http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Jeong Hyunjin,Hong Eun-Hye,Ahn Jae-Hee,Cho Jaewon,Jeong Jae-Hyeon,Kim Chae-Won,Yoon Byung-Il,Koo Ja Hyun,Park Yun-Yong,Yang Yoon Mee,Iwawaki Takao,Bruce A. Vallance,Chang Sun-Young,Ko Hyun-Jeong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Endoplasmic reticulum stress is closely associated with the onset and progression of inflammatory bowel disease. ERdj5 is an endoplasmic reticulum-resident protein disulfide reductase that mediates the cleavage and degradation of misfolded proteins. Although ERdj5 expression is significantly higher in the colonic tissues of patients with inflammatory bowel disease than in healthy controls, its role in inflammatory bowel disease has not yet been reported. In the current study, we used ERdj5-knockout mice to investigate the potential roles of ERdj5 in inflammatory bowel disease. ERdj5 deficiency causes severe inflammation in mouse colitis models and weakens gut barrier function by increasing NF-κB-mediated inflammation. ERdj5 may not be indispensable for goblet cell function under steady-state conditions, but its deficiency induces goblet cell apoptosis under inflammatory conditions. Treatment of ERdj5-knockout mice with the chemical chaperone ursodeoxycholic acid ameliorated severe colitis by reducing endoplasmic reticulum stress. These findings highlight the important role of ERdj5 in preserving goblet cell viability and function by resolving endoplasmic reticulum stress.
Jeong, Jaewon,Kim, Soojin,Lim, Da-Sol,Kim, Seo-Hea,Doh, Heeju,Kim, So-Dam,Song, Yun Seon The Korean Society for Brain and Neural Science 2017 Experimental Neurobiology Vol.26 No.4
<P>Postconditioning has been shown to protect the mouse brain from ischemic injury. However, the neuroprotective mechanisms of postconditioning remain elusive. We have found that toll-like receptor 5 (TLR5) plays an integral role in postconditioning-induced neuroprotection through Akt/nuclear factor kappa B (NF-κB) activation in cerebral ischemia. Compared to animals that received 30 min of transient middle cerebral artery occlusion (tMCAO) group, animals that also underwent postconditioning showed a significant reduction of up to 60.51% in infarct volume. Postconditioning increased phospho-Akt (p-Akt) levels and NF-κB translocation to the nucleus as early as 1 h after tMCAO and oxygen-glucose deprivation. Furthermore, inhibition of Akt by Akt inhibitor IV decreased NF-κB promoter activity after postconditioning. Immunoprecipitation showed that interactions between TLR5, MyD88, and p-Akt were increased from postconditioning both <I>in vivo</I> and <I>in vitro</I>. Similar to postconditioning, flagellin, an agonist of TLR5, increased NF-κB nuclear translocation and Akt phosphorylation. Our results suggest that postconditioning has neuroprotective effects by activating NF-κB and Akt survival pathways via TLR5 after cerebral ischemia. Additionally, the TLR5 agonist flagellin can simulate the neuroprotective mechanism of postconditioning in cerebral ischemia.</P>
정재원(Jeong, Jaewon) 한국교양교육학회 2020 교양교육연구 Vol.14 No.6
이 논문은 청년 세대 젠더 갈등 문제가 확산 되고 있는 한국사회에서 이에 대한 대안으로 특권을다루는 구체적인 교육 방법을 모색해 보고자 하였다. 여성 피해자, 남성 가해자라는 이분법적인 도식을넘어서 다양한 억압체계와 젠더의 관계를 성찰하며, 복잡한 억압의 그물망 속에서 자신의 위치를 자각하는 특권에 대한 이해를 높이는 교수법을 탐색해 보고자 하였다. 이를 위해 차별과 특권에 대한 페미니스트페다고지의 이론적 쟁점을 살펴보고, 수업 현장에서 적용할 수 있는 교육 모듈을 제시하였다. 교육모듈은 3가지 주제로 구성되었다. 첫 번째 모듈은 교차성에 기반한 특권을 인식할 수 있도록 정체성을탐색하는 과정이며, 두 번째 모듈은 특권을 가시화하기 위한 특권 걷기 실험을 진행하며, 세 번째모듈은 성별화된 특권 목록을 작성해 보는 과정을 통해서 성인지 감수성을 향상시킨다. 본 연구는청년 세대 젠더 갈등이 심각한 상황에서 성별 인식의 간극을 좁히고 타인에 대한 깊은 공감과 배려를향상시킬 수 있는 교육방법에 대해서 탐색하였다는데 그 의미가 있다. This paper aims to search for educational methods to deal with privileges as an alternative in Korean society, where the issue of youth gender conflict is spreading. Beyond the dichotomous scheme of female victims and male perpetrators, this paper considered various oppressive systems and gender relationships, and sought to explore some teaching methods that enhance the understanding of the privilege of self-awareness of one s position in the complex web of oppression. To this end, the theoretical issues of feminist pedagogy on discrimination and privilege were examined, and the education modules applicable to the classroom were presented. The training module consisted of three theme: the first module is the process of exploring identity so that you can recognize privileges based on intersections. The second module conducts “privilege walking” experiments in order to help students visualize privileges, and the third module heightens gender sensitivity by illustrating a list of gender-based privileges. This study is meaningful in that it explored educational methods that foster a deeper empathy and consideration for others in the face of serious gender conflicts experienced among the younger generation.