http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Jaromír Kulhánek (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Hyaluronic Acid Fibres in Solid Phase Peptide Synthesis - Their Properties, Morphology and Stability
Sergej Karel,Jana Starigazdová,Hana Vágnerová,Jaromír Kulhánek,Lucie Horáčková,Martin Flegel,Pavel Drašar,Jiří Brožek,Vladimír Velebný 한국섬유공학회 2020 Fibers and polymers Vol.21 No.12
Different methods and materials can be used for peptide synthesis. One of the most common approaches issynthesis on a solid phase. In this paper, we describe fibres based on hyaluronic acid (HA) and their properties under solidphasepeptide synthesis (SPPS) conditions. The fibres were prepared by wet spinning technology and were used to study theirstability and mechanical properties under the reaction conditions for direct peptide synthesis or conjugation with apre-synthesized peptide. Fibres in the form of a non-woven textile were then used as a proof of concept for the adhesion ofcells on short cell-adhesion peptides. The methods, solvents and reaction conditions used showed no significant influence onthe necessary stability of the HA fibres when the Fmoc/tBu strategy was applied. Furthermore, the stability of the HA fibresin aqueous solution was strongly improved. The stabilization and presence of cell-adhesive peptides supported the adhesionof cardiomyocyte cells, which confirmed the functionality of the modified textile. Therefore, HA carriers bearing peptidescould be advantageously employed in various biomedical applications as repair patches.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
