사염화탄소로 유발된 간손상에서의 효소 활성도의 변화로 본 홍화자 분획물의 간손상 보호 작용

정춘식,정기화,정정숙 德成女子大學校 藥學硏究所 1999 藥學論文誌 Vol.10 No.1

본 연구소에서는 사염화탄소로 유발된 간손상에 대한 홍화자 메탄올 추출물과 이를 계통 분획한 분획물의 보호 효과를 이미 보고하였다. 본 실험에서는 혈장과 조직 생화학적 분석으로 홍화자 분획물의 간보호 효과를 확인하며, 간보호 작용에 대한 기전을 살펴보기 위하여 약물 대사 효소에 미치는 영향을 측정하였다. 홍화자 butanol subfractions 중 BS-5 분획물은 CCl_4로 간손상을 유발시킨 흰쥐에서의 혈장 ALT와 AST 활성과 간조직 중 cholesterol and triglyceride를 감소시켰으며, 이러한 BS-5 분획물의 CCl_4로 유발된 간손상에 대해 보호 작용은 cytochrome P450 감소와 glutathione S-transferase의 활성 증가에 기인된 것으로 생각된다. Previous studies have shown that methanol extract and its butanol fraction of Carthamus tinctorius L. Semen have the hepatoprotective effect on the CCl_4-induced hepatotoxicity. The hepatoprotective effect of subfractions has been evaluated by analyzing blood and hepatocyte biochemical analyses and biotransformation enzyme analyses. Treatment of BS-5 subfraction has significantly decreased the activities of alanine aminotransferase and aspartate aminotransferase. In addition, the levels of cholesterol and triglyceride in liver have been decreased as compared with that of CCl_4 treated rats. The hepatoprotective effect of BS-5 subfraction on the CCl_4-induced hepatotoxicity would be mediated of the attenuation of the level of cytochrome P450 and the enhancement of the activity of glutathion S-transferase.

부산점토의 토목지질학적 특성에 관한 연구

장정욱,박춘식,박진규 국립7개대학공동논문집간행위원회 2003 공업기술연구 Vol.3 No.-

This study examined geological characteristics of the clay in the area around Kaduck-do, Kangseo-gu, Pusan, to figure out the characteristic fundamentals of the clay. The results are shown in the following. (1) The physical and chemical characteristics are summarized in he following table. There were no meaningful changes according to the depth degree. ◁ 원문 표 참조 ▷ (2) The geological characteristics 1) Sedimetological and geochemical characteristics showed that the clay layer was formed under oceanic circumstances. 2) The mineralogy mainly includes clay materials such as quartz, feldspar, illite, chlorite, and kaolinite. 3) The results of radiocarbon dating by AMS showed 3,692±50 yr.B.P for the upper samples and 16,650±200 yr.B.P. for the lower samples.

부산점토의 공학적 특성에 관한 연구

장정욱,박춘식,정창덕 국립7개대학공동논문집간행위원회 2003 공업기술연구 Vol.3 No.-

This thesis studied an lower ground clay of Pusan New Port Project site, in order to grasp engineering characteristics of Pusan clay. The physical and mechanical found in the clay are summarized as follows. (1) The physical characteristics are summarized in the following table. ◁ 원문 표 참조 ▷ (2) The mechanical characteristics are summarized in the following table. ◁ 원문 표 참조 ▷

연약지반의 점·탄소성 이론 적용성에 관한 연구

장정욱,박춘식,류민영 국립7개대학공동논문집간행위원회 2003 공업기술연구 Vol.3 No.-

This study performed the consolidation analysis on soft ground that had been embanked step by step. The analysis adopted the Cam-Clay model(elasto-plastic model) and the Sekiguchi-Ohta model(elasto-viscoplastic model). The result was compared with the result of one dimensional consolidation calculation and the measured value. The conclusions are presented in the following. (1) Both the elasto-plastic model and the elasto-viscoplastic model showed less amount of settlement than the measured value in the early stages of the analysis, whereas the amount of settlement approximated to the measured value in the later stages. It was also found that the elasto-viscoplastic model approximated to the measured value more closely. (2) The result of one dimensional consolidation calculation tended to be generally less than the measured value, and showed greater differences from the results of the elasto-plastic model and elasto-viscoplastic model as stages became later. (3) The exclusion of viscosity seems to be the reason why the amount of settlement in the Cam-Clay model was less than that in the Sekiguchi-Ohta model. (4) It is assumed that application of the Sekiguchi-Ohta model to the step-by-step embankment field would contribute to predictions for long-term settlement.

