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Dal Rhee, S.,Kim, C.H.,Seon Park, J.,Hoon Jung, W.,Bum Park, S.,Youn Kim, H.,Hwan Bae, G.,Jan Kim, T.,Young Kim, K. North-Holland ; Elsevier Science Ltd 2012 european journal of pharmacology Vol.691 No.1
Carbenoxolone is the 3-hemisuccinate of glycyrrhetinic acid, the active principal of licorice (Glycyrrhiza glabra). It was reported that carbenoxolone improved glucose tolerance with increased insulin sensitivity in mice with high fat diet-induced obesity. In the present study, we elucidated the protective effect of carbenoxolone in fatty liver animal models of C57BL/6-Lep<SUP>ob/ob</SUP> mice through inhibition of hepatic lipogenesis and apoptosis. In addition, the potential mechanisms by which carbenoxolone could exert such protection were elucidated. Carbenoxolone was daily administrated by gavage for 28 days in C57BL/6 and C57BL/6-Lep<SUP>ob/ob</SUP> mice. Carbenoxolone prevented the plasma triglyceride and free fatty acid accumulation associated with the reduction of the expression of sterol regulatory element binding protein-1c, liver X receptor, fatty acid synthase and acethyl-CoA carboxylase in the livers of C57BL/6-Lep<SUP>ob/ob</SUP> mice. Carbenoxolone also prevented hepatic injury through anti-apoptotic action in the livers of C57BL/6-Lep<SUP>ob/ob</SUP> mice, accompanied by increased Bcl-2 expression and suppressed Bax and cytochrome c expression. As a mechanism, increased inflammatory cytokine expressions were inhibited by carbenoxolone in the fatty livers of C57BL/6-Lep<SUP>ob/ob</SUP> mice. Furthermore, carbenoxolone inhibited free fatty acid (oleate/palmitate) induced reactive oxygen species formation and reversed free fatty acid induced mitochondrial membrane depolarization in HepG2 cells. Carbenoxolone prevents the development of fatty liver by inhibiting sterol regulatory element binding protein-1c expression and activity with an anti-apoptotic mechanism via the inhibition of inflammatory cytokine and reactive oxygen species formation in the livers of C57BL/6-Lep<SUP>ob/ob</SUP> mice. It is suggested that carbenoxolone prevents the development and progression of fatty liver disease in patients with insulin resistance.
Reversible O−O Bond Cleavage and Formation between Mn(IV)-Peroxo and Mn(V)-Oxo Corroles
Kim, Sun Hee,Park, Hyejin,Seo, Mi Sook,Kubo, Minoru,Ogura, Takashi,Klajn, Jan,Gryko, Daniel T.,Valentine, Joan Selverstone,Nam, Wonwoo American Chemical Society 2010 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.132 No.40
<P>Mn(IV)-peroxo and Mn(V)-oxo corroles were synthesized and characterized with various spectroscopic techniques. The intermediates were directly used in O−O bond cleavage and formation reactions. Upon addition of proton to the Mn(IV)-peroxo corrole, the formation of the Mn(V)-oxo corrole was observed. Interestingly, addition of base to the Mn(V)-oxo corrole afforded the formation of the Mn(IV)-peroxo corrole. Thus, we were able to report the first example of reversible O−O bond cleavage and formation reactions using in situ generated Mn(IV)-peroxo and Mn(V)-oxo corroles.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2010/jacsat.2010.132.issue-40/ja1066465/production/images/medium/ja-2010-066465_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja1066465'>ACS Electronic Supporting Info</A></P>
Lee, E. J.,Jan, A. T.,Baig, M. H.,Ahmad, K.,Malik, A.,Rabbani, G.,Kim, T.,Lee, I.-K.,Lee, Y. H.,Park, S.-Y. Federation of American Societies for Experimental 2018 The FASEB Journal Vol. No.
<P>Interactions between myoblasts and the surrounding microenvironment led us to explore the role of fibromodulin (FMOD), an extracellular matrix protein, in the maintenance of myoblast stemness and function. Microarray analysis of FMODkd myoblasts and in silico studies were used to identify the top most differentially expressed genes in FMODkd, and helped establish that FMOD-based regulations of integral membrane protein 2a and clusterin are essential components of the myogenic program. Studies in knockout, obese, and diabetic mouse models helped characterize the operation of a novel FMOD-based regulatory circuit that controls myoblast switching from a myogenic to a lipid accumulation fate. FMOD regulation of myoblasts is an essential part of the myogenic program, and it offers opportunities for the development of therapeutics for the treatment of different muscle diseases.</P>
Günter Theiβen,Annette Becker,Jorge Cacharron,Wim Deleu,Alexandra Di Rosa,Wolfram Faigl,Akira Kanno,Jan T. Kim,Charlotte Kirchner,Zheng Meng,Thomas Munster,Sunsane Werth,Luzie Ursula Wingen,Kai-U Plant molecular biology and biotechnology research 1998 Proceedings the 2nd Korean-Germany joint symposium Vol.1998 No.-
MADS-box genes (Schwarz-Sommer et al. 1990) contribute significantly to the development of inflorescences and flowers, e.g. by acting as floral meristem or organ identity genes (for recent reviews, see Thei?en and Saedler 1995; Thei?en et al. 1996;Riechmann and Meyerowitz 1997). Up to now, MADS-box genes have mainly been studied in the scientific context of developmental biology, and in eudicotyledonous model plants of little commercial value, such as Antirrhinum and Arabidopsis. The focus of our group is to apply our current knowledge about flower development to breeding research and evolutionary biology. Therefore, we are currently characterizing the MADS-box gene family in the important monocotyledonous crop plant maize (Zea mays ssp. mays), and in other phylogenetic informative taxa, such as the monocots lily (Lilium regale) and tulip (Tulipa gesneriana), the basal angiosperm Cabomba, and non-flowering plnats including the gymnosperm Gnetum gnemon and the ferns Ceratopteris and Ophioglossum.
Genetic variants of inducible costimulator are associated with allergic asthma susceptibility
Andiappan, Anand Kumar,Narayanan, Sriram,Myers, Rachel A.,Lee, Bernett,Nieuwenhuis, Maartje A.,Nardin, Alessandra,Park, Choon-Sik,Shin, Hyoung Doo,Kim, Jeong-Hyun,Westra, Harm-Jan,Franke, Lude,Esko, T Elsevier 2015 The journal of allergy and clinical immunology Vol.135 No.2