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Erythropoietin(EPO)에 대한 변이원성시험
제정환(Jeong-Hwan Che),이광훈(Guang-Xun Lu),박진성(Jin-Sung Park),윤준원(Jun-Won Yun),김태원(Tae-Won Kim),김형섭(Hyung-Sub Kim),박지은(Jie-eun Park),윤신근(Sin-Keun Youn),이영순(Yong-Soon Lee) 한국독성학회 1999 Toxicological Research Vol.15 No.3
In order to evaluate the mutagenic potential of erythropoietin (EPO), Salmonella typhimurium reversion assay, chromosomal aberration test on chinese hamster lung cells and in vivo micronucleus assay using mouse bone marrow cells were performed. In the reverse mutation test using Salmonella typhimurium TA98, TA100, TA1535, TA1537, TA102 did not increase the number of revertant at any of the concentration tested in this study. EPO did not increase the number of cells having structural or numerical chromosome aberration in cytogenetic test. In mouse micronucleus test, no significant increase in the occurrence of micro nucleated polychromatic erythrocytes was observed in ICR male mice intraperitoneally administered with EPO. These results indicate that EPO has no mutagenic effects under these experimental conditions.
Intralipidos에 대한 급성독성 및 4주간 정맥 내 반복투여 독성시험
이광훈,제정환,강병철,이원우,임종희,정지윤,이병희,남정석,박재학,이영순,Li, Guang-Xun,Che, Jeong-Hwan,Kang, Byeong-Cheol,Lee, Won-Woo,Ihm, Jong-Hee,Jung, Ji-Yun,Yi, Beoung-Hi,Nam, Jeong-Seok,Park, Jae-Hak,Lee, Yong-Soon 한국독성학회 1998 Toxicological Research Vol.14 No.3
This sutdy was carried out to investigate the acute toxicity and foru-week intravenous toxicity of the intralipidos in rats and rabbits. The acute toxicity study of Intralipidos was performed in Spragur-Dawley (SD) rats. Intralipidos was administered by intravenous to maximum dose 200 ml/kg. $LD_{50}$ of intralipidos was found 139.5ml/kg and 153.8ml/kg in male female SD rats. Four-week toxicity of intralipidos using New Zealand White Rabbit and SD rats. The Rabbit and Rats were administered by intravenous seven days per week for 28 days, with dosage of 15, 6, 2 ml/kg/day and 20, 6, 2ml/kg/day, respectively. Animals treated with intralipidos did not cause any death and show any clinical signs. They did not show any significant changes of body weight, feed uptake and water consumption. They were not significantly different from the control group in urinalysis, ocular examination hematological, serum biochemical value and histopathological examination. Therefore, Intralipidos was not indicated to have any toxic effect in the Rabbits and Rats, when it was administrated by intravenous below the dosage 15ml/kg/day and 20 ml/kg/day for four weeks.
기니픽, 마우스 그리고 랫드에서 Intralipidos의 항원성
이병희,제정환,이광훈,강병철,이원우,임종희,정지윤,이영순,Yi, Beoung-Hi,Che, Jeong-Hwan,Li, Guang-Xun,Kang, Byeong-Cheol,Lee, Won-Woo,Ihm, Jong-Hee,Jung, Ji-Youn,Lee, Yong-Soon 한국독성학회 1998 Toxicological Research Vol.14 No.3
The antigenicity of intralipidos was investigated in guinea pig, mice and rats. Antigenicity tests-active systemic anaphylaxis (ASA), passive systemic anaphylaxis (PSA), passive cutaneous anaphylaxix (PCA) of this materials were performed. The results were followed: 1. After sensitizaion with YPL, YPL+intralipidos, and intralipidos, emulsified with complete Freund's adjuvant (CFA), guinea pigs didn's show any anaphylatic shock symptom in the ASA test, 2. These materials didn't show any anaphylatic shock symptom in the PSA test, 3. After sensitization with antisera of YPL, YPL+intralipidos, and intralipidos sensitized mice, blue spots were not observed on the hypodermis of back of rats in the PCA test. From the results of this investigation, the antigenicity of YPL, intralipidos was negative under the present experimental condition.
랫드에서 Alginase의 급성 및 4주간 정맥 내 반복투여 독성시험에 관한 연구
임종희,남정석,제정환,이광훈,이학모,이원우,이병희,정지윤,박재학,이영순,Ihm, Jong-Hee,Nam, Jeong-Seok,Che, Jeong-Hwan,Li, Guang-Xun,Lee, Hak-Mo,Lee, Won-Woo,Yi, Beoung-Hi,Jung, Ji-Youn,Park, Jae-Hak,Lee, Yong-Soon 한국독성학회 1998 Toxicological Research Vol.14 No.3
Alginase$Alginase^{ⓡ}$ (Arginine esterase) is one of the snake venoms which is mainly consisted of arginine esterase and acts as a thrombus -forming inhibitor/thrombus-lysin. These present studies were performed to investigate of the acute and subacute toxicity of the Alginase$Alginase^{ⓡ}$ in rats. In acute toxicity study, rats were single administered intravenously with dosages of 0.001, 0.01. 0.1, 1 and 10U/kg B.W. and examined the number of death, clinical sign, body weight and pathological change for 7days after administration of Alginase$Alginase^{ⓡ}$. At maximum dose level (10U/kg B.W.), Alginase$Alginase^{ⓡ}$ induced symptoms of shock with cyanosis and dyspnea. But these symptoms dissappeared after 30~50 minutes and we could not find any other toxic effect in rats. Therefore, $LD_{50}$ Value of Alginase was over 10U/kg B.W. in rats. In four-week intravenous toxicity study of Alginase$Alginase^{ⓡ}$, rats were administered intravenously seven days per week for 28 days, with dosages of 0, 0.0125, 0.125 and 1.25U/kg B.W./day, respectively. Alginase$Alginase^{ⓡ}$ did not caused any death and showed any clinical signs in rats. No significant Alginase$Alginase^{ⓡ}$ -related changes were found in feed uptake, water consumption, hematology, serum biochemistry, urinalysis, ocular examination, organ weight and histopathological examination. From the results, Alginase$Alginase^{ⓡ}$ seems not to have any toxic effect in rats when it were given daily intravenous injections below the dosage 1.25U/kg B.W./day for four weeks.
Acute Toxicity Test with the Ginkgo biloba Extract(EGb 761) in Rats and Rabbits
Yong-Soon Lee(이영순),Jeong-Seok Nam(남정석),Jeong-Hwan Che(제정환),Suk-Man Lee(이석만),Jae-Man Yang(양재만),Byeong-Cheol Kang(강병철),Hak-Mo Lee(이학모),Jae Hak Park(박재학),Sung-An Kang(강성안) 한국실험동물학회 1996 Laboratory Animal Research Vol.12 No.1