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Jhun JooYeon,우진석,Kwon Ji Ye,Na Hyun Sik,Cho Keun-Hyung,김선애,Kim Seok Jung,문수진,Park Sung-Hwan,조미라 대한면역학회 2022 Immune Network Vol.22 No.4
Osteoarthritis (OA) is the most common form of arthritis associated with ageing. Vitamin D has diverse biological effect on bone and cartilage, and observational studies have suggested it potential benefit in OA progression and inflammation process. However, the effect of vitamin D on OA is still contradictory. Here, we investigated the therapeutic potential of vitamin D in OA. Six-week-old male Wistar rats were injected with monosodium iodoacetate (MIA) to induce OA. Pain severity, cartilage destruction, and inflammation were measured in MIA-induced OA rats. Autophagy activity and mitochondrial function were also measured. Vitamin-D (1,25(OH)2D3) and celecoxib were used to treat MIA-induced OA rats and OA chondrocytes. Oral supplementation of vitamin D resulted in significant attenuations in OA pain, inflammation, and cartilage destruction. Interestingly, the expressions of MMP-13, IL-1β, and MCP-1 in synovial tissues were remarkably attenuated by vitamin D treatment, suggesting its potential to attenuate synovitis in OA. Vitamin D treatment in OA chondrocytes resulted in autophagy induction in human OA chondrocytes and increased expression of TFEB, but not LC3B, caspase-1 and -3, in inflamed synovium. Vitamin D and celecoxib showed a synergistic effect on antinociceptive and chondroprotective properties in vivo. Vitamin D showed the chondroprotective and antinociceptive property in OA rats. Autophagy induction by vitamin D treatment may be a promising treatment strategy in OA patients especially presenting vitamin D deficiency. Autophagy promoting strategy may attenuate OA progression through protecting cells from damage and inflammatory cell death.
Capability of Gray Scale in Bistable Chiral Splay Nematic Liquid Crystal Display
Jhun, Chul Gyu,Kim, Sun-Kyung,Park, Sang-Hyun,Min, Kwan-Sik,Kwon, Soon-Bum,Yoon, Tae-Hoon,Kim, Jae Chang TaylorFrancis 2009 Molecular Crystals and Liquid Crystals Vol.507 No.1
<P> In the bistable chiral splay nematic (BCSN) mode, the splay and π twist states are used for the two stable states. The transition between the memory states accompanies the motion of the disclination line, due to the topologically inequivalent from each other. The switching time is consistently coupled with the propagation velocity of the disclination line, which strongly depends on the amplitude of the applied voltage. In this paper, we demonstrate the gray scale of BCSN liquid crystal display (LCD) by the control of the domain density of the splay and twist states during the transition process.</P>
Electronic structure of charged bilayer and trilayer phosphorene
Jhun, Bukyoung,Park, Cheol-Hwan American Physical Society 2017 Physical Review B Vol.96 No.8
<P>We have investigated the electronic structure of charged bilayer and trilayer phoshporene using first-principles density functional theory calculations. We find that the effective dielectric constant for an external electric field applied perpendicular to phosphorene layers increases with the charge density and is twice as large as in an undoped system if the electron density is around 5 x 10(13) cm(-2). It is known that if few-layer phosphorene is placed under such an electric field, the electron band gap decreases, and if the strength of the electric field is further increased, the band gap closes. We show that the electronic screening due to added charge carriers reduces the amount of this reduction in the band gap and increases the critical strength of the electric field for gap closure. If the electron density is around 4 x 10(13) cm(-2), for example, this critical field for trilayer phosphorene is 40% higher than that for a charge-neutral system. The results are directly relevant to experiments on few-layer phosphorene with top and bottom electrical gates and/or with chemical dopants.</P>
$L^1$ Bandwidth Selection in Kernel Regression Function Estimation
Jhun, Myong-Shic The Korean Statistical Society 1988 Journal of the Korean Statistical Society Vol.17 No.1
Kernel estimates of an unknown regression function are studied. Bandwidth selection rule minimizing integrated absolute error loss function is considered. Under some reasonable assumptions, it is shown that the optimal bandwidth is unique and can be computed by using bisection algorithm. Adaptive bandwidth selection rule is proposed.
Amikacin Inhalation as Salvage Therapy for Refractory Nontuberculous Mycobacterial Lung Disease
Jhun, Byung Woo,Yang, Bumhee,Moon, Seong Mi,Lee, Hyun,Park, Hye Yun,Jeon, Kyeongman,Kwon, O Jung,Ahn, Jungmin,Moon, Il Joon,Shin, Sung Jae,Daley, Charles L.,Koh, Won-Jung American Society for Microbiology 2018 Antimicrobial Agents and Chemotherapy Vol.62 No.7
<P>Although guidelines recommend amikacin (AMK) inhalation therapy for difficult-to-treat nontuberculous mycobacterial lung disease (NTM-LD), data are limited regarding the safety and clinical efficacy of this salvage therapy. We retrospectively evaluated the treatment outcomes of 77 patients with refractory NTM-LD caused by Mycobacterium abscessus complex (MABC) or M. avium complex (MAC) who initiated AMK inhalation therapy between February 2015 and June 2016. MABC was the most common etiology (n = 48, 62%), followed by MAC (n = 20, 26%) and mixed infections (n = 9, 12%). Isolates with macrolide resistance and baseline AMK resistance were identified in 63 (82%) patients and 5 (6%) patients, respectively. At 12 months after AMK inhalation therapy, 49% of patients had symptomatic improvement, whereas 42% had radiological improvement. Conversion to a negative sputum culture occurred in 14 (18%) patients, and the culture conversion rate was higher in patients infected with macrolide-susceptible isolates (7/14, 50%) than in those infected with macrolide-resistant isolates (7/63, 11%) (P = 0.003). Significant decreases in sputum semiquantitative culture positivity occurred after AMK inhalation therapy (P < 0.001). On multivariate analysis, conversion to a negative sputum culture was associated with mixed infections (P = 0.009), a forced expiratory volume in 1 s of greater than 60% (P = 0.008), and the absence of macrolide resistance (P = 0.003). Thirty-eight percent of patients experienced adverse effects, with ototoxicity (n = 15) being the most common. AMK inhalation salvage therapy may improve the treatment responses in some patients with refractory NTM-LD. However, considering the common adverse effects, further evaluation of the optimal dosage and intervals for AMK inhalation therapy is needed.</P>
Jhun, Hyung-Joon,Kim, Ho,Cho, Sung-Il The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.5
<P>We examined time trend and age-period-cohort effects on acute myocardial infarction (AMI) mortality in Korean adults from 1988 to 2007. Annual AMI mortality data and population statistics from 1988 to 2007 were obtained from the STATISTICS KOREA website. Age adjusted mortality for four 5-yr calendar periods (1988-1992 to 2003-2007) was calculated by direct standardization using the Year 2000 WHO world standard population. A log-linear Poisson regression model was used to estimate age, period, and cohort effects on AMI mortality. In both genders, age-adjusted AMI mortality increased from period one (1988-1992) to period three (1998-2002) but decreased in period four (2003-2007). An exponential age effect was noted in both genders. The rate ratio of the cohort effect increased up to the 1943 birth cohort and decreased gradually thereafter, and the rate ratio of the period effect increased up to period three (1998-2002) and decreased thereafter. Our results suggest that AMI mortality in Korean adults has decreased since the period 1998-2002 and age, period, and cohort effects have influenced on AMI mortality.</P>