거주자 감성을 위한 주거환경 평가도구 개발 연구

강혜은,이윤희,연태경,장지혜,이연숙 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

The purpose of this study was to develop the evaluation instrument for sensible aspects of housing environment. In terms of importance of sensibility which people persceive their housing environment, researches on the sensible environment has been done in several academic fields. However, evaluation tool for sensible aspects of housing environment has not existed until now. Therefore, there is a need to develop evaluation tool to measure the fit between dwelling environment and human sensibility. For this purpose, this study reviewed literatures and test results about ergonomics and human factors according to five senses. Based on keywords about five senses and housing environment, a checklist was developed.

구인 Lumbricus terestris Goto et Hatai의 藥理學的 硏究 : 구인의 Methanol 엑스가 家兎血淸中 Total Cholesterol 含量變化 및 血糖量에 미치는 影響 The Effectes of Vermis-extracts on the Serum Total Cholesterol and Blood-Sugar Levels from Rabbits

陳惠英,李尙仁,姜孝信,鄭址昌 中央醫學社 1975 中央醫學 Vol.28 No.1

The effects of Vermis-(Lumbricus terestris Goto et Hatai)extracts on. The serum cholesterol and blood-sugar levels from normal and alloxan-diabetic rabbits were observed. The crude drug was extracted by methanol, and extracted samples were orally administrated to the normal and alloxan-diabetic rabbits. The serum total cholesterol and blood-sugar Ievels of normal rabbits admistrated with sample, no significant variation were detected. The serum cholesterol and blood-sugar levels of alloxan-diabetic rabbits were significantly increased after 3 days. The increased serum total cholesterol levels of alloxan-diabetic rabbits were significantly decreased by administration of the Vermis-extracts, and were returned to the control levels after 11days. However, the increased blood-sugar levels of alloxan-diabetic rabbits were not significantly decreased by administration of the drug. According to the above results, it would be concluded that the Vermis-extracts influences for the recovery of the increased serum total cholesterol levels.

학문 분야별 감성의 적용사례 분석 연구

장지혜,이윤희,연태경,강혜은,이연숙 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

The purpose of this study was to analyze application cases of human sensibility in various fields. Nowadays in various fields human sensibility and ergonomic have been studied using variety of methods. Studies on human sensibility have been widely carried in various field such as design and making instruments, selling products and marketing skills even if environmental design fields and human interface by computers. The results have been well applied in of industry. Therefore, understanding rationality. Through this study, ways of creating and measuring environment to improve our living quality, and living places can be developed. From such a viewpoint, this study did the following; First, it reviewed the literatures of studies and results of the tests for application of human sensibility in various field, and organized contents of studies and measurement tools which were used in the studies or tests. Second, it summarized the measurement methods of human sensibility according to three parts; physiological measurement, psychological measurement, and physical measurement. This study was expected to braden the sight on research methodologies and relevant applicable areas.

푸드뱅크 기탁식품의 안전성 확보를 위한 HACCP 제도 적용

김철재,박현신,배현주,이지해,양일선,강혜승 한국식생활문화학회 2002 韓國食生活文化學會誌 Vol.17 No.3

The purpose of this study was to analyze the problems arising from the actual conditions of the Foodbank, and to implement the HACCP system as a solution in terms of increasing the safety of donated food within the Foodbank. In order to apply HACCP system, the entire Foodbank working process such as preparation, collection, transportation, division, and distribution was considered and analyzed to decide the application point for CCPs. Donated foods mainly consisted of processed foods, raw materials, lunch boxes, and cooked foods from mass catering establishments, which dominated over the others in terms of quantity. Cooked foods were divided into three groups based on menu-types and processing methods. Temperature, pH, and aw were measured on cooked foods, and Total Plate Count, Coliforms, E. coli, Salmonella spp., Staphylococcus aureus, Listeria monocytogenes, and E. coli O157:H7 were conducted in order to apply a HACCP plan. Form these experiments, temperature, pH, and aw of donated food were likely contributed to microbial growth. Donated foods before HACCP implementation showed high numbers in terms of total plate count and Coliforms, both well over the acceptable standard levels. By setting the CCPs on maintenance of donated food below 10℃ and using a 75 ℃ reheating method, microbiological hazard levels were able to be controlled and lowered. From these results, it is concluded that in order to guarantee food safety, foods donated to the Foodbank must not only maintain a reasonable level of initial microbiological growth, but also must be handled properly through time and temperature controls within the Foodbank system. Furthermore, in terms of implementing the HACCP plan within the Foodbank management structure, basic food safety and sanitation measures, such as reheating facilities and various cold chain systmes such as refrigerated vehicle for food transportation are importantly needed. The training and education of Foodbank personnel and management in areas such as awareness of hygiene and safe food handling and practice are also required and necessary.