경사하중이 작용하는 연약지반의 압밀침하 산정에 관한 연구

박춘식,장정욱,김범수 국립7개대학공동논문집간행위원회 2004 공업기술연구 Vol.4 No.-

This study determined consolidation settlement in soft ground with the tilted load by means of Terzaghi's one-dimensional consolidation theory and FEM. It was also compared with field measured value. The conclusions are summarized in the following. ⅰ) The consolidation settlement from Terzaghi's one-dimensional consolidation theory differ considerably from the measured value, but showed almost similar to that from FEM. ⅱ) Terzaghi's one-dimensional consolidation theory showed variable consolidation settlement according to methods to obtain △P. ⅲ) Consolidation settlement determined by FEM turned out to better evaluate the field settlement than Terzaghi's one-dimensional consolidation theory.

말뚝 시공 허용오차범위에 관한 연구

장정욱,박춘식,이정환 국립7개대학공동논문집간행위원회 2004 공업기술연구 Vol.4 No.-

This thesis studied an allowable error range of construction distance between piles, Our experiment has altered the distance between piles in various ways to observe characteristics of the piles bearing capacity according to the changes. It was observed that the range of changes in the piles bearing capacity was insignificant when the distance between piles were great, where as the range became greater inversely to the distance between piles. The pulling resistance exceeded the allowable range when the distance between piles was less than 2.0D. It turned out that the allowable error range of construction was 1.0D for the field of our interest.

유한요소법에 의한 호안의 강제치환 형상에 관한 변형예측 및 현장계측

박춘식,장정욱,하주화 국립7개대학공동논문집간행위원회 2005 공업기술연구 Vol.5 No.-

This study used the finite element method analysis to estimate enforced replacement shapes and replacement depth. The data were expected to be used as the fundamental data of the design through the comparison with the results of the elastic wave exploration and investigation. The results of the research are summarized in the following. (1) After dividing the breakwater into 5models, on which elastic wave exploration was performed, the enforced replacement shape has been obtained by the finite element method. The result was satisfactory compared to the results of the elastic wave exploration. (2) The enforced replacement shapes of the breakwater were compared in different ways; in the design, in the elastic wave exploration in field and in this study. While the enforced replacement shape in the design is substantially different from that in elastic wave exploration in field, it turned out to be similar to the results of this research. (3)If an enforced replacement shape is standardized in configuration of breakwater, depth of soft soil and th value of soil property, it can be used as the standardized section in designing breakwaters.

SUNEX와 PLAXIS에 의한 흙막이벽의 안정해석 비교 연구

장정욱,박춘식,정창덕 국립7개대학공동논문집간행위원회 2005 공업기술연구 Vol.5 No.-

This study compared the results of the two programs, SUNEX and PLAXIS, regarding the stability of earth retaining wall. The conclusions of the study are as follows. (1) The stability analysis of earth retaining wall in soft clay ground showed the instable result from PLAXIS than SUNEX. (2) In sand ground, the results of SUNEX appeared less stable than PLAXIS. (3) In the composite ground, the results of both programs turned out almost the same except the maximum settlement.

盛土에 의한 橋臺의 側方移動에 대한 硏究

박춘식,장정욱,유기재,최성민 國立 昌原大學校 産業技術硏究所 2002 産技硏論文集 Vol.16 No.-

This Study investigated a possibility of lateral movement in the reconstruction field of Nongso bridge at Nongso-ri, Joochon-myeon, Kimhae. The methods applied in this study were the judgement formula and the Finite Element Method(FEM). The conclusions are shown in the following. 1) The application of the FEM, as well as the judgement formula resulted in the lateral movement. 2) Bridge abutment and foundation must be constructed after completing consolidation. 3) The occurrence possibility of lateral movement should be judged by the FEM that can re-present field conditions. 4) Lateral movement will take place in the case. Hence, settlement of proper countermeasure method should be followed by the construction.

측방유동 저감을 위한 Pile Slab의 적용성에 관한 연구

장정욱,박춘식,장일석 국립7개대학공동논문집간행위원회 2005 공업기술연구 Vol.5 No.-

This study analyzed the reductive effect of lateral flow by the section and height of reinforcement of Pile Slab. The conclusions of the study are as follows. (1) The lateral flow of abutment increased linearly as the reinforcement section decreased. (2) The lateral flow of abutment showed the minimum value when the reinforcement height was 0.5h~0.6h. (3) The reinforcement section was found to have a close relationship with the reinforcement height. We conclude that more economical reinforcement methods would require consideration of this relationship between the two variables.