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Zeng, Yu-Jie,Liu, Lu,Wu, Heng,Lai, Wei,Cao, Jie-Zhi,Xu, He-Yang,Wang, Jie,Chu, Zhong-Hua Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10
Background: The gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) is the most common type of neuroendocrine neoplasm. We summarized data in our centre to investigate the clinicopathological features, diagnostic methods, therapeutic approaches and prognosis for this neoplasm to increase knowledge of this disease in Asian populations. Method: A total of 122 patients treated at Sun Yet-san Memorial Hospital of Sun Yat-sen University between January 2000 and December 2011 were analyzed retrospectively. Results: Pancreas was the most common site of involvement (65/122, 53.3%); this disease has no special symptoms; positive rates of chromogranin A (CgA) and synaptophysin (Syn) were 81.1% and 87.7%, respectively. The positive rate of Syn had statistical difference among the three grades, but not CgA. Some 68 patients had G1 tumors, 32 G2 tumors and 22 G3 tumors, and Chi-square test showed that higher grading was correlated with worse prognosis (${\chi}^2=32.825$, P=0.0001). A total of 32 patients presented with distant metastasis, and 8 cases emerged during following up. Cox proportional hazards regression modeling showed that the tumor grade (P=0.01), lymphatic metastasis (P=0.025) and distant metastasis (P=0.031) were predictors of unfavorable prognosis. The overall 5-year survival rate was 39.6%, the 5-year survival rate of G1 was 55.7%, and the G2 and G3 were 34.2% and 0%, respectively. Conclusions: The incidence of gastroenteropancreatic neuroendocrine tumors has risen over the last 12 years. All grades of these diseases metastasize readily, and further research regarding the treatment of patients after radical surgery is needed to prolong disease-free survival.
Model averaging procedure for varying-coefficient partially linear models with missing responses
Jie Zeng,Weihu Cheng,Guozhi Hu,Yaohua Rong 한국통계학회 2018 Journal of the Korean Statistical Society Vol.47 No.3
This paper is concerned with model averaging procedure for varying-coefficient partially linear models with missing responses. The profile least-squares estimation process and inverse probability weighted method are employed to estimate regression coefficients of the partially restricted models, in which the propensity score is estimated by the covariate balancing propensity score method. The estimators of the linear parameters are shown to be asymptotically normal. Then we develop the focused information criterion, formulate the frequentist model averaging estimators and construct the corresponding confidence intervals. Some simulation studies are conducted to examine the finite sample performance of the proposed methods. We find that the covariate balancing propensity score improves the performance of the inverse probability weighted estimator. We also demonstrate the superiority of the proposed model averaging estimators over those of existing strategies in terms of mean squared error and coverage probability. Finally, our approach is further applied to a real data example.
Sensitization of Cervical Carcinoma Cells to Paclitaxel by an IPP5 Active Mutant
Zeng, Qi-Yan,Huang, Yu,Zeng, Lin-Jie,Huang, Min,Huang, Yong-Qi,Zhu, Qi-Fang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19
Paclitaxel is one of the best anticancer agents that has been isolated from plants, but its major disadvantage is its dose-limiting toxicity. In this study, we obtained evidence that the active mutant IPP5 ($8-60hIPP5^m$), the latest member of the inhibitory molecules for protein phosphatase 1, sensitizes human cervix carcinoma cells HeLa more efficiently to the therapeutic effects of paclitaxel. The combination of $8-60hIPP5^m$ with paclitaxel augmented anticancer effects as compared to paclitaxel alone as evidenced by reduced DNA synthesis and increased cytotoxicity in HeLa cells. Furthermore, our results revealed that $8-60hIPP5^m$ enhances paclitaxel-induced G2/M arrest and apoptosis, and augments paclitaxel-induced activation of caspases and release of cytochrome C. Evaluation of signaling pathways indicated that this synergism was in part related to downregulation of NF-${\kappa}B$ activation and serine/threonine kinase Akt pathways. We noted that $8-60hIPP5^m$ downregulated the paclitaxel-induced NF-${\kappa}B$ activation, $I{\kappa}B{\alpha}$ degradation, PI3-K activity and phosphorylation of the serine/threonine kinase Akt, a survival signal which in many instances is regulated by NF-${\kappa}B$. Together, our observations indicate that paclitaxel in combination with $8-60hIPP5^m$ may provide a therapeutic advantage for the treatment of human cervical carcinoma.
