Integrating the strengths of cVAE and cGAN into cAAE for advanced inverse design of colloidal quantum dots

Jang Deokho,Kim Jungho 한국물리학회 2024 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.85 No.5

Colloidal quantum dots (QDs) exhibit unique structures, which often result in distinctive optical properties such as emission and absorption spectra. However, QDs with diferent structures can sometimes show very similar emission and absorption spectra, making it difcult to inversely design their precise structural parameters from a given target emission and absorption spectra. To overcome this so-called one-to-many mapping problem, this paper introduces a novel deep-learning-based generative model for the inverse design of QDs. In particular, we implement three types of conditional generative models: the conditional generative adversarial network (cGAN), the conditional variational autoencoder (cVAE), and the conditional adversarial autoencoder (cAAE). Each model is designed and trained to predict possible layer thicknesses of QDs that can provide a given target emission and absorption spectra, thus providing possible multiple solutions rather than a single deterministic outcome. This multi-solution approach not only increases the fexibility in QD structure design, but also enhances the accuracy and efciency of the predictive process. According to calculation results, the cAAE stands out by efectively combining the strengths of both cGAN and cVAE. This integration allows cAAE to produce a more diverse and accurate inversely designed structures of InP/ZnSe/ZnS QDs.

Numerical comparison of quantum-confined Stark effect on emission spectra between InP- and CdSe-based colloidal quantum dots

Jang Deokho,Kim Jungho 한국물리학회 2023 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.83 No.10

We numerically compare the quantum-confned Stark efect (QCSE) on emission spectra between InP/ZnSe/ZnS and CdSe/ ZnSe/ZnS colloidal quantum dots (QDs). Because the bandgap energy of InP is greater than that of CdSe, the total layer thickness of an InP/ZnSe/ZnS QD is determined to be less than that of a CdSe/ZnSe/ZnS QD for both QDs to have the same emission peak wavelength of 563 nm. After strain-modifed band-edge energies for electron and heavy hole are calculated, a three-dimensional Schrödinger equation is numerically solved based on the fnite element method. The changes in groundstate energy levels, wave-function overlap integrals, and exciton binding energies of the thick CdSe-based QD are much greater than those of the thin InP-based QD when the external electric feld intensity increases from 0 to 100 kV/cm. In calculated emission spectra, the CdSe-based QD shows the integrated emission intensity reduction of 6% and ground-state emission peak shift of 0.91 nm. In contrast, the integrated emission intensity decreases by 0.02% and its ground-state emission peak shifts by 0.06 nm for the InP-based QD. Because the degree of the QCSE is proportional to the size of QDs, the emission spectrum of thin InP-based QDs is less sensitive to the QCSE than that of thick CdSe-based QDs when they have the similar peak emission wavelength.

전문대학과 기초지방자치단체 간 연계.협력사업 구축 전략에 대한 현장 전문가들의 관점 탐색 연구

장덕호(Deokho Jang),김효선(Hyosun Kim) 한국직업교육학회 2022 職業 敎育 硏究 Vol.41 No.1

본 연구의 목적은 전문대학과 기초지방자치단체 간 연계･협력을 위한 관련 사업기획의 과정에서 대두되는 핵심적인 이슈들을 발굴하고 이와 연관된 문제점을 심도 있게 파악하여 향후 기초지방자치단체와 연계하여 지역 기반 전문대학 활성화를 위한 혁신 전략이 무엇인가를 탐색하는데 있다. 이를 위해 관련한 사업을 수행한 경험이 있는 전문대학 및 기초지방자치단체 소속 현장 관계자들을 대상으로 3회에 걸친 초점집단면담(Focus group interview)을 실시하였다. 연구결과, 연계와 협력을 위한 성공요인으로 전문대학-지자체 간 상호 호혜적 교류와 선행될 필요가 있고, 지역산업체와 지역주민들까지 참여하는 개방적 소통 거버넌스 창출이 필요함을 알 수 있었다. 전문대학은 지역의 특성에 부합하는 교육과정의 개발이 중요하고, 지역 관계자들의 직업교육에 대한 인식개선과 사업운영의 자율성 확보가 필요함을 발견하였다. 이상의 연구결과를 토대로 상호 협력을 위한 요구분석 시행, 고등직업교육의 본질적 가치 회복, 지구단위 사업의 원활한 시행을 위한 기초 인프라 구축 등을 제언하였다. The purpose of this study was to discover key issues emerging in the process of planning related projects for linkage and cooperation between junior colleges and local governments. Also, the research aimed to identify problems, and explore strategies to revitalize the colleges in the future. From it, three focus group interviews were conducted for experts and officials belonging to junior colleges and local governments with experience in carrying out related projects. As a result of the study, it was found that mutually beneficial exchanges between junior colleges and local governments need to precede as a success factor for linkage and cooperation, and that open communication governance needs to be created in which local industries and local residents participate. It was found that it is important to develop a innovative curriculum that meets the characteristics of the community, and it is necessary to improve the awareness of the values of vocational education of local officials and secure autonomy in the project operation. Based on the above research results, suggestions such as implementing prior need assessment analysis for mutual cooperation, restoring the essential value of higher vocational education, and establishing basic infrastructure through design as a district-level project were presented.