Feasibility of CD147 for an Eruption-Related Molecule during Rat Molar Development

Jee-Hae Kang(강지혜),Joon-Yong Jung(정준용),Hyun-Jin Kim(김현진),Hyun-Mi Ko(고현미),Ji-Yeon Jung(정지연),Min-Seok Kim(김민석),Won-Jae Kim(김원재),Eun-Ju Lee(이은주),Sun-Hun Kim(김선헌) 대한체질인류학회 2009 대한체질인류학회지 Vol.22 No.3

발생기 치아 이돋이는 이돋이 관련 물질의 조절 아래 이루어지며 따라서 이돋이 관련 물질의 구명은 이 분야의 연구에서 주된 과제가 되어 왔다. 발생기 이돋이 관련 물질은 치아주머니세포로부터 유리되며 뼈파괴세포의 형성과 관여하는 것으로 알려져 있다. 그러나 이틀뼈를 포함한 주위 조직의 흡수가 이돋이경로 형성을 위하여 필수적이다. 따라서 치아주머니세포로부터 바탕질분해 관련 단백질이 분비되어 이돋이경로 형성에 관여하리라 가정된다. 또한 법랑질모세포와 상아질모세포가 이돋이 관련 물질을 분비하여 인접 조직에 영향을 미침으로써 이돋이를 도울 수 있다. 본 연구는 현재까지 치아에서 보고된 바 없는 바탕질단백질의 일종인 CD147과 바탕질분해효소의 치아 이돋이 과정에서 역할을 구명하고자 시행되었다. 출생 후 흰쥐 3, 6, 9일에서 발생기 위턱 둘째 및 셋째 어금니를 적출하여 면역조직화학염색과 RT-PCR을 이용하여 발현을 평가하였다. 발생중인 치아 상방에 출현한 뼈파괴세포는 이돋이 상태를 평가하기 위하여 조사되었다. CD147 mRNA와 mmp-2 및 mmp-9 mRNA는 발생 9일에 뿌리형성기에 있는 둘째어금니에서 모자시기에 있는 셋째어금니보다 발현양이 훨씬 많았다. 또한 mmp-2 및 mmp-9 발현은 둘째어금니 발생 3 (후기 종시기), 6 (치아머리시기), 9일(뿌리형성기)에 발생시간 의존적으로 증가되었다. 대조적으로 동일 시기에 mmp-13 mRNA 발현 변화는 관찰되지 않았다. 면역조직학적 관찰에서 CD147은 법랑질모세포와 상아질모세포 외에 치아주머니세포와 뼈파괴세포에서 강하게 발현되었다. 둘째어금니 교합면 위 이틀뼈에 출현한 뼈파괴세포 수는 뿌리형성기에서 유의하게 증가하였다. 이상의 결과로 보아 CD147은 mmp-2 및 mmp-9과 함께 치아 이돋이경로 형성에 관여할 것으로 생각된다. Understanding the genetic control of tooth eruption is one of the major issues in tooth development. Thus far, it is known that eruption-related molecules are secreted from follicular cells surrounding the germs and are related mainly to osteoclast formation. This study examined the involvement of CD147 and its downstream molecules in the eruption of rat developing molars using immunohistochemistry, RT-PCR and histomorphometry. CD147 was expressed differentially in the cap (3rd molar germs) and root formation (2nd molar germs) stages in tooth development. CD147 was localized immunohistochemically in the follicular cells and osteoclasts as well as in the ameloblasts and odontoblasts. The expression pattern of CD147 and mmps was investigated because CD147 is an mmp inducer. The expression of both mmp-2 and -9 increased at the root formation stage compared to that at the cap stage and increased in a stage dependent manner. However, the level of mmp-13 was not changed notably. The histomorphometrical study suggested that the number of osteoclasts that appeared occlusal to the molar germs for the resorption of alveolar bone increased significantly during development. These results suggest that CD147 may play an important role in the formation of the eruption pathway along with the mmps.

