Harmonic-Percussive Sound Separation from Monaural Music Using Generalized Complementary Diffusion

Jeongsoo Park(박정수),Jaeyoung Shin(신재영),Kyogu Lee(이교구) 한국통신학회 2016 한국통신학회 학술대회논문집 Vol.2016 No.6

Postoperative radiation therapy following keloidectomy

( Jeongsoo Kim ),( Shinyoung Song ),( Seha Park ),( Seulki Lee ),( Heejoo Kim ),( Jinok Baek ),( Jooyoung Roh ),( Hyangjoon Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Keloid is a problem that dermatologists encounter. Patients typically present with cosmetic concerns, although keloids can cause pruritus, pain. Keloids have been treated with multimodal therapy. Radiotherapy treatment after keloidectomy is known to be an effective method for reducing the rate of recurrence. A 40-year-old male presented with erythematous hard plaques on chin, shoulder, right foot. He was treated with steroid intradermal injection for several years but there was no improvement. A 26-year-old female presented an erythematous hard plaque on Lt. upper arm appeared 20 years earlier because of vaccination. She was performed surgical excision but keloid recurred. They had thought in common about new treatment. They were treated with steroid intralesional injection three times before surgery. Keloids were treated with surgical excision, followed by a total radiation dose of 1,800 cGy in three fractions over three days. We will observe their lesion whether keloids recur for 18 months. Postoperative electron-beam irradiation may control collagen synthesis by inhibiting the promotion of abnormal activated and normal fibroblasts. Furthermore, many researchers are trying to set the proper protocols of radiation, keloids should be treated with dose protocols customized by site. Postoperative electron-beam irradiation expects effectively to prevent recurrence of keloid and a safe treatment modality due to absence of complications.

[P300] Two cases of primary cutaneous nocardiosis caused by intralesional injection

( Jeongsoo Kim ),( Seha Park ),( Seul Ki Lee ),( Ha Ryeong Ryu ),( Heejoo Kim ),( Joo Young Roh ),( Hyang Joon Park ),( Jinok Baek ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Nocardiosis is a rare localized or systemic suppurative disease caused by several species of bacteria of the genus Nocardia. Nocardia is an aerobic, filamentous gram-positive, partially acid-fast bacteria belonging to the Actinomycetales order and found in soil, decayed organic matter, water, and air worldwide. Cutaneous nocardiosis is an uncommon infectious disease that presents a primary cutaneous infection or as a part of disseminated pulmonary nocardiosis. First case is a 50-year-old woman who had erythematous patches with swelling on her right arm, who had been treated with triamcinolone intralesional injection at the private clinic. Histopathology of the skin showed diffuse lymphohistiocytic infiltration in the dermis and subcutaneous layer. On Gram staining, gram-positive bacilli were seen, and on modified AFB staining, the branching hyphae stained red purple. White colonies were formed on blood agar medium in pus culture. By bacterial culture and rDNA gene sequencing, the causative organism was identified as N. farcinica. Second case is a 34-year-old woman who presented with erythematous patches and tenderness on Lt.arm. She had been also treated with triamcinolone intralesional injection for keloid at the same clinic as the first patient. She was diagnosed with primary cutaneous nocardiosis by pus culture. Herein, we report rare two cases of primary cutaneous norcardiosis after intralesional injection.

A case of drug-induced hemolytic anemia associated with antibiotic prophylaxis

( Jeongsoo Kim ),( Shinyoung Song ),( Seha Park ),( Seulki Lee ),( Heejoo Kim ),( Jinok Baek ),( Jooyoung Roh ),( Hyangjoon Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

A 68-year-old male patient presented with a dark brownish nodule on nose. In a local clinic, he underwent skin biopsy and was diagnosed as basal cell carcinoma. We performed wide excision to remove remaining lesion and clear margin obtained. Immediately before and after the operation he received intravenous cefotetan for antibiotic prophylaxis. On post-operate day 8, he felt dizziness and fell down. Hemoglobin was 3.5g/dL and hematocrit was 12.8%, whereas the initial CBC was normal. There was no evidence of bleeding on physical exam. Total bilirubin (6.86mg/dL), reticulocyte (6.2%) were elevated and direct antiglobulin test was positive. He was diagnosed as drug-induced immune hemolytic anemia (DIIHA) due to cefotetan. After systemic steroid treatment and transfusion a CBC revealed a hemoglobin of 9.4g/dL and hematocrit of 29.3%. He had complete resolution of symptoms and was discharged 5 days later. DIIHA is a rare acquired form of hemolytic anemia caused by interaction of drug with the immune system. Drug adsorption, drug-dependent antibody, and autoimmune induction are the three mechanism of hemolysis. Cefotetan-induced hemolytic anemia (CIHA) has been described to occur through all three mechanisms. Prompt diagnosis and massive systemic steroid administration are essential in minimizing mortality from hemolysis. Herein, we report a rare case of CIHA and hope to be aware of occurrence of CIHA associated with antibiotic prophylaxis.

