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李炳基,高正愛,殷鍾旋 全北大學校 1987 論文集 Vol.29 No.-
In order to investigate the effects fo anther stage, optimal basic media, kinds and concentrations of plant growth regulators, sucrose concentrations for callus and embryo formation, pollen dimorphism and low temperature pretreatment of floral bud on the emergence of embryogenic S pollen of Anemone coronaria in vivo or in vitro, anthers of Anemone coronaria were cultured in Murashige & Skoog's(M&S) and Bourgin & Nitsch's(H) basic media with the combination of auxins and cytodinins. The measurement of anther length could be reliable criterion in determining the optimal anther stages, while floral bud length and anther color could not be a reliable criterion because same sized floral buds showed various degree of microspore development. M&S basic media was more effective on callus formation than H basic media. The addition of plant growth regulators of NAA and BA with M&S basic media was effective on callus formation than 2,4-D and kinetin. The best results was obtained from the combination of 0.5mg/l NAA and 2.0 mg/l BA. The best response of calus formation was obtained from 3% sucrose concentration on M&S basic medium supplemented with 0.5mg/l NAA and 2.0mg/l BA. B type of S pollen was formed on each anther stages except anther stage I in vitro. Callus formation was effective just before or just after at first pollen mitosis, while callus formation was less effective at tetrad or mature pollen staes. Low temperature pretreatment on the first pollen mitosis anthers with 1℃ or 5℃ for 10 days induced above 25% of S pollen. Embryogenic S pollen were divided mostly into A type at 10℃ for 10 days pretreatment and rate of B type pollen was appeared 4.3% which was 5 times more than control. Callus formation was effective at 10℃ for 10 days pretreatment.
金正默,林聖愛,李來華,金炳斗,安禹洪,李敏炯,金基學 慶北大學校 師範大學 1977 敎育硏究誌 Vol.19 No.-
The following conclusion has been derived from the foregoing results of analysis and observation. First, we found, in this proposed system, reliability, objecivity, and individuality. Second, this type of system must be able to measure numerable testees. Third, testees are regulated that they are brought to the same condition in which their willful adventage are not allowed, Fourth, when considering the foundamental physical strength and skills can be evaluated in general throughout all skills areas of physical education, the following items of skills are recognized to have the advantages and disadvantages which relatively lack or relieve one another. However, under various conditions of the prevailing system of the entrance physical test, the following measurable items of physical skills selected are concluded as having highest validity primarily for the physical entrance examination. 1. Side Step B Style 2. Zigzag Run 3. Wall Pass 4. Standing Long Jump
도심내 역사적 건축물의 시지각적 접근에 관한 연구 - 부산광역시에 위치한 망미루를 중심으로 -
정민애(Jeong Min-Ae),김기환(Kim Ki-Hwan),조홍정(Cho Hong-Jeong) 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2
The purposes of this study were to analyze the Visual-Perceptual approach of the Historic Building in downtown. For this purpose, Mang-Mi-Ru in Busan-city was surveyed and analyzed. In details, Mang-Mi-Ru was analyzed Visible distance and D/H ratio of roadside building. The result of the study, Visual-Perceptual approach of the Mang-Mi-Hu was fine from Mang-Mi-Ru 12.02~13.0m, but the remainder section had the Visual-Perceptual approach on a low level.
