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Lee, Sungx2010,Eun,Park, Sung Soo,Jeon, Youngx2010,Woo,Yoon, Jaex2010,Ho,Cho, Byungx2010,Sik,Eom, Kix2010,Seong,Kim, Yoox2010,Jin,Lee, Seok,Min, Changx2010,Ki,Kim, Heex2010,Je,Cho, Seo John Wiley Sons, Inc. 2018 American journal of hematology Vol.93 No.11
<P><B>Abstract</B></P><P>This prospective study explored an optimal conditioning regimen to ensure engraftment with minimal toxicity in adult patients with severe aplastic anemia (SAA) who received haplo‐identical stem cell transplantation from a related mismatched donor (Haplo‐SCT). We explored a safe and sufficient dose of rabbit ATG (Thymoglobulin) in combination with 800 cGy total body irradiation (TBI) and fludarabine (Flu, 30 mg/m<SUP>2</SUP>/day) for 5 days using step‐by‐step dose de‐escalation. The dose of ATG was de‐escalated from 10 mg/kg (group 1), to 7.5 mg/kg (group 2), to 5 mg/kg (group 3), and the TBI dose was reduced to 600 cGy (group 4) beginning in October 2014. If one patient developed transplant‐related mortality (TRM) with engraftment in a group, we moved to the next lower dose group. Thirty‐four patients were enrolled in groups 1‐3 (<I>n</I> = 10) and 4 (<I>n</I> = 24). All patients achieved primary engraftment. The incidence of acute GVHD (grade ≥ 2) and chronic GVHD (≥ moderate) was 29.4% and 14.7%, respectively. With a median follow‐up of 56.6 and 21.8 months in groups 1‐3 and group 4, respectively, the 2‐year probability of overall survival (91.7% in group 4 vs 70% in groups 1‐3, <I>P</I> = 0.155) and GVHD‐free survival (78.4% in group 4 vs 50% in groups 1‐3, <I>P</I> = 0.115) was shown tended to be better in group 4. This study explored an optimal conditioning with step‐by‐step de‐escalation dosage of ATG and TBI to reduce TRM with sustained graft function. TBI‐600 cGy/Flu/intermediate‐dose ATG resulted in feasible outcomes of Haplo‐SCT for adult patients with SAA.</P>
Lee, Chulx2010,Ho,Kim, Yongx2010,Jin,Hong, Young Joon,Jeon, Seong‐,Ran,Bae, Sukang,Hong, Byung Hee,Yi, Gyux2010,Chul WILEY‐VCH Verlag 2011 ADVANCED MATERIALS Vol.23 No.40
<P>Inorganic‐based flexible light‐emitting diodes (LEDs) using single‐crystalline GaN/ZnO coaxial nanorod heterostructures grown directly on large graphene films are reported on page 4614 by Gyu‐Chul Yi and co‐workers. The LEDs demon‐strate reliable operation in a flexible form, with no significant degradation in their electroluminescent or electrical characteristics. This approach provides a general and rational route to develop many different inorganic optoelectronics in flexible or stretchable forms. </P>
Sclerodermatous chronic graft‐versus‐host disease induced by host T‐cell‐mediated autoimmunity
Lee, You Jeong,Min, Hye Sook,Kang, Eun Ha,Park, Hyo Jin,Jeon, Yoon Kyung,Kim, Ju Hyun,Wu, Hong Gyun,Lee, Eunx2010,Bong,Park, Chungx2010,Gyu,Yoon, Sungx2010,Soo,Park, Seong Hoe,Jung, Kyeong Cheon Nature Publishing Group 2012 Immunology and cell biology Vol.90 No.3
<P>Despite a long‐standing hypothesis that chronic graft‐versus‐host disease (cGVHD) is an autoimmune disorder, most mouse models of cGVHD have been developed on the assumption that donor T cells are essential for its development. Here we show that cGVHD may be caused by autoreactive host T cells in mice that have been lethally irradiated and grafted with T‐cell‐depleted allogeneic bone marrow cells. In this chimera, host T cells derived from radioresistant intrathymic T‐cell precursors caused dermal fibrosis and periportal inflammation, without the requirement for donor T cells. The lack of host DCs within the thymus after high‐dose irradiation allowed autoreactive host T cells to escape thymic negative selection. Moreover, the homeostatic expansion of these T cells may augment their autoreactivity. These findings indicate that host T‐cell‐mediated cGVHD is an autoimmune process that occurs following the grafting of T‐cell‐depleted BM cells into hosts with functioning thymuses. We propose, based on the present data, that host T‐cell‐dependent autoimmunity is a potential mechanism by which cGVHD is induced.</P>
Lee, Kwangx2010,Hoon,Lee, Seong‐,Gyu,Eun Lee, Kyung,Jeon, Hyesung,Robinson, Howard,Oh, Byungx2010,Ha Wiley Subscription Services, Inc., A Wiley Company 2012 Proteins Vol.80 No.11
