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AIVariant: a deep learning-based somatic variant detector for highly contaminated tumor samples
Jeon Hyeonseong,Ahn Junhak,Na Byunggook,Hong Soona,Sael Lee,Kim Sun,Yoon Sungroh,Baek Daehyun 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
The detection of somatic DNA variants in tumor samples with low tumor purity or sequencing depth remains a daunting challenge despite numerous attempts to address this problem. In this study, we constructed a substantially extended set of actual positive variants originating from a wide range of tumor purities and sequencing depths, as well as actual negative variants derived from sequencer-specific sequencing errors. A deep learning model named AIVariant, trained on this extended dataset, outperforms previously reported methods when tested under various tumor purities and sequencing depths, especially low tumor purity and sequencing depth.
Improvement of ITO Properties in Green-light-emitting Devices by using N2:O2 Plasma Treatment
Hyeonseong Jeon,Seongjong Kang,Hwan Sool Oh 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.68 No.2
Plasma treatment reduces the roughness of the indium-tin-oxide (ITO) interface in organic light emitting diodes (OLEDs). Oxygen gas is typically used in the plasma treatment of conventional OLED devices. However, in this study, nitrogen and oxygen gases were used for surface treatment to improve the properties of ITO. To investigate the improvements resulting from the use of nitrogen and oxygen plasma treatment, fabricated green OLED devices. The device’s structure was ITO (600 °A) / -NPD (500 °A) / Alq3:NKX1595 (400 °A:20 °A,5%) / LiF / Al:Li (10 °A:1000 °A). The plasma treatment was performed in a capacitive coupled plasma (CCP) type plasma treatment chamber similar to that used in the traditional oxygen plasma treatment. The results of this study show that the combined nitrogen/oxygen plasma treatment increases the lifetime, current density, and brightness of the fabricated OLED while decreasing the operating voltage relative to those of OLEDs fabricated using oxygen plasma treatment.
2-(2-Aminopyrimidin-4-yl)phenol Analogs as PIM Kinase Inhibitors
Hyeonseong Choo,Mingyu Jeon,Victor Sukbong Hong,Jinho Lee 계명대학교 자연과학연구소 2022 Quantitative Bio-Science Vol.41 No.2
PIM kinases, a family of serine/threonine kinases, are major downstream effectors of the Janus kinase/signal transducer and activator of transcription signaling cascade, which drive cell growth, proliferation, and metastasis in solid tumors and hematological cancers. Therefore, PIM kinases are potential targets for anticancer therapies. 2,4-Bis(2-aminopyrimidin-4-yl) phenol is a potential anticancer agent that targets the cyclin-dependent kinase family. As this compound showed submicromolar potency in a PIM-1 kinase assay, we designed 2-(2-aminopyrimidin-4-yl)phenol analogs as PIM kinase inhibitors. Systematic modifications at the 2- and 4- positions of the phenol ring led to the discovery of PIM kinase inhibitor 16, which showed sub-micromolar potency against PIM-2 and double-digit nanomolar potency against PIM-1 and PIM-3 isoforms. Based on molecular docking studies, compound 16 was predicted to bind to the adenosine triphosphate pocket of PIM-1 kinase with two hydrogen bonding interactions and hydrophobic interactions.