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- 검색키워드
- 저자 : Jayoung Jeong (검색결과 60 건)
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Jeong, Jiyoung,Lee, Seonghan,Kim, Sung-Hyun,Han, Youngju,Lee, Dong-Keon,Yang, Jun-Young,Jeong, Jayoung,Roh, Changhyun,Huh, Yun Suk,Cho, Wan-Seob Informa UK (TaylorFrancis) 2016 Nanotoxicology Vol.10 No.10
<P>Although surface area metric was suggested as an appropriate dose metric for acute lung inflammation of NPs, it might not be effective for fast-dissolving NPs because they lose their reactive surface when dissolved in the phagolysosomes. Herein, we evaluated the dose metric for fast-dissolving NPs using a rat intratracheal instillation model. A panel of fast-dissolving NPs (CoO, CuO and ZnO) and their constituent metal ions (CoCl2, CuCl2 and ZnCl2) were compiled and each compound was intratracheally instilled into the lungs of female Wistar rats at the same molar concentrations in the NP doses (40, 100 and 400g/rat). The toxicity endpoints including cytological and biochemical data in bronchoalveolar lavage fluid were evaluated at 24h after instillation. To evaluate the dose metric, each toxicity endpoint was plotted against the instilled dose (mass or surface area) or the equivalent dose (mass or surface area) that was weighted by the ratio of specific dose-generated responses between metal chlorides. Dose-response curves of fast-dissolving NPs about percentage of granulocytes, lactate dehydrogenase levels and total protein levels showed similar pattern but slightly less potential than those of their respective metal chlorides. When each toxicity endpoint was plotted against the equivalent mass dose, three types of NPs showed more overlapping dose-response curves than other dose metrics. In conclusion, this study implies that the equivalent mass dose is an appropriate dose metric for fast-dissolving NPs and the main factor determining the slope of the dose-response curve is the intrinsic toxicity of the their constituent ions.</P>
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Jeong In Hwa,Kim Jong-Hun,Kwon Min-Jung,Kim Jayoung,Huh Hee Jin,Kim Byoungguk,Lee Junewoo,Nam Jeong-hyun,Kang Eun-Suk 대한의학회 2024 Journal of Korean medical science Vol.39 No.5
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally, leading to the coronavirus disease 2019 (COVID-19) pandemic. Because a significant proportion of the COVID-19 confirmed cases were concentrated in the capital metropolitan area of South Korea, and a large proportion of the population in the area had been adequately vaccinated against COVID-19, we conducted a seroprevalence surveillance study focusing on the residents of the capital metropolitan area in South Korea. Methods: We used a quota-sampling method to obtain blood samples from 1,000 individuals per round, equally stratified across seven age categories and sexes and regions, from five medical institutions located within the capital metropolitan area of South Korea. During five consecutive months (rounds) between January 2022 and May 2022, a total of 5,000 samples were analyzed for anti-spike (S) and anti-nucleocapsid (N) antibodies. Results: High anti-S seropositivity was observed in all age groups, which corresponded to the vaccine coverage during the study period. Both the cumulative incidence based on polymerase chain reaction (PCR) and the estimated seroprevalence based on anti-N seropositivity increased in the fourth and fifth rounds, which corresponded to April 2022 and May 2022. Seroprevalence coincided with the cumulative incidence during the first three rounds, but exceeded from the fourth survey onwards when infection with omicron variants was increased rapidly in Korea. Conclusion: Seroprevalence confirmed the number of infection cases outside of PCR testing-based surveillance. Seroepidemiological surveillance can help us understand vaccine responses and detect hidden infections, thereby providing appropriate public health guidance for achieving population-level immunity.
