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Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide
Jin, Mi Sun,Kim, Sung Eun,Heo, Jin Young,Lee, Mi Eun,Kim, Ho Min,Paik, Sang-Gi,Lee, Hayyoung,Lee, Jie-Oh Elsevier 2007 Cell Vol.130 No.6
<P><B>Summary</B></P><P>TLR2 in association with TLR1 or TLR6 plays an important role in the innate immune response by recognizing microbial lipoproteins and lipopeptides. Here we present the crystal structures of the human TLR1-TLR2-lipopeptide complex and of the mouse TLR2-lipopeptide complex. Binding of the tri-acylated lipopeptide, Pam<SUB>3</SUB>CSK<SUB>4</SUB>, induced the formation of an “m” shaped heterodimer of the TLR1 and TLR2 ectodomains whereas binding of the di-acylated lipopeptide, Pam<SUB>2</SUB>CSK<SUB>4</SUB>, did not. The three lipid chains of Pam<SUB>3</SUB>CSK<SUB>4</SUB> mediate the heterodimerization of the receptor; the two ester-bound lipid chains are inserted into a pocket in TLR2, while the amide-bound lipid chain is inserted into a hydrophobic channel in TLR1. An extensive hydrogen-bonding network, as well as hydrophobic interactions, between TLR1 and TLR2 further stabilize the heterodimer. We propose that formation of the TLR1-TLR2 heterodimer brings the intracellular TIR domains close to each other to promote dimerization and initiate signaling.</P>
Mycoplasma pneumoniae infection in patients with Kawasaki disease
Lee, Mi-Na,Cha, Jie-Hae,Ahn, Hye-Mi,Yoo, Jeong-Hyun,Kim, Hae-Soon,Sohn, Se-Jung,Hong, Young-Mi The Korean Pediatric Society 2011 Clinical and Experimental Pediatrics (CEP) Vol.54 No.3
Purpose: Kawasaki disease (KD) is the main cause of acquired heart disease in children. In addition to cardiovascular involvement, many complications have been recognized in KD. However, respiratory complications have been rarely reported. We investigated the differences in clinical characteristics, laboratory findings, radiography findings, and echocardiography findings of Mycoplasma pneumoniae infection and other types of pneumonia in KD patients. Methods: Among 358 patients with KD, 54 developed concurrent pneumonia. Among the 54 patients, 12 (22.2%) with high titers of anti-M. pneumoniae antibody (AMA) (>1:640) were grouped in the M. pneumoniae group and 42 were included in the control group. Serum AMA was measured in each patient. Clinical laboratory findings and total duration of fever were analyzed. Results: The duration of fever, serum hemoglobin, white blood cell count, platelet count, erythrocyte sedimentation rate, C-reactive protein level, albumin level, and the incidence of coronary arterial lesions showed no statistical difference in the 2 groups. Neutrophil count was significantly higher in the M. pneumoniae group than in the control group. Among various radiography findings observed in pneumonia, consolidation and pleural effusion were more frequent in the M. pneumoniae group than in the control group. On the other hand, parahilar peribronchial opacification, diffuse interstitial lesion, and normal findings prevailed in the control group. Conclusion: KD patients can have concurrent infections, especially pulmonary symptoms. The cause of KD is likely to be associated with M. pneumoniae infection. Thus, immediate treatment of M. pneumoniae infection in KD patients is very important.
Choi, Yong-Woo;Kim, Sun-Mi;Jin, Xiong-Jie;Kwak, Ji-Yeong;Jung, Ju-Yang;Mun, Jun-II;Lim, Hong-Seok 중앙대학교 의과대학 의과학연구소 2012 中央醫大誌 Vol.37 No.1/2
The use of drug eluting stent (DES) has been increased in recent years because of its ability to inhibit neointimal proliferation. However, it may affect the normal healing process of the vessel wall after vascular injury and may be associated with coronary artery aneurysm formation in rare cases. We report a case of angiographic spontaneous resolution of coronary aneurysm developed after implantation of sirolimus-eluting coronary stent at the left anterior descending artery, diagonal branch, and left circumflex artery. But, there was discrepancy between intravascular ultrasound (IVUS) and coronary angiographic findings. IVUS demonstrated no significant shrinkage of maximal external elastic membrane (EEM) compared to earlier examination but echogenic tissue was filled in the free space between the stent and EEM at the stented segments where the angiographic resolution of the aneurysm occurred. We found out that an angiographic resolution of coronary aneurysm does not always guarantee real shrinkage of vessel wall, and fill-up of aneurismal space with thrombus or tissue could be an important mechanism of spontaneous resolution of DES related coronary aneurysm. Optimal treatment could be decided based on longer-term follow-up of patients which provide more accurate characterization of the consequences of DES-related aneurysm.
( Jie Hun Kang ),( Hyun Chul Jang ),( Jung Mi Choi ),( Jae Young Hyeon ),( Jung Hyun Sok ) 대한금속재료학회(구 대한금속학회) 2014 대한금속·재료학회지 Vol.52 No.1
The replacement for indium tin oxide (ITO) in electronic displays should have comparable optical transmittance and electrical conductivity while being easy to source and manufacture. However, novel materials such as singlewalled carbon nanotubes (SWCNTs) and reduced graphene oxides (RGOs) are incapable of addressing these challenges. We demonstrate a simple method to fabricate good transparent conductive films (TCFs) by combining and leveraging the superior optical transparency of RGOs and the excellent electrical conductivity of SWCNTs. This method affords thin multilayers of SWCNTs and RGOs with excellent optical and electrical properties because these properties are correlated with spraying time and the amount of SWCNTs or RGOs. In general, transmittance is advantageous to RGO as conductance is to CNTs. With a view to finding good TCFs with reduced sheet resistance, but with little sacrifice of transmittance, it is natural to explore the combination of CNT and RGO. The sandwiched multilayer of SWCNTs and RGOs exhibited a low sheet resistance of 214.2 Ω/sq, which was comparable to that of SWCNTs, and a transmittance of 60% at a wavelength of 550 nm. To further reduce the sheet resistance and improve the transparency of the multilayer TCFs, Au doping was carried out. The doping, in combination with controlled spraying of the amount of SWCNTs and RGOs, led to multilayers with resistance/transmittance combinations of 141.3 Ω/sq and 70% and 371.5 Ω/sq and 83%. These properties meet the requisite criteria for an ITO replacement.