Inhibitory effects of novel SphK2 inhibitors on migration of cancer cells

Jung, Deokho,Jung, Junghyun,Lee, Euiyeon,Mok, Chang,Jeon, Hyunjin,Park, Chang,Jang, Wonhee,Kwon, Youngeun BENTHEM SCIENCE PUBLISHERS LTD 2017 ANTICANCER AGENTS IN MEDICINAL CHEMISTRY Vol.17 No.999

Chemical biology-based approaches on fluorescent labeling of proteins in live cells

Jung, Deokho,Min, Kyoungmi,Jung, Juyeon,Jang, Wonhee,Kwon, Youngeun The Royal Society of Chemistry 2013 Molecular bioSystems Vol.9 No.5

<P>Recently, significant advances have been made in live cell imaging owing to the rapid development of selective labeling of proteins <I>in vivo</I>. Green fluorescent protein (GFP) was the first example of fluorescent reporters genetically introduced to protein of interest (POI). While GFP and various types of engineered fluorescent proteins (FPs) have been actively used for live cell imaging for many years, the size and the limited windows of fluorescent spectra of GFP and its variants set limits on possible applications. In order to complement FP-based labeling methods, alternative approaches that allow incorporation of synthetic fluorescent probes to target POIs were developed. Synthetic fluorescent probes are smaller than fluorescent proteins, often have improved photochemical properties, and offer a larger variety of colors. These synthetic probes can be introduced to POIs selectively by numerous approaches that can be largely categorized into chemical recognition-based labeling, which utilizes metal-chelating peptide tags and fluorophore-carrying metal complexes, and biological recognition-based labeling, such as (1) specific non-covalent binding between an enzyme tag and its fluorophore-carrying substrate, (2) self-modification of protein tags using substrate variants conjugated to fluorophores, (3) enzymatic reaction to generate a covalent binding between a small molecule substrate and a peptide tag, and (4) split-intein-based C-terminal labeling of target proteins. The chemical recognition-based labeling reaction often suffers from compromised selectivity of metal–ligand interaction in the cytosolic environment, consequently producing high background signals. Use of protein–substrate interactions or enzyme-mediated reactions generally shows improved specificity but each method has its limitations. Some examples are the presence of large linker protein, restriction on the choice of introducible probes due to the substrate specificity of enzymes, and competitive reaction mediated by an endogenous analogue of the introduced protein tag. These limitations have been addressed, in part, by the split-intein-based labeling approach, which introduces fluorescent probes with a minimal size (∼4 amino acids) peptide tag. In this review, the advantages and the limitations of each labeling method are discussed.</P> <P>Graphic Abstract</P><P>This review summarizes various approaches to incorporate synthetic fluorescent probes to target proteins in live cells as well as current efforts to control the fluorescent signal using external stimuli. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2mb25422k'> </P>

국내 시추조사 자료 정밀도 시계열 분석

장용구(Yonggu Jang),김영선(Youngsun Kim),채덕호(Deokho Chae),조완제(Wanjei Cho) 한국지반환경공학회 2015 한국지반환경공학회논문집 Vol.16 No.3

