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Jeoung Yoon Seo,Johannes Jager 대한환경공학회 2014 Environmental Engineering Research Vol.19 No.2
Percolation is the important process of extracting the soluble constituents of a fine mesh, porous substance by passage of a liquid through it. In this study, bio-wastes were percolated under various conditions through continuous percolation processes, and the energy potential of percolate was evaluated. The representative bio-wastes from the K composting plant in Darmstadt, Germany were used as the sample for percolation. The central objective of this study was to determine the optimal amount of process water and the optimum duration of percolation through the bio-wastes. For economic reasons, the retention time of the percolation medium should be as long as necessary and as short as possible. For the percolation of the bio-wastes, the optimal percolation time was 2 hr and maximum percolation time was 4 hr. After 2 hr, more than two-thirds of the organic substances from the input material were percolated. In the first percolation process, the highest yields of organic substance were achieved. The best percolation of the bio-wastes was achieved when the process water of 2 L for the first percolation procedure and then the process water of 1.5 L for each further percolation procedure for a total 8 L for all five procedures were used on 1,000 g fresh bio-waste. The gas formation potentials of 0.83 and 0.96 Nm3/ton fresh matter (FM) were obtained based on the percolate from 1 hr percolation of 1,000 g bio-waste with the process water of 2 L according to the measurement of the gas formation in 21 days (GB21). This method can potentially contribute to reducing fossil fuel consumption and thus combating climate change.
Quantifying the Precision of Single-Molecule Torque and Twist Measurements Using Allan Variance
van Oene, Maarten M.,Ha, Seungkyu,Jager, Tessa,Lee, Mina,Pedaci, Francesco,Lipfert, Jan,Dekker, Nynke H. Elsevier 2018 Biophysical journal Vol.114 No.8
<P><B>Abstract</B></P> <P>Single-molecule manipulation techniques have provided unprecedented insights into the structure, function, interactions, and mechanical properties of biological macromolecules. Recently, the single-molecule toolbox has been expanded by techniques that enable measurements of rotation and torque, such as the optical torque wrench (OTW) and several different implementations of magnetic (torque) tweezers. Although systematic analyses of the position and force precision of single-molecule techniques have attracted considerable attention, their angle and torque precision have been treated in much less detail. Here, we propose Allan deviation as a tool to systematically quantitate angle and torque precision in single-molecule measurements. We apply the Allan variance method to experimental data from our implementations of (electro)magnetic torque tweezers and an OTW and find that both approaches can achieve a torque precision better than 1 pN · nm. The OTW, capable of measuring torque on (sub)millisecond timescales, provides the best torque precision for measurement times</P> <P> ≲ 10 s, after which drift becomes a limiting factor. For longer measurement times, magnetic torque tweezers with their superior stability provide the best torque precision. Use of the Allan deviation enables critical assessments of the torque precision as a function of measurement time across different measurement modalities and provides a tool to optimize measurement protocols for a given instrument and application.</P>
Stand-alone ClpG disaggregase confers superior heat tolerance to bacteria
Lee, Changhan,Franke, Kamila B.,Kamal, Shady Mansour,Kim, Hyunhee,Lunsdorf, Heinrich,Jager, Jasmin,Nimtz, Manfred,Trč,ek, Janja,Jansch, Lothar,Bukau, Bernd,Mogk, Axel,Romling, Ute National Academy of Sciences 2018 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.115 No.2
<P><B>Significance</B></P><P>Severe heat stress causes massive protein loss by aggregation ultimately causing cell death. Cellular survival relies on protein disaggregation mediated by the Hsp70-ClpB (Hsp100) bichaperone system in most bacteria. <I>Pseudomonas aeruginosa</I> additionally codes for two stand-alone ClpG disaggregases, which had been acquired by horizontal gene transfer by the species and most abundant clone C strains, respectively. These ClpG disaggregases largely contribute to the resolution of protein aggregates to confer superior heat tolerance partially replacing the DnaK-ClpB system.</P><P>AAA+ disaggregases solubilize aggregated proteins and confer heat tolerance to cells. Their disaggregation activities crucially depend on partner proteins, which target the AAA+ disaggregases to protein aggregates while concurrently stimulating their ATPase activities. Here, we report on two potent ClpG disaggregase homologs acquired through horizontal gene transfer by the species <I>Pseudomonas aeruginosa</I> and subsequently abundant <I>P. aeruginosa</I> clone C. ClpG exhibits high, stand-alone disaggregation potential without involving any partner cooperation. Specific molecular features, including high basal ATPase activity, a unique aggregate binding domain, and almost exclusive expression in stationary phase distinguish ClpG from other AAA+ disaggregases. Consequently, ClpG largely contributes to heat tolerance of <I>P. aeruginosa</I> primarily in stationary phase and boosts heat resistance 100-fold when expressed in <I>Escherichia coli</I>. This qualifies ClpG as a potential persistence and virulence factor in <I>P. aeruginosa</I>.</P>
HDAC-targeting epigenetic drug screening for biliary tract cancer
Christian MAYR,Tobias KIESSLICH,Sara ERBER,Dino BEKRIC,Heidemarie DOBIAS,Markus RITTER,Tarkan JAGER,Bettina NEUMAYER,Paul WINKELMANN,Eckhard KLIESER,Daniel NEUREITER 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.-