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Won, Yu Deok,Kim, Jae-Min,Ryu, Je-Il,Koh, Seong-Ho,Han, Myung-Hoon,Cheong, Jin-Hwan The Korean Neurosurgical Society 2021 Journal of Korean neurosurgical society Vol.64 No.5
Objective : Hemorrhagic transformation (HT) can be occurred after acute cerebral infarction. HT can worse symptoms in severe cases and adversely affect long-term prognosis. As bone and vascular smooth muscle are composed of type 1 collagen, we aimed to identify a potential relationship between bone mineral density (BMD) and HT after acute cardioembolic stroke. Methods : As an indicator of BMD, we used mean frontal skull Hounsfield unit (HU) values on brain computed tomography (CT). Multivariative hazard ratios were calculated using Cox regression analysis to identify whether the osteoporotic condition was an independent predictor of HT after acute cardioembolic stroke. Results : This 11-year analysis enrolled 506 patients who diagnosed as acute cardioembolic infarction. The first tertile of skull HU value was an independent predictor of HT development compared to the third tertile (hazard ratio, 2.12; 95% confidence interval, 1.13-3.98; p=0.020). We observed no interactions between age and skull HU with respect to HT statistically. Conclusion : The results of this study revealed an association between osteoporotic conditions and HT development after acute cardioembolic stroke. A convenient method to measure the cancellous bone HU value of the frontal skull using brain CT images may be useful for predicting HT in patients with acute cerebral infarction.
Selumetinib Inhibits Melanoma Metastasis to Mouse Liver via Suppression of EMT-targeted Genes
RYU, SEUNG-HEE,HEO, SEUNG-HO,PARK, EUN YOUNG,CHOI, KYUNG-CHUL,RYU, JE-WON,LEE, SEOK HO,LEE, SANG-WOOK Potamitis Press 2017 Anticancer research Vol. No.
<P>Aim: We investigated the therapeutic effects of a mitogen-activated protein (MEK) inhibitor, selumetinib, in a hepatic melanoma metastasis model and studied its possible mechanism of action. Materials and Methods: Melanoma cell lines were exposed to selumetinib under different experimental conditions. We established a mouse model of liver metastasis and treated mice orally with vehicle or selumetinib and then evaluated metastasis progress. Results: Growth inhibition was observed in melanoma cells as a consequence of G(1)-phase cell-cycle arrest and the subsequent induction of apoptosis in a doseand time-dependent manner. Mice with established liver metastases that were treated with selumetinib exhibited significantly less tumor progression than vehicle-treated mice. c-Myc expression in metastasized liver tissues were suppressed by selumetinib. Moreover, oral treatment with selumetinib modulated expression of epithelial-tomesenchymal transition-and metastasis-related genes, including integrin alpha-5 (ITGA5), jagged 1 (JAG1), zinc finger E-box-binding homeobox 1 (ZEB1), NOTCH, and serpin peptidase inhibitor clade E (SERPINE1). Conclusion: We established a mouse model of hepatic metastasis using a human melanoma cell line, such models are essential in elucidating the therapeutic effects of anti-metastatic drugs. Our data suggest the possibility that selumetinib presents a new strategy to treat liver metastasis in patients with melanoma by suppressing epithelial-to-mesenchymal transition-related genes.</P>
Curvature tailoring of unsymmetric laminates with an initial curvature
Ryu, Junghyun,Kong, Jung-Pyo,Kim, Seung-Won,Koh, Je-Sung,Cho, Kyu-Jin,Cho, Maenghyo SAGE Publications 2013 Journal of composite materials Vol.47 No.25
<P>An unsymmetric laminated composite having bi-stability is interesting as a morphing structure because it can sustain large deformation without energy supply and the deformed state is stable. Especially, inducing different curvature values at each stable state is important for the practical application of unsymmetric laminates. In this study, we propose a method for tailoring the curvature of unsymmetric cross-ply laminates by curing the composite on a curved tool plate. The results show that the final normal curvature tensor of unsymmetric laminates is the summation of the tool plate curvature tensor and the normal curvature tensor of the laminates.</P>
Ryu, BoMi,Choi, Il-Whan,Qian, Zhong-Ji,Heo, Soo-Jin,Kang, Do-Hyung,Oh, Chulhong,Jeon, You-Jin,Jang, Chul Ho,Park, Won Sun,Kang, Kyong-Hwa,Je, Jae-Young,Kim, Se-Kwon,Kim, Young-Mog,Ko, Seok-Chun,Kim, G The Korean Society of Phycology 2014 ALGAE Vol.29 No.4
Despite the extensive literature on marine algae over the past few decades, a paucity of published research and studies exists on red algae. The purpose of this study was to evaluate the potential therapeutic properties of the ethanol extract of the red alga Callophyllis japonica against lipopolysaccharide (LPS)-stimulated macrophage inflammation. The C. japonica extract (CJE) significantly inhibited the nitric oxide (NO) production and the induced dose-dependent reduction of the protein and mRNA levels of inducible nitric oxide synthase and cyclooxygenase-2. Additionally, the CJE reduced the mRNA levels of inflammatory cytokines, including tumor necrosis factor-${\alpha}$, interleukin (IL)-$1{\beta}$, and IL-6. We investigated the mechanism by which the CJE inhibits NO by examining the level of mitogen-activated protein kinases (MAPKs) activation, which is an inflammation-induced signaling pathway in macrophages. The CJE significantly suppressed the LPS-induced phosphorylation of c-Jun N-terminal kinase, extracellular signal-regulated kinase and p38 MAPK. Taken together, the results of this study demonstrate that the CJE inhibits LPS-induced inflammation by blocking the MAPK pathway in macrophages.