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Lee, Jeong-A,Kim, Mi-Kyung,Kim, Hyoung-Mi,Lee, Jong Kwon,Jeong, Jayoung,Kim, Young-Rok,Oh, Jae-Min,Choi, Soo-Jin Dove Medical Press 2015 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.10 No.-
<P><B>Background</B></P><P>Orally administered particles rapidly interact with biological fluids containing proteins, enzymes, electrolytes, and other biomolecules to eventually form particles covered by a corona, and this corona potentially affects particle uptake, fate, absorption, distribution, and elimination in vivo. This study explored relationships between the biological interactions of calcium carbonate particles and their biokinetics.</P><P><B>Methods</B></P><P>We examined the effects of food grade calcium carbonates of different particle size (nano [N-Cal] and bulk [B-Cal]: specific surface areas of 15.8 and 0.83 m<SUP>2</SUP>/g, respectively) on biological interactions in in vitro simulated physiological fluids, ex vivo biofluids, and in vivo in gastrointestinal fluid. Moreover, absorption and tissue distribution of calcium carbonates were evaluated following a single dose oral administration to rats.</P><P><B>Results</B></P><P>N-Cal interacted more with biomatrices than bulk materials in vitro and ex vivo, as evidenced by high fluorescence quenching ratios, but it did not interact more actively with biomatrices in vivo. Analysis of coronas revealed that immunoglobulin, apolipoprotein, thrombin, and fibrinogen, were the major corona proteins, regardless of particle size. A biokinetic study revealed that orally delivered N-Cal was more rapidly absorbed into the blood stream than B-Cal, but no significant differences were observed between the two in terms of absorption efficiencies or tissue distributions. Both calcium carbonates were primarily present as particulate forms in gastrointestinal fluids but enter the circulatory system in dissolved Ca<SUP>2+</SUP>, although both types showed partial phase transformation to dicalcium phosphate dihydrate. Relatively low dissolution (about 4%), no remarkable protein–particle interaction, and the major particulate fate of calcium carbonate in vivo gastrointestinal fluids can explain its low oral absorption (about 4%) regardless of particle size.</P><P><B>Conclusion</B></P><P>We conclude that calcium carbonate nanoparticles can act more actively with biological matrices in vitro and ex vivo, but that in vivo, their biological interactions and biokinetics are not affected by particle size.</P>
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Prenatal development toxicity study of zinc oxide nanoparticles in rats
Hong, Jeong-Sup,Park, Myeong-Kyu,Kim, Min-Seok,Lim, Jeong-Hyeon,Park, Gil-Jong,Maeng, Eun-Ho,Shin, Jae-Ho,Kim, Meyoung-Kon,Jeong, Jayoung,Park, Jin-A,Kim, Jong-Choon,Shin, Ho-Chul Dove Medical Press 2014 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.9 No.2
<P>This study investigated the potential adverse effects of zinc oxide nanoparticles ([ZnO<SUP>SM20(+)</SUP> NPs] zinc oxide nanoparticles, positively charged, 20 nm) on pregnant dams and embryo–fetal development after maternal exposure over the period of gestational days 5–19 with Sprague-Dawley rats. ZnO<SUP>SM20(+)</SUP> NPs were administered to pregnant rats by gavage at 0, 100, 200, and 400 mg/kg/day. All dams were subjected to a cesarean section on gestational day 20, and all of the fetuses were examined for external, visceral, and skeletal alterations. Toxicity in the dams manifested as significantly decreased body weight after administration of 400 mg/kg/day NPs; reduced food consumption after administration of 200 and 400 mg/kg/day NPs; and decreased liver weight and increased adrenal glands weight after administration of 400 mg/kg/day NPs. However, no treatment-related difference in: number of corpora lutea; number of implantation sites; implantation rate (%); resorption; dead fetuses; litter size; fetal deaths and placental weights; and sex ratio were observed between the groups. On the other hand, significant decreases between treatment groups and controls were seen for fetal weights after administration of 400 mg/kg/day NPs. Morphological examinations of the fetuses demonstrated significant differences in incidences of abnormalities in the group administered 400mg/kg/day. Meanwhile, no significant difference was found in the Zn content of fetal tissue between the control and high-dose groups. These results showed that oral doses for the study with 15-days repeated of ZnO<SUP>SM20(+)</SUP> NPs were maternotoxic in the 200 mg/kg/day group, and embryotoxic in the 400 mg/kg/day group.</P>
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Modulation of the pharmacokinetics of zinc oxide nanoparticles and their fates in vivo.