Korean Children and Adolescents with Crohn's Disease Are More Likely to Present with Perianal Fistulizing Disease at Diagnosis Compared to Their European Counterparts

Kang, Ben,Kim, Jung Eun,Jung, Jae Hun,Choe, Jae Young,Kim, Mi Jin,Choe, Yon Ho,Kim, Seung,Koh, Hong,Lee, Yoo Min,Lee, Jee Hyun,Lee, Yoon,Lee, Ji-Hyuk,Lee, Hae Jeong,Jang, Hyo-Jeong,Choi, Youjin,Choi, The Korean Society of Pediatric Gastroenterology 2020 Pediatric gastroenterology, hepatology & nutrition Vol.23 No.1

Purpose: We aimed to investigate the disease phenotype of Korean pediatric Crohn's disease (CD) patients at diagnosis according to the Paris classification by comparison with patients from the European multicenter 5-years recruitment of children with newly developed IBD (EUROKIDS registry). Methods: Korean children and adolescents who had been newly diagnosed with CD at the age of <18 years during 2013-2016 were included in this multicenter retrospective study. Disease phenotype at diagnosis was classified according to the Paris classification, and compared with the published data from the EUROKIDS study. Results: A total of 255 patients were included. The median diagnosis age was 14.7 years (range, 0.8-17.9 years). No significant difference was observed in male-to-female ratio with EUROKIDS (1.9:1 vs. 1.45:1, p=0.062). The proportion of children aged <10 years was significantly lower in Koreans (7.1% vs. 19.6%, p<0.001). Colonic disease was less prominent (10.0% vs. 27.3%, p<0.001), while upper GI involvement was more prominent in Korean children (59.3% vs. 46.2%, p<0.001). The proportion with perianal fistulizing disease at diagnosis was significantly higher in Korean patients (44.8% vs. 8.2%, p<0.001). A separate analysis of Korean patients revealed that perianal fistulizing disease at diagnosis was positively associated with male sex and body mass index z-score (odds ratio [OR]=2.12, 95% confidence interval [CI]=1.20-3.76, p=0.010; and OR=1.29, 95% CI=1.05-1.58, p=0.015, respectively). Conclusion: Approximately half of pediatric CD patients in Korea present with perianal fistulas and/or abscesses at diagnosis, which is a distinct feature of CD in Korean children and adolescents compared to their European counterparts. An underlying genetic difference between ethnicities may play a role in this expression of different phenotypes in pediatric CD.

Alexander Disease

Kang, Ji Hae,Hong, Seung Jee,Kim, Doo-Kwun Korean Society of Medical Genetics and Genomics 2013 대한의학유전학회지 Vol.10 No.2

Alexander disease (ALXD) is a rare demyelinating disease of the white matter of the brain that is caused by a mutation in the glial fibrillary acidic protein (GFAP) gene. The overexpression of GFAP in astrocytes induces a failure in the developmental growth of the myelin sheath. The neurodegenerative destruction of the myelin sheath of the white matter is accompanied by an accumulation of abnormal deposits of Rosenthal fibers in astrocytes, which is the hallmark of ALXD. The disease can be divided into four groups based on the onset age of the patients: neonatal, infantile, juvenile, or adult. Early-onset disease is more severe, progresses rapidly, and results in a shorter life span than late-onset cases. Magnetic resonance imaging and genetic tests are mostly used for diagnostic purposes. Pathological tests of brain tissue for Rosenthal fibers are definitive diagnostic methods. Therapeutic strategies are being investigated. Ceftriaxone, which is an enhancer of glial glutamate transporter (GLT-1) expression, is currently in clinical trials for the treatment of patients with ALXD. To date, there are no clinically available treatments. The cause, pathology, pathophysiology, inheritance, clinical features, diagnosis, and treatment of ALXD will be reviewed comprehensively.

