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SSP 기후변화 시나리오에 따른 농업용 저수지 홍수조절능력 분석
김지혜 ( Kim¸ Jihye ),곽지혜 ( Kwak¸ Jihye ),황순호 ( Hwang¸ Soonho ),전상민 ( Jun¸ Sang Min ),이성학 ( Lee¸ Sunghack ),이재남 ( Lee¸ Jae Nam ),강문성 ( Kang¸ Moon Seong ) 한국농공학회 2021 한국농공학회논문집 Vol.63 No.5
The objective of this study was to evaluate the flood control capacity of the agricultural reservoir based on state-of-the-art climate change scenario - SSP (Shared Socioeconomic Pathways). 18 agricultural reservoirs were selected as the study sites, and future rainfall data based on SSP scenario provided by CMIP6 (Coupled Model Intercomparison Project 6) was applied to analyze the impact of climate change. The frequency analysis module, the rainfallrunoff module, the reservoir operation module, and their linkage system were built and applied to simulate probable rainfall, maximum inflow, maximum outflow, and maximum water level of the reservoirs. And the maximum values were compared with the design values, such as design flood of reservoirs, design flood of direct downstream, and top of dam elevation, respectively. According to whether or not the maximum values exceed each design value, cases were divided into eight categories; I-O-H, I-O, I-H, I, O-H, O, H, X. Probable rainfall (200-yr frequency, 12-h duration) for observed data (1973∼2020) was a maximum of 445.2 mm and increased to 619.1∼1,359.7 mm in the future (2011∼2100). For the present, 61.1% of the reservoirs corresponded to I-O, which means the reservoirs have sufficient capacity to discharge large inflow; however, there is a risk of overflowing downstream due to excessive outflow. For the future, six reservoirs (Idong, Baekgok, Yedang, Tapjung, Naju, Jangsung) were changed from I-O to I-O-H, which means inflow increases beyond the discharge capacity due to climate change, and there is a risk of collapse due to dam overflow.
A Pneumatic Haptic Module for Simulation of Catheters Used in Gastrointestinal Endoscopy
Jihye Hwang,Yunjin Gu,Doo Yong Lee 제어로봇시스템학회 2016 제어로봇시스템학회 국제학술대회 논문집 Vol.2016 No.10
This paper proposes a haptic module for simulation of catheters used in GI (gastrointestinal) endoscopy. The designed haptic interface provides translational force feedback in one degree-of-freedom using the pneumatic module made of silicon rubber. The pneumatic module has a cylindrical shape with a hollow space inside. The space inside of the module can be filled with air activated by a syringe pump. The module grasps the catheter traveling through the module. The syringe pump is controlled to insufflate or remove air into the space in real-time. Experimental results show that the feedback force and the amount of injected air to the module have a linear relationship. The proposed interface is able to generate necessary force feedback during catheter simulation.
Development of Cell-Penetrating Asymmetric Interfering RNA Targeting Connective Tissue Growth Factor
Hwang, Jihye,Chang, Chanil,Kim, Ji Hyun,Oh, Chang Taek,Lee, Ha Neul,Lee, Changki,Oh, Donghoon,Lee, Changjin,Kim, Beomjoon,Hong, Sun Woo,Lee, Dong-Ki Elsevier 2016 The Journal of investigative dermatology Vol.136 No.11
<P>Connective tissue growth factor (CTGF) is a multifunctional matricellular protein, playing a role as a central mediator in tissue remodeling and fibrosis. A number of reports have shown the pivotal roles of CTGF in the progression of fibrosis, suggesting CTGF as a promising therapeutic target for the treatment of fibrotic disorders including hypertrophic scars and keloids. In this study, we present the development of an interfering RNA molecule that efficiently inhibits the expression of CTGF via RNA interference mechanism both in vitro and in vivo. Chemical modifications were introduced to the asymmetric interfering RNA (asiRNA) backbone structure. The resulting RNA molecule, termed cell-penetrating asiRNA (cp-asiRNA), entered into cells and triggered RNA interference-mediated gene silencing without delivery vehicles. The gene-silencing activity of cp-asiRNA targeting CTGF (cp-asiCTGF) was examined both in vitro and in vivo. Furthermore, the administration of cp-asiCTGF in the rat skin excision wound model efficiently reduced the induction of CTGF and collagens during the wound-healing process. These results suggest that the cp-asiCTGF molecule could be developed into antifibrotic therapeutics such as antiscar drugs.</P>
Evaluation of transdermal exposure of phthalates in childrens products
Jihye Hwang,Young-Wook Lim,Ji-Yeon Yang,Dong-Chun Shin 환경독성보건학회 2022 환경독성보건학회지 Vol.37 No.1
In this study, 16 children’s products with the highest detection potential of phthalates were selected, and a phthalate assay and transdermal delivery analysis (NIER, US EPA Wipe [stress condition], US EPA Wipe [physiological condition], and US EPA Hand Wipe) were conducted with these products. The content of 6 controlled phthalates (DBP, BBP, DEHP, DNOP, DINP, and DIDP) was measured and most products contained more phthalates than the regulated guidelines (a total content of 6 phthalates to be ≤0.1%). For transdermal delivery, all items were found to be lower in the NIER transdermal delivery test method compared to the US EPA Hand Wipe (stress condition and physiological condition) transdermal delivery test method. For the US EPA Hand Wipe (stress condition and physiological condition) transdermal delivery test method, a similar result was observed, except for DINP. The average daily dose (ADD) estimated by determining the exposure algorithm for each transdermal delivery test method was highest in mats with a large contacting surface area and a long exposure time in the respective test methods. Conclusively, there was a difference between the NIER transdermal delivery test method and the US EPA Wipe transdermal delivery test method.