<P><B>Abstract</B></P><P>Many prokaryotic organisms acquire immunity against foreign genetic material by incorporating a short segment of foreign DNA called spacer into chromosomal loci, termed clustered regularly interspaced short palindromic repeats (CRISPRs). The encoded RNAs are processed into small fragments that guide the silencing of the invading genetic elements. The CRISPR‐associated (Cas) proteins are the main executioners of these processes. Herein, we report the crystal structure of Stu0660 of <I>Streptococcus thermophilus</I>, a Cas protein involved in the acquisition of new spacers. By homotetramerization, Stu0660 forms a central channel which is decorated with basic amino acids and binds linear double‐stranded DNA (dsDNA), but not circular dsDNA. Despite undetectably low sequence similarity, two N‐terminal domains of Stu0660 are similar to the entire structure of an <I>Enterococcus faecalis</I> Csn2 protein, which also forms a homotetramer and binds dsDNA. Thus, this work identifies a previously unknown group of Stu0660‐like Csn2 proteins (∼350 residues), which are larger than the known canonical Csn2 proteins (∼220 residues) by containing an extra C‐terminal domain. The commonly present central channel in the two subgroups appears as a design to selectively interact with linear dsDNA. Proteins 2012. © 2012 Wiley Periodicals, Inc.</P>
Park, Sang Min,Kim, Jungx2010,Sun,Ko, Youngx2010,Guk,Choi, Donghoon,Hong, Myeongx2010,Ki,Jang, Yangsoo,Kang, Woong Chol,Ahn, Taehoon,Kim, Byoungx2010,Keuk,Oh, Seong Jin,Jeon, Dong Woon,Yang, J Wiley Subscription Services, Inc., A Wiley Company 2011 Catheterization and cardiovascular interventions Vol.77 No.1
<P><B>Abstract</B></P><P>Objectives: The aims of this study were to identify the efficacy of optimal stent expansion (OSE) according to the Multicenter Ultrasound Stenting in Coronaries Study (MUSIC Study) criteria in drug‐eluting stent (DES) and compare paclitaxel‐eluting stent (PES) to sirolimus‐eluting stent (SES). Background: Although poststent high‐pressure balloon dilatation is proposed after bare metal stent implantation according to OSE, defined by the criteria of the MUSIC Study, very little data are available in DES. Methods: Two hundred fifty patients (M:F = 149:101; age, 61.5 ± 9.2 years) who underwent 9‐month follow‐up angiography in the Poststent Optimal Stent Expansion Trial (POET) were included in this study. We assessed angiographic in‐stent restenosis (ISR) and neointima volume (NV) using IVUS at 9 months. Results: At 9‐month follow up, there were no significant differences in ISR and NV index (NV/stent length, mm<SUP>2</SUP>) between patients with and without OSE. However, the rate of ISR and NV index were higher in PES [ISR: 18 (13.7%) and 4 (3.4%), <I>P</I> = 0.004; NV index: 1.02 ± 0.99 mm<SUP>2</SUP> and 0.21 ± 0.37, <I>P</I> < 0.001 in PES and SES]. Conclusions: OSE according to the MUSIC Study criteria was not related to ISR and NV in the DES era but PES had a significantly higher ISR rate and NV than SES after poststent high‐pressure balloon dilatation. © 2010 Wiley‐Liss, Inc.</P>
Chromatin interacting factor Os VIL 2 increases biomass and rice grain yield
Yang, Jungil,Cho, Laex2010,Hyeon,Yoon, Jinmi,Yoon, Hyeryung,Wai, Antt Htet,Hong, Woox2010,Jong,Han, Muho,Sakakibara, Hitoshi,Liang, Wanqi,Jung, Kix2010,Hong,Jeon, Jongx2010,Seong,Koh, Heex20 John Wiley and Sons Inc. 2019 Plant biotechnology journal Vol.17 No.1
<P><B>Summary</B></P><P>Grain number is an important agronomic trait. We investigated the roles of chromatin interacting factor <I>Oryza sativa </I>VIN3‐LIKE 2 (OsVIL2), which controls plant biomass and yield in rice. Mutations in <I>OsVIL2</I> led to shorter plants and fewer grains whereas its overexpression (OX) enhanced biomass production and grain numbers when compared with the wild type. RNA‐sequencing analyses revealed that 1958 genes were up‐regulated and 2096 genes were down‐regulated in the region of active division within the first internodes of OX plants. Chromatin immunoprecipitation analysis showed that, among the downregulated genes, OsVIL2 was directly associated with chromatins in the promoter region of <I>CYTOKININ OXIDASE/DEHYDROGENASE2</I> (<I>OsCKX2</I>), a gene responsible for cytokinin degradation. Likewise, active cytokinin levels were increased in the OX plants. We conclude that OsVIL2 improves the production of biomass and grain by suppressing <I>OsCKX2</I> chromatin.</P>
Lee, Jeong Hoon,Choi, Kee Don,Jung, Hwoonx2010,Yong,Baik, Gwang Ho,Park, Jong Kyu,Kim, Sung Soo,Kim, Byungx2010,Wook,Hong, Su Jin,Lim, Hyun,Shin, Cheol Min,Lee, Si Hyung,Jeon, Seong Woo,Kim, Ji Hy John Wiley and Sons Inc. 2018 Helicobacter Vol.23 No.2