Hong Ki Min,Hyeongsu Kim,Ho Jin Jeong,Se Hee Kim,Hae-Rim Kim,Sang-Heon Lee,KunSei Lee,Soon-Ae Shin,Jong Heon Park 한국역학회 2023 Epidemiology and Health Vol.45 No.-
OBJECTIVES: This study investigated whether Janus kinase inhibitors (JAKis) raise the risk of cardiovascular disease (CVD), venous thromboembolism (VTE), and cancer in patients with rheumatoid arthritis (RA). METHODS: We conducted a real-world retrospective observational study using data obtained from the Korean National Health Insurance Service database. Two data sets were analyzed: tumor necrosis factor inhibitor (TNFi)/JAKi-naive RA patients (set 1) and all RA patients who used TNFis or JAKis (set 2). The incidence rate ratios (IRRs) and hazard ratios (HRs) for acute myocardial infarction (AMI), stroke, cardiovascular (CV)-related mortality, major adverse cardiovascular events (MACE), VTE, arterial thromboembolism (ATE), cancer, and all-cause mortality were compared between the JAKi and TNFi groups. RESULTS: Set 1 included 1,596 RA patients (JAKi group: 645; TNFi group: 951), and set 2 included 11,765 RA patients (JAKi group: 2,498; TNFi group: 9,267). No adverse events (AEs) showed significantly higher IRRs in the JAKi groups than in the TNFi groups of sets 1 and 2. The HRs for MACE in the JAKi groups of sets 1 and 2 were 0.59 (95% confidence [CI], 0.35 to 0.99) and 0.80 (95% CI, 0.67 to 0.97), respectively. The JAKi group of set 2 showed a significantly higher risk of all-cause mortality (HR, 1.71; 95% CI, 1.32 to 2.20), but the other AEs did not demonstrate increased risks in the JAKi groups. CONCLUSIONS: In this study, JAKis did not increase the risk of AMI, stroke, CV-related mortality, MACE, VTE, ATE, or cancer in Korean RA patients relative to TNFis.
Yeon, Seul Ki,Choi, Ji Won,Park, Jong-Hyun,Lee, Ye Rim,Kim, Hyeon Jeong,Shin, Su Jeong,Jang, Bo Ko,Kim, Siwon,Bahn, Yong-Sun,Han, Gyoonhee,Lee, Yong Sup,Pae, Ae Nim,Park, Ki Duk Elsevier 2018 Bioorganic & medicinal chemistry Vol.26 No.1
<P><B>Abstract</B></P> <P>Benzyloxyphenyl moiety is a common structure of highly potent, selective and reversible inhibitors of monoamine oxidase B (MAO-B), safinamide and sembragiline. We synthesized 4-(benzyloxy)phenyl and biphenyl-4-yl derivatives including halogen substituents on the terminal aryl unit. In addition, we modified the carbon linker between amine group and the biaryl linked unit. Among synthesized compounds, <B>12c</B> exhibited the most potent and selective MAO-B inhibitory effect (hMAO-B IC<SUB>50</SUB>: 8.9 nM; >10,000-fold selectivity over MAO-A) as a competitive inhibitor. In addition, <B>12c</B> showed greater MAO-B inhibitory activity and selectivity compared to well-known MAO-B inhibitors such as selegiline, safinamide and sembragiline. In the MPTP-induced mouse model of Parkinson’s disease (PD), <B>12c</B> significantly protected the tyrosine hydroxylase (TH)-immunopositive DAergic neurons and attenuated the PD-associated behavioral deficits. This study suggests characteristic structures as a MAO-B inhibitor that may provide a good insight for the development of therapeutic agents for PD.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Child-Pugh B군인 간세포암 환자에서 sorafenib과 경동맥화학색전술 병합 치료
이종식 ( Jong Sik Lee ),문선영 ( Sun Young Moon ),이경언 ( Kyung Ann Lee ),민재기 ( Jae Ki Min ),전성진 ( Sung Jin Jeon ),김인애 ( In Ae Kim ),이강훈 ( Kang Hoon Lee,),최원혁 ( Won Hyeok Choe ),김정한 ( Jeong Han Kim ),권소영 ( So 대한간암학회 2014 대한간암학회지 Vol.14 No.1
combined with transarterial chemoembolization (TACE) in Child-Pugh (CP) class-B patients with hepatocellular carcinoma (HCC). Methods: A total of 12 CP class-B patients who were initially treated with sorafenib combined with TACE were retrospectively reviewed. At 14 days after the first TACE, patients were continuously treated with sorafenib until unacceptable adverse events (AEs) or diseaseprogression. Consecutive TACEs were also performed, if patients were tolerable. Results: Of 12 patients, 8, 3 and 1 patients had CP-score 7, 8, and 9, respectively. The median overall survival was 85 days. Patients underwent median 2 sessions of TACE (range 1-4) and the median duration of sorafenib was 48days (range, 12-92 days). Three patients refused repeated TACEs and 4 patients required delay of the consecutive TACE due to AEs of sorafenib. Six patients required transient or permanent discontinuation of sorafenib, due to its AEs (grade 1/2 AEs, 2 patients; grade 3/4 AEs, 4 patients). High CP score (score 8/9 vs. 7) was tended to be association with interruption of sorafenib (P=0.061) and requirement of refusal/ delay of consecutive TACE (P=0.081). Conclusions: Sorafenib combined with TACE were frequently interrupted or delayed in CP class-B patients, mostly because of its side effects, even though there were not serious. Our experiences suggest that combination with sorafenib and TACE might interface with each other due to its side effects in CP class-B patients, especially patients with CP score 8/9 liver cirrhosis.