PARK, JE WON,SONG, BEOM SEOK,RYU, DOJIN,LEE, CHAN,KIM, YOUNG BAE 한국미생물 · 생명공학회 2002 Journal of microbiology and biotechnology Vol.12 No.6
A novel antibacterial metabolite, ARK42, was isolated from a xerophilic fungal strain K42, and identified as Asperillus repens based on its morphological characteristic. The metabolite exhibited antibacterial activities towards Staphylococcus aureus, Bacillus cereus, and Pseudomonas aeruginosa, with MICs of 25, 12.5, and 3.125 ㎍/ml, respectively, and killed Pseudomonas aeruginosa with minimal bactericidal concentration (MBC) of 12.5 ㎍/ml. Furthermore, acticancer activities were demonstrated against human colon cancer DLD-1 and lung cancer LXFL529 cells with an IC_50 of 10 and 1 ㎍/ml, respectively.
한국인 전립선암 환자에서 술 전 중등도위험군에서 술 후 고위험군으로 이행할 수 있는 인자
유제국(Je Guk Ryu),황인상(Insang Hwang),임동훈(Dong Hun Im),정영범(Young Beom Jeong),박승철(Seung Chol Park),노준화(Joonwha Noh),권동득(Dong Deuk Kwon),강택원(Taek Won Kang) 대한비뇨기종양학회 2013 대한비뇨기종양학회지 Vol.11 No.3
Purpose: We aimed to examine a change and relevant predictors in intermediate-risk prostate cancer which have a wide range of treatment options from active surveillance to radical prostatectomy (RP). Materials and Methods: Of 1,159 patients who underwent RP in multi-institution between January 2009 and December 2012, 390 patients who were classified as intermediate-risk prostate cancer group by preoperative evaluation according to NCCN guideline were enrolled in this retrospective study. The rates of Gleason score upgrading, upstaging and migrating to high-risk prostate cancer group at final pathology and there risk factors were assessed. Results: The mean age of enrolled patients were 67.33±6.17 years with mean PSA level of 9.34±4.34 ng/ml. The number of patients with worsening upgrading, worsening upstaging and worsening prognosis were 42 (10.77%), 83 (21.28%) and 108 (27.7%), respectively. In analysis compared between upgrading group and non-upgrading group, there was no difference in patient’s features. However, in analysis on upstaging and worsening prognosis, serum PSA (p=0.029, p=0.042) and %positive biopsy core (p=0.010, p=0.013) showed significant difference. In univariable analysis, serum PSA (p=0.030, p=0.042) and %positive biopsy core (p=0.004, p=0.014) were predictive of upstaging and worsening prognosis, also, in multivariable analysis, serum PSA (p=0.016) and %positive biopsy core (p=0.042) were statistically relevant factors of worsening upstaging. Conclusions: In this study, 27.7% of patients with preoperative intermediate-risk prostate cancer were re-stratified into high-risk prostate cancer group after RP. Serum PSA and %positive biopsy core were the predictive factors for migrating to high risk group.
군 병원 근무자의 책임 운영기관제도 인식 수준에 관한 연구
박원필 ( Won Pill Park ),허제강 ( Je Gang Heo ),류시창 ( Si Chang Ryu ),맹순주 ( Sun Ju Maeng ) 국군의무사령부 2010 대한군진의학학술지 Vol.41 No.1
Objective: The Armed Foeces Capital Hospital is operated Military Executive Agencies from 2009.1.1 by Ministry of National Defense Policy. So that study on level of Military Executive Agencies of military hospital employee and present improvement plan. Method: Executes questionnaire to 300 The Armed Foeces Capital Hospitall employee in services to October 9 from September 16, 2009 and utilized 285 respondents questionnaire on interpretation. Analysis executes statistical analysis and interpretation and enforced frequency analysis, reliability analysis, analysis of variance (ANOVA) using SPSS 15.0 programs. Result: The Armed Foeces Capital Hospital Should consider organization culture satisfaction elevation plan and enforce. To heighten realization level of reform direction with change, Mutual understanding and persistent education for conversion of work form between director of a hospital and employees should be achieved. Should change and autonomy about first engineer's greetingㆍbudget etc.. to business system of competitive Performance first by professional worker supplement and Incentive induction for guarantee. Need to introduce 'Customer service' or 'Customer service center' etc. for customer center service and medical treatment open of common people university hospital level and establish and operate. Customers satisfaction does and should propels continuously ordinary of questionnaire. Conclusions: Also, for success of responsibility operation engine system legal. I need active support by upper echelon's Sympathy formation and field in systematic connection guideline trial.