Association between Mismatch Repair Gene MSH3 codons 1036 and 222 Polymorphisms and Sporadic Prostate Cancer in the Iranian Population

Jafary, Fariba,Salehi, Mansoor,Sedghi, Maryam,Nouri, Nayereh,Jafary, Farzaneh,Sadeghi, Farzaneh,Motamedi, Shima,Talebi, Maede Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

The mismatch repair system (MMR) is a post-replicative DNA repair mechanism whose defects can lead to cancer. The MSH3 protein is an essential component of the system. We postulated that MSH3 gene polymorphisms might therefore be associated with prostate cancer (PC). We studied MSH3 codon 222 and MSH3 codon 1036 polymorphisms in a group of Iranian sporadic PC patients. A total of 60 controls and 18 patients were assessed using the polymerase chain reaction and single strand conformational polymorphism. For comparing the genotype frequencies of patients and controls the chi-square test was applied. The obtained result indicated that there was significantly association between G/A genotype of MSH3 codon 222 and G/G genotype of MSH3 codon 1036 with an increased PC risk (P=0.012 and P=0.02 respectively). Our results demonstrated that MSH3 codon 222 and MSH3 codon 1036 polymorphisms may be risk factors for sporadic prostate cancer in the Iranian population.

Vibration and instability of nanocomposite pipes conveying fluid mixed by nanoparticles resting on viscoelastic foundation

Abolfazl Jafari Natanzi,Gholamreza Soleimani Jafari,Reza Kolahchi 사단법인 한국계산역학회 2018 Computers and Concrete, An International Journal Vol.21 No.5

In this study, nonlinear vibration and stability of a polymeric pipe reinforced by single-walled carbon naotubes (SWCNTs) conveying fluid-nanoparticles mixture flow is investigated. The Characteristics of the equivalent composite are determined using Mori-Tanaka model considering agglomeration effects. The surrounding elastic medium is simulated by orthotropic visco-Pasternak medium. Employing nonlinear strains-displacements, stress-strain energy method the governing equations were derived using Hamilton's principal. Differential quadrature method (DQM) is used for obtaining the frequency and critical fluid velocity. The influence of volume percent of SWCNTs, agglomeration, geometrical parameters of pipe, viscoelastic foundation and fluid velocity are shown on the frequency and critical fluid velocity of pipe. Results showed the increasing volume percent of SWCNTs leads to higher frequency and critical fluid velocity.

Designing an Emotional Intelligent Controller for IPFC to Improve the Transient Stability Based on Energy Function

Jafari, Ehsan,Marjanian, Ali,Solaymani, Soodabeh,Shahgholian, Ghazanfar The Korean Institute of Electrical Engineers 2013 Journal of Electrical Engineering & Technology Vol.8 No.3

The controllability and stability of power systems can be increased by Flexible AC Transmission Devices (FACTs). One of the FACTs devices is Interline Power-Flow Controller (IPFC) by which the voltage stability, dynamic stability and transient stability of power systems can be improved. In the present paper, the convenient operation and control of IPFC for transient stability improvement are considered. Considering that the system's Lyapunov energy function is a relevant tool to study the stability affair. IPFC energy function optimization has been used in order to access the maximum of transient stability margin. In order to control IPFC, a Brain Emotional Learning Based Intelligent Controller (BELBIC) and PI controller have been used. The utilization of the new controller is based on the emotion-processing mechanism in the brain and is essentially an action selection, which is based on sensory inputs and emotional cues. This intelligent control is based on the limbic system of the mammalian brain. Simulation confirms the ability of BELBIC controller compared with conventional PI controller. The designing results have been studied by the simulation of a single-machine system with infinite bus (SMIB) and another standard 9-buses system (Anderson and Fouad, 1977).

