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Hyaluronic Acid Fibres in Solid Phase Peptide Synthesis - Their Properties, Morphology and Stability
Sergej Karel,Jana Starigazdová,Hana Vágnerová,Jaromír Kulhánek,Lucie Horáčková,Martin Flegel,Pavel Drašar,Jiří Brožek,Vladimír Velebný 한국섬유공학회 2020 Fibers and polymers Vol.21 No.12
Different methods and materials can be used for peptide synthesis. One of the most common approaches issynthesis on a solid phase. In this paper, we describe fibres based on hyaluronic acid (HA) and their properties under solidphasepeptide synthesis (SPPS) conditions. The fibres were prepared by wet spinning technology and were used to study theirstability and mechanical properties under the reaction conditions for direct peptide synthesis or conjugation with apre-synthesized peptide. Fibres in the form of a non-woven textile were then used as a proof of concept for the adhesion ofcells on short cell-adhesion peptides. The methods, solvents and reaction conditions used showed no significant influence onthe necessary stability of the HA fibres when the Fmoc/tBu strategy was applied. Furthermore, the stability of the HA fibresin aqueous solution was strongly improved. The stabilization and presence of cell-adhesive peptides supported the adhesionof cardiomyocyte cells, which confirmed the functionality of the modified textile. Therefore, HA carriers bearing peptidescould be advantageously employed in various biomedical applications as repair patches.