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RISS 인기검색어
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- 저자 : Jiahao Peng (검색결과 4 건)
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Targeting treatment of bladder cancer using PTK7 aptamer-gemcitabine conjugate
Xiang Wei,Peng Yongbo,Zeng Hongliang,Yu Chunping,Zhang Qun,Liu Biao,Liu Jiahao,Hu Xing,Wei Wensu,Deng Minhua,Wang Ning,Liu Xuewen,Xie Jianfei,Hou Weibin,Tang Jin,Long Zhi,Wang Long,Liu Jianye 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Gemcitabine (GEM) is one of the first-line chemotherapies for bladder cancer (BC), but the GEMs cannot recognize cancer cells and have a low long-term response rate and high recurrence rate with side effects during the treatment of BC. Targeted transport of GEMs to mediate cytotoxicity to tumor and avoid the systemic side effects remains a challenge in the treatment of BC.Based on a firstly confirmed biomarker in BC-protein tyrosine kinase 7 (PTK7), which is overexpressed on the cell membrane surface in BC cells, a novel targeting system protein tyrosine kinase 7 aptamer-Gemcitabine conjugate (PTK7-GEMs) was designed and synthesized using a specific PTK7 aptamer and GEM through auto-synthesis method to deliver GEM against BC. In addition, the antitumor effects and safety evaluation of PTK7-GEMs was assessed with a series of in vitro and in vivo assays.PTK7-GEMs can specifically bind and enter to BC cells dependent on the expression levels of PTK7 and via the macropinocytosis pathway, which induced cytotoxicity after GEM cleavage from PTK7-GEMs respond to the intracellular phosphatase. Moreover, PTK7-GEMs showed stronger anti-tumor efficacy and excellent biosafety in three types of tumor xenograft mice models.These results demonstrated that PTK7-GEMs is a successful targeted aptamer-drug conjugates strategy (APDCs) to treat BC, which will provide new directions for the precision treatment of BC in the field of biomarker-oriented tumor targeted therapy.
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Achieve 100% transmission via grafting hydroxyl groups on CNT nanomotors
Li Rui,Liu Jiahao,Zheng Xu,Peng Qing 한국물리학회 2021 Current Applied Physics Vol.29 No.-
Nanomotors are essential in nanorobots and nanoenergy. The critical issues include stability and efficiency. Here, we have investigated the influence of hydroxyl groups on the transmission behavior of carbon nanotube based nanomotors using molecular dynamic simulations. The results showed that 100% transmission efficiency occurred in kinetic energy transmission, irrespective to the diameters and chiral angles of carbon nanotubes. Such stable and efficient transmission was attributed to the hydrogen bonds formed between hydroxyl groups on motor and rotor. The fastened responses were observed in the systems with zigzag and armchair carbon nanotube motor. Our results provide atomic insights into improving stability and efficiency in nanomotors.
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Stability study on tenon-connected SHS and CFST columns in modular construction
Yisu Chen,Chao Hou,Jiahao Peng 국제구조공학회 2019 Steel and Composite Structures, An International J Vol.30 No.2
Modular construction is an emerging technology to accommodate the increasing restrictions in terms of construction period, energy efficiency and environmental impacts, since each structural module is prefabricated offsite beforehand and assembled onsite using industrialized techniques. However, some innate structural drawbacks of this innovative method are also distinct, such as connection tying inaccessibility, column instability and system robustness. This study aims to explore the theoretical and numerical stability analysis of a tenon-connected square hollow section (SHS) steel column to address the tying and stability issue in modular construction. Due to the excellent performance of composite structures in fire resistance and buckling prevention, concrete-filled steel tube (CFST) columns are also taken into account in the analysis to evaluate the feasibility of adopting composite sections in modular buildings. Characteristic equations with three variables, i.e., the length ratio, the bending stiffness ratio and the rotational stiffness ratio, are generated from the fourth-order governing differential equations. The rotational stiffness ratio is recognized as the most significant factor, with interval analysis conducted for its mechanical significance and domain. Numerical analysis using ABAQUS is conducted for validation of characteristic equations. Recommendations and instructions in predicting the buckling performance of both SHS and CFST columns are then proposed.
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Sneha Shaha,Yinglin Gao,Jiahao Peng,Kendrick Che,John J. Kim,Wasseem Skef 대한소화기내시경학회 2023 Clinical Endoscopy Vol.56 No.5
Background/Aims: We aimed to study the effects of sedation on endoscopic ultrasound-guided tissue acquisition. Methods: We conducted a retrospective study evaluating the role of sedation in endoscopic ultrasound-guided tissue acquisition bycomparing two groups: anesthesia care provider (ACP) sedation and endoscopist-directed conscious sedation (CS). Results: Technical success was achieved in 219/233 (94.0%) in the ACP group and 114/136 (83.8%) in the CS group (p=0.0086). Inmultivariate analysis, the difference in technical success between the two groups was not significant (adjusted odds ratio [aOR], 0.5;95% confidence interval [CI], 0.234–1.069; p=0.0738). A successful diagnostic yield was present in 146/196 (74.5%) in the ACP groupand 66/106 (62.3%) in the CS group, respectively (p=0.0274). In multivariate analysis, the difference in diagnostic yield between thetwo groups was not significant (aOR, 0.643; 95% CI, 0.356–1.159; p=0.142). A total of 33 adverse events (AEs) were observed. The incidenceof AEs was significantly lower in the CS group (5/33 CS vs. 28/33 ACP; OR, 0.281; 95% CI, 0.095–0.833; p=0.022). Conclusions: CS provided equivalent technical success and diagnostic yield for malignancy in endoscopic ultrasound-guided tissueacquisition. Increased AEs were associated with anesthesia for the endoscopic ultrasound–guided tissue acquisition.
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