한일관계의 현상과 미래비전 : 동아시아 공동발전을 향한 A한일 공통과제,공통정책의 가능성

정선철 경기대학교 부설 민족사상연구소 2005 민족사상연구 Vol.13 No.-

East Asia history is in the process of entering at 4th round. Currently, the Past history problem, the Chinese Taiwan problem exists with crisis element. When seeing but from 2020 point of view, the East Asia crisis element is many. It is environment cirsis, energy crisis and economic crisis. But the most big crisis element is the problem solving ability is insufficient. One side the military power is magnified with means of the risk managenent. But it will not be able to solve a crisis element by military force. East Asia the new security is necessary. The past history problem of Fapan is disrupting East Asia Cooperation. We must prevent a crisis. Korea and Japan must cooperate in East Asia commonness development. A first of all, it develops new environment and a social welfare demand. The industrial circle must create a new environment industry and a social welfare industry. The finance must invest in this industrial developement. The trust relationship of common policy will be able to create peace. And We must form EAU(Eastern Asia Union) in the future.

저선량 감마선 조사가 왕겨의 항산화능에 미치는 영향

정석문,김정한,김동열,육홍선,변명우,이승철 慶南大學校 附設 基礎科學硏究所 2002 硏究論文集 Vol.16 No.-

왕겨에 200, 400, 600, 800 및 1000 Gy의 저선량의 감마선을 조사하여 항산화능의 변화를 관찰하였다. 총 페놀 화합물의 양은 무처리구의 경우 0.184 mM를 나타내었고, 200 Gy로 감마선을 조사하였을 때는 0.215 mM로 약간 증가함을 보였으나 이후 차츰 감소하였다. 전자 공여능은 무처리구에 비해 처리구의 경우 조사 선량별로 조금씩의 차이만 있을 뿐, 조사 선량에 대한 왕겨의 전자 공여능은 유의적인 큰 변화 없이 비슷한 활성을 보였다. Fe^2+-ions 킬레이팅 활성은 무처리구의 경우 68.25%를 나타내었으며, 200, 400, 600 및 800 Cy 에서는 각각 86.45, 85.61, 86.65 및 82.84%로서 무처리구보다는 증가함을 보였으나, 1000 Gy에서는 74.67%로 감소하였다. 지질 과산화 억제능은 무처리구에 비해 처리구는 약간의 증가를 보였으나 효과는 미비하였다. We studied the effect of small-dose of γ-irradiation to rice hull(RH) for its antioxidant ability. The RH was treated with 200, 400, 600, 800, and 1000 Gy of γ-ray at 70 Gy/min. Total phenol amount of unirradiated RH was 0,184 mM, after irradiation at 200 Gy it increased to 0,215 mM, while irradiation above 400 Gy up to 1000 Gy decreased that to unirradiated level. The electron donating ability of RH did not show significant change depend on irradiation. The chelating ability for Fe^2+ of unirradiated RH was 68.25 %, while that of 200, 400, 600 and 800 Gy irradiated RH showed 86.45, 85.61, 86.65 and 82.84 % respectively, but, 1000 Gy was decreased to 74.67 %. According to TBARS analyses, inhibition ability of lipid peroxidation by RH was not affected by γ-irradiation.

미생물 포괄 고정화방식을 이용한 수산물 가공공장 폐수처리

정병철,장수현,김종배,김건배,최선남,이근우,정병곤 7개 국립대학교 환경연구논문집 공동발행 위원회 2005 공업기술연구 Vol.5 No.-

Feasibility of simultaneous removal of organic and nitrogen is evaluated as applying microbial entrapping method to treat fish processing wastewater. Treatability test is conducted immobilizing activated sludge from municipal sewage treatment plant to gel matrix made of cellulose triacetate. Stable operation can be possible when applying organic and nitrogen loading rate increasingly to wastewater treatment system composed of anoxic and oxic tank. Organic loading rate and nitrogen loading rate are applied 0.65-1.72kg COD/㎥/d and 0.119-0.317kg T-N/㎥/d, respectively. In case of wastewater from fish processing plant used in this study, it is evaluated that 0.3kg T- N/㎥/d is upper limit of applicable space loading rate because effluent T-N concentration is exceed 60mg/L, legal effluent dishargeable limit of T-N concentration in Korea, when space loading rate is exceed 0.3kg T-N/㎥/d. It is evaluated that nitrification of system is performed efficiently regardless fo variation of applied loading rate because removal efficiency of NH_(4)^(+)-N is relatively constant when the applied NH_(4)^(+)-N loading rate is increased gradually, while decrease of T-N removal efficiency is apparent when the applied loading rate is increased gradually. Nitrate removal efficiency in this study is varied from 98.62% to 99.51% depending on applied loading rate, while nitrification efficiency of oxic reactor is varied from 94.0% to 96.9%. It is showed that COD removal efficiency is varied from 94.2% to 96.6% and T-N removal efficiency is varied from 73.4% to 83.4% depending on loading rate applied in this study.

