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Systemic Lupus Erythematosus를 동반한 Multiple sclerosis
이지현,이기주,윤성호,부귀범,손현화,박유환,정춘해,김진호,정원영 조선대학교 부설 의학연구소 1998 The Medical Journal of Chosun University Vol.23 No.2
Multiple sclerosis and lupus erythematosus are chronic, potentially disabling diseases of unknown cause. It is a rare occasion that the finding of both diseases occurs in one patient. Because both diseases may affect the central nervous system, it may be difficult at times to differentiate symptoms of lupus erythematosus from those of multiple sclerosis. As far as we know, there was no case report of SLE in multilple sclerosis in Korea. We report a case of multiple sclerosis accompanied by SLE.
마이크로니들의 형태 및 적용방법이 약물의 피부 투과에 미치는 영향
임지호,이경록,이은주,조정원 충남대학교 약학대학 의약품개발연구소 2012 藥學論文集 Vol.27 No.-
The purpose of this study is to develop the microneedle using biodegradable and biocompatible polymer and to pioneer the new route of drug delivery through the research to apply the most desirable administration form of small molecules, peptides, proteins, genes, biological products including vaccines. Various biocompatible microneedles were manufactured. To apply drug to microneedle, drug formulation using ethylene vinyl acetate patch or polyacryl acid gel was developed. Drug permeation into rat skin based on the application method of patch or gel with microneedle was studied using Franz diffusion cell system. In vitro drug permeation results showed that the permeation by the application of hollow microneedle was not increased compared with solid microneedle. When G60 or G60*2 microneedle was used, the permeated amount of calcein was increased compared to when solid microneedle was used. The permeated amount of lidocaine HCl in 12 hr was increased when microneedle was used was increased. Skin irritation followed by microneedle showed there was little difference in the decrease of redness after microneedle application based on application time.
TTAC-0001, a human monoclonal antibody targeting VEGFR-2/KDR, blocks tumor angiogenesis
Lee, Weon Sup,Pyun, Bo-Jeong,Kim, Sung-Woo,Shim, Sang Ryeol,Nam, Ju Ryoung,Yoo, Ji Young,Jin, Younggeon,Jin, Juyoun,Kwon, Young-Guen,Yun, Chae-Ok,Nam, Do-Hyun,Oh, Keunhee,Lee, Dong-Sup,Lee, Sang Hoon Taylor Francis 2015 mAbs Vol.7 No.5
Lee, Seunghwan,Shin, Dongwook,Park, Mansoo,Hong, Jongsup,Kim, Hyoungchul,Son, Ji-Won,Lee, Jong-Ho,Kim, Byung-Kook,Lee, Hae-Weon,Yoon, Kyung Joong Elsevier 2017 Journal of the European Ceramic Society Vol.37 No.5
<P><B>Abstract</B></P> <P>Gadolinia-doped ceria (GDC) has emerged as one of the most essential component materials for next-generation solid oxide fuel cells (SOFCs). The refractory nature of GDC has been a major hurdle for its successful implementation, and precise control of the thermal behavior is crucial. Here, we report a particle-dispersed glycine-nitrate process (PD-GNP) that leads to the formation of fast-sintering nanoparticles uniformly conjugated to the surface of slow-sintering inclusion particles. The independent regulation of nanoparticles and sintering aids based on <I>in situ</I> co-assembly process enables precise control over the individual stages of the sintering process and grain growth, resulting in complete densification at desired temperatures. This work highlights a simple and cost-effective way to produce exquisitely tailored GDC nanopowder for specific purposes in the manufacturing of SOFCs; furthermore, it expands opportunities to effectively exploit nanotechnology in the fabrication of a wide range of multilayer ceramic devices.</P>
Highly Dense Mn-Co Spinel Coating for Protection of Metallic Interconnect of Solid Oxide Fuel Cells
Lee, Sung-Il,Hong, Jongsup,Kim, Hyoungchul,Son, Ji-Won,Lee, Jong-Ho,Kim, Byung-Kook,Lee, Hae-Weon,Yoon, Kyung Joong The Electrochemical Society 2014 Journal of the Electrochemical Society Vol.161 No.14
