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JianYan Huang,Lingmin Zhang,Peng Chen,Shitao Chen,Yueheng Wu,ShunQing Tang 한국물리학회 2011 Current Applied Physics Vol.11 No.3
Agarose-grafting-hyaluronan (Ag-g-HA) has been proved to be a potential carrier for oral insulin, but it needs to clarify that insulin loaded in Ag-g-HA microparticle is effectively transported across epithelial layer. In this paper, Caco-2 cell monolayer was used for imitation of epithelial layer in small intestine to evaluate Ag-g-HA copolymer enhanced insulin transportation crossing epithelial layer. Ag-g-HA/insulin polyelectrolyte complexes were formed via electrostatic interaction at pH 3e5.4 and could spontaneously form microparticles with average diameter of 2 μm. Caco-2 cells in transwell dish were attached in tight monolayer after 21 d proliferation, and some features of Caco-2 cell monolayer, such as trans-epithelial electrical resistance (TEER) value being over 400 Ω/cm^2, alkaline phosphatase (ALP) activity being 0.7184 ± 0.095, and apparent permeability coefficient value (Papp) of propranonol being 1 × 10^-6 cm/s,were similar to those of epithelial layer in small intestine. These results revealed that Caco-2 cellmonolayer was suitable to be a model of small intestine epithelium layer for imitation of insulin crossing small intestine. P_app of insulin crossing Caco-2 monolayer reached 0.592 ± 0.067 × 10^-6 cm/s, which was significantly greater than the control groups. This meant Ag-g-HA as insulin carrier significantly promoted insulin crossing Caco-2 cell monolayer. These findings demonstrate that Caco-2 cell monolayer is a suitable model for drug transportation crossing epithelial layer, and Ag-g-HA has a promise as oral insulin carrier.
Urata, Yuji,Huang, Kuiyun,Im, Myungshin,Lee, Induk,Deng, Jinsong,Ip, WingHuen,Krimm, Hans,Liping, Xin,Ohno, Masanori,Qiu, Yulei,Sugita, Satoshi,Tashiro, Makoto,Wei, Jianyan,Yamaoka, Kazutaka,Zheng, We IOP Publishing 2009 ASTROPHYSICAL JOURNAL LETTERS - Vol.706 No.1
<P>We present multi-band results for GRB071010B based on Swift, Suzaku, and ground-based optical observations. This burst is an ideal target to evaluate the robustness of the E-peak(src) - E-iso and E-peak(src) - E-gamma relations, whose studies have been in stagnation due to the lack of the combined estimation of E-peak(src) and long-term optical monitoring. The joint prompt spectral fitting using Swift/Burst Alert Telescope and Suzaku/Wide-band All-sky Monitor data yielded the spectral peak energy as E-peak(src) of 86.5(-6.3)(+6.4) keV and E-iso of 2.25(-0.16)(+0.19) x 10(52) erg with z = 0.947. The optical afterglow light curve is well fitted by a simple power law with temporal index alpha = -0.60 +/- 0.02. The lower limit of temporal break in the optical light curve is 9.8 days. Our multi-wavelength analysis reveals that GRB071010B follows E-peak(src) - E-iso but violates the E-peak(src) - E-gamma and E-iso - E-peak(src) - t(jet)(src) at more than the 3 sigma level.</P>