2軸휨과 軸力을 받는 鐵筋콘크리트 正方形斷面柱에 關한 解析的硏究

장철인,정호철,김선자 서강정보대학 1999 산업과학연구 Vol.1 No.-

In this paper, Reinforced concrete square section column which is under bi-axial bending moment and axial force was studied, in an attempt to analyze the effect of axial force ratio changes on the stress and strain behavior of the concrete and reinforcing bar. Experimental data was utilized to divide the column into 169 concrete elements and 12 reinforcing bar elements. The relationship between the stress increment and the strain increment was derived from the equilibrium equation of force for each element. This was used to arrive at the equilibrium equation of axial force and bending moment, followed by the determination of curvature increment and bending moment increment. From the above results, a relationship between the axial force and the bending moment or deformation of the column was discovered. In addition, an equation was proposed which can deduce the bending moment and deformation of the square column by means of axial force ratios.

외상후 스트레스 장애의 다면적 인성검사 특성

은헌정,이선미,장광철 大韓神經精神醫學會 1994 신경정신의학 Vol.33 No.2

본 연구는 외상후 스트레스 장애와 정상인을 의미있게 구별하여 주는 다면적 인성검사 반응 특성을 확인하고, 외상후 스트레스 장애군 내의 다면적 인성검사 프로화일 특성을 분류하고자 시도하였다. 연수 대상은 1991년 1월부터 1993년 3월까지 전주 예수병원에 입원 또는 외래로 내원한 외상후 스트레서 장애 환자 45명과 정상인 55명을 대상으로 하였다. 결과는 다음과 같다: 1) 외상후 스트레스 장애군이 L척도를 제외한 모든 척도에서 정상집단보다 의미있게 더 높은 점수를 보였다. 2) 판별 분석에서 두 집단을 잘 판별해주는 척도는 D, Mf, Pt,Si척도이고, 이 척도들은 외상후 스트레스 장애군을 88.9% 정확헤게 판별해 주었으며, 정상 대조군은 94.5% 정확하게 판별해주었다. 3) 외상후 스트레스 장애군의 다면적 인성검사 반응을 군집 분석한 결과 3개의 하위 집단이 추출되었다. a. 첫번째 집단은(54.3%) L, F, K척도의 프로화일이 역전된 'V' 형태이고 Hs, D, Hy, Pd , Pt, Sc척도의 점수가 60년에서 71점 사이의 점수를 보이고 있다. b. 두번째 집단은(36%) L, F, K척도의 점수가 47점에서 56점 사이의 범위를 보이고 있고, 모든 임상 척도가 42점에서 59점 사이의 점수를 보이고 있는 정상 프로화일이었다. c. 세번째 집단은 (11.1%) L, F, K척도가 56점에서 70점의 점수에 속하고, Mf척도를 제외한 모든 임상척도들이 60점에서 80점의 점수를 보이고 있다. 이러한 결과들은 다면적 인성검사가 외상후 스트레스 장애군을 구별하는데 신뢰할만한 판별력을 가진다는 것을 시사해 준다. This study was attempted to identify MMPI responses which significantly discriminate between the PTSD and the normal on the basis of MMPI scores. And it was designed to classify the types of MMPI profiles in the PTSD. Subjects were 55 healthy control and 45 PTSD who were inpatient or outpatient in Presbyterian Medical Center from January, 1991 to March, 1993. The results were as follows : 1) In MMPI subscales, except L scale, PTSD had significantly higher score than the normal group. 2) In discriminant analysis, it was D, Mf, Pt, ans Si that discriminate these two groups. Also, it classified 88.9% of PTSD group and 94.5% of normal group correctly. 3) Three subgroups were extracted from the PTSD by cluster analysis of MMPI. a. The first subgroups(54.3%) showed a profile which T score of L, F scale configured a reverted "V" pattern, and T scores of Hs, D, Hy, Pd, Pt, and Sc scale belonged to the range of 60 to 71 point. b. The second subgroup(36%) showed a normal profile which had L, F, and K scale with normal range of 47 to 56 T score and all clinical scales with 42 to 59 T score. c. The third subgroup(11.1%) showed a profile which had L, F, and K scale belonged to the range of 56 to 70 T score and all clinical scales belonged to the range of 60 to 80 T score except Mf scale. These findings suggest MMPI has a remarkable discriminant power in PTSD group.