2007년 <지반조사 성과 전산화 및 활용에 관한 지침>에 따라 국토지반정보 통합DB센터화 사업이 추진되어 건설현장에 생성되는 지반정보와 관련된 각종 조사, 정보의 효율적인 수집 및 활용을 위하여 시추정보 유통프로세스 사업이 진행되고 있다. 국토지반정보 통합DB센터에 따르면 2014년 6월을 기준으로 약 18만공의 지반정보가 정리되어 있으며 현재에도 지반정보에 대한 데이터베이스 구축이 활발하게 진행되고 있다. 본 연구는 이러한 지반정보 유통프로세스 사업이 시추정보 정밀도에 미치는 영향을 살펴보기 위하여 현장에서 가장 많이 활용되고 있는 지하수위와 지층심도에 관한 시추정보를 이용하여 정밀도 시계열 분석을 실시하였다. 정밀도 분석은 정규분포와 첨도를 통한 통계학적 방법을 이용하였다. 결과적으로 유통프로세스 사업이 시추정보 정밀도 향상에 긍정적인 영향을 미치는 것을 확인할 수 있었으며 보다 많은 정보를 바탕으로 다양한 시추정보의 정밀도 검증을 수행할 경우 각 지역에 따른 시추정보 정밀도 평가도 수행할 수 있을 것으로 기대된다. Since the introduction of ‘the rule for computerizing subsoil investigation results and its application’ in 2007, the DB construction of the national geotechnical information by Ministry of Land, Transport and Maritime Affairs (MOLTMA) has been performed. According to the Integrated DB Center of National Geotechnical Information, there have been 180 thousands borehole information stored in the system. In this study, the time-series analyses of precision on the most used information, the depth of stratum and ground water level, were performed to evaluate the effect of the initiation of the rule established in 2007. The precisions were evaluated based on the statistical analyses using kurtosis and normal distribution. Based on the results, the increase of precision after 2007 and the affirmative effects of the rule established in 2007 are confirmed. Furthermore, the precision of the regional information can be achieved with the precision analyses on the information from various areas.

Surface modified gold nanorods for thyroid cell targeting

Yoshie ARAI,Deokho JUNG,Youngeun KWON,Wonhee JANG 한국생물공학회 2012 한국생물공학회 학술대회 Vol.2012 No.4

Case Series Study on the Use of BU Pharmacopuncture Treatment in Patients with Acute Lumbar Sprain

Yang, Muhack,Jang, Jongwon,Cha, Eunhye,Ahn, Byungsoo,Bang, Younghee,Song, Beomyong,Shin, Jiyong,Ahn, Chankeun,Kim, Deokho,Kim, Sungchul KOREAN PHARMACOPUNCTURE INSTITUTE 2018 Journal of pharmacopuncture Vol.21 No.2

Objective: The purpose of this study was to investigate the clinical effects of BU pharmacopuncture therapy consisting of bear's gall(fel ursi) and ox bezoar(bovis calculus) on acute lumbar sprain. Methods: 12 patients diagnosed as acute lumbar sprain in 6 designated local Korean medicine clinics from October 2017 to February 2018 were treated by BU pharmacopuncture. Several acupoints in abdomen and lumbar region were selected by clinicians at their own discretion. The effectiveness of the therapy was evaluated using VAS and ODI. After that we reviewed the medical records of all these patients to evaluate the effectiveness and safety of the therapy. Results: The VAS and ODI scales were significantly decreased after BU pharmacopuncture therapy. And no major complications and adverse effects were reported. Conclusion: BU pharmacopuncture showed rapid pain relief in patients with acute lumbar sprain. It is possible to shorten the treatment period of acute lumbar sprain and prevent progressing to chronic back pain in advance. To establish the effects of BU pharmacopuncture therapy, more succeeding clinical and laboratory studies are needed.

국내 지질 및 지반조사 자료 관리 현황에 대한 실용적 고찰

장용구(Yonggu Jang),전흥수(Heungsoo Jeon),채덕호(Deokho Chae),조완제(Wanjei Cho) 한국지반환경공학회 2013 한국지반환경공학회논문집 Vol.14 No.4