Bone formation with alloplastic graft substitutes in critical-sized rat calvarial defects
( Ki Pyo No ),( Su Gwan Kim ),( Ji Su Oh ),( Jong Won Jung ),( Sung Soo Yang ),( Sung Yong Lee ),( Jin Sung Park ),( Sung Chul Lim ),( Mi Ae Jeong ) 조선대학교 치의학연구원 2011 Oral Biology Research (Oral Biol Res) Vol.35 No.2
The purpose of this study was to evaluate whether the level of bone formation differed according to the ratio of the hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP) components. Materials and Methods: In the cranial area of 60 rats, bone grafts were performed using four bone graft materials with different ratios of HA/β-TCP: (1) unfilled defect, (2) HA (100%), (3) HA (70%)/β-TCP (30%), (4) HA (30%)/β-TCP (70%), and (5) β-TCP (100%). The rats were sacrificed after 4 weeks or 8 weeks, and the bone formation area was evaluated under a light microscope. Results: In the 4-week groups, the bone formation area in the rats grafted with β-TCP (100%) was 0.75±0.21 mm2, and slightly larger bone formation areas were observed than in other groups; nonetheless, these values were not statistically significant in comparison with the other groups. Similarly, significant differences were not shown among any other groups. In the 8-week groups, in the rats grafted with HA (100%) and HA (30%)/β-TCP (70%), bone formation was observed to be 2.60±1.03 mm2 and 2.56±0.93 mm2, respectively. Thus, more abundant bone formation was observed in these two groups than in the other three groups, and this difference was statistically significant. Conclusion: Based on the results, the amount of new bone formation is greatest when bone grafts are performed using the graft materials HA 100% or HA (30%)/β-TCP (70%); thus, good bone formation outcomes are expected when using these materials in humans.
Ki, Mi-Ran,Hong, Il-Hwa,Park, Jin-Kyu,Hong, Kyung-Sook,Hwang, Ok-Kyung,Han, Jung-Yuan,Ji, Ae-Ri,Park, Se-Il,Lee, Seung-Keun,Yoo, Sung-Eun,Jeong, Kyu-Shik Potamitis Press 2009 Anticancer research Vol.29 No.6
<P>BACKGROUND: The recombinant vacuolating cytotoxin (rVacA) of Helicobacter pylori that retains native conformational epitopes was evaluated as a vaccine antigen for anti-H. pylori treatment. METHODS: s1m1 vacA gene fraction encoding the mature VacA protein was expressed as a soluble protein in E. coli at low temperature. The efficacy of anti-rVacA antibody against VacA or H. pylori was assessed in vitro using AGS cells and in vivo using a murine model. RESULTS: The rabbit antisera against rVacA completely neutralized the vacuolating activity and partially inhibited the cell death induced by VacA in AGS cells. Oral immunization of C57BL/6 mice with rVacA plus CpG-oligodeoxynucleotide (ODN) as an ajuvant stimulated specific anti-VacA antibody and mucosal immune responses which correlated with decreased systemic immune responses and gastric urease activities (p>0.05). CONCLUSION: The rVacA antigen possessing conformational epitopes may have potential as a vaccine component and may be useful in serological and histopathological analysis.</P>