Eosinophils play a role in the pathogenesis of psoriasis by stimulating inflammatory cytokine and chemokine production and neutrophil chemotaxis

( Jeongsoo Kim ),( Seha Park ),( Seulki Lee ),( Haryeong Ryu ),( Jinok Baek ),( Jooyoung Roh ),( Hyangjoon Park ),( Heejoo Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Eosinophilic cytokine profile including IL-23/Th17 axis and their immunomodulatory interaction with other immune cells imply their possible involvement in psoriasis pathogenesis. Objectives: This study was to examine the potential role of eosinophils in imiquimod (IMQ)-induced psoriasiform dermatitis using ΔdblGATA mice, an eosinophil lineage-ablated mouse line. Methods: After topical IMQ application, inflammatory cytokine gene expression and Inflammatory cell populations were analyzed by qRT-PCR and flow cytometry, respectively. Results: Psoriatic features like epidermal thickening, erythema, and scale were less prominent in ΔdblGATA mice after IMQ treatment. Inflammatory cytokines important in psoriasis, like IL-1β, IL-6, IL-22, IL-23, and IL-17, and Th1-/neutrophil-related chemokines CCL2 and CXCL12 were also downregulated, and neutrophils were constantly decreased in the skin, LN, and spleen of ΔdblGATA mice compared to WT mice after IMQ treatment. Although IMQ application increased eosinophils in the skin of WT mice, the absolute cell count was much lower than neutrophils, a major player in psoriasis. Conclusion: The small size of eosinophil population and constant reduction of neutrophil in ΔdblGATA mice than WT mice after IMQ treatment suggest that eosinophils would influence psoriasis indirectly via their inflammatory profile and affecting other mediators in psoriasis, such as neutrophils.

High fluence 1064-nm Q-Switched Nd:YAG laser : safe and effective treatment of cafe-au-lait macules in Asian patients

( Jeongsoo Kim ),( Seha Park ),( Seulki Lee ),( Haryeong Ryu ),( Heejoo Kim ),( Jooyoung Roh ),( Hyangjoon Park ),( Jinok Baek ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Cafe-au-lait macules (CALMs) are benign cutaneous hyperpigmentary disorders. Usually, laser therapies for cosmetic concerns result in more severe side effects in the people of Asian descent than that of Caucasians. Unfortunately, there is no gold standard for the laser treatment of CALMs in skin of people of Asian descent. Objectives: To investigate the efficacy and safety of a high fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser treatment of CALMs in Asian patients. Methods: The medical records of thirty-five Korean patients (age range: 1 to 40 years old, mean age : 18.5 years) diagnosed with isolated CALMs were reviewed retrospectively. The patients were treated with a 1064-nm Q-switched Nd:YAG laser. The parameters were a spot size of 7 mm, a fluence of 2.2-2.4 J/cm2 with a slow single sliding-stacking pass, and a pulse rate of 10Hz with a one-week interval for 20-50 sessions. Results: At the week of the final treatment, all treated CALMs showed considerable pigmentation removal without any permanent side effects, such as scaring, mottled hypopigmentation, and post-inflammatory hyperpigmentation (PIH). All treated CALMs showed more than 50% clinical improvement. No recurrence was observed in any of the patients after 12 months of follow up. Conclusion: A high fluence 1064-nm Q-switched Nd:YAG laser treatment of CALMs in Asian patients is a safe and effective method without side effects and recurrence.