<P><B>Abstract</B></P><P><B>Background</B></P><P>The Korean College of <I>Helicobacter</I> and Upper Gastrointestinal Research has studied <I>Helicobacter pylori (H. pylori)</I> prevalence since 1998 and found a dynamic change in its prevalence in Korea. The aim of this study was to determine the recent <I>H. pylori</I> prevalence rate and compare it with that of previous studies according to socioeconomic variables.</P><P><B>Methods</B></P><P>We planned to enroll 4920 asymptomatic Korean adults from 21 centers according to the population distribution of seven geographic areas (Seoul, Gyeonggi, Gangwon, Chungcheong, Kyungsang, Cholla, and Jeju). We centrally collected serum and tested <I>H. pylori</I> serum IgG using a chemiluminescent enzyme immunoassay.</P><P><B>Results</B></P><P>We analyzed 4917 samples (4917/4920 = 99.9%) from January 2015 to December 2016. After excluding equivocal serologic results, the <I>H. pylori</I> seropositivity rate was 51.0% (2414/4734). We verified a decrease in <I>H. pylori</I> seroprevalence compared with previous studies performed in 1998, 2005, and 2011 (<I>P </I><<I> </I>.0001). The <I>H. pylori</I> seroprevalence rate differed by area: Cholla (59.5%), Chungcheong (59.2%), Kyungsang (55.1%), Jeju (54.4%), Gangwon (49.1%), Seoul (47.4%), and Gyeonggi (44.6%). The rate was higher in those older than 40 years (38.1% in those aged 30‐39 years and 57.7% in those aged 40‐49 years) and was lower in city residents than in noncity residents at all ages.</P><P><B>Conclusions</B></P><P><I>Helicobacter pylori</I> seroprevalence in Korea is decreasing and may vary according to population characteristics. This trend should be considered to inform <I>H. pylori</I>‐related policies.</P>
Impact of parathyroidectomy on allograft outcomes in kidney transplantation
Jeon, Hee Jung,Kim, Yoon Jung,Kwon, Hyuk Yong,Koo, Tai Yeon,Baek, Seon Ha,Kim, Hyox2010,Jin,Huh, Woo Seong,Huh, Kyu Ha,Kim, Myoung Soo,Kim, Yu Seun,Park, Sux2010,Kil,Ahn, Curie,Yang, Jaeseok Blackwell Publishing Ltd 2012 Transplant international Vol.25 No.12
<P><B>Summary</B></P><P>We performed retrospective, multi‐center study of the impacts of parathyroidectomy (PTX) after or before kidney transplantation on allograft outcomes. A total of 63 patients who underwent PTX after kidney transplantation were identified. Deterioration in eGFR by more than 25% at 1 month after PTX occurred in 20% of the patients. The baseline eGFR was significantly lower in impairment group than nonimpairment group [adjusted odds ratio (OR) 0.87, 95% confidence interval (CI) 0.77–0.99, <I>P </I>= 0.033]. Low iPTH concentration after PTX was also a significant risk factor for the renal impairment (OR 0.96, CI 0.94–0.99, <I>P</I> = 0.009). A total of 37 patients who underwent PTX before transplantation were identified. Thirty‐six percent of the patients had persistent hyperparathyroidism by 1 year after transplantation. A high iPTH level before PTX was a significant risk factor for persistent post‐transplant hyperparathyroidism (adjusted OR 1.002, CI 1.000–1.005, <I>P</I> = 0.039). Finally, eGFR values during the first 5 years after transplantation were significantly lower in the patients who underwent PTX at less than 1 year after transplantation, than the pretransplant PTX patients (<I>P</I> = 0.032). As PTX after kidney transplantation has a risk of deterioration of allograft function, pretransplant PTX should be considered for patients with severe hyperparathyroidism, who could undergo post‐transplant PTX.</P>
Endoscope‐assisted intraoral resection of external dermoid cyst
Kim, Jin Pyeong,Park, Jung Je,Jeon, Seax2010,Yuong,Ahn, Seong‐,Ki,Hur, Dong Gu,Kim, Daex2010,Woo,Park, Hyun Woo,Woo, Seung Hoon,Rosenthal, Eben L. Wiley Subscription Services, Inc., A Wiley Company 2012 Head & neck Vol.34 No.6
<P><B>Abstract</B></P><P><B>Background</B></P><P>Surgical removal of a dermoid cyst is usually accomplished through an external neck incision. However, this procedure inevitably results in a neck scar.</P><P><B>Methods</B></P><P>We report the case of a 17‐year‐old woman with a submental mass. We implemented a modified approach to dermoid cyst removal through the floor of the mouth using an endoscope system.</P><P><B>Results</B></P><P>The patient received a modified approach to dermoid cyst removal and remains free of disease 6 months after excision.</P><P><B>Conclusion</B></P><P>Resection of the submental type dermoid cyst can be performed by an intraoral endoscope‐assisted approach through the floor of the mouth. We describe the procedure of the endoscope‐assisted intraoral resection. © 2011 Wiley Periodicals, Inc. Head Neck, 2011</P>