6-DOF extension of memory-based passivation approach for stable haptic interaction

Jafari, A.,Ryu, J. H. SPRINGER SCIENCE + BUSINESS MEDIA 2015 Intelligent service robotics Vol.8 No.1

Optimizing Bi-Objective Multi-Echelon Multi-Product Supply Chain Network Design Using New Pareto-Based Approaches

Jafari, Hamid Reza,Seifbarghy, Mehdi Korean Institute of Industrial Engineers 2016 Industrial Engineeering & Management Systems Vol.15 No.4

The efficiency of a supply chain can be extremely affected by its design which includes determining the flow pattern of material from suppliers to costumers, selecting the suppliers, and defining the opened facilities in network. In this paper, a multi-objective multi-echelon multi-product supply chain design model is proposed in which several suppliers, several manufacturers, several distribution centers as different stages of supply chain cooperate with each other to satisfy various costumers' demands. The multi-objectives of this model which considered simultaneously are 1-minimize the total cost of supply chain including production cost, transportation cost, shortage cost, and costs of opening a facility, 2-minimize the transportation time from suppliers to costumers, and 3-maximize the service level of the system by minimizing the maximum level of shortages. To configure this model a graph theoretic approach is used by considering channels among each two facilities as links and each facility as the nodes in this configuration. Based on complexity of the proposed model a multi-objective Pareto-based vibration damping optimization (VDO) algorithm is applied to solve the model and finally non-dominated sorting genetic algorithm (NSGA-II) is also applied to evaluate the performance of MOVDO. The results indicated the effectiveness of the proposed MOVDO to solve the model.

Participation of the Women Covered by Family Physicians in Breast Cancer Screening Program in Kerman, Iran

Jafari, Mohammad,Nakhaee, Nouzar,Goudarzi, Reza,Zehtab, Nooshin,Barouni, Mohsen Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.11

Background: Mammography screening is a method for reducing breast cancer mortality in women over 40 years old. A participation rate of at least 70% is a prerequisite for screening programs. This study aimed at determining the participation rate of women in breast cancer screening in Iran. Materials and Methods: The study population in this prospective research consisted of 35 to 69 years old women in the villages and towns Kerman District, in 2013. The data were collected by a well-validated risk assessment questionnaire. The questionnaires were completed with the help of health workers and technicians in the health centers, who were trained on breast cancer screening program. Results: As a whole, 19,651 women were invited to complete the questionnaire, of whom 15,794 women (80.37%) completed it. In the urban region, of 3150 eligible women 2728 women (86.60%) participated in the study. The acceptance rates for mammography in rural and urban regions were 34.95% and 8.75%, respectively. Conclusions: Finally, 3.8% and 16.34% of 35 to 69 years old women in the urban regions were mammographed, respectively. Conclusion: The low participation of eligible women in breast cancer screening program alerts us against including the program in the health insurance package.

REMARKS ON THE INNER POWER OF GRAPHS

JAFARI, S.,ASHRAFI, A.R.,FATH-TABAR, G.H.,TAVAKOLI, Mostafa The Korean Society for Computational and Applied M 2017 Journal of applied mathematics & informatics Vol.35 No.1

Let G be a graph and k is a positive integer. Hammack and Livesay in [The inner power of a graph, Ars Math. Contemp., 3 (2010), no. 2, 193-199] introduced a new graph operation $G^{(k)}$, called the $k^{th}$ inner power of G. In this paper, it is proved that if G is bipartite then $G^{(2)}$ has exactly three components such that one of them is bipartite and two others are isomorphic. As a consequence the edge frustration index of $G^{(2)}$ is computed based on the same values as for the original graph G. We also compute the first and second Zagreb indices and coindices of $G^{(2)}$.