[P231] Hair collar sign in an infant with aplasia cutis congenita associated with nevus flammeus

( Jeongsoo Kim ),( Seha Park ),( Seul Ki Lee ),( Ha Ryeong Ryu ),( Heejoo Kim ),( Jinok Baek ),( Hyang Joon Park ),( Joo Young Roh ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Aplasia cutis congenita (ACC) is a heterogeneous group of disorders in which localized or widespread areas of skin are absent at birth. ACC manifests as a solitary defect on the scalp in 70% of cases. Although most commonly seenon the scalp, ACC can affect any part of the body. Although pathogenesis of ACC is still unclear, proposed hypotheses are divided into two categories : endogenous causes (developmental failure, congenital syndromes) and exogenous ones (intrauterine trauma, infarction, skin fissure caused by rapid growth). Hair collar sign is a ring of darker and coarser terminal hairs on the scalp, typically surrounding ACC, dermoid cyst, encephalocele, or meningocele. It has been described as a relatively specific marker of neuroectodermal defect. A 5-month-old boy presented with round bald patches with underlying a large reddish patch on posterior occiput. It was surrounded by a rim of terminal hairs. Hair collar sign can be a specific clue for diagnosing ACC. Pregnancy and the delivery had been unremarkable and the baby wasotherwise healthy. Histopathology of the skin showed flattened epidermis, vascular dilatation in the superficial dermis, thickening of vessel walls in the reticular dermis, and absence of adnexal structures. It is assumed that association of ACC with nevus flammeus is that fetal skin development including capillary network formation might have been affected since cranial tube was not closed properly.

"δειν και λνειν"

박정수(Jeongsoo Park) 한국신약학회 2003 신약논단 Vol.10 No.2

헬레니즘 시대 유대 묵시문학의 시·공간적인 세계관

박정수(Jeongsoo Park) 한국신약학회 2011 신약논단 Vol.18 No.3

헬레니즘 시대의 대표적인 묵시문학서 에녹1서는 팔레스타인의 유대 묵시문학의 시·공간적 세계관을 반영한다. 이것은 시간적인 차원에서는 10주간이나, 70세대와 같은 시간측정단위들을 통해서 심판을 통한 역사의 주기적 회복을 묘사한다. 공간적인 차원에서는 땅과 하늘을 계시적으로 매개하는 ‘에녹’의 기능이 중심이 되고 있는데, 이는 당시에 토라를 해석하는 새로운 권위의 출현을 반영하고 있다. 이 묵시문학의 세계관은 기원전 175~167년 팔레스타인에서의 위기상황에서 가장 극적으로 표현된다. 배교와 성전의 타락, 이스라엘의 고난과 같은 파국적인 상황은 현재의 임박한 심판을 통해서 정화되는데, 현재의 심판은 고난의 역사에 ‘매듭’을 지음으로써 이스라엘의 종말론적인 회복의 한 국면을 형성한다.

자살과 죽음에 대한 신학적 성찰

박정수(Park, Jeongsoo) 한국복음주의신약학회 2011 신약연구 Vol.10 No.1

The ancient Graeco-Roman notion of 'noble death' was expressed by ancient philosophers, especially by the stoic heros who executed voluntary death. However, these concepts were not easily acceptable to Old Testament, because the fear of death itself is an object for human being to avoid. Suicide was, therefore in Old Testament the extreme case taken only by kings or leaders losing their dignity in a defeated battle. These notions are infused with the New Testament tradition describing the death of Jesus in the Gospels. In the background of Jesus' conflict story with his opponents play the basic values of ancient society, 'honor and shame' a great role. According to the Gospel tradition, Jesus was not only slain, but willing to accommodate himself to death. "Therefore God also highly exalted him and gave him the name that is above every name"(Phil 2:9). In this context, Paul's struggles for life, suffering and also against death show some features: For him death is something to be accepted in the providence of God. It shows a positive attitude to the notion of 'noble death' as for stoicism, e.g. "It is better to die rather than a painful life." Nevertheless, the speculations of the ancient philosopher on death are not applicable to Paul's extreme situations of life. He could see the whole process of his life under the eschatological perspectives realized through the resurrection of Jesus Christ. Furthermore, he has an utilitarian perspective on 'life and death': "To live" could be "a fruit of his work," but also "the death benefit." For him, death as well as life is something to be chosen. This is revealed clearly with his speculations: "I do not know which to choose"(Phil 1:22). A teleological perspective on 'life and death' may be in this case stronger than a deontological. However, he did make prefer "to remain in flesh because of you"(the community) "rather than to be with Christ" though the latter is much better to him(Phil 1:23-24). This perspective is so 'strange' for us who live under a strict taboo about suicide. But on the other sides, it leads us to make a deep theological reflection and to broaden the horizons on the types of dying including suicide and then to understand those who are left by the dead.