최근 들어, 건설 시공의 정보화에 더불어 이를 이용한 원가 및 비용 절감 방안에 대한 연구가 많이 수행되고 있는 실정이다. 이러한 상황에서 구조물의 설계에서 필수적으로 이용되고 있는 지질 및 지반정보의 관리 현황을 파악하여 비교ㆍ분석하여 보다 나은 활용성을 가진 관리 시스템을 만드는 것은 매우 중요하다고 생각된다. 현재 지질 및 지반 정보는 한국 지질자원 연구원의 지질도 및 지질공학도 그 외 여러 가지 주제도, 한국광물공사의 국가광물자원지리정보망, 한국건설기술연구원 국토지반정보 포털시스템의 시추정보, 서울특별시의 지반정보시스템, 해양조사원의 종합해양정보시스템을 통하여 수집 및 관리되고 있다. 이와 더불어 건설 시공과 밀접한 관련이 있는 지하수 정보는 한국수자원공사의 국가지하수정보센터와 한국농어촌공사의 농어촌지하수넷을 통하여 그 정보를 수집·관리하고 있다. 따라서, 본 연구에서는 현재 정부 출연 연구소에서 수집 및 관리되고 있는 지질 및 지반 정보의 종류를 소개하며, 미국, 일본, 유럽에서 사용되고 있는 관리 시스템과의 비교를 통하여 적극적으로 활용될 수 있는 형태의 자료제공 및 관리 시스템의 방향을 제시하였다. Recently, there have been various researches on the cost reduction and savings during the construction activities with the development of automation and computerized information system. Considering the cost savings during the construction, the development of the geological and geotechnical information system with high practical use becomes very important since the geologic and geotechnical data are required for the design of the various structures. Currently, the geological and geotechnical data are collected and distributed as a geological/geotechnical map or engineering geology map and map with other specific purpose through geoinfo system at Korea Institute of Geoscience and Mineral Resources, Korea Mineral Resources GIS at Korea Mineral Resources Corporation, Geotechnical Information Portal System at Korea Institute of Construction Technology, Geotechnical Information System at the City of Seoul and the Ocean Data Integration Material System at Korea Hydrographic and Oceanographic Administration. Furthermore, the information on the groundwater is monitored and collected via Integrated Ground Water Information Service at Korea Water Resources Corporation and Rural Groundwater net at Korea Rural Community Corporation. Therefore, in this study, the contents of the geological and geotechnical data collected from the above mentioned government organization are compared and the DB and distribution system with higher utilization are suggested based on the comparisons with those from other countries such as United States of America, Japan and Germany.

국내 지반조사 자료 정밀도 평가

장용구(Yonggu Jang),전흥수(Heungsoo Jeon),채덕호(Deokho Chae),조완제(Wanjei Cho) 한국지반환경공학회 2014 한국지반환경공학회논문집 Vol.15 No.4

전국 건설 현장에서는 매년 막대한 양의 시추정보가 생산되고 있으며 건설 시공의 정보화와 더불어 시추정보에 대한 데이터베이스 구축이 활발하게 진행되고 있다. 이러한 구축된 정보는 현재 15만공 이상이 되고 있으며 구축된 정보에 대한 신뢰도를 분석하여 그 활용성을 높일 필요성이 증대되고 있다. 따라서 본 연구에서는 시추정보의 정밀도 검증 시범지역을 선정하여 각 지역의 지층 심도, 지하수위, 표고를 정밀도 검증 항목으로 선정하고 현재 DB화되어있는 시추정보들의 정밀도를 정규분포를 통해 평가하였다. 지층정보의 경우 심도가 깊어짐에 따라 오차가 커지는 경향을 나타내었으며, 조사 시기에 따라서도 다른 정밀도를 나타내었다. 추가 연구를 통하여 보다 많은 정보를 바탕으로 다양한 시추정보의 정밀도 검증을 수행할 경우, 구축된 자료의 신뢰성 확보로 지하공간정보의 활용성을 높일 수 있을 것으로 판단된다. There have been vast amounts of the site investigation data from the domestic construction sites every year and various national research institutes are constructing the database for the site investigation data. According to the Ministry of Land, Transport and Maritime Affairs, the database for the site investigation has been constructed for covering 154,000 individual boreholes since the computerization project for the geotechnical information started at 2000. It is considered to be high time to evaluate the reliability of the stored DB so that the current DB should be utilized to the various fields related to the planning and site investigation of the construction activities. Therefore, the precision of the stored site investigation data was evaluated via normal distribution for more active sharing and utilization. As a preliminary evaluation of the precision, the locations of the encountered strata from two different sites were analyzed. After the precision of the stored data is determined, the level of reliability of the each category of the stored geotechnical information would be determined and the users would be able to decide which information could be utilized.