Survival in Frontotemporal Lobar Degeneration in a Korean Population :

Kang, Sue J.,Cha, Kyung Ryeol,Seo, Sang Won,Kim, Eun A.,Cheong, Hae-Kwan,Kim, Eun-Joo,Na, Duk L.,Jeong, Jee H. Ovid Technologies (Wolters Kluwer) - Lippincott Wi 2010 ALZHEIMER DISEASE AND ASSOCIATED DISORDERS Vol.24 No.4

<P>Frontotemporal lobar degeneration (FTLD) can be subdivided into frontotemporal dementia (FTD), FTD combined with motor neuron disease (FTD-MND), semantic dementia (SD), and progressive nonfluent aphasia (PNFA). FTLD has been considered a rare disorder, and its' demographic and survival data have rarely been studied in Asian population. A survival analysis using the Kaplan-Meier method was performed for 121 consecutive patients with clinically diagnosed FTLD who attended the Memory Disorder Clinic at Samsung Medical Center in Seoul, Republic of Korea, between January 1995 and September 2006. The overall median survival from the onset of the first symptom was 9.6 years (95% CI=8.3-10.8 y). The survival was shortest in FTD-MND (3 y) and longest in SD (11.3 y). The median survival time of FTD (9.8 y) was shorter than that of SD and longer than that of FTD-MND and PNFA. The use of the Cox proportional-hazards model to examine the effect of demographics on survival revealed that only age at onset was associated with survival. In general, our data are comparable with those from the Western countries. However, the female proportion was greater across all subtypes of FTLD and the survival of patients with PNFA was shorter than those of other groups.</P>

Incidence of Acute Kidney Injury after Adrenalectomy in Patients with Primary Aldosteronism

Jee Young Lee,Hyoungnae Kim,Hyung Woo Kim,Geun Woo Ryu,Yooju Nam,Seonyeong Lee,Young Su Joo,Sangmi Lee,Jung Tak Park,Seung Hyeok Han,Shin-Wook Kang,Tae-Hyun Yoo,Hae-Ryong Yun 전해질고혈압연구회 2019 Electrolytes & Blood Pressure Vol.17 No.2

Background: Aldosterone-induced glomerular hyperfiltration can lead to masked preoperative renal dysfunction in primary aldosteronism(PA) patients. We evaluated whether PA patients had a higher prevalence of acute kidney injury (AKI) after unilateral adrenalectomy. In addition, we identified risk factors for AKI in these subjects. Methods: This retrospective study included 107 PA patients, and 186 pheochromocytoma patients as a control group, all of whom underwent adrenalectomy between January 2006 and November 2017 at Yonsei University Severance Hospital. The primary outcome was AKI within 48 hours after adrenalectomy. Univariate and multivariate logistic regression analyses were performed to identify predictors of AKI after adrenalectomy. Results: Overall incidence of AKI was 49/293 (16.7%). In PA patients, the incidence of AKI was 29/107 (27.1%). In contrast, incidence of AKI was 20/186 (10.7%) in pheochromocytoma patients. Univariate and multivariate logistic regression analysis both showed a higher risk of postoperative AKI in PA patients compared to pheochromocytoma patients. In addition, old age, diabetes, longer duration of hypertension, lower preoperative estimated glomerular filtration rate, high aldosterone-cortisol ratio (ACR) and lateralization index (LI) were identified as independent risk factors for postoperative AKI in PA patients after unilateral adrenalectomy. Conclusion: Incidence and risk of postoperative AKI were significantly higher in PA patients after surgical treatment. High ACR on the tumor side and high LI were associated with higher risk of AKI in PA patients compared to pheochromocytoma patients.

Risk Based Decision Support for Final Closing Section of a Sea Dike

Jee, Sung Hyun,Kang, Seong Hae,Kim, Jeong Hwan,Seo, Jong Won Korea Institute of Construction Engineering and Ma 2013 Journal of construction engineering and project ma Vol.3 No.2

A sea dike construction has been increased in Korea because of the actively deployed reclamation project in basis of efficient application in land. The degree of completion in sea dike construction is affected by final closing construction, which has a lot of uncertainty that often results in higher accidents rate. Therefore, this research identified risk factors of final closing construction and classified them. This research examines the likelihood and its impact for each risk factor and calculates the risk degree as to the risk matrix. Based on this, the impact and the environmental conditions that affect to risk factors are investigated and further responsive methods are established for each risk factor. Ultimately, this research attempts to provide the risk retrenchment method for inspectors by proposing risk estimation model, responsive action list, and risk management process.