Paek, Hee-Jeong,Lee, Youn-Joung,Chung, Hea-Eun,Yoo, Nan-Hui,Lee, Jeong-A,Kim, Mi-Kyung,Lee, Jong Kwon,Jeong, Jayoung,Choi, Soo-Jin RSC Pub 2013 Nanoscale Vol.5 No.23
<P>In the present study, the effects of particle size (20 nm or 70 nm) and surface charge (negative or positive) on the pharmacokinetics, tissue distributions, and excretion of ZnO nanoparticles were examined following the administration of a single oral dose to rats. Pharmacokinetic profiles and biodistributions were not affected by particle size or gender. However, ZnO (-) particles were markedly more absorbed by the systemic circulation than ZnO (+) particles. Furthermore, the kinetic behaviors of ZnO nanoparticles differed from those of zinc ions, as evidenced by the low dissolution (13-14%) of ZnO nanoparticles under gastric conditions. The kidneys, liver, and lungs were found to be target organs. However, the major biological fate of ZnO nanoparticles in tissues was the ionic form, not the particulate form, and this was independent of exposure routes (oral and intravenous). Particle size was only found to affect excretion kinetics, and 20 nm particles were more rapidly eliminated. Most nanoparticles were excreted via the biliary and fecal routes, but a small amount of the nanoparticles was excreted via urine. The study shows that surface charge, rather than particle size or gender, is the critical modulator of the pharmacokinetic behavior of ZnO nanoparticles.</P>
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Jayoung Kim,Seonghwan Jeong,Jong-Oh Park,Han-Sol Lee,Cheong Lee,Chang-Sei Kim 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.3
Herein, we present a novel electromagnetic field control methodology against a heating problem that can perform both desired actuation and lower heating of an electromagnet actuator comprising several electromagnets for magnetically actuated microrobot. The proposed method can balance the heating temperature of each electromagnet in a multiple coiled electromagnetic actuator which should be sustained in a similar state to prevent overheating while maintaining a desired magnetic force. Based on the conventional magnetic field model, the controller employs a real-time updated minimum weighted norm of induced currents by considering the physically limited current source and temperature feedback of each coil. The simulation results indicate that the heating temperature is lower than the conventional method during the same operation time. The performance of capsule motion and respective heating temperature through the proposed method was validated in ex-vivo experiments in a pig intestine for the actual clinical application. During the whole motion cycle of a wireless magnetic capsule in the intestine sample, the measured heating temperature could be significantly reduced. Hence, the temperatures of all the electromagnets were balanced at a similar level without any extremely high temperatures for specific electromagnets. Eventually, the proposed control method can extend the operating time of the conventional electromagnetic actuator and enhance the capability of real application.
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An Optimization Algorithm for The Pickup and Delivery Problem With Time Windows
Jayoung Kang(강자영),Hee Jeong Zang(장희정),Jangha Kang(강장하),Sungsoo Park(박성수) 대한산업공학회 2007 대한산업공학회지 Vol.33 No.1
The pickup and delivery problem with time windows generally involves the construction of optimal routes which satisfy a set of transportation requests under pairing, precedence, time window, vehicle capacity, and availability constraints. In this paper, we added some constraints to the problem and adopted an objective function based on number of used vehicles, total travel distance and total schedule duration to consider more realistic problems. A branch and price algorithm for the problem is proposed and an enumeration method is used for the subproblems. The algorithm was tested on randomly generated instances and computational results were reported.
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Jayoung Lee,Ju Hye Lee,Hanbin Yoon,Ho Jeong Lee,Hosang Jeon,Jiho Nam 대한방사선종양학회 2017 Radiation Oncology Journal Vol.35 No.2
Primary liver tumor, especially hepatocellular carcinoma (HCC), is a common cause of cancer death worldwide. The incidence is generally higher in Asian countries than in western countries. Carcinogenesis of HCC is often associated with hepatitis viral infections. Current standard treatment of HCC is surgical resection or transplantation in patients with early stage disease. However, the patient with advanced stage disease, surgical resection is often limited. Sorafenib or other treatment modalities are not so effective as well. We report a case of unusual radiation super-sensitivity in advanced stage HCC, and review the literature.
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