Successive Deposition of Silver on Silver Nanoplates: Lateral versus Vertical Growth
Zeng, Jie,Xia, Xiaohu,Rycenga, Matthew,Henneghan, Patrick,Li, Qingge,Xia, Younan WILEY‐VCH Verlag 2011 Angewandte Chemie Vol.123 No.1
<P><B>Zugangsbeschränkung</B>: Die epitaktische Abscheidung von Ag auf Ag‐Nanoplättchen konnte durch den Zusatz von Natriumcitrat oder Poly(vinylpyrrolidon) (PVP) in seitliche bzw. senkrechte Richtung gelenkt werden (siehe Bild), sodass Kantenlänge und Dicke der Ag‐Nanoplättchen um das 100‐ bzw. 40‐Fache zunahmen. Raman‐Streusignale für Ag‐Nanokügelchen auf den Ag‐Nanoplättchen wurden mit zunehmender Dicke der Plättchen intensiver.</P>
Zeng Jie,Mu Li-Li,Jin Lin,Ali Anjum Ahmad,Li Guo-Qing 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.2
Henosepilachna vigintioctopunctata, a major threat to commercial potato production, is sensitive to RNA inter ference (RNAi), a gene-silencing mechanism triggered by double stranded RNA (dsRNA) matching a specific target gene sequence. Vacuolar ATPases (vATPases) are ATP-driven proton pumps involved in numerous bio logical processes. A holoenzyme vATPase consists of at least 14 different subunits and accessory proteins. Pre vious results reveal that silencing vATPaseB decreases survival rate, reduces food consumption and inhibits development in H. vigintioctopunctata. In this report, we identified two other subunit genes (vATPasea and vATPased) and compared the RNAi efficacy of vATPasea and vATPased with that of vATPaseB. We found the highest expression level of HvvATPasea, HvvATPaseB and HvvATPased occurred in the hindgut, followed by those in the foregut, Malpighian tubules and midgut, and lowest in the epidermis and fat body. When the fourth-instar larvae were allowed to ingest corresponding dsRNA for three days, the relative transcript levels of HvvATPasea, HvvATPaseB and HvvATPased were significantly decreased by 79%, 83% and 73%, respectively. Knockdown of HvvATPasea, HvvATPaseB and HvvATPased caused 50%, 85% and 100% larval lethality. After the third-instar larvae had exposed to corresponding dsRNA for three days, the levels of HvvATPasea and HvvATPased signifi cantly reduced by 91% and 96% respectively. All the treated larvae were dead. Our results demonstrate that RNAi efficiencies varied among different vATPase subunit genes and various development stages. Moreover, our data imply the feasibility of RNAi as an alternative method for controlling this critical potato pest.
g-C₃N₄ based Nanocomposites for Hydrogen Production
Zeng Jie(증지에),Jaesool Shim(심재술) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.4
Graphitic carbon nitride (g-C<SUB>3</SUB>N<SUB>4</SUB>), as a metal-free and visible light-responsive photocatalyst in the field of solar energy conversion and environmental remediation, has become a hot spot and has attracted widespread interdisciplinary attention [1], thanks to its unique electronic band structure, high physical and chemical stability and rich earth properties. This important review summarizes the latest developments related to the design and construction of original g-C<SUB>3</SUB>N<SUB>4</SUB> and g-C<SUB>3</SUB>N<SUB>4</SUB>-based nanocomposites, including (i) the nano architecture design of bare g-C<SUB>3</SUB>N<SUB>4</SUB>, such as hard and soft templates methods, supramolecular pre-organization assembly, exfoliation and template-free synthesis; (ii) functionalization of g-C<SUB>3</SUB>N<SUB>4</SUB> by element doping or copolymerization, and (iii) formation of heterostructures/junctions. The structure and characteristics of each classification of the heterojunction system will be strictly reviewed, namely metal-g-C<SUB>3</SUB>N<SUB>4</SUB>, semiconductor-g-C<SUB>3</SUB>N<SUB>4</SUB>, homotype g-C<SUB>3</SUB>N<SUB>4</SUB>/g-C<SUB>3</SUB>N<SUB>4</SUB>, graphitic carbon-g-C<SUB>3</SUB>N<SUB>4</SUB>, conductive polymer-g-C<SUB>3</SUB>N<SUB>4</SUB>, sensitizer-g-C<SUB>3</SUB>N<SUB>4</SUB> and multi-component heterojunction. This Viewpoint outlines the latest major developments in high-performance g-C<SUB>3</SUB>N<SUB>4</SUB>-based photocatalysts designed to generate hydrogen under visible light irradiation. Describes reasonable strategies, such as nanostructure design, band gap engineering, dye sensitization, and heterostructure fabrication. Finally, this Viewpoint focuses on the challenges and opportunities faced by the future development of g-C<SUB>3</SUB>N<SUB>4</SUB>-based photocatalysts in the exciting research field.