Exploring Factors Related to Metastasis Free Survival in Breast Cancer Patients Using Bayesian Cure Models

Jafari-Koshki, Tohid,Mansourian, Marjan,Mokarian, Fariborz Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22

Background: Breast cancer is a fatal disease and the most frequently diagnosed cancer in women with an increasing pattern worldwide. The burden is mostly attributed to metastatic cancers that occur in one-third of patients and the treatments are palliative. It is of great interest to determine factors affecting time from cancer diagnosis to secondary metastasis. Materials and Methods: Cure rate models assume a Poisson distribution for the number of unobservable metastatic-component cells that are completely deleted from the non-metastasis patient body but some may remain and result in metastasis. Time to metastasis is defined as a function of the number of these cells and the time for each cell to develop a detectable sign of metastasis. Covariates are introduced to the model via the rate of metastatic-component cells. We used non-mixture cure rate models with Weibull and log-logistic distributions in a Bayesian setting to assess the relationship between metastasis free survival and covariates. Results: The median of metastasis free survival was 76.9 months. Various models showed that from covariates in the study, lymph node involvement ratio and being progesterone receptor positive were significant, with an adverse and a beneficial effect on metastasis free survival, respectively. The estimated fraction of patients cured from metastasis was almost 48%. The Weibull model had a slightly better performance than log-logistic. Conclusions: Cure rate models are popular in survival studies and outperform other models under certain conditions. We explored the prognostic factors of metastatic breast cancer from a different viewpoint. In this study, metastasis sites were analyzed all together. Conducting similar studies in a larger sample of cancer patients as well as evaluating the prognostic value of covariates in metastasis to each site separately are recommended.

Induction of Apoptosis and Cell Cycle Arrest by Dorema Glabrum Root Extracts in a Gastric Adenocarcinoma (AGS) Cell Line

Jafari, Naser,Zargar, Seyed Jalal,Yassa, Narguess,Delnavazi, Mohammad Reza Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.12

Objective: Dorema glabrum Fisch. & C.A. Mey is a perennial plant that has several curative properties. Anti-proliferative activity of seeds of this plant has been demonstrated in a mouse fibrosarcoma cell line. The aim of the present study was to evaluate cytotoxicity of D. glabrum root extracts in a human gastric adenocarcinoma (AGS) cell line and explore mechanisms of apoptosis induction, cell cycle arrest and altered gene expression in cancer cells. Materials and Methods: The MTT assay was used to evaluate IC50 values, EB/AO staining to analyze the mode of cell death, and flow cytometry to assess the cell cycle. Quantitative real-time polymerase chain reaction (qRT-PCR) amplification was performed with apoptosis and cell cycle-related gene primers, for cyclin D1, c-myc, survivin, VEGF, Bcl-2, Bax, and caspase-3 to determine alteration of gene expression. Results: Our results showed that n-hexane and chloroform extracts had greatest toxic effects on gastric cancer cells with IC50 values of $6.4{\mu}g/ml$ and $4.6{\mu}g/ml$, respectively, after 72 h. Cell cycle analysis revealed that the population of treated cells in the G1 phase was increased in comparison to controls. Cellular morphological changes indicated induction of apoptosis. In addition, mRNA expression levels of Bax and caspase-3 were increased, and of bcl-2 survivin, VEGF, c-myc and cyclin D1 were decreased. Conclusion: Our study results suggest that D. glabrum has cytotoxic effects on AGS cells, characterized by enhanced apoptosis, reduced cell viability and arrest of cell cycling.

Phage Particles as Vaccine Delivery Vehicles: Concepts, Applications and Prospects

Jafari, Narjes,Abediankenari, Saeid Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.18

The development of new strategies for vaccine delivery for generating protective and long-lasting immune responses has become an expanding field of research. In the last years, it has been recognized that bacteriophages have several potential applications in the biotechnology and medical fields because of their intrinsic advantages, such as ease of manipulation and large-scale production. Over the past two decades, bacteriophages have gained special attention as vehicles for protein/peptide or DNA vaccine delivery. In fact, whole phage particles are used as vaccine delivery vehicles to achieve the aim of enhanced immunization. In this strategy, the carried vaccine is protected from environmental damage by phage particles. In this review, phage-based vaccine categories and their development are presented in detail, with discussion of the potential of phage-based vaccines for protection against microbial diseases and cancer treatment. Also reviewed are some recent advances in the field of phagebased vaccines.