<P>The major degradation issues of solid oxide fuel cells (SOFC) are associated with the oxide scale growth and Cr evaporation of the metallic interconnect. To address these challenges, a highly dense spinel oxide coating was fabricated on a ferritic stainless steel interconnect using a cost-competitive ceramic processing route. The nano-scale Mn<SUB>1.5</SUB>Co<SUB>1.5</SUB>O<SUB>4</SUB> spinel powder was synthesized using a glycine-nitrate method, and the particle agglomerates were effectively disintegrated by a high-energy attrition milling process. The spinel protective coating, which was applied by screen printing, was sintered to a nearly full density, without causing damage to the metallic substrate, by a high-temperature annealing process in a reducing environment, followed by re-oxidation at a moderate temperature. The dense spinel coating remarkably reduced the growth rate of chromia scale and restrained the evaporation of chromium species, as verified by area specific resistance (ASR) measurements and analysis on chromium distribution over the cross-section. Strong adhesion between the coating and substrate was confirmed after 500-hour operation. The sintering mechanism involved in reduction-oxidation heat-treatment was studied based on dilatometry measurements and microstructural features. The implication of the ASR change and the chromium migration for stability of practical SOFC stacks was discussed in detail.</P>
Ji Young Lee,Ji Young Park,Na Mi Lee,Ki Wook Yun,Soo Ahn Chae,In Seok Lim,Eung Sang Choi,Sin Weon Yun 중앙대학교 의과대학 의과학연구소 2013 中央醫大誌 Vol.38 No.3
Positive-pressure ventilation can cause various life-threatening barotraumas in cases of extremely low birth weight (ELBW) prematurity with lung disease. Isolated tension pneumopericardium unaccompanied by other barotraumas is very rare and can rapidly deteriorate. Sudden unexplainable hemodynamic collapse in premature infants receiving mechanical ventilation always requires urgent investigation. Here, we describe a case of isolated tension pneumopericardium in an ELBW premature male infant. The gestational age of 23 weeks, and the birth weight was 636 g. The infant was diagnosed with severe respiratory distress syndrome. After application of surfactant and conventional ventilation, oxygenation and vital signs improved briefly. However, the hypoxia worsened, requiring a higher pressure setting to maintain oxygenation and ventilation. When the oxygen saturation did not improve despite the higher pressure, we switched to a high-frequency oscillatory ventilator. At this point, the infant's condition suddenly deteriorated. We took a chest radiograph, started resuscitation, and quickly recognized a large amount of air compressing the heart. Vigorous resuscitation, including pericardial decompression, was actively performed but ultimately unsuccessful. We wish to bring this case to the attention of clinicians, who should always be aware of this fatal but treatable disease. Prompt recognition and intervention could be the only way to save the lives of affected infants.
Lee, Su-Jun,Jung, Il-Sun,Jung, Eun-Ji,Choi, Ji-Yeop,Yeo, Chang-Woo,Cho, Doo-Yeoun,Kim, Yang-Weon,Lee, Sang-Seop,Shin, Jae-Gook Elsevier 2011 Thrombosis research Vol.127 No.3
<P><B>Abstract</B></P><P><B>Introduction</B></P><P>Although P2Y12 has a significant role in normal hemostasis and thrombosis, no genetic study has been described about the association between P2Y12 variants and the extent of ADP-induced platelet activation in the Korean population.</P><P><B>Materials and Methods</B></P><P>The expression levels of two reference sequences of <I>P2Y12</I> mRNA transcripts (variants 1 and 2) were examined in the whole blood before direct DNA sequencing. The subjects were screened for single-nucleotide polymorphisms (SNPs) in <I>P2Y12</I> by direct DNA sequencing (n=50). Frequencies of <I>P2Y12</I> single nucleotide polymorphisms (SNPs), linkage disequilibrium blocks, haplotype structures, and haplotype-tagging SNPs were determined. The effects of genetic variation in the <I>P2Y12</I> gene on the extent of ADP-induced platelet aggregation were studied in healthy Korean men (n=40).</P><P><B>Results</B></P><P>Variant 2 (NM 176876.1) was the predominantly expressed form in all subjects, but variant 1 was also weakly expressed in all cases (n=10). A total of 20 SNPs were identified: 2 in exons, 5 in introns, and 8 and 5 in the 5’-untranslated regions of the known <I>P2Y12</I> RNA variants 1 and 2, respectively. Genetic analysis of the <I>P2Y12</I> SNPs and haplotypes revealed a statistically significant association between <I>P2Y12</I> haplotype, denoted H3, and an increase in the ADP-induced platelet aggregation response relative to that for the reference haplotype H1 (<I>P</I>=0.01).</P><P><B>Conclusions</B></P><P>Application of these findings to the development of a multivariate model might be useful in explaining the variable outcome of antiplatelet drug therapy in Asian populations.</P>