Bipolar release와 Z-Plasty를 이용한 선천적 사경증의 치험례

최재선,이정삼,김건중,정종철,민흥기 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.3

Congenital muscular torticollis(CMT) is a disorder characterized by shortening of at least one of the cervical muscles and tilting of the head to opposite side. The most commonly affected muscle is the sternocleidomastoid muscle. Pathogenesis and etiology of congenital muscular torticollis were not clearly identified, but considered as fetal malposition, birth trauma, vascular accident, heredity, infection and CNS pathology. Untreated congenital muscular torticollis often causes facial asymmetry and This is the rasult of tensional rotation of the face toward affected side. So early treatment may prevent facial and neck asymmetry and limitation of neck movement. There are many treatment methods in CMT, including conservative and operative method, but presently Bipolar release and Z-Plasty of SCM muscle has been introduced when the conservative treatment had failed. The benefits of this method are to preservation of the normal Neck V-contour and improvement of the neck motion. We treated CMT using Bipolar release and Z-plasty in two patients. After that the patients improved on the range of neck motion and maintained the normal V-conture of the neck, so we report two cases of CMT with literatures.

관상 동맥 질환에서 아포 E 지단백 유전자 다형성과 혈청 지질치와의 관계

곽선영,김성구,정호석,이유경,이광희,김철현,최태명,현민수,권영주 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Background and aims: The Apolipoprotein E is a ligand of both the protein component LDL receptor as well as the apo E LDL-Receptor related protein (LRP). It modulates the receptor binding of lipoproteins, with the apolipoprotein E found on cell surfaces as its component, thus serving an important role in the lipid metabolism by carrying out the intracellular transport of cholesterol in lipoproteins. The gene for apolipoprotein E is the product of three common genotypes as well as many more rare alleles. The common genotypes are ε2, ε3, and ε4, and are expressed in the three phenotype isoforms of E2, E3, and E4. In the event that E4 is the main component, a rise in the cholesterol level, as the result of down-regulation of the LDL receptor, is observed. Therefore, those samples with E4 genotypes are known to be in much higher risk of coronary artery disease than those with ε3/ε3, while those with ε2 are in low risk (with the exception of hypertiglyceremai Ⅲ). The aim of this study is to analyze in patients with ischemic heart disease the role of aplipoprotein E alleles in order to seek its correlation with coronary artery disease, as well as to seek whether the polymorphism of apo E produces any differences in the severity of coronary artery disease according to plasma lipid levels. Methods: The subjects for study were 273 patients admitted to the Internal Cardiology Division of the Soonchunhyang University Hospital form December 1998 to February 1999. The subjects were divided into the two groups of which one was ischemic heart disease (IHD) experiment group totaling 105 (avg.60.1 years of age, male/female ratio = 69/36) and the control group totaling 168 (avg. 59.7 years of age, male/female = 73:95). The coronary angiogram was given to 127 subjects, and of this total, 94 have developed significant stenosis in the coronary artery. The stages of the analyzing of the apo E phenotype was first, the separation of DNA from the blood samples, subjecting it to the PCR from with 228 base pairs of expanded products were obtained. The band was determined by means of the reverse hybridization principle on the nitrocellulose strip. Results: From the 105 patients the distributions of apo E phenotypes were as follows: ε3/2(5.7%), ε4/2(1.9%), ε3/3(70%), ε4/3(20%), ε4/4(1.9%). The relative frequencies of each allele are as follow: ε2 (0.038), ε3 (0.833), ε4 (0.128). The results show as follows: ⅰ) The IHD experiment group to have a higher occurrence of ε4/3 phenotypes as well as ε4 alleles than the control group. ⅱ) Both the control group and IHD group showed the largest distribution of ε3/3 for phenotypes, and ε4 for alleles. ⅲ) The IHD group showed less ε2/3 phenotypes as well as significantly less allele frequency of ε3 in comparison to the control group. ⅳ) the IHD group showed a much lower level of HDL in comparison to the control group, while the LDL was significantly higher; samples including the apo ε2 showed a significantly higher level of HDL than those without. Among the control group, samples including apo ε2 showed a significantly higher level of TG (triglyceride) than samples without. No significant difference was found between the experiment apo ε4 sample and the control plasma lipid sample. ⅴ) No significant correlation was found between an apo E polynorphism and the number of involved arteries of a coronary angiogram. Conclusion: Between the experiment IHD group and control group were found differences in the frequency of alleles. The polymorphism of apo E alleles may contribute as a risk factor to the development of heart disease by involving itself in the metabolism and modulation of plasma lipids.

구리 지역에서 조사한 고혈압의 인지도, 치료률 및 관리률

홍철호,김순길,홍택원,이제,신진호,이재웅,김경수,김정현,임헌길,이방헌 대한간질학회 2003 대한간질학회지 Vol.9 No.1

Alginate 배양내에서 Transglutaminase가 연골막세포에 미치는 영향

박정선,공차배,김충현,안현정,정미현,성상철,김희중,조현철,이상훈,이명철 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

신경교세포 및 RAW 264.7 세포에서 Protein kinase의 활성에 의한 유도성 Nitric oxide synthase의 발현

박상철,노삼길,배소현,박지선,이충재,허강민,석정호,이재흔 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

NO(nitric oxide) plays an important role as neurotransmitter or cytokine, and pathologic factor for some diseases by the large amount production with iNOS(inducible NO synthase) expression in macrophages or glial cells. The expression of iNOS is regulated by various cytokines, protein kinases and transcription factors. In this experiment, to investigate the roles of progein kinase and NF-kB for iNOS expression, the effects of PMA(phorbol 12-myristate 13-acetate), cAMP, and various protein kinase inhibitors on LPS(lipopolysaccharide)-induced iNOS mRNAN expression and nuclear NF-kB binding complex were examined in C6 glial cells and RAW 264.7 cells. In C6 glial cells, iNOS mRNA expression by LPS was induced from 1 hour and peak at 3 hour after treatment. In RAW 264.7 cells, the mRNA was observed from 3 hour and peak at 6 hour. PMA enhanced markedly LPS-induced iNOS mRNA expression and NF-kB binding complex in C6 glial cells, but did not much influence on LPS-induced iNOS mRNA expression in RAW 264.7 cells, in spite of increased LPS-induced NF-kB binding complex at 30 min. cAMP(dibutyryl cAMP) did not much influence on LPS-induced iNOS mRNA expression, by increased LPS-induced NF-kB binding complex in C6 glial cells. However, in RAW 264.7 cells, cAMP increased slightly LPS-induced iNOS mRNA expression without change of NF-kB binding complex. Staurosporine did not influence on LPS-induced iNOS mRNA expression and NF-kB binding complex in C6 glial cells, but in RAW 264.7 cells, decreased LPS-induced iNOS mRNA expression and NF-kB binding complex. Ro-31-8220 did not much influence on LPS-induced iNOS mRNA expression and NF-kB binding complex in C6 glial cells, but in RAW 264.7 cells, decreased significantly LPS-induced iNOS mRNA expression in spite of increased LPS-induced NF-kB binding complex for 3hours. G 6976 did not much influence on LPS-induced iNOS mRNA expression with decreased NF-kB binding complex in C6 glial cells, but in RAW 264.7 cells, decreased iNOS mRNA expression without influence on LPS-induced NF-kB binding complex. Genistein did not influence on LPS-induced iNOS mRNA expression and NF-kB binding complex in C6 glial cells, but in RAW 264.7 cells, decreased LPS-induced iNOS mRNA expression inspite of increased NF-kB binding complex. These results suggest that LPS-induced regulation of iNOS expression or NF-kB activity in C6 glial cells, might be different from RAW 264.7 cells through various protein kinases or other factors.