 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.67 No.4
Although tuberculosis is a chronic infectious disease that can occur in any section of the body, oral tuberculosis is rare. Here, we report a case of oral tuberculosis in which the patient sought treatment for a painful oral lesion. A histopathologic examination revealed the characteristics of tuberculosis and pulmonary lesions were detected on subsequent examination. The patient was treated with antituberculosis therapy, and his symptoms improved. This case emphasizes the importance of including oral tuberculosis as part of the differential diagnosis for mucosal lesions.
USP14 Inhibition Regulates Tumorigenesis by Inducing Autophagy in Lung Cancer In Vitro
Han, Kyung Ho,Kwak, Minseok,Lee, Tae Hyeong,Park, Min-soo,Jeong, In-ho,Kim, Min Ji,Jin, Jun-O,Lee, Peter Chang-Whan MDPI AG 2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.20 No.21
<P>The ubiquitin-proteasome system is an essential regulator of several cellular pathways involving oncogenes. Deubiquitination negatively regulates target proteins or substrates linked to both hereditary and sporadic forms of cancer. The deubiquitinating enzyme ubiquitin-specific protease 14 (USP14) is associated with proteasomes where it trims the ubiquitin chain on the substrate. Here, we found that USP14 is highly expressed in patients with lung cancer. We also demonstrated that USP14 inhibitors (IU1-47 and siRNA-USP14) significantly decreased cell proliferation, migration, and invasion in lung cancer. Remarkably, we found that USP14 negatively regulates lung tumorigenesis not only through apoptosis but also through the autophagy pathway. Our findings suggest that USP14 plays a crucial role in lung tumorigenesis and that USP14 inhibitors are potent drugs in lung cancer treatment.</P>