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Genetic and molecular regulation of flower pigmentation in soybean
Jagadeesh Sundaramoorthy,박규태,이정동,김정회,서학수,송종태 한국응용생명화학회 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.4
Flower color is one of the key traits, which has been widely considered for genetic studies on soybean. A variety of flower colors, such as dark purple, purple, purple blue, purple throat, magenta, pink, near white, and white, has been identified in cultivated soybean (Glycine max). Out of the 19,649 soybean accessions deposited in the United States Department of Agriculture-Germplasm Resources Information Network database, 67 % have purple flowers, 32 % have white flowers, and merely 1 % have flowers with different colors. In contrast, almost all accessions of wild soybean (Glycine soja) have only purple flowers. Flavonoids, mainly anthocyanins, are the most common pigments contributing to flower coloration in soybean. In the recent decades, the flavonoid biosynthesis pathway for anthocyanins has been well established, and some of the genes controlling flower color in soybean have been identified and characterized. Flower pigmentation of soybean is mainly controlled by six independent loci (W1, W2, W3, W4, Wm, and Wp) along with the combination of various other factors such as anthocyanin structure, vacuolar pH, and co-pigments. In this review, we summarize the current status of genetic and molecular regulation of flower pigmentation in cultivated and wild varieties of soybean.
Jagadeesh Sundaramoorthy,Gyu Tae Park,Sajeesh Kappachery,Jeong-Dong Lee,Hak Soo Seo,Jong Tae Song 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07
Soybean [Glycine max (L.) Merr.] seeds are abundant in high-quality proteins and fats. In addition, soybean seeds are also rich in secondary metabolites, such as isoflavones, lecithin, and saponins. Triterpene saponins are major components of these physiologically active metabolites in soybean seeds. Soybean saponins are classified as group A and DDMP saponins. Among them group A saponins are undesirable component of food products due to bitterness and astringency and also cause foaming in tofu production. Whereas, DDMP saponins and their derivatives are less bitter and astringent and beneficial to human health when consumed as regular diet. Therefore, reducing the group A saponins or increasing the DDMP saponins are required to improve the food quality. The present study focused to identify and characterize the gene which is encoding a protein responsible for biosynthesis of DDMP saponins. EMS mutant lines (sg-7-1 & sg-7-2) which lack DDMP saponins were developed. The breeding cross has been made with these two mutants with two cultivars, Pungsannamul and Wooram to study the segregation and genetic linkage analysis, respectively. The segregation analysis showed that the mutant phenotype is controlled by single recessive gene. TLC analysis for phenotyping F2 population of Wooram X sg-7-1 showed mutant, wild and heterozygous types. To surprise two more patterns were detected and they were named as strange type1 (ST1) and strange type2 (ST2). Further, SSR marker analysis will be carried out to locate the gene which encoding a protein responsible for biosynthesis of DDMP saponins.
Isolation of soybean mutants with high and low inorganic phosphorus
( Jagadeesh Sundaramoorthy ),( Yean Joo Seo ),( Gyu Tae Park ),( Jeong-dong Lee ),( Soon-ki Park ),( Hak Soo Seo ),( Jong Tae Song ) 한국응용생명화학회 2016 Journal of Applied Biological Chemistry (J. Appl. Vol.59 No.3
In soybean (Glycine max (L.) Merr.) seeds, phosphorus (P) is primarily stored in the form of phytate, which is generally indigestible by monogastric animals such as human, pig, poultry, and fish. Thus, this study was conducted to isolate soybean mutants with high available P. Inorganic P content was assessed in a total of 1,266 ethyl methanesulfonate (EMS) M4 lines from the Pungsannamul cultivar. Among the tested lines, four EMS lines (PE379, PE432, PE2205, and PE2503) showed higher mean inorganic P (1.21-1.56 g kg-1) than did the Pungsannamul cultivar (0.90 g kg-1). Additionally, six EMS lines (PE718, PE828, PE1466, PE1552, PE3378, and PE3386) showed lower mean inorganic P (0.38-0.60 g kg-1). The high inorganic P mutants isolated in this study will be further investigated for phytate and total P levels. Moreover, the high and low inorganic P lines will be utilized in a future study of the biochemical pathway of phytate.
Non-canonical vs. Canonical Functions of Heme Oxygenase-1 in Cancer
Jagadeesh Achanta Sri Venakata,Fang Xizhu,김성훈,Guillen-Quispe Yanymee N.,Zheng Jie,서영준,Kim Su-Jung 대한암예방학회 2022 Journal of cancer prevention Vol.27 No.1
Heme oxygenase-1 (HO-1) is a critical stress-responsive enzyme that has antioxidant and anti-inflammatory functions. HO-1 catalyzes heme degradation, which gives rise to the formation of carbon monoxide (CO), biliverdin, and iron. The upregulation of HO-1 under pathological conditions associated with cellular stress represents an important cytoprotective defense mechanism by virtue of the anti-oxidant properties of the bilirubin and the anti-inflammatory effect of the CO produced. The same mechanism is hijacked by premalignant and cancerous cells. In recent years, however, there has been accumulating evidence supporting that the upregulation of HO-1 promotes cancer progression, independently of its catalytic activity. Such non-canonical functions of HO-1 are associated with its interaction with other proteins, particularly transcription factors. HO-1 also undergoes post-translational modifications that influence its stability, functional activity, cellular translocation, etc. HO-1 is normally present in the endoplasmic reticulum, but distinct subcellular localizations, especially in the nucleus, are observed in multiple cancers. The nuclear HO-1 modulates the activation of various transcription factors, which does not appear to be mediated by carbon monoxide and iron. This commentary summarizes the non-canonical functions of HO-1 in the context of cancer growth and progression and underlying regulatory mechanisms.
Current Trends in Viral Gene Therapy for Human Orthopaedic Regenerative Medicine
Jagadeesh Kumar Venkatesan,Ana Rey-Rico,Magali Cucchiarini 한국조직공학과 재생의학회 2019 조직공학과 재생의학 Vol.16 No.4
Background: Viral vector-based therapeutic gene therapy is a potent strategy to enhance the intrinsic reparative abilities of human orthopaedic tissues. However, clinical application of viral gene transfer remains hindered by detrimental responses in the host against such vectors (immunogenic responses, vector dissemination to nontarget locations). Combining viral gene therapy techniques with tissue engineering procedures may offer strong tools to improve the current systems for applications in vivo. Methods: The goal of this work is to provide an overview of the most recent systems exploiting biomaterial technologies and therapeutic viral gene transfer in human orthopaedic regenerative medicine. Results: Integration of tissue engineering platforms with viral gene vectors is an active area of research in orthopaedics as a means to overcome the obstacles precluding effective viral gene therapy. Conclusions: In light of promising preclinical data that may rapidly expand in a close future, biomaterial-guided viral gene therapy has a strong potential for translation in the field of human orthopaedic regenerative medicine.