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Congcong Zeng,Zhengzhong Yuan,Jiahui Zhu,Yintong Wang,Yongyong Xie,Ren Ye,Jinguo Cheng 한국한의학연구원 2021 Integrative Medicine Research Vol.10 No.-
Background Wenzhou has achieved great progress in the prevention and control of the growing coronavirus disease 2019 (COVID-19) pandemic, and traditional Chinese medicine (TCM) has played an indispensable role in this fight. This study aimed to investigate the efficacy of Maxingshigan-Weijing decoction (MWD) in treating infected patients. Methods This study was an open-label randomized controlled trial. Inpatients with mild or moderate symptoms caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were randomly treated with routine supportive care alone or a combination of routine supportive care and MWD. The primary outcome was the rate of symptom (fever, fatigue, cough and difficulty breathing) recovery. Results Fifty-nine inpatients were enrolled, of whom 29 received routine supportive care alone (control group) and 30 received combination therapy (treatment group). The rate of symptom recovery was significantly higher in the treatment group than in the control group. The time to recovery of fever (3 vs. 7 days), fatigue (9 vs. 12 days), coughing (9 vs. 14 days) and difficulty breathing (4.5 vs. 9.5 days) was also significantly shorter in the treatment group (all p < 0.001). The syndrome score was lower after MWD treatment. However, neither group differed in the viral assay findings, hospitalization days, medication time or the rate of conversion to severe cases. Conclusions MWD increased the rate of symptom recovery and shortened the time to recovery of clinical symptoms without deterioration to death or critical care. These findings may provide opportunities for the use of complementary medicine in treating this infection. Clinical trial registration Chinese Clinical Trial Registry, ChiCTR2000030759. Background Wenzhou has achieved great progress in the prevention and control of the growing coronavirus disease 2019 (COVID-19) pandemic, and traditional Chinese medicine (TCM) has played an indispensable role in this fight. This study aimed to investigate the efficacy of Maxingshigan-Weijing decoction (MWD) in treating infected patients. Methods This study was an open-label randomized controlled trial. Inpatients with mild or moderate symptoms caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were randomly treated with routine supportive care alone or a combination of routine supportive care and MWD. The primary outcome was the rate of symptom (fever, fatigue, cough and difficulty breathing) recovery. Results Fifty-nine inpatients were enrolled, of whom 29 received routine supportive care alone (control group) and 30 received combination therapy (treatment group). The rate of symptom recovery was significantly higher in the treatment group than in the control group. The time to recovery of fever (3 vs. 7 days), fatigue (9 vs. 12 days), coughing (9 vs. 14 days) and difficulty breathing (4.5 vs. 9.5 days) was also significantly shorter in the treatment group (all p < 0.001). The syndrome score was lower after MWD treatment. However, neither group differed in the viral assay findings, hospitalization days, medication time or the rate of conversion to severe cases. Conclusions MWD increased the rate of symptom recovery and shortened the time to recovery of clinical symptoms without deterioration to death or critical care. These findings may provide opportunities for the use of complementary medicine in treating this infection. Clinical trial registration Chinese Clinical Trial Registry, ChiCTR2000030759.
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Jingmei Xu,Xuan Chen,Mengchi Ju,Jiahui Ren,Pengyun Zhao,Lingxin Meng,Jinxuan Lei,Qingyuan Shi,Zhe Wang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.119 No.-
In this study, a sulfonated poly (ether ketone sulfone) with multiple sulfonic acid groups was preparedand named as MSP, where the multiple sulfonic acid groups in the polymer were located on its sidechains of uneven length. And a series of hybrid membranes were prepared by introducing organic–inorganicfillers (ZIF-67/GO) into this side chain type polymer matrix. Among them, ZIF-67 was chemicallygrafted onto the GO sheet through coordination between Co+ and the carboxyl group of GO, bound toGO and grown uniformly. The ZIF-67/GO and hybrid membranes were characterized by FT-IR, XRD,SEM, AFM and 1H NMR. The hybrid membranes exhibited increasingly high proton conductivity fromMSP (0.0876 S cm1) to MSP-1 % ZIF-67/GO (0.1426 S cm1) at 100 C and 100 % relative humidity. Moreover, the hybrid membranes have excellent chemical stability. The results indicated that ZIF-67/GO was important for constructing of proton transport channels, and the prepared hybrid membranesshowed